Otay Mesa Hotels, San Diego
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for Otay Mesa hotels
Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay MesaOtay Mesa
7.0 out of 10, Good, (1,003 reviews)
"Great staff.. location close to the airport!"
Vivian
The price is NZ$203
includes taxes & fees
3 May - 4 May
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHGOtay Mesa
8.0 out of 10, Very good, (1,694 reviews)
"Great breakfast!"
Susan
The price is NZ$227
includes taxes & fees
3 May - 4 May
Crowne Plaza San Diego - Mission Valley by IHG
Crowne Plaza San Diego - Mission Valley by IHG29.8 km from Otay Mesa
8.0 out of 10, Very good, (1,026 reviews)
"Great place to stay"
Kimberly
The price is NZ$221
includes taxes & fees
12 Apr - 13 Apr
Sycuan Casino Resort
Sycuan Casino Resort28.5 km from Otay Mesa
9.2 out of 10, Wonderful, (1,830 reviews)
"Awesome place "
Jonathan
The price is NZ$178
includes taxes & fees
8 Apr - 9 Apr
Ocean Villa Inn
Ocean Villa InnOcean Beach, 33.7 km from Otay Mesa
8.0 out of 10, Very good, (1,218 reviews)
"Amazing def will stay again "
Tanya
The price is NZ$216
includes taxes & fees
8 Apr - 9 Apr
Lafayette Hotel & Club
Lafayette Hotel & Club26.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,567 reviews)
"Everything about that stay was perfect"
Victoria
The price is NZ$501
includes taxes & fees
8 Apr - 9 Apr
Wyndham Garden San Diego Near SeaWorld
Wyndham Garden San Diego Near SeaWorld31.3 km from Otay Mesa
7.4 out of 10, Good, (4,219 reviews)
"great place"
souheil
The price is NZ$197
includes taxes & fees
8 Apr - 9 Apr
SpringHill Suites by Marriott Chula Vista Eastlake
SpringHill Suites by Marriott Chula Vista Eastlake10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (619 reviews)
"By far, one of the best hotels we have stayed at! Very clean, friendly and knowledgeable front desk staff, amenities galore and right across the street from family friendly entertainment venues like play city and ninja factory. The pool was amazing - we had all a great time! "
Daniel
The price is NZ$330
includes taxes & fees
19 Apr - 20 Apr
Sheraton San Diego Resort
Sheraton San Diego Resort28.1 km from Otay Mesa
8.4 out of 10, Very good, (3,436 reviews)
"Nice hotel with great location "
DIANA
The price is NZ$489
includes taxes & fees
12 Apr - 13 Apr
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Studio 6 Suites San Ysidro, CA -San Diego South Bay6.9 km from Otay Mesa
8.0 out of 10, Very good, (1,579 reviews)
"Good location"
Joshua
The price is NZ$150
includes taxes & fees
8 Apr - 9 Apr
Valli Hi Motel
Valli Hi Motel7.9 km from Otay Mesa
8.4 out of 10, Very good, (1,008 reviews)
"Great location, near shops, restaurants and beaches. "
Miguelina
The price is NZ$151
includes taxes & fees
8 Apr - 9 Apr
Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town
Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town30.8 km from Otay Mesa
9.2 out of 10, Wonderful, (801 reviews)
"Excellence breakfast and near to downtown with best rates and wonderful supporting staff and cleanliness."
Apinder
The price is NZ$368
includes taxes & fees
26 Apr - 27 Apr
Best Western Americana Inn
Best Western Americana Inn8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,250 reviews)
"Great place and service. Will definitely stay there again. "
Maria
The price is NZ$244
includes taxes & fees
12 Apr - 13 Apr
Ocean Beach Hotel
Ocean Beach HotelOcean Beach, 33.5 km from Otay Mesa
8.8 out of 10, Excellent, (1,289 reviews)
"Cute place, easy location & staff was so friendly. "
Ericka A
The price is NZ$334
includes taxes & fees
13 Apr - 14 Apr
Courtyard by Marriott San Diego Airport/Liberty Station
Courtyard by Marriott San Diego Airport/Liberty Station29.7 km from Otay Mesa
9.2 out of 10, Wonderful, (1,309 reviews)
"Great hotel"
Amy
The price is NZ$356
includes taxes & fees
26 Apr - 27 Apr
San Diego Mission Bay Resort
San Diego Mission Bay ResortMission Bay, 33.1 km from Otay Mesa
8.4 out of 10, Very good, (1,395 reviews)
"The restaurant on site was delicious "
Blanca
The price is NZ$513
includes taxes & fees
13 Apr - 14 Apr
Kings Inn San Diego
Kings Inn San Diego29.1 km from Otay Mesa
8.8 out of 10, Excellent, (3,671 reviews)
"The Waffle Spot is absolutely fantastic, great dining on site."
