Photo by cyclone_trudy
Adults Only & Resorts in James Island
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check availability on James Island Adults Only
Best James Island Adults Only
Top James Island Hotel Reviews
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels near popular Charleston Attractions
Explore more hotels
- Hyatt Place Charleston/Historic District
- The Charleston Place
- West Ashley Inn
- Tides Folly Beach, Charleston's Oceanfront Hotel
- The Restoration
- Holiday Inn Express & Suites Charleston Dwtn - Westedge by IHG
- The Palms Oceanfront Hotel
- Mills House Charleston, Curio Collection by Hilton
- Town & Country Inn and Suites
- Hampton Inn Charleston-Historic District
- Hyatt Place Charleston Airport/Convention Center
- Andrew Pinckney Inn
- Planters Inn
- DoubleTree by Hilton Hotel & Suites Charleston Airport
- Quality Inn Mt. Pleasant - Charleston
- The Beach Club at Charleston Harbor Resort and Marina
- The Vendue
More ways to book
Expedia's Latest Trends
Hotels
Flights
Holiday Rentals