Serra Mesa Holidays

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to NZ$616 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Our guide on where to stay in Serra Mesa

Find the best Serra Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Serra Mesa
Default Image

Downtown San Diego

3 out of top 10 points of interest in this area
4.5/5(100 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Our pick of the best Serra Mesa Hotel Deals

Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S San Diego CA
Fully refundableReserve now, pay when you stay
The price is NZ$231 per night from 15 Dec to 16 Dec
NZ$231
15 Dec - 16 Dec
includes taxes & fees
8/10 Very Good! (2,149 reviews)
After initially giving me a room that had not yet been cleaned, the second room was perfectly nice. Front desk staff was super friendly and helpful. Decent location, especially if you have a room facing away from the highway.

Reviewed on 9 Nov 2025

Hilton San Diego Mission Valley
Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

3 out of 5
3888 Greenwood St San Diego CA
Fully refundableReserve now, pay when you stay
The price is NZ$226 per night from 7 Dec to 8 Dec
NZ$226
7 Dec - 8 Dec
includes taxes & fees
9/10 Wonderful! (267 reviews)
Great selections

Reviewed on 8 Nov 2025

Hampton Inn & Suites by Hilton San Diego SeaWorld
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NZ$411 per night from 19 Nov to 20 Nov
NZ$411
19 Nov - 20 Nov
includes taxes & fees
8.8/10 Excellent! (3,060 reviews)
It is my second time to choose hard rock hotel，and the experience was great. They always have the classic rock and roll vibes. The room is clean and new. The hotel locates in the middle of the gaslight area with lots of food options.

Reviewed on 10 Nov 2025

Hard Rock Hotel San Diego
See all 8,953 properties in Serra Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Serra Mesa holiday package cost?
Be ready to book, because a trip to Serra Mesa starts from just . When you bundle your hotels, flights and car rentals into a package, you'll land the lowest prices.
How do I get a cheap travel package to Serra Mesa?
One of the simplest ways to save dollars (and time) is to bundle your bookings with Expedia. Flights, hotels, activities and rental cars — we've got everything you need. Pick the combination that best suits you and watch your savings pile up. Of course, a travel package is never one-size-fits-all. That's why we offer more than 550 partner airlines and 1 000 000 hotel options worldwide, which lets you customize your Serra Mesa holiday.
Where should I stay in Serra Mesa?
Most visitors to Serra Mesa put both San Diego Zoo and Balboa Park on their itineraries. Why not go for a hotel that's close to these fantastic attractions?
What are the top hotels in Serra Mesa?
Get your escape off to an excellent start by locking in a room at Central Location - 3br/2ba. Stay Weekly. Clean. It's one of most sought-after properties in Serra Mesa. Another comfortable option is Newly Remodeled Beautiful Beach Bound And Centrally Located San Diego Home.
How far in advance should I book my Serra Mesa holiday?
It's difficult to pick the best time for airfares, but we normally say the earlier, the better. Most international flights on Expedia become available up to 12 months in advance. If you're booking late, fear not. Budget prices appear from time to time just weeks before departure dates.
What does an Expedia Serra Mesa travel package include?
From flights and hotels to rental cars, Expedia can help you craft a Serra Mesa package that's perfect for you. Holidaying for a few weeks? Consider a flight, hotel and rental car bundle. If your break is short, a flight and hotel deal could be what you're after. Experiences can also be added once you've made your booking. Our travel packages make it a cinch to plan and save.
What should I know before booking a Serra Mesa travel package?
You can save a tidy sum by combining your hotels, airfares and rental cars. Once you've made your booking, you can add on things like day tours or experiences. Your next unforgettable holiday is only a few clicks away.
Can I choose my airline with a Serra Mesa Expedia holiday package?
With a holiday package, you're the one in charge. Whether you'd like to fly to Serra Mesa in economy or first class, simply choose from the available airline options. Expedia has access to over 550 partner airlines all over the world.
If I'm not able to travel, can I cancel my Serra Mesa holiday package?
Plans can change in the blink of an eye, so yes. You may be able to cancel or alter your Serra Mesa holiday package at no cost if you've booked in the last 24 hours. For bookings made more than 24 hours ago, you can still make the necessary changes, but your car rental company, hotel or airline may impose a charge. Want more information? Check out our Customer Service Portal. We'll help make sure your getaway goes off without a hitch.

Discover the most popular places to visit in Serra Mesa

San Diego Zoo which includes a pond, zoo animals and landscape views

San Diego Zoo

4.5/5(26 reviews)

Admire the animal kingdom in all its fascinating glory at one of America’s largest zoos.

San Diego Zoo
Mission Bay showing a beach

Mission Bay

4/5(10 reviews)

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay
Petco Park

Petco Park

4.5/5(10 reviews)

Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.

Petco Park

Activities

LEGOLAND® California Resort

LEGOLAND® California Resort

NZ$102
per adult
82% of travellers recommend
LEGOLAND® California Resort
San Diego Old Town Trolley Hop-On Hop-Off Tour

San Diego Old Town Trolley Hop-On Hop-Off Tour

NZ$165
per adult
94% of travellers recommend
San Diego Old Town Trolley Hop-On Hop-Off Tour
San Diego Whale Watching Tour

San Diego Whale Watching & Dolphin Cruise

NZ$99
per adult
86% of travellers recommend
San Diego Whale Watching & Dolphin Cruise
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.