Otay Mesa Travel Guide
Tourist Guide
Popular places to visit
San Diego Zoo
Admire the animal kingdom in all its fascinating glory at one of America’s largest zoos.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and entertainment choices.
SeaWorld
Meet the ocean’s most fascinating creatures face to face at this exhilarating and informative aquatic attraction.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Balboa Park
Discover endless entertainment possibilities in San Diego’s world-famous urban park.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Activities
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
Tijuana Downtown Self Guided Walking Tour
Crossing Borders: Tijuana Day Trip from San Diego
Crossing Borders: Tijuana Day Trip from San Diego
Stand up Paddle Board Lesson on The San Diego Bay
Our pick of the best Otay Mesa Hotel Deals
Sheraton San Diego Resort
The room was clean, the staff was great. We left for the day and forgot to remove the "privacy" sign. We didn't get clean towels and our dirty ones were on the floor. It was totally our fault that we didn't get clean towels. I requested some and they were very understanding and very prompt at getting ...
Reviewed on 1 Jan 2026
Bay Club Hotel & Marina
Comfortable beds
Reviewed on 1 Jan 2026
The DEXTRO Little Italy, BW Premier Collection
Great time!
Reviewed on 1 Jan 2026
Courtyard by Marriott San Diego Downtown Little Italy
The big surprise is the Saturday farmers market right around the corner—such a great location!
Reviewed on 2 Jan 2026
DoubleTree by Hilton Hotel San Diego - Mission Valley
Great location, close to the Mission Valley mall. Also we could walk to Barns and Nobles for 5 min. A small store on the 1st floor is also good.
Reviewed on 30 Dec 2025
Hilton San Diego Mission Valley
Loved the easy check in process via the app!
Reviewed on 28 Dec 2025
Other neighbourhoods around Otay Mesa
East Village
Travellers choose East Village for its great bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Marina District
Known for its fantastic nightlife and captivating waterfront views, there's plenty to explore in Marina District. Check out top attractions like Seaport Village and The Rady Shell at Jacobs Park, and jump on the metro at Seaport Village Station or Convention Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Otay Mesa Travel Guide
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