Joshua
The price is NZ$183
includes taxes & fees
12 Apr - 13 Apr
Cherokee Lodge
Cherokee Lodge24 km from Otay Mesa
9.4 out of 10, Exceptional, (868 reviews)
"Hidden Gem. "
Jennifer
The price is NZ$383
includes taxes & fees
8 Apr - 9 Apr
El Cordova Hotel on Coronado Island
El Cordova Hotel on Coronado Island23.5 km from Otay Mesa
8.8 out of 10, Excellent, (1,001 reviews)
"Best hotel i have stayed"
araceli
The price is NZ$395
includes taxes & fees
14 Apr - 15 Apr
Old Town Western Inn & Suites
Old Town Western Inn & SuitesOld Town San Diego, 29.6 km from Otay Mesa
7.6 out of 10, Good, (1,010 reviews)
"This hotel is in a great location. Walking distance to old town, shops and restaurants."
Diane
The price is NZ$188
includes taxes & fees
8 Apr - 9 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Our guide on where to stay in Otay Mesa
Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Pacific Beach
Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.
Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.
Gaslamp Quarter
The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.
Ocean Beach
Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Dog Beach and Sunset Cliffs Natural Park.
Top Otay Mesa Hotel Reviews
The DEXTRO Little Italy, BW Premier Collection
10/10 Excellent
Frequently asked questions
Explore a world of travel with Expedia
- Otay Hotels
- Hotels near Len Moore Skate Park
- Marina District Hotels
- Chula Vista Hotels
- Hotels near San Diego-Coronado Bridge
- East Village Hotels
- San Ysidro Hotels
- San Diego Hotels
- Jamacha Hotels
- Nestor Hotels
- Hotels near Brown Field Municipal
- Spring Valley Hotels
- Otay Mesa West Hotels
- Cortez Hill Hotels
- Encanto Hotels
- Logan Heights Hotels
- Jamul Hotels
- Imperial Beach Hotels
- Lemon Grove Hotels
- Hotels near Palm Ave Trolley Station
- Bonita Hotels
- Eastlake Hotels
- Hotels near Sky Zone San Diego Indoor Trampoline Park
- Hotels near Coronado Beach
- Hotels near San Ysidro Border Crossing
- National City Hotels
- Hotels near Chula Vista Elite Athlete Training Center
- B&B in San Diego Coast
- Apartments in Chula Vista
- Residences in Chula Vista
- B&B in Chula Vista
- Hostels in San Ysidro
- Cottages in National City
- Serviced Apartments in South Bay
- Villas in South Bay
- Apartments in South Bay
- Cottages in South Bay
- Holiday Homes in South Bay
- Guest Houses in South Bay
- Apartments in Imperial Beach
- Holiday Homes in Imperial Beach
- Boutique Hotels in South Bay
- Cheap Hotels in Otay Mesa
- Beach Hotels in South San Diego
- Family Hotels in South San Diego
- Romantic Hotels in South San Diego
- All Inclusive Hotels in San Diego Coast
- Best Western Hotels in San Ysidro
- Flights from Brown Field Municipal
- Flights from Los Angeles (LAX) to San Diego (SDM)
- Flights from Boston (BOS) to San Diego (SDM)
- Flights from Denver (DEN) to San Diego (SDM)
- Flights from Long Beach (LGB) to San Diego (SDM)
- Flights from Hartford (BDL) to San Diego (SDM)
- Flights from Henderson (HSH) to San Diego (SDM)
- Flights from Orange County (SNA) to San Diego (SDM)
- Flights from Sydney (SYD) to San Diego (SDM)
- Flights from Las Vegas (LAS) to San Diego (SDM)
- Flights from Hong Kong (HKG) to San Diego (SDM)
- Flights from San Francisco (SFO) to San Diego (SDM)
- Flights from Houston (IAH) to San Diego (SDM)
- Flights to San Ysidro
- Flights to National City
- Flights to Chula Vista
- San Ysidro Border Crossing
- Sky Zone San Diego Indoor Trampoline Park
- Silver Strand State Beach
- Sharp Chula Vista Medical Center
- Chula Vista Center
- Chula Vista Elite Athlete Training Center
- North Island Credit Union Amphitheatre
- Kaiser Permanente Otay Mesa Medical Offices
- Atlantis Laser Tag
- Las Americas Premium Outlets
- Visit Otay Mesa
- Visit Encanto
- Visit Chula Vista
- Visit Eastlake Greens
- Visit Otay Mesa West
- Visit Bonita
- Visit National City
- Visit Rancho del Rey
- Visit Otay
- Visit Bay Terraces