Otay Mesa West Holidays

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Our guide on where to stay in Otay Mesa West

Find the best Otay Mesa West areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa West
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Downtown San Diego

3 out of top 10 points of interest in this area
4.5/5(100 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Our pick of the best Otay Mesa West Hotel Deals

Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
The price is NZ$284 per night from 5 Jan to 6 Jan
NZ$284
5 Jan - 6 Jan 2026
includes taxes & fees
8.2/10 Very Good! (3,178 reviews)
Yes , nicest hotel I have ever seen

Reviewed on 15 Dec 2025

Sheraton San Diego Resort
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd San Diego CA
Fully refundableReserve now, pay when you stay
The price is NZ$453 per night from 29 Dec to 30 Dec
NZ$453
29 Dec - 30 Dec
includes taxes & fees
9.2/10 Wonderful! (1,336 reviews)
Fun place with lots of energy. It is a big party almost all the time. Beware of loud music and this place is not for everyone, but it is very cool!

Reviewed on 15 Dec 2025

Lafayette Hotel & Club
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundableReserve now, pay when you stay
The price is NZ$206 per night from 28 Dec to 29 Dec
NZ$206
28 Dec - 29 Dec
includes taxes & fees
8.8/10 Excellent! (733 reviews)
Room was clean with comfortable bed. View facing the habor is interesting.Outdoor facilities is well coming, nice sitting area. There is an adequate gymn, with treadmill , benche and various free weights, all and all fantastic to get a good workout. Staff are courteous and polite. I would stay again.. ...

Reviewed on 13 Dec 2025

The DEXTRO Little Italy, BW Premier Collection
See all 6,872 properties in Otay Mesa West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa West holiday package cost?
Discover the best of Otay Mesa West from as little as . Choose from a wonderful selection of flights, hotels and rental cars to suit every style and budget. You can score even better deals when you add some experiences or tours to your package.
How do I get a cheap travel package to Otay Mesa West?
Booking an Otay Mesa West holiday package with Expedia is the easiest way to save. We have over 550 partner airlines and 1 000 000 properties across the globe. With such an awesome range to select from, you'll have no trouble putting together your next dream holiday.
Where should I stay in Otay Mesa West?
You'll want to stay where the action is. Many people book hotels around popular attractions, like Las Americas Premium Outlets, North Island Credit Union Amphitheatre and Aquatica.
How far in advance should I book my Otay Mesa West holiday?
Smart travellers will likely want to book early. You can normally start comparing international fares on Expedia up to a year before your intended flight. If you're booking last minute, don't despair. Low prices sometimes appear just weeks before departure dates.
What does an Expedia Otay Mesa West travel package include?
It all depends on what type of getaway you're contemplating. Otay Mesa West holiday deals can include hotels, car rentals and flights. You can mix and match to find the travel package that fits your needs. You can also add on experiences and activities after you've booked to score even bigger discounts.
What should I know before booking an Otay Mesa West travel package?
Get ready to save with an Expedia travel package. Bundle your airfares, rental cars and hotels and pick up fabulous discounts. You're not limited to hotels, though. Book with us and select from beach villas, mountain cabins and everything in between!
Can I choose my airline with an Otay Mesa West Expedia holiday package?
With a holiday package, you're the boss. Whether you'd like to fly to Otay Mesa West in economy or business class, simply pick from the available airline options. Expedia has access to over 550 partner airlines all over the world.
If I'm not able to travel, can I cancel my Otay Mesa West holiday package?
You can. We get that even the best-laid plans can go awry, so we're here to help if you need to make changes to your Otay Mesa West holiday package. You may be able to cancel or change your itinerary for free if you've booked within 24 hours. Your hotel, airline or car rental company may impose a fee if you booked more than 24 hours ago. Head to our Customer Service Portal for further information. Also, be sure to check your itinerary for the nitty-gritty on change fees.

Discover the most popular places to visit in Otay Mesa West

San Diego Zoo which includes a pond, zoo animals and landscape views

San Diego Zoo

4.5/5(26 reviews)

Admire the animal kingdom in all its fascinating glory at one of America’s largest zoos.

San Diego Zoo
Mission Bay showing a beach

Mission Bay

4/5(10 reviews)

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay
Petco Park

Petco Park

4.5/5(10 reviews)

Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.

Petco Park

Activities

LEGOLAND® California Resort

LEGOLAND® California Resort

NZ$111
per adult
84% of travellers recommend
LEGOLAND® California Resort
San Diego Old Town Trolley Hop-On Hop-Off Tour

San Diego Old Town Trolley Hop-On Hop-Off Tour

NZ$95
per adult
94% of travellers recommend
San Diego Old Town Trolley Hop-On Hop-Off Tour
San Diego City Lights Night Tour

San Diego City Lights Night Tour

NZ$76
per adult
94% of travellers recommend
San Diego City Lights Night Tour
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.