Destination Hotels in James Island from NZ$361

A lighthouse on a pier extending into a calm body of water.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for James Island Destination Hotels

A hotel with multiple swimming pools, outdoor seating areas, and a large building with balconies.

1. Wild Dunes Resort – Sweetgrass Inn and Boardwalk Inn

Isle of Palms

Rebecca

includes taxes & fees

15 Nov - 16 Nov

A beachfront hotel with a pool, beach access, and a sunset view.

2. Wild Dunes Resort – Residences at Sweetgrass

Isle of Palms

Jeff

includes taxes & fees

15 Nov - 16 Nov

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Top James Island Hotel Reviews

Emeline

10/10 Excellent

"Fabulous location! Staff were so kind. It was a great stay all around."

Cambria Hotel Mount Pleasant – Charleston

8/10 Good

"The location very close to all the restaurants and maybe a 20 minutes ride to downtown Charleston. The handicap parking is to far from the main entrance but it was ok, didn't serve breakfast only coffee and no pastries unless you buying from the concession stand. Sydney very nice and friendly"

Harborside at Charleston Harbor Resort and Marina

10/10 Excellent

"The Harbor Marina is beautiful. The staff were amazingly helpful, nice and cheerful. They did not offer an airport shuttle, which was disappointing and they only have 2 restaurants, and only one of them offers breakfast, but they do offer a daily free shuttle into downtown Charleston. We did not use the shuttle, instead we paid and went to Charleston daily via the water taxi, which was fun and inexpensive and great experience. I would recommend this place to others, and I would stay here again."