Otay Mesa Hotels, San Diego

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Otay Mesa hotels

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,004 reviews)
"Great staff.. location close to the airport!"
United States
Vivian
The price is NZ$204
includes taxes & fees
1 Mar - 2 Mar
Quality Suites San Diego Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.0 out of 10, Very good, (1,652 reviews)
"Clean, great breakfast, good service."
United States
Sara
The price is NZ$246
includes taxes & fees
8 Mar - 9 Mar
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.2 out of 10, Wonderful, (1,759 reviews)
"Very clean resort. "
United States
Petrina
Sycuan Casino Resort

Days Inn by Wyndham San Diego-East/El Cajon

Days Inn by Wyndham San Diego-East/El Cajon
2.0 star property
27.3 km from Otay Mesa
7.6 out of 10, Good, (1,002 reviews)
"Great service.room was clean and included breakfast "
United States
Antonio
The price is NZ$155
includes taxes & fees
26 Feb - 27 Feb
Days Inn by Wyndham San Diego-East/El Cajon

Courtyard by Marriott San Diego El Cajon

Courtyard by Marriott San Diego El Cajon
3.0 star property
26.3 km from Otay Mesa
9.2 out of 10, Wonderful, (1,001 reviews)
"Clean, quiet, beautiful "
United States
Attia
The price is NZ$302
includes taxes & fees
1 Mar - 2 Mar
Courtyard by Marriott San Diego El Cajon

Motel 6 El Cajon, CA - San Diego

Motel 6 El Cajon, CA - San Diego
2.0 star property
27 km from Otay Mesa
7.4 out of 10, Good, (1,551 reviews)
"We only stayed one night but it was comfortable and clean "
United States
Brandy
The price is NZ$121
includes taxes & fees
26 Feb - 27 Feb
Motel 6 El Cajon, CA - San Diego

Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego
2.5 star property
24.6 km from Otay Mesa
8.4 out of 10, Very good, (1,005 reviews)
"Room was clean, pleasant staff and great breakfast "
United States
Wendy
The price is NZ$205
includes taxes & fees
23 Feb - 24 Feb
Best Western Plus La Mesa San Diego

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (582 reviews)
"Clean room and friendly staff "
United States
Michael
The price is NZ$332
includes taxes & fees
15 Mar - 16 Mar
SpringHill Suites by Marriott Chula Vista Eastlake

Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,118 reviews)
"Great location "
United States
Irma
The price is NZ$380
includes taxes & fees
22 Feb - 23 Feb
Ayres Hotel San Diego South - Chula Vista

Heritage Inn La Mesa

Heritage Inn La Mesa
2.0 star property
24.3 km from Otay Mesa
7.0 out of 10, Good, (1,291 reviews)
"Very friendly at front desk I wish it was a little cheaper and I would stay the whole trip here"
United States
Haley
The price is NZ$118
includes taxes & fees
24 Feb - 25 Feb
Heritage Inn La Mesa

Lamplighter Inn & Suites at SDSU

Lamplighter Inn & Suites at SDSU
2.5 star property
24.4 km from Otay Mesa
9.0 out of 10, Wonderful, (1,365 reviews)
"Good accommodations for the price point."
United States
Martin
Lamplighter Inn & Suites at SDSU

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
7.8 out of 10, Good, (1,620 reviews)
"Clean rooms and the breakfast was amazing "
United States
Vanessa
The price is NZ$190
includes taxes & fees
22 Feb - 23 Feb
Best Western Chula Vista/Otay Valley Hotel

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,549 reviews)
"The room was very clean and the staff was very nice."
United States
Rod
The price is NZ$180
includes taxes & fees
15 Mar - 16 Mar
La Quinta Inn by Wyndham San Diego Chula Vista

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.2 out of 10, Very good, (1,353 reviews)
"It’s very comfortable and wonderful place. "
United States
Carmen
The price is NZ$194
includes taxes & fees
1 Mar - 2 Mar
Comfort Inn Chula Vista San Diego South

Valli Hi Motel

Valli Hi Motel
2.5 star property
7.9 km from Otay Mesa
8.4 out of 10, Very good, (1,005 reviews)
"Excelente "
Mexico
Julio
Valli Hi Motel

Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
14.4 km from Otay Mesa
7.2 out of 10, Good, (2,157 reviews)
"Good stay, quiet,place was easy to find."
United States
Annie
The price is NZ$122
includes taxes & fees
22 Feb - 23 Feb
Hotel Palmeras Chula Vista

Hotel Milagro

Hotel Milagro
2.0 star property
14.9 km from Otay Mesa
7.8 out of 10, Good, (1,005 reviews)
"Great frienly and welcoming staff. Clean and comfy."
United States
Raquel
The price is NZ$122
includes taxes & fees
1 Mar - 2 Mar
Hotel Milagro

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,030 reviews)
"Clean, Spacious Room, Polite Staff, Nice Breakfast"
United States
ALFREDO
The price is NZ$207
includes taxes & fees
15 Mar - 16 Mar
Holiday Inn Express San Diego South - Chula Vista by IHG

Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
13.6 km from Otay Mesa
8.6 out of 10, Excellent, (1,380 reviews)
"Excellent service and spotless place. "
United States
Ruslan
The price is NZ$183
includes taxes & fees
26 Feb - 27 Feb
Hercor Hotel - Urban Boutique

Berkshire Motor Hotel

Berkshire Motor Hotel
2.5 star property
North Park, 26.7 km from Otay Mesa
8.4 out of 10, Very good, (1,003 reviews)
"Clean, very chill easy check in"
United States
Susana
The price is NZ$170
includes taxes & fees
22 Feb - 23 Feb
Berkshire Motor Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our guide on where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach and Dog Beach.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

Explore a world of travel with Expedia