A rustic wooden interior with a table, a basket, and a painting on easels.

Destination Hotels in James Island from NZ$556

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
22 Sept - 23 Sept
Tomorrow
23 Sept - 24 Sept
This weekend
25 Sept - 27 Sept
Next weekend
2 Oct - 4 Oct

Our top choices for James Island Destination Hotels

A modern kitchen with a central island, wooden ceiling, and large windows.
A modern kitchen with a central island, a spiral staircase, and a large window providing natural light.
A hot tub in a backyard with a house in the background.
A modern kitchen with white cabinets, a central island with stools, a spiral staircase, and a large window.

1. Private Hot Tub Island Cottage Near Folly Beach

Private Hot Tub Island Cottage Near Folly Beach
James Island
United States
Holly K.
NZ$601
includes taxes & fees
27 Sept - 28 Sept
Private Hot Tub Island Cottage Near Folly Beach
A modern living room with a grey sofa, a wooden coffee table, and a dining table with chairs. There is a ceiling fan, a world map on the wall, and a window with curtains.
A bedroom with a bed, bedside tables, a ceiling fan, a window with curtains, a wall-mounted TV, and a potted plant.
An outdoor patio with a fire pit, two chairs, and a table.
A kitchen with a stainless steel refrigerator, a sink, wooden countertops, and shelves with bowls and a globe.

2. Clean, Private Guesthouse-9 min. to Downtown Charleston, 15 min. to FollyBeach!

Clean, Private Guesthouse-9 min. to Downtown Charleston, 15 min. to FollyBeach!
James Island
United States
Hannah
NZ$340
includes taxes & fees
27 Sept - 28 Sept
Clean, Private Guesthouse-9 min. to Downtown Charleston, 15 min. to FollyBeach!
An outdoor deck with a grill, bar area, and hammock.
A modern kitchen with white cabinets, a central island with stools, a spiral staircase, and a large window.
A spacious kitchen with a central island, a dining area with a table and chairs, a staircase leading to an upper level, and a large window with a view.
A cozy living room with a wooden ceiling, a sofa, a coffee table, a TV, and a view of the outdoors.

3. Island Retreat - Great for Large Groups

Island Retreat - Great for Large Groups
James Island
United States
Adam P.
NZ$1,373
includes taxes & fees
20 Oct - 21 Oct
Island Retreat - Great for Large Groups
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Top James Island Hotel Reviews

La Quinta Inn & Suites by Wyndham Charleston Riverview

La Quinta Inn & Suites by Wyndham Charleston Riverview

10/10 Excellent
"Very clean room everything was excellent I would stay there again."
Julia 6-night trip
Posted 1 hour ago
La Quinta Inn & Suites by Wyndham Charleston Riverview
Hotel Indigo Mount Pleasant by IHG

Hotel Indigo Mount Pleasant by IHG

10/10 Excellent
"Clean Room Staff were great and very nice Breakfast was easily the best thing though that french toast was the best i ever had in my life"
David 1-night trip
Posted 1 hour ago
Hotel Indigo Mount Pleasant by IHG
Harborside at Charleston Harbor Resort and Marina

Harborside at Charleston Harbor Resort and Marina

10/10 Excellent
"Great place to stay. Rooms were comfortable and very spacious, Bathrooms were massive and had everything you could possibly want, including a separate door for the toilet. Pool are was well spread out so you didn't feel like you were at a waterpark. Fish House was convenient and delicious and came in handy when we didn't want to leave the property. Plenty of places for walks, from marina to trails surrounding the property."
DEREK 4-night trip
Posted 3 hours ago
Harborside at Charleston Harbor Resort and Marina
Drury Plaza Hotel North Charleston

Drury Plaza Hotel North Charleston

10/10 Excellent
"Great place! Really enjoyed my stay and would definitely stay here again."
Merlyn Jasmine 1-night trip
Posted 4 hours ago
Drury Plaza Hotel North Charleston
Andrew Pinckney Inn

Andrew Pinckney Inn

10/10 Excellent
"Second time staying here and I loved it just as much. The view during breakfast is beautiful and the rooms are very nice!"
Christine 2-night trip
Posted 5 hours ago
Andrew Pinckney Inn
The Ansonborough

The Ansonborough

10/10 Excellent
"Great hotel and location. Easy walk to all the East Bay restaurants and local tours. Staff was great and nice small bar and breakfast"
Thomas 3-night trip
Posted 5 hours ago
The Ansonborough
The Palms Oceanfront Hotel

The Palms Oceanfront Hotel

10/10 Excellent
"Located right on the beach with fun beach bars/restaurants next door. Great for a one night get away. I would definitely stay here again."
susan 1-night trip
Posted 19 hours ago
The Palms Oceanfront Hotel
The Charleston Place

The Charleston Place

10/10 Excellent
"Everyone was so helpful and cheerful! I loved having beautiful cans of cold water at my convenience and with no charge. Additionally our breakfast was delicious. The location of the hotel was amazing"
Heather 2-night trip
Posted 20 hours ago
The Charleston Place
Seaside Inn Oceanfront

Seaside Inn Oceanfront

10/10 Excellent
"Unique quaint experience"
Haley 1-night trip
Posted 20 hours ago
Seaside Inn Oceanfront

Explore a world of travel with Expedia