Otay Mesa West Travel Guide

Tourist Guide

Photo by Leonardo De Leon
Photo by Leonardo De Leon

Popular places to visit

Activities


Our pick of the best Otay Mesa West Hotel Deals

Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
The price is NZ$244 per night from 17 Aug to 18 Aug
NZ$244
17 Aug - 18 Aug
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
8/10 Very Good! (1,885 reviews)
"It was a nice, quiet area. Perfect for a lowkey getaway"

Reviewed on 20 Jul. 2025

Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
The price is NZ$325 per night from 28 July to 29 July
NZ$325
28 July - 29 July
includes taxes & fees
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
8.2/10 Very Good! (5,767 reviews)
"Walking distance from everything"

Reviewed on 22 Jul. 2025

Wyndham San Diego Bayside
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
The price is NZ$471 per night from 28 July to 29 July
NZ$471
28 July - 29 July
includes taxes & fees
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
9/10 Wonderful! (2,791 reviews)
"Enjoyed my stay at this place. Friendly and courteous staff"

Reviewed on 21 Jul. 2025

Manchester Grand Hyatt San Diego
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
The price is NZ$343 per night from 10 Aug to 11 Aug
NZ$343
10 Aug - 11 Aug
includes taxes & fees
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
8.8/10 Excellent! (3,577 reviews)
"Love the resort!!"

Reviewed on 21 Jul. 2025

The Dana on Mission Bay
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4 out of 5
333 W Harbor Dr, San Diego, CA
The price is NZ$525 per night from 28 July to 29 July
NZ$525
28 July - 29 July
includes taxes & fees
Book a stay at this spa hotel in San Diego. Enjoy 2 outdoor pools, a full-service spa, and 5 restaurants. Our guests praise the pool and the helpful staff in ...
9/10 Wonderful! (1,770 reviews)
"Great hotel, everything nice"

Reviewed on 19 Jul. 2025

Marriott Marquis San Diego Marina
The Dextro Hotel, BW Premier Collection

The Dextro Hotel, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
The price is NZ$235 per night from 29 July to 30 July
NZ$235
29 July - 30 July
includes taxes & fees
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
7.6/10 Good! (1,030 reviews)
"Parking was confusing and the staff was knowledgeable about the area. The room is OK and the location was great. I had asked for my room to be cleaned twice and they were only doing it one time but it wasn’t a dealbreaker. I’d stay here again because now I know the lay of the land"

Reviewed on 22 Jul. 2025

The Dextro Hotel, BW Premier Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Otay Mesa West

Gaslamp Quarter featuring a bar, street scenes and a city

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

Gaslamp Quarter
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Downtown San Diego

4.5/5(100 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Downtown San Diego
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Little Italy

Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.

Little Italy
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North Park

North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.

North Park
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Mid-City

While you're in Mid-City, take in top sights like Cal Coast Credit Union Open Air Theater or Viejas Arena, and hop on the metro to see more of the city at SDSU Transit Center Station or Alvarado Station.

Mid-City
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Hillcrest

Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.

Hillcrest

Otay Mesa West Travel Guide

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