Serra Mesa Hotels, San Diego

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Our top choices for Serra Mesa hotels

Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
4.0 star property
Mission Bay, 10.3 km from Serra Mesa
8.4 out of 10, Very good, (1589)
"Totally Recommend! Rooms are really clean and comfortable, the staff are great as well. "
United States
Fernando
The price is NZ$359
includes taxes & fees
10 Jan - 11 Jan
Hyatt Regency Mission Bay Spa and Marina

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
29.1 km from Serra Mesa
9.2 out of 10, Wonderful, (1651)
"Very nice getaway for the family "
United States
Richard
Sycuan Casino Resort

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
9.9 km from Serra Mesa
8.4 out of 10, Very good, (6015)
"Always an amazing stay"
United States
Jana
The price is NZ$314
includes taxes & fees
4 Jan - 5 Jan
Wyndham San Diego Bayside

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 7.1 km from Serra Mesa
8.4 out of 10, Very good, (1318)
"Room was super clean and updated, location up against the bay was perfect. We really enjoyed our stay and want to come back soon!"
United States
Haley
The price is NZ$364
includes taxes & fees
4 Jan - 5 Jan
San Diego Mission Bay Resort

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 10.4 km from Serra Mesa
9.4 out of 10, Exceptional, (1001)
"Great location "
United States
Mohammad
The price is NZ$235
includes taxes & fees
2 Jan - 3 Jan
Staypineapple, Hotel Z, Gaslamp San Diego

DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley
4.0 star property
4.2 km from Serra Mesa
8.4 out of 10, Very good, (1448)
"Great hotel in a great area - would definitely stay here again."
United States
Bhupinder
The price is NZ$236
includes taxes & fees
4 Jan - 5 Jan
DoubleTree by Hilton Hotel San Diego - Mission Valley

Comfort Inn San Diego Old Town

Comfort Inn San Diego Old Town
2.5 star property
Old Town San Diego, 7.9 km from Serra Mesa
8.2 out of 10, Very good, (1921)
"Great stay "
United States
Vanessa
The price is NZ$181
includes taxes & fees
20 Jan - 21 Jan
Comfort Inn San Diego Old Town

Fairfield Inn & Suites by Marriott San Diego Pacific Beach

Fairfield Inn & Suites by Marriott San Diego Pacific Beach
2.5 star property
Pacific Beach, 7 km from Serra Mesa
8.8 out of 10, Excellent, (814)
"Good location, good basic breakfast, good parking, recommended. "
United States
Leyla
The price is NZ$206
includes taxes & fees
6 Jan - 7 Jan
Fairfield Inn & Suites by Marriott San Diego Pacific Beach

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
9 km from Serra Mesa
7.4 out of 10, Good, (4130)
"Get location to the airport, safe, great staff, & overall wonderful stay"
United States
Tyler
The price is NZ$168
includes taxes & fees
25 Jan - 26 Jan
Wyndham Garden San Diego Near SeaWorld

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
Marina District, 10.7 km from Serra Mesa
9.0 out of 10, Wonderful, (2884)
"Lovely hotel with friendly staff."
United States
Lynnea
The price is NZ$449
includes taxes & fees
2 Jan - 3 Jan
Manchester Grand Hyatt San Diego

Bay Club Hotel & Marina

Bay Club Hotel & Marina
3.5 star property
12.6 km from Serra Mesa
9.2 out of 10, Wonderful, (3238)
"Great stay and location!"
United States
Jason
The price is NZ$214
includes taxes & fees
4 Jan - 5 Jan
Bay Club Hotel & Marina

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Marina District, 11.1 km from Serra Mesa
8.6 out of 10, Excellent, (1893)
"Great options for breakfast Beautiful property"
United States
Melissa
The price is NZ$381
includes taxes & fees
4 Jan - 5 Jan
Hilton San Diego Bayfront

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
9.3 km from Serra Mesa
8.8 out of 10, Excellent, (835)
"would stay again and recommend "
United States
Brendi
The price is NZ$223
includes taxes & fees
4 Jan - 5 Jan
The DEXTRO Little Italy, BW Premier Collection

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
10.1 km from Serra Mesa
8.4 out of 10, Very good, (3183)
"The stay and staff were wonderful and very helpful.."
United States
Elsie
The price is NZ$310
includes taxes & fees
4 Jan - 5 Jan
Sheraton San Diego Resort

Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
18.6 km from Serra Mesa
7.2 out of 10, Good, (2028)
"Great stay"
United States
Bobby
The price is NZ$119
includes taxes & fees
4 Jan - 5 Jan
Hotel Palmeras Chula Vista

DoubleTree by Hilton San Diego - Del Mar

DoubleTree by Hilton San Diego - Del Mar
4.0 star property
Carmel Valley, 17.4 km from Serra Mesa
8.4 out of 10, Very good, (1934)
"Nice hotel"
United States
Xiaoyang
The price is NZ$236
includes taxes & fees
9 Jan - 10 Jan
DoubleTree by Hilton San Diego - Del Mar

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Gaslamp Quarter, 10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1241)
"Clean, courteous staff, good location. "
United States
Carla
The price is NZ$295
includes taxes & fees
3 Jan - 4 Jan
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
3.0 star property
12.9 km from Serra Mesa
8.8 out of 10, Excellent, (1562)
"Staff was great, easy check in and great location"
United States
Alysa
The price is NZ$235
includes taxes & fees
14 Jan - 15 Jan
Best Western Plus Island Palms Hotel & Marina

Kings Inn San Diego

Kings Inn San Diego
2.5 star property
6 km from Serra Mesa
8.8 out of 10, Excellent, (3583)
"Nice staff, clean rooms and the Waffle Spot!!!!"
United States
brent
Kings Inn San Diego

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Marina District, 10.7 km from Serra Mesa
9.2 out of 10, Wonderful, (1964)
"Great place to stay, everything close by"
United States
Manjinder
The price is NZ$460
includes taxes & fees
9 Jan - 10 Jan
Marriott Marquis San Diego Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our guide on where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter

The historic heart of San Diego has a fascinating history, and today is a thriving hub for food, retail and entertainment.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Dog Beach and Sunset Cliffs Natural Park.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What's it like in Serra Mesa?
Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
How many hotels can I expect to find in the Serra Mesa area?
Expedia has 36 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.
What can I see and do in this San Diego neighbourhood?
Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.

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