A red train on tracks, palm trees, and modern buildings.

Central San Diego Holiday Rentals

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months

Our top choices for Central San Diego holiday rentals

1. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (246 reviews)
"Excellent location, near little Italy, zoo and airport. Be aware that you are near airport so expect more noise than normal"
United States
Willie
The price is NZ$297
includes taxes & fees
29 Nov - 30 Nov
City24 Hotel Little Italy Mission Hills

2. Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very good, (523 reviews)
"Front desk service was amazing and love the central location to all the LGBTQ bars and restaurants."
United States
Victor
The price is NZ$183
includes taxes & fees
30 Nov - 1 Dec
Uptown Inn by Vantaggio - Limited Service Apart-Hotel

3. Large Group Wellness Retreat w Spa & Gym

Large Group Wellness Retreat w Spa & Gym
3.0 star property
University City
The price is NZ$2,298
includes taxes & fees
10 Dec - 11 Dec
Large Group Wellness Retreat w Spa & Gym

4. Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego
3.5 star property
Downtown San Diego
9.4 out of 10, Exceptional, (1,271 reviews)
"Nice accommodations"
United States
Michael
The price is NZ$301
includes taxes & fees
30 Nov - 1 Dec
Marriott Vacation Club®, San Diego

5. Winners Circle Solana Beach Del Mar Resort

Winners Circle Solana Beach Del Mar Resort
2.5 star property
Solana Beach
9.2 out of 10, Wonderful, (437 reviews)
"clean room, great location, friendly staff and great outdoor pool"
United States
Lea
The price is NZ$316
includes taxes & fees
15 Nov - 16 Nov
Winners Circle Solana Beach Del Mar Resort

6. Coronado Beach Resort

Coronado Beach Resort
3.0 star property
Historic Downtown Coronado
9.2 out of 10, Wonderful, (842 reviews)
"Great property and great staff. I would recommend it to anyone."
United States
Brent
The price is NZ$338
includes taxes & fees
29 Nov - 30 Nov
Coronado Beach Resort

7. Little Italy Inn - Limited Service Apart Hotel

Little Italy Inn - Limited Service Apart Hotel
2.5 star property
Downtown San Diego
8.4 out of 10, Very good, (420 reviews)
"clean, affordable, safe, such a great stay!"
United States
Beatriz
The price is NZ$204
includes taxes & fees
14 Dec - 15 Dec
Little Italy Inn - Limited Service Apart Hotel

8. Kasa Little Italy San Diego

Kasa Little Italy San Diego
4.5 star property
Downtown San Diego
9.6 out of 10, Exceptional, (567 reviews)
"Super nice amenities - would stay again. Great location"
United States
Nirmeen
The price is NZ$510
includes taxes & fees
15 Nov - 16 Nov
Kasa Little Italy San Diego

9. 945 Fourth Ave

945 Fourth Ave
Downtown San Diego
The price is NZ$406
includes taxes & fees
15 Nov - 16 Nov
945 Fourth Ave

10. Riviera Oaks Resort by Coolvacay

Riviera Oaks Resort by Coolvacay
3.0 star property
San Diego Country Estates
9.6 out of 10, Exceptional, (1,114 reviews)
"Beautiful and cozy property!"
United States
Kristin
The price is NZ$217
includes taxes & fees
25 Nov - 26 Nov
Riviera Oaks Resort by Coolvacay

11. Wave Crest Resort

Wave Crest Resort
3.0 star property
Del Mar
9.2 out of 10, Wonderful, (165 reviews)
"Beautiful property and proximity to the beach."
United States
Howland
The price is NZ$398
includes taxes & fees
13 Dec - 14 Dec
Wave Crest Resort

12. Stroll to Shore + Mission Blvd: Dog-friendly Home

Stroll to Shore + Mission Blvd: Dog-friendly Home
3.0 star property
Mission Beach
The price is NZ$1,078
includes taxes & fees
19 Nov - 20 Nov
Stroll to Shore + Mission Blvd: Dog-friendly Home

13. San Diego Country Estates

San Diego Country Estates
2.5 star property
San Diego Country Estates
9.4 out of 10, Exceptional, (318 reviews)
"This was the perfect location for me during my visit with my daughters. I will for sure be looking to stay here again in my next visits."
United States
Charles
The price is NZ$230
includes taxes & fees
6 Dec - 7 Dec
San Diego Country Estates

14. 2 Bedroom Townhome 2 Mins. to the Beach

2 Bedroom Townhome 2 Mins. to the Beach
3.5 star property
Mission Beach
5.8 out of 10, (7 reviews)
"The owner of property cancelled my stay and I can not get anyone to give me a refund. I would appreciate someone getting back to me for this. I will not let it go unsettled. "
United States
Randy
The price is NZ$1,425
includes taxes & fees
24 Nov - 25 Nov
2 Bedroom Townhome 2 Mins. to the Beach

15. Kasa Gaslamp Quarter San Diego

Kasa Gaslamp Quarter San Diego
3.5 star property
Downtown San Diego
7.8 out of 10, Good, (242 reviews)
"Wonderful place!"
Canada
Eric
The price is NZ$202
includes taxes & fees
16 Nov - 17 Nov
Kasa Gaslamp Quarter San Diego

16. Rooftop w/ Views: Modern Little Italy Townhome

Rooftop w/ Views: Modern Little Italy Townhome
3.5 star property
Downtown San Diego
10.0 out of 10, Exceptional, (1 review)
Rooftop w/ Views: Modern Little Italy Townhome

17. < 2 Mi to Pacific Beach! Sunny San Diego Escape

< 2 Mi to Pacific Beach! Sunny San Diego Escape
3.0 star property
Pacific Beach
7.4 out of 10, Good, (3 reviews)
"Strategic location for beach, amusement parks and restaurants. Close to major freeways and airport. House has plenty of room across the three floors. Kids loved seeing the seaworld fireworks from the open air rooftop patio. This property has it all. Owner quickly addressed any of our questions and needs. "
United States
Thomas
The price is NZ$1,288
includes taxes & fees
15 Nov - 16 Nov
< 2 Mi to Pacific Beach! Sunny San Diego Escape
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Central San Diego Hotel Reviews

Find out more about Central San Diego

You always said you would go on a dream holiday someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannonball into the deep end. Go ahead, unplug and unwind in style. When you book one of our Central San Diego holiday rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your holiday just got upgraded.

As much as you love your vacation rental, it’s always good to get out and explore to soak up Central San Diego. Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in Central San Diego. Seeing all the best attractions is bound to make you fall in love with Central San Diego. Who knows, you may even be tempted to extend your stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true. 

It’s your escape so why share it? You deserve your own slice of paradise. Booking your holiday rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in Central San Diego short-term rentals, that won’t be hard to do.

Explore a world of travel with Expedia