Otay Mesa Travel Guide
Tourist Guide
Popular places to visit

San Diego Zoo
Admire the animal kingdom in all its fascinating glory at one of America’s largest zoos.

San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's acclaimed art galleries and entertainment choices.

Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

SeaWorld
Meet the ocean’s most fascinating creatures face to face at this exhilarating and informative aquatic attraction.

Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.

Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Activities

Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego

Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

Tijuana Downtown Self Guided Walking Tour

Crossing Borders: Tijuana Day Trip from San Diego
Our pick of the best Otay Mesa Hotel Deals

Hotel del Coronado, Curio Collection by Hilton
Room was amazing! They upgraded us to a garden view. Very clean. Loved the resort!
Reviewed on 12 Nov 2025

Legacy Resort Hotel & Spa
Room was clean and spacious
Reviewed on 14 Nov 2025

Hilton San Diego Mission Valley
Room was spotless, nice room. Good area
Reviewed on 15 Nov 2025

Bay Club Hotel & Marina
Dining was lovely overlooking the marina. Staff was friendly, courteous. Would stay here again
Reviewed on 15 Nov 2025

Hampton Inn & Suites by Hilton San Diego SeaWorld
Hotel, inside and outside clean. Rooms, lobby and gym and hallways clean, spacious, sufficient elevators. Modern, new and spacious. Gym was real nice with good equipment. The staff was real professional and friendly. Breakfast was delicious. The streets/areas/traffic near me of the hotel were ...
Reviewed on 15 Nov 2025

Hard Rock Hotel San Diego
Great time comfy bed great customer service. I will be back
Reviewed on 15 Nov 2025
Other neighbourhoods around Otay Mesa

East Village
Travellers choose East Village for its great bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.

Mid-City
While you're in Mid-City, take in top sights like Cal Coast Credit Union Open Air Theater or Viejas Arena, and hop on the metro to see more of the city at SDSU Transit Center Station or Alvarado Station.

Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.

Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.

Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Otay Mesa Travel Guide
- Places of interest
- What kind of hotels are in Otay Mesa?
- Hotels Near San Diego, California
- More holiday ideas
What kind of hotels are in Otay Mesa?
Are there hotels near Otay Mesa?
Expedia's Latest Trends
- Visit Downtown Los Angeles
- Visit Century City
- Visit Union Square
- Visit Koreatown
- Visit Fisherman's Wharf
- Visit Toluca Lake
- Visit Haight-Ashbury
- Visit Hollywood Hills
- Visit Bel Air
- Visit Hollywood
- Visit Mid-Wilshire
- Visit Downtown San Francisco
- Visit Ocean Beach
- Visit Nob Hill
- Visit Crenshaw
- Visit Mission District
- Visit Montecito
- Visit Skid Row


