Otay Mesa Holidays

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Our guide on where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
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Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(100 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Our pick of the best Otay Mesa Hotel Deals

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NZ$324 per night from 26 Oct to 27 Oct
NZ$324
26 Oct - 27 Oct
includes taxes & fees
8.2/10 Very Good! (6,004 reviews)
"Great that there is an airport shuttle. Very convenient to cruise terminal."

Reviewed on 12 Oct 2025

Wyndham San Diego Bayside
Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

3 out of 5
3888 Greenwood St, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NZ$262 per night from 27 Oct to 28 Oct
NZ$262
27 Oct - 28 Oct
includes taxes & fees
9/10 Wonderful! (165 reviews)
"Nice hotel, love the remodeling and colors."

Reviewed on 16 Oct 2025

Hampton Inn & Suites by Hilton San Diego SeaWorld
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NZ$579 per night from 29 Oct to 30 Oct
NZ$579
29 Oct - 30 Oct
includes taxes & fees
9/10 Wonderful! (2,853 reviews)
"We had a studio suite on the 38th floor and the view was amazing. It was a nice, spacious room, but the bathroom was so tiny and the bed was not very comfortable. The bellman mentioned that there are upgrades planned in the near future though..."

Reviewed on 17 Oct 2025

Manchester Grand Hyatt San Diego
See all 4,835 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa holiday package cost?
Starting from as low as , a holiday package is your ticket to cheaper travel. Create your own Otay Mesa escape by choosing from our wide range of hotels, airfares and rental cars.
How do I get a cheap travel package to Otay Mesa?
Our Otay Mesa holiday packages mean plenty of savings for the savvy wanderer. For the best deal, simply bundle your hotel, flights and extras (such as activities) into a neat and tidy package. But impressive bargains are only the start of your next amazing adventure. When you book with Expedia, you'll have more than 550 air carriers and 1 000 000 hotel options all over the world to pick from. No matter your budget or style, there's a package that's perfect for you.
Where should I stay in Otay Mesa?
A getaway to Otay Mesa wouldn't be complete without paying a visit to North Island Credit Union Amphitheatre, Aquatica and White Water Canyon. Spend your evenings close to these tourist attractions and make sightseeing simple.
What are the top hotels in Otay Mesa?
Book a stay at Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel. It's one of this neighbourhood's most sought-after hotels. Another reputable option in Otay Mesa is Quality Suites San Diego Otay Mesa.
How far in advance should I book my Otay Mesa holiday?
Your best bet is to book early. Air carriers typically release flights around a year prior to departure, and this is an ideal opportunity to score some rock-bottom prices. Boss just told you to take your holiday time next month? That's alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia Otay Mesa travel package include?
It comes down to what you want. If you're travelling alone, you might decide to bundle flights and hotels. Bringing the entire family to Otay Mesa? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking an Otay Mesa travel package?
When you book your flights, hotels and car rentals together, you'll land terrific discounts. Whether you're organising an island getaway in a villa or prefer to stay in a cosy apartment in the city, Expedia can help make it happen.
Can I choose my airline with an Otay Mesa Expedia holiday package?
You can, and with over 550 airlines to select from worldwide, you have loads of choice. Look through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Otay Mesa holiday package?
Don't worry if you're rethinking your Otay Mesa holiday package — it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We get that life can sometimes throw a spanner in the works, so make your way to our Customer Service Portal if that happens. When you're ready to make changes, we're ready to help.

Discover the most popular places to visit in Otay Mesa

San Diego Zoo which includes a pond, zoo animals and landscape views

San Diego Zoo

4.5/5(26 reviews)

Admire the animal kingdom in all its fascinating glory at one of America’s largest zoos.

San Diego Zoo
Mission Bay showing a beach

Mission Bay

4/5(10 reviews)

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay
Petco Park

Petco Park

4.5/5(10 reviews)

Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.

Petco Park

Activities

Having a taste of Mexico

Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego

NZ$128
per adult
92% of travellers recommend
Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

NZ$233
per adult
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
Tijuana Downtown Self Guided Walking Tour

Tijuana Downtown Self Guided Walking Tour

NZ$17
per adult
100% of travellers recommend
Tijuana Downtown Self Guided Walking Tour
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.