Otay Mesa West Travel Guide

Tourist Guide

Photo by Leonardo De Leon
Photo by Leonardo De Leon

Popular places to visit

Activities


Our pick of the best Otay Mesa West Hotel Deals

Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
8/10 Very Good! (1,921 reviews)
Exceptional Staff / Front Desk Experience
"This hotel experience was exceptional because of the staff (thanks Pamela!) and care they took to ensure our stay was the best possible. I was there for Comic-Con and through the chaos we had a shuttle that ran every 15-20 minutes, a room with comfortable pillows and a view of the pool, reasonable ..."

Reviewed on 27 Jul. 2025

Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NZ$343 per night from 31 July to 1 Aug
NZ$343
31 July - 1 Aug
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,794 reviews)
"Very nice property and friendly staff."

Reviewed on 27 Jul. 2025

Wyndham San Diego Bayside
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
The price is NZ$486 per night from 28 Aug to 29 Aug
NZ$486
28 Aug - 29 Aug
includes taxes & fees
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,810 reviews)
"Just the perfect area with a view."

Reviewed on 28 Jul. 2025

Manchester Grand Hyatt San Diego
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
The price is NZ$320 per night from 25 Aug to 26 Aug
NZ$320
25 Aug - 26 Aug
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.8/10 Excellent! (3,599 reviews)
"Very clean, everyday the staff would come to clean the room. Ambience very calm suitable for family."

Reviewed on 26 Jul. 2025

The Dana on Mission Bay
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4 out of 5
333 W Harbor Dr, San Diego, CA
The price is NZ$527 per night from 17 Aug to 18 Aug
NZ$527
17 Aug - 18 Aug
includes taxes & fees
Book a stay at this spa hotel in San Diego. Enjoy 2 outdoor pools, a full-service spa, and 5 restaurants. Our guests praise the pool and the helpful staff in ...
9/10 Wonderful! (1,791 reviews)
"Great place to stay."

Reviewed on 26 Jul. 2025

Marriott Marquis San Diego Marina
The Dextro Hotel, BW Premier Collection

The Dextro Hotel, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
The price is NZ$262 per night from 4 Aug to 5 Aug
NZ$262
4 Aug - 5 Aug
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
7.6/10 Good! (1,055 reviews)
"Wish there were more dining options"

Reviewed on 27 Jul. 2025

The Dextro Hotel, BW Premier Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Otay Mesa West

Gaslamp Quarter featuring a bar, street scenes and a city

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

Gaslamp Quarter
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Downtown San Diego

4.5/5(100 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Downtown San Diego
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Little Italy

Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.

Little Italy
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North Park

North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.

North Park
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Mid-City

While you're in Mid-City, take in top sights like Cal Coast Credit Union Open Air Theater or Viejas Arena, and hop on the metro to see more of the city at SDSU Transit Center Station or Alvarado Station.

Mid-City
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Hillcrest

Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.

Hillcrest

Otay Mesa West Travel Guide

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