Otay Mesa Hotels, San Diego

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Our top choices for Otay Mesa hotels

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,000 reviews)
"Friendly staff, clean room fair rates"
Canada
Mikael
The price is NZ$196
includes taxes & fees
25 May - 26 May
Quality Suites San Diego Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.2 out of 10, Very good, (1,741 reviews)
"great breakfast and nice staff"
United States
rosita
The price is NZ$269
includes taxes & fees
25 May - 26 May
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
29.8 km from Otay Mesa
8.2 out of 10, Very good, (1,001 reviews)
"Great stay "
United States
Katherine
The price is NZ$199
includes taxes & fees
26 May - 27 May
Crowne Plaza San Diego - Mission Valley by IHG

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
28.1 km from Otay Mesa
8.4 out of 10, Very good, (3,538 reviews)
"Excellent food, friendly staff, easy check-in, and beautiful setting. "
United States
Emily
The price is NZ$417
includes taxes & fees
25 May - 26 May
Sheraton San Diego Resort

Hampton Inn & Suites Imperial Beach San Diego

Hampton Inn & Suites Imperial Beach San Diego
2.5 star property
13.7 km from Otay Mesa
9.4 out of 10, Exceptional, (1,000 reviews)
"Good time and stay "
United States
Ana
The price is NZ$280
includes taxes & fees
31 May - 1 June
Hampton Inn & Suites Imperial Beach San Diego

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,942 reviews)
The price is NZ$206
includes taxes & fees
26 May - 27 May
Sycuan Casino Resort

The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld
2.5 star property
30.2 km from Otay Mesa
8.2 out of 10, Very good, (91 reviews)
"The breakfast was great and I enjoyed my stay!"
United States
Felix
The price is NZ$162
includes taxes & fees
26 May - 27 May
The Alcala Hotel Mission Valley/Seaworld

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 33.1 km from Otay Mesa
8.6 out of 10, Excellent, (1,444 reviews)
"Great resort!"
United States
Jean-Michelle
The price is NZ$417
includes taxes & fees
25 May - 26 May
San Diego Mission Bay Resort

Best Western San Diego Pacific Beach/Mission Bay

Best Western San Diego Pacific Beach/Mission Bay
2.5 star property
Bay Park, 33.6 km from Otay Mesa
8.2 out of 10, Very good, (395 reviews)
"The rooms were great, i love the bed and the pillows, parking was easy and so was checkin"
United States
Bernadette
The price is NZ$154
includes taxes & fees
31 May - 1 June
Best Western San Diego Pacific Beach/Mission Bay

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,276 reviews)
"Everything was very pleasant,the place was super clean, and the breakfast was delicious👍"
United States
Nancy
The price is NZ$221
includes taxes & fees
28 May - 29 May
Best Western Americana Inn

Motel 6 El Cajon, CA - San Diego

Motel 6 El Cajon, CA - San Diego
2.0 star property
27 km from Otay Mesa
7.4 out of 10, Good, (1,679 reviews)
"It was good"
United States
Omar
The price is NZ$142
includes taxes & fees
27 May - 28 May
Motel 6 El Cajon, CA - San Diego

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
26.8 km from Otay Mesa
9.4 out of 10, Exceptional, (1,660 reviews)
"This is a must stay place in San Diego"
United States
Kristi
The price is NZ$487
includes taxes & fees
26 May - 27 May
Lafayette Hotel & Club

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3,828 reviews)
"Great resort "
United States
Ines
The price is NZ$298
includes taxes & fees
25 May - 26 May
Best Western Plus Marina Gateway Hotel

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,619 reviews)
"Great stay"
United States
Helda
The price is NZ$200
includes taxes & fees
25 May - 26 May
La Quinta Inn by Wyndham San Diego Chula Vista

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
31.3 km from Otay Mesa
7.4 out of 10, Good, (4,226 reviews)
"Nice stay, clean room"
United States
Luis
The price is NZ$185
includes taxes & fees
31 May - 1 June
Wyndham Garden San Diego Near SeaWorld

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,169 reviews)
"Very nice place to stay"
United States
Lingzhi
The price is NZ$237
includes taxes & fees
25 May - 26 May
Holiday Inn Express San Diego South - Chula Vista by IHG

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.2 out of 10, Very good, (1,509 reviews)
"Laundry room was extremely clean breakfast pretty nice staff was excellent "
United States
Victoria
The price is NZ$196
includes taxes & fees
14 June - 15 June
Comfort Inn Chula Vista San Diego South

Comfort Inn Sea World Area

Comfort Inn Sea World Area
3.5 star property
30.8 km from Otay Mesa
8.6 out of 10, Excellent, (3,690 reviews)
"Room is clean, staff are especially helpful and courteous, breakfast was great…all in all made my stay comfortable and convenient because just minutes away from the airport…would stay here again"
United States
Parley Vinn Anastacius
The price is NZ$204
includes taxes & fees
25 May - 26 May
Comfort Inn Sea World Area

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
25.7 km from Otay Mesa
8.4 out of 10, Very good, (6,160 reviews)
"Great place for a family vacation!"
United States
Ann
The price is NZ$361
includes taxes & fees
28 May - 29 May
Wyndham San Diego Bayside

Best Western Yacht Harbor Hotel

Best Western Yacht Harbor Hotel
2.5 star property
29.9 km from Otay Mesa
8.4 out of 10, Very good, (1,895 reviews)
"The rooms were well kept and the breakfast was great!"
United States
Jessica
The price is NZ$217
includes taxes & fees
7 June - 8 June
Best Western Yacht Harbor Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our guide on where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

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