Sant' Ambrogio Hotels, Florence

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Check prices for these dates

Tonight
25 Dec - 26 Dec
Tomorrow
26 Dec - 27 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

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Our top choices for Sant' Ambrogio hotels

View from property
Hotel Cardinal Of Florence

Hotel Cardinal Of Florence

Hotel Cardinal Of Florence
3.0 star property
Sant' Ambrogio
8.6 out of 10, Excellent, (315)
"Booked this hotel for the view on the rooftop and it did not disappoint. Also great loccation."
Canada
Ed
The price is NZ$162
includes taxes & fees
7 Jan - 8 Jan 2026
Hotel Cardinal Of Florence
Interior entrance
Hotel D'Azeglio

Hotel D'Azeglio

Hotel D'Azeglio
2.0 star property
Sant' Ambrogio
7.8 out of 10, Good, (340)
"The place was walking distance very clean and quiet stuff very friendly a plus including breakfast "
United States
Beatriz
The price is NZ$113
includes taxes & fees
25 Dec - 26 Dec
Hotel D'Azeglio
View from property
B&B di Piazza del Duomo

B&B di Piazza del Duomo

B&B di Piazza del Duomo
Sant' Ambrogio
9.2 out of 10, Wonderful, (245)
"great location."
Australia
Ankur
The price is NZ$314
includes taxes & fees
11 Jan - 12 Jan 2026
B&B di Piazza del Duomo
Property entrance
Residenza D'Epoca Sant'Egidio

Residenza D'Epoca Sant'Egidio

Residenza D'Epoca Sant'Egidio
Sant' Ambrogio
7.2 out of 10, Good, (102)
"It is beautiful! A few stairs to get there but well worth it!!!!! "
United Kingdom
Daniella
The price is NZ$138
includes taxes & fees
7 Jan - 8 Jan 2026
Residenza D'Epoca Sant'Egidio
Bar (on property)
Hotel Villa Liana

Hotel Villa Liana

Hotel Villa Liana
3.0 star property
Sant' Ambrogio
8.6 out of 10, Excellent, (343)
"the breakfast was delicious!"
United States
Catherine
Hotel Villa Liana
Interior detail
Alfieri9

Alfieri9

Alfieri9
3.0 star property
Sant' Ambrogio
9.6 out of 10, Exceptional, (158)
"Hotel was in a nice quiet neighborhood, but still only a short walk to main attractions. The breakfast was excellent. Staff interactions were good."
United States
Colin
Alfieri9
Interior
Mamo Florence - Dante & Virgilio Apartments

Mamo Florence - Dante & Virgilio Apartments

Mamo Florence - Dante & Virgilio Apartments
Sant' Ambrogio
9.8 out of 10, Exceptional, (9)
"Great little 2 bedroom apartment for our family. Very convenient and nice area. "
Australia
Doan
The price is NZ$388
includes taxes & fees
8 Jan - 9 Jan 2026
Mamo Florence - Dante & Virgilio Apartments
Garden
Hotel Regency

Hotel Regency

Hotel Regency
5.0 star property
Sant' Ambrogio
9.4 out of 10, Exceptional, (442)
"Amazing stay as always. Beautiful hotel but the staff make it great. Feels like a home away from home. Perfect location that is easily walkable everywhere in the historic center."
United States
Aaron
The price is NZ$569
includes taxes & fees
16 Jan - 17 Jan 2026
Hotel Regency
40-inch flat-screen TV with satellite channels
Dimora del Cardinale - Residenza d'epoca

Dimora del Cardinale - Residenza d'epoca

Dimora del Cardinale - Residenza d'epoca
Sant' Ambrogio
9.8 out of 10, Exceptional, (56)
"We had an easy check-in. Friendly staff welcomed us and we settled in quickly so we could enjoy the sites. We walked to all tours and restaurants. The restaurant next door was so good, we ate their twice! The property is well located to everything - food, shopping and more!"
United States
Stacey
The price is NZ$209
includes taxes & fees
19 Jan - 20 Jan 2026
Dimora del Cardinale - Residenza d'epoca
City view
Iris Apartments by Mmega

Iris Apartments by Mmega

Iris Apartments by Mmega
Sant' Ambrogio
7.8 out of 10, Good, (12)
"Excellent location bit a bit noisy at night."
United States
Stephen
The price is NZ$365
includes taxes & fees
24 Jan - 25 Jan 2026
Iris Apartments by Mmega
Deluxe Villa
Villa Tortorelli

Villa Tortorelli

Villa Tortorelli
Sant' Ambrogio
9.6 out of 10, Exceptional, (66)
"Beautiful property! Loved our stay here! "
United States
Olga
Villa Tortorelli
Restaurant
Hotel Bodoni

Hotel Bodoni

Hotel Bodoni
2.0 star property
Sant' Ambrogio
8.2 out of 10, Very good, (792)
"Nice people and convenient location!!!!"
United States
julio
The price is NZ$144
includes taxes & fees
21 Jan - 22 Jan 2026
Hotel Bodoni
Interior entrance
Hotel Bavaria

