Otay Mesa Travel Guide
Tourist Guide
Popular places to visit

San Diego Zoo
Admire the animal kingdom in all its fascinating glory at one of America’s largest zoos.

San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and entertainment choices.

Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.

Mission Beach
Soak up the perfect holiday atmosphere at this enduring, lively seaside village.

SeaWorld
Meet the ocean’s most fascinating creatures face to face at this exhilarating and informative aquatic attraction.
Activities

Crossing Borders: Tijuana Day Trip from San Diego

San Diego USS Midway with Waterfront Walking Tour

Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego

From Tijuana: Valle de Guadalupe Private Winery Tour
Our pick of the best Otay Mesa Hotel Deals

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Reviewed on 21 Jul. 2025

Handlery Hotel
Reviewed on 23 Jul. 2025

Wyndham San Diego Bayside
Reviewed on 22 Jul. 2025

Manchester Grand Hyatt San Diego
Reviewed on 21 Jul. 2025

The Dana on Mission Bay
Reviewed on 24 Jul. 2025

Marriott Marquis San Diego Marina
Reviewed on 19 Jul. 2025
Other neighbourhoods around Otay Mesa

Mid-City
While you're in Mid-City, take in top sights like Cal Coast Credit Union Open Air Theater or Viejas Arena, and hop on the metro to see more of the city at SDSU Transit Center Station or Alvarado Station.

Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.

Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.

Del Cerro
While there might not be top attractions in Del Cerro, you can explore the larger area and discover places like Cal Coast Credit Union Open Air Theater and Viejas Arena.
- Places of interest
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- Hotels Near San Diego, California
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