Otay Mesa Travel Guide
Tourist Guide
Popular places to visit
San Diego Zoo
Admire the animal kingdom in all its fascinating glory at one of America’s largest zoos.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and acclaimed art galleries.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Mission Beach
Soak up the perfect holiday atmosphere at this enduring, lively seaside village.
SeaWorld
Meet the ocean’s most fascinating creatures face to face at this exhilarating and informative aquatic attraction.
Balboa Park
Discover endless entertainment possibilities in San Diego’s world-famous urban park.
Activities
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
Tijuana Downtown Self Guided Walking Tour
Crossing Borders: Tijuana Day Trip from San Diego
Tijuana: Guided City Tour with Local Food and Beer Tasting
Our pick of the best Otay Mesa Hotel Deals
Paradise Point Resort & Spa
Family & per friendly resort! Fast service, staff are accommodating! We love to comeback again!
Reviewed on 4 Apr 2026
Best Western Seven Seas
No breakfast
Reviewed on 3 Apr 2026
Hard Rock Hotel San Diego
Handlery Hotel
A little outdated but clean.
Reviewed on 4 Apr 2026
The DEXTRO Little Italy, BW Premier Collection
Near busy highway and overpass . Pool area noisy due to highway. Gym ok Could walk to little Italy restaraunts
Reviewed on 4 Apr 2026
Manchester Grand Hyatt San Diego
Great overall experience. The staff we’re helpful and polite. The room was nice and the views are amazing. The hotel has many great food options, you don’t have to go far to enjoy your visit.
Reviewed on 4 Apr 2026
Other neighbourhoods around Otay Mesa
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Mission Valley
Known for its stunning beaches and popular shops, there's plenty to explore in Mission Valley. Check out top attractions like Mission Valley Mall and Fashion Valley Mall, and jump on the metro at Hazard Center Station or Mission Valley Center Station to see more of the city.
Otay Mesa Travel Guide
Explore a world of travel with Expedia
- Otay Hotels
- Hotels near Len Moore Skate Park
- Chula Vista Hotels
- Otay Mesa Hotels
- San Ysidro Hotels
- Nestor Hotels
- Hotels near Brown Field Municipal
- Otay Mesa West Hotels
- Hotels near Palm Ave Trolley Station
- Bonita Hotels
- Eastlake Hotels
- Hotels near Sky Zone San Diego Indoor Trampoline Park
- Hotels near San Ysidro Border Crossing
- Hotels near Chula Vista Elite Athlete Training Center
- Boutique Hotels in South Bay
- Cheap Hotels in Otay Mesa
- Beach Hotels in South San Diego
- Romantic Hotels in South San Diego
- Family Hotels in South San Diego
- Apartments in Chula Vista
- B&B in Chula Vista
- Residences in Chula Vista
- Hostels in San Ysidro
- Villas in South Bay
- Holiday Homes in South Bay
- Cottages in South Bay
- Guest Houses in South Bay
- Serviced Apartments in South Bay
- Apartments in South Bay
- Holiday Homes in Imperial Beach
- Apartments in Imperial Beach
- Best Western Hotels in San Ysidro
- Flights from Los Angeles (LAX) to San Diego (SDM)
- Flights from Denver (DEN) to San Diego (SDM)
- Flights from Houston (IAH) to San Diego (SDM)
- Flights from Hartford (BDL) to San Diego (SDM)
- Flights from Orange County (SNA) to San Diego (SDM)
- Flights from San Francisco (SFO) to San Diego (SDM)
- Flights from Long Beach (LGB) to San Diego (SDM)
- Flights from Hong Kong (HKG) to San Diego (SDM)
- Flights from Las Vegas (LAS) to San Diego (SDM)
- Flights from Sydney (SYD) to San Diego (SDM)
- Flights from Henderson (HSH) to San Diego (SDM)
- Flights from Boston (BOS) to San Diego (SDM)
- Flights to San Ysidro
- Flights to Chula Vista
- Flights from Brown Field Municipal
- San Ysidro Border Crossing
- Sky Zone San Diego Indoor Trampoline Park
- Sharp Chula Vista Medical Center
- Chula Vista Center
- Chula Vista Elite Athlete Training Center
- North Island Credit Union Amphitheatre
- Kaiser Permanente Otay Mesa Medical Offices
- Las Americas Premium Outlets
- Visit Coronado
- Visit Jamul
- Visit University Heights
- Visit Encanto
- Visit Chula Vista
- Visit Logan Heights
- Visit Eastlake Greens
- Visit East County
- Visit Dulzura
- Visit Otay Mesa West
- Visit La Mesa
- Visit El Cajon
- Visit Bonita
- Visit San Diego County
- Visit Jamacha
- Visit National City
- Visit Barrio Logan
- Visit Marina District
- Visit Point Loma
- Visit Lemon Grove
- Visit Tierrasanta
- Visit San Diego
- Visit Liberty Station
- Visit Civic Core
- Visit Little Italy
- Visit Rancho del Rey
- Visit Gaslamp Quarter
- Visit Bostonia
- Visit Otay
- Visit Bay Terraces