Hotel Bavaria

Hotel Bavaria
1.0 star property
Sant' Ambrogio
8.2 out of 10, Very good, (408)
"Hermes was very helpful on how to get around the city. He recommended a place to eat. We loved it so much that we went twice. "
United States
Juan
The price is NZ$126
includes taxes & fees
21 Jan - 22 Jan 2026
Hotel Bavaria
Comfort Apartment | Living area
Don Giovanni by Mmega

Don Giovanni by Mmega

Don Giovanni by Mmega
Sant' Ambrogio
9.0 out of 10, Wonderful, (7)
"Perfect location Very clean Nicely appointed"
United States
Luanne
The price is NZ$454
includes taxes & fees
7 Jan - 8 Jan 2026
Don Giovanni by Mmega
Deluxe Apartment | Living area
Oriuolo Prestige by Mmega

Oriuolo Prestige by Mmega

Oriuolo Prestige by Mmega
Sant' Ambrogio
9.0 out of 10, Wonderful, (7)
"Nice appartement, nice experience."
Canada
Robert
The price is NZ$375
includes taxes & fees
25 Dec - 26 Dec
Oriuolo Prestige by Mmega
Exterior
Residenza d'Epoca Borgo Albizi

Residenza d'Epoca Borgo Albizi

Residenza d'Epoca Borgo Albizi
Sant' Ambrogio
8.0 out of 10, Very good, (253)
"Perfect place for our stay in Florence."
United States
Rachel
The price is NZ$325
includes taxes & fees
30 Dec - 31 Dec
Residenza d'Epoca Borgo Albizi
Apartment | Living area
Mamo Florence - Gilbe One Apartment

Mamo Florence - Gilbe One Apartment

Mamo Florence - Gilbe One Apartment
Sant' Ambrogio
10.0 out of 10, Exceptional, (1)
"El lugar era muy bonito, espacioso y confortable Todo muy limpio y ordenado"
Mexico
Janeth
The price is NZ$440
includes taxes & fees
23 Jan - 24 Jan 2026
Mamo Florence - Gilbe One Apartment
Comfort Apartment | Living area
Blue Santa Croce by MMega

Blue Santa Croce by MMega

Blue Santa Croce by MMega
Sant' Ambrogio
The price is NZ$378
includes taxes & fees
7 Jan - 8 Jan 2026
Blue Santa Croce by MMega
Garden
Locanda Orchidea - B&B

Locanda Orchidea - B&B

Locanda Orchidea - B&B
Sant' Ambrogio
9.2 out of 10, Wonderful, (233)
"Perfect location, superb room, + wonderful staff - a brilliant stay all round! "
United Kingdom
TARA
Locanda Orchidea - B&B
Deluxe Apartment | Terrace/patio
Duomo Luxury House by Mmega

Duomo Luxury House by Mmega

Duomo Luxury House by Mmega
Sant' Ambrogio
8.0 out of 10, Very good, (3)
"Outstanding, large place with nice bathrooms, lots of windows and fresh air, balcony onto a courtyard where bunnies hang out. It’s in an ideal location. You step onto the street and the duomo looms. Property management company is excellent. We had a great time. "
United States
Trampas
Duomo Luxury House by Mmega
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our guide on where to stay in Sant' Ambrogio

Find the best Sant' Ambrogio areas for the activities you enjoy most.

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Piazza di Santa Maria Novella or Via de' Calzaiuoli while you're exploring the neighbourhood.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Uffizi Gallery which includes street scenes as well as a large group of people

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Top Sant' Ambrogio Hotel Reviews

Hotel Villa Liana

Hotel Villa Liana

10/10 Excellent
"the breakfast was delicious!"
Catherine 3-night trip
Posted 5 days ago
Hotel Villa Liana

Frequently asked questions

What's it like in Sant' Ambrogio?
Guests are sure to enjoy their time checking out all that Florence's Sant' Ambrogio neighbourhood has to offer. Make sure that you visit Piazza Massimo D'Azeglio and Mercato di Sant'Ambrogio as part of your Sant' Ambrogio travel plans.
What's a favourite hotel to stay in Sant' Ambrogio?
Based on Expedia customer reviews, Alfieri9 is the highest ranked property in Sant' Ambrogio. This hotel is a short 15-minute walk from Piazza del Duomo, and it offers free WiFi and valet parking. Other favourite options in the area include B&B di Piazza del Duomo and Hotel Regency.
How many hotels can I expect to find in Sant' Ambrogio?
If you're searching for places to stay in Florence, Expedia has something to meet your needs with 516 Sant' Ambrogio hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in Sant' Ambrogio, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best options available in Sant' Ambrogio.
What is there to do around this Florence neighbourhood?
Landmarks in Sant' Ambrogio that you won't want to miss include Great Synagogue of Florence and Church of Santa Maria Maddalena dei Pazzi. Piazza Massimo D'Azeglio and Mercato di Sant'Ambrogio are also a couple of places to visit in the neighbourhood. A few places to visit in the area around Sant' Ambrogio include Piazza di Santa Maria Novella, Jewish Museum and FiesoleBike Day Tours. When you're sightseeing in Florence, Galleria d'Arte Civico69 and Teatro della Pergola are also worth a stop.

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