Otay Mesa Hotels, San Diego

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Our top choices for Otay Mesa hotels

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,001 reviews)
"Great staff.. location close to the airport!"
United States
Vivian
The price is NZ$187
includes taxes & fees
15 Feb - 16 Feb
Quality Suites San Diego Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.0 out of 10, Very good, (1,643 reviews)
"Clean, great breakfast, good service."
United States
Sara
The price is NZ$243
includes taxes & fees
8 Mar - 9 Mar
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
29.8 km from Otay Mesa
8.0 out of 10, Very good, (1,003 reviews)
"Great stay"
United States
Viviann
The price is NZ$185
includes taxes & fees
8 Mar - 9 Mar
Crowne Plaza San Diego - Mission Valley by IHG

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.4 out of 10, Very good, (3,322 reviews)
"Love this hotel will always stay here when I come to San Diego "
United States
Darlene
The price is NZ$414
includes taxes & fees
7 Mar - 8 Mar
Sheraton San Diego Resort

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
7.8 out of 10, Good, (1,613 reviews)
"Clean rooms and the breakfast was amazing "
United States
Vanessa
The price is NZ$188
includes taxes & fees
8 Mar - 9 Mar
Best Western Chula Vista/Otay Valley Hotel

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.2 out of 10, Wonderful, (1,732 reviews)
"Very clean resort. "
United States
Petrina
The price is NZ$215
includes taxes & fees
17 Feb - 18 Feb
Sycuan Casino Resort

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
26.8 km from Otay Mesa
9.4 out of 10, Exceptional, (1,468 reviews)
"Stunning hotel, I could have stayed there all day looking at every little design detail. "
United States
Holly
The price is NZ$435
includes taxes & fees
23 Feb - 24 Feb
Lafayette Hotel & Club

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3,724 reviews)
"My favorite place to stay"
United States
Rubidia
The price is NZ$261
includes taxes & fees
15 Feb - 16 Feb
Best Western Plus Marina Gateway Hotel

Motel 6 El Cajon, CA - San Diego

Motel 6 El Cajon, CA - San Diego
2.0 star property
27 km from Otay Mesa
7.4 out of 10, Good, (1,537 reviews)
"We only stayed one night but it was comfortable and clean "
United States
Brandy
The price is NZ$119
includes taxes & fees
22 Feb - 23 Feb
Motel 6 El Cajon, CA - San Diego

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 33.1 km from Otay Mesa
8.4 out of 10, Very good, (1,348 reviews)
"Great place for our family getaway! Loved the S’mores on the beach! "
United States
Dani
The price is NZ$466
includes taxes & fees
1 Mar - 2 Mar
San Diego Mission Bay Resort

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
31.3 km from Otay Mesa
7.4 out of 10, Good, (4,149 reviews)
"Good location friendly staff"
United States
Anya
The price is NZ$161
includes taxes & fees
22 Feb - 23 Feb
Wyndham Garden San Diego Near SeaWorld

Ocean Villa Inn

Ocean Villa Inn
2.5 star property
Ocean Beach, 33.7 km from Otay Mesa
8.0 out of 10, Very good, (1,169 reviews)
"Beds are super comfy clean and renovated"
United States
Esmeralda
Ocean Villa Inn

Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town
3.0 star property
30.8 km from Otay Mesa
9.2 out of 10, Wonderful, (623 reviews)
"Great place to stay, nice room Highly recommended !!"
United States
Wilfredo
The price is NZ$225
includes taxes & fees
22 Feb - 23 Feb
Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (581 reviews)
"Clean room and friendly staff "
United States
Michael
The price is NZ$328
includes taxes & fees
15 Mar - 16 Mar
SpringHill Suites by Marriott Chula Vista Eastlake

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,211 reviews)
"Great stay"
United States
Elisa
The price is NZ$217
includes taxes & fees
22 Feb - 23 Feb
Best Western Americana Inn

Bahia Resort Hotel

Bahia Resort Hotel
3.5 star property
Central Mission Beach, 34.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,878 reviews)
"Amazing place "
United States
Richard
The price is NZ$382
includes taxes & fees
1 Mar - 2 Mar
Bahia Resort Hotel

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
25.7 km from Otay Mesa
8.4 out of 10, Very good, (6,028 reviews)
"Great place to stay"
United States
David
The price is NZ$350
includes taxes & fees
16 Feb - 17 Feb
Wyndham San Diego Bayside

Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego
2.5 star property
24.6 km from Otay Mesa
8.4 out of 10, Very good, (1,006 reviews)
"Room was clean, pleasant staff and great breakfast "
United States
Wendy
The price is NZ$203
includes taxes & fees
22 Feb - 23 Feb
Best Western Plus La Mesa San Diego

Paradise Point Resort & Spa

Paradise Point Resort & Spa
4.0 star property
Mission Bay, 34.5 km from Otay Mesa
8.6 out of 10, Excellent, (2,412 reviews)
"Clean Rooms, staff very friendly, very relaxing place "
United States
AlmaDelia
The price is NZ$385
includes taxes & fees
1 Mar - 2 Mar
Paradise Point Resort & Spa

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,538 reviews)
"The room was very clean and the staff was very nice."
United States
Rod
The price is NZ$173
includes taxes & fees
1 Mar - 2 Mar
La Quinta Inn by Wyndham San Diego Chula Vista
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our guide on where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Seaport Village and Petco Park are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach and Dog Beach.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Quality Suites San Diego Otay Mesa is the highest ranked property in Otay Mesa. This hotel offers free breakfast and free parking.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

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