Otay Mesa Hotels, San Diego
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Our top choices for Otay Mesa hotels
7.2 out of 10, Good, (1004)
"Clean, convenient location "
Mary
The price is NZ$198
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHGOtay Mesa
8.0 out of 10, Very good, (1576)
"Great place to stay. Really clean and helpful staff "
Zulma
The price is NZ$233
includes taxes & fees
11 Jan - 12 Jan 2026
8.4 out of 10, Very good, (1000)
"Great spot"
Alexandro
The price is NZ$158
includes taxes & fees
4 Jan - 5 Jan 2026
9.0 out of 10, Wonderful, (1008)
"Loved this stay, they were very accommodating "
Maurizio
The price is NZ$369
includes taxes & fees
4 Jan - 5 Jan 2026
8.6 out of 10, Excellent, (1009)
"Good place to stay for convenient restaurants and bars. Right by the Marina for boat excursions and fishing. Reasonable room rates. "
Christopher
Courtyard by Marriott Old Town
Courtyard by Marriott Old TownOld Town San Diego, 29.7 km from Otay Mesa
8.6 out of 10, Excellent, (1006)
"Great stay!!! Will be staying again! "
Raven
The price is NZ$235
includes taxes & fees
18 Jan - 19 Jan 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Our guide on where to stay in Otay Mesa
Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Gaslamp Quarter
The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.
Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.
Mission Beach
If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.
Ocean Beach
Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Dog Beach and Sunset Cliffs Natural Park.
Top Otay Mesa Hotel Reviews
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