Otay Mesa Travel Guide
Tourist Guide
Popular places to visit
Gaslamp Quarter
The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.
San Diego Zoo
Admire the animal kingdom in all its fascinating glory at one of America’s largest zoos.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and acclaimed art galleries.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Mission Beach
Soak up the perfect holiday atmosphere at this enduring, lively seaside village.
SeaWorld
Meet the ocean’s most fascinating creatures face to face at this exhilarating and informative aquatic attraction.
Activities
Crossing Borders: Tijuana Day Trip from San Diego
Crossing Borders: Tijuana Day Trip from San Diego
From Tijuana: Valle de Guadalupe Shared Winery Tour
Stand up Paddle Board Lesson on The San Diego Bay
Our pick of the best Otay Mesa Hotel Deals
Paradise Point Resort & Spa
Best Western Seven Seas
No breakfast
Reviewed on 3 Apr 2026
Hard Rock Hotel San Diego
Handlery Hotel
Bathrooms are very small.
Reviewed on 3 Apr 2026
The DEXTRO Little Italy, BW Premier Collection
I wasn't aware of the airport shuttle, took an expensive cab. a cruise shuttle would have been great, given the close proximity to the port. The hotel had a good bar with a wonderful bartender.
Reviewed on 2 Apr 2026
Manchester Grand Hyatt San Diego
We booked two rooms for two nights. When we arrived, the rooms weren’t ready so they offered us an upgrade to the penthouse suite at no additional charge. The suite belonged to the former owner of the hotel as a private residence. It was beautiful, spacious, first class with amazing views. The thermostat ...
Reviewed on 2 Apr 2026
Other neighbourhoods around Otay Mesa
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Mission Valley
Known for its stunning beaches and popular shops, there's plenty to explore in Mission Valley. Check out top attractions like Mission Valley Mall and Fashion Valley Mall, and jump on the metro at Hazard Center Station or Mission Valley Center Station to see more of the city.
Otay Mesa Travel Guide
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