Otay Mesa Hotels, San Diego

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
8 Nov - 9 Nov
Tomorrow
9 Nov - 10 Nov
Next weekend
13 Nov - 15 Nov
In two weeks
20 Nov - 22 Nov

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Otay Mesa hotels

A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.4 out of 10, Very good, (1,960 reviews)
"Good place to stay for work."
United States
Renato
The price is NZ$267
includes taxes & fees
6 Dec - 7 Dec
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
A breakfast station with bread, bagels, waffles, and a coffee machine.

2. Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.2 out of 10, Good, (1,002 reviews)
"clean room nice place to stay"
Mexico
Anonymous traveller
The price is NZ$223
includes taxes & fees
6 Dec - 7 Dec
Quality Suites San Diego Otay Mesa
A modern kitchen area with a self-serve station, including a waffle maker, coffee machine, and various food items.

3. Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
8.0 out of 10, Very good, (2,042 reviews)
"Me and my husband loved it we tried different ones and this one is one of the best from now on is going to be our favorite to stay,very clean and breakfast was so good so many options for breakfast"
United States
Edna
The price is NZ$218
includes taxes & fees
15 Nov - 16 Nov
Best Western Chula Vista/Otay Valley Hotel
A spacious lobby with a modern design, featuring a large seating area, a reception desk, and large windows offering views of the city.

4. Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,029 reviews)
"I was very impressed with this hotel. The rooms were comfortable and modern and the staff was warm and welcoming."
United States
Rosemary
The price is NZ$338
includes taxes & fees
29 Nov - 30 Nov
Ayres Hotel San Diego South - Chula Vista
A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.

5. Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.4 out of 10, Very good, (1,729 reviews)
"The breakfast and the staff were great!"
United States
Xochitl
The price is NZ$206
includes taxes & fees
29 Nov - 30 Nov
Comfort Inn Chula Vista San Diego South
A breakfast bar with La Quinta branding, a coffee machine, and a waffle display.

6. La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,795 reviews)
"Clean room , friendly staff , always helpful, breakfast good , always great to return"
United States
Luis
The price is NZ$206
includes taxes & fees
22 Nov - 23 Nov
La Quinta Inn by Wyndham San Diego Chula Vista
A buffet with various food items, including omelets and other dishes, served in metal trays.

7. Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,652 reviews)
"Great stay"
United States
Daniel
The price is NZ$308
includes taxes & fees
6 Dec - 7 Dec
Holiday Inn Express San Diego South - Chula Vista by IHG
A motel with a sign indicating amenities like Wi-Fi, TV, and pool.

8. Valli Hi Motel

Valli Hi Motel
2.0 star property
7.9 km from Otay Mesa
8.2 out of 10, Very good, (1,168 reviews)
"Clean rooms and nice staff"
United States
Wendy
The price is NZ$166
includes taxes & fees
9 Nov - 10 Nov
Valli Hi Motel
Bar (on property)

9. Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (4,228 reviews)
"Great property, friendly staff and a restaurant with good food and live music next door. Had an excellent time!"
United States
Candas
The price is NZ$267
includes taxes & fees
29 Nov - 30 Nov
Best Western Plus Marina Gateway Hotel
A room with two teal armchairs, a small round table with a lamp, and a large cityscape painting on the wall.

10. SureStay Hotel by Best Western Chula Vista San Diego Bay

SureStay Hotel by Best Western Chula Vista San Diego Bay
3.0 star property
14.7 km from Otay Mesa
8.0 out of 10, Very good, (2,022 reviews)
"A good hotel, with a good location at a very good price, has a reasonable breakfast."
Brazil
Sergio
The price is NZ$197
includes taxes & fees
22 Nov - 23 Nov
SureStay Hotel by Best Western Chula Vista San Diego Bay
View from property

11. SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (817 reviews)
"Great hotel"
United States
leslie
The price is NZ$409
includes taxes & fees
17 Nov - 18 Nov
SpringHill Suites by Marriott Chula Vista Eastlake
A retro-themed arcade with classic games, a foosball table, and a long communal table with stools.

12. The Rambler Hotel

The Rambler Hotel
3.0 star property
14.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,208 reviews)
"Solid place to stay"
United States
Neal
The price is NZ$184
includes taxes & fees
1 Dec - 2 Dec
The Rambler Hotel
A spacious lobby with a fireplace, wooden furniture, and a chandelier.

13. Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
8.8 out of 10, Excellent, (1,421 reviews)
"Great service from the staff!"
United States
Erika
The price is NZ$215
includes taxes & fees
22 Nov - 23 Nov
Best Western Americana Inn
A modern hotel with a prominent 'Hercor Hotel' sign, multiple balconies, and a 'Urban Boutique' label.

14. Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
13.6 km from Otay Mesa
8.8 out of 10, Excellent, (1,577 reviews)
"Great stay"
United States
fannie
The price is NZ$221
includes taxes & fees
18 Nov - 19 Nov
Hercor Hotel - Urban Boutique
A hotel room with two beds, a desk, and a chair.

15. Howard Johnson by Wyndham National City/San Diego South

Howard Johnson by Wyndham National City/San Diego South
2.0 star property
18.3 km from Otay Mesa
7.6 out of 10, Good, (1,192 reviews)
"Great stay for a stay !"
United States
Monserrat
The price is NZ$144
includes taxes & fees
9 Nov - 10 Nov
Howard Johnson by Wyndham National City/San Diego South
A hotel room with a bed, a desk with a chair, a nightstand, and a wall-mounted TV displaying a sunset scene.

16. Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
14.4 km from Otay Mesa
7.4 out of 10, Good, (2,456 reviews)
"Clean rooms nice staff"
United States
Wendy
The price is NZ$136
includes taxes & fees
9 Nov - 10 Nov
Hotel Palmeras Chula Vista
An outdoor seating area with fire pits, lounge chairs, and string lights against a sunset backdrop.

17. Loews Coronado Bay Resort

Loews Coronado Bay Resort
4.0 star property
17.1 km from Otay Mesa
9.0 out of 10, Wonderful, (1,167 reviews)
"Lovely place to stay, beautiful scenery. The only downside is everything is far away- gas station, restaurants, you have to UBER or have a rental car to travel for amenities outside of what the resort offers."
United States
Josh
The price is NZ$485
includes taxes & fees
29 Nov - 30 Nov
Loews Coronado Bay Resort
A modern outdoor seating area with wicker chairs, a round table, and a fire pit.

18. TownePlace Suites by Marriott San Diego Downtown

TownePlace Suites by Marriott San Diego Downtown
3.0 star property
25 km from Otay Mesa
8.8 out of 10, Excellent, (1,000 reviews)
"Clean and spacious rooms, great staff, great service!"
United States
Brajesh
The price is NZ$265
includes taxes & fees
1 Dec - 2 Dec
TownePlace Suites by Marriott San Diego Downtown
A hotel room with a large window offering a city view, a bed, a chair, and a small table.

19. The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
25.4 km from Otay Mesa
8.8 out of 10, Excellent, (2,363 reviews)
"Really enjoyed my stay!"
United States
Kelly
The price is NZ$265
includes taxes & fees
15 Nov - 16 Nov
The DEXTRO Little Italy, BW Premier Collection
A hotel entrance with a stone archway, a reception desk, and potted plants.

20. Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
28.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,101 reviews)
"Great family hotel. Simple and clean yummy breakfast inexpensive and perfect for our short stay in sd"
United States
Alejandra
The price is NZ$282
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn Express San Diego Airport - Old Town by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Otay Mesa

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
8.4
Very good
1,960 reviews
View
A breakfast station with bread, bagels, waffles, and a coffee machine.
Quality Suites San Diego Otay Mesa
2.5 star property
7.2
Good
1,002 reviews
View
A spacious lobby with a fireplace, wooden furniture, and a chandelier.
Best Western Americana Inn
2.5 star property
8.8
Excellent
1,421 reviews
View
A spacious lobby with a modern design, featuring a large seating area, a reception desk, and large windows offering views of the city.
Ayres Hotel San Diego South - Chula Vista
3.0 star property
9.8
Exceptional
1,029 reviews
View
A modern living room with a large window, a fireplace, and a kitchen area.
Rodeway Inn San Diego South San Ysidro Border
2.0 star property
8.0
Very good
321 reviews
View

Our guide on where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

A pier extending into the ocean with buildings at the end, under a partly cloudy sky.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

Top Otay Mesa Hotel Reviews

A motel with a sign indicating amenities like Wi-Fi, TV, and pool.
Valli Hi Motel

Valli Hi Motel

Valli Hi Motel
San Ysidro

10/10 Excellent

Great hotel
Australia
christine
Reviewed August 2, 2025
Valli Hi Motel

Frequently Asked Questions

What's it like in Otay Mesa?

Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on our traveller data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! Most room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.

What is there to do in this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

Explore a world of travel with Expedia