Santo Domingo Hotels, Mexico City

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
17 Dec - 18 Dec
Tomorrow
18 Dec - 19 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santo Domingo hotels

Front of property
Camino Real Aeropuerto Mexico

Camino Real Aeropuerto Mexico

Camino Real Aeropuerto Mexico
4.0 star property
Venustiano Carranza, 14.5 km from Santo Domingo
8.8 out of 10, Excellent, (11900)
"Great option to stay close the airport"
United States
Alexandra
The price is NZ$262
includes taxes & fees
16 Jan - 17 Jan 2026
Camino Real Aeropuerto Mexico
Breakfast, lunch, dinner served; Mexican cuisine
Hotel Catedral

Hotel Catedral

Hotel Catedral
4.0 star property
Historic Center, 12.4 km from Santo Domingo
9.4 out of 10, Exceptional, (2616)
"Clean room, best pillows Best breakfast I have had in hotels."
United States
Isabel
The price is NZ$184
includes taxes & fees
22 Dec - 23 Dec
Hotel Catedral
Interior
Courtyard Mexico City Airport

Courtyard Mexico City Airport

Courtyard Mexico City Airport
4.0 star property
Venustiano Carranza, 14.8 km from Santo Domingo
9.4 out of 10, Exceptional, (1814)
"Great staff clean room and so easy to access from airport "
Canada
Jean
The price is NZ$323
includes taxes & fees
16 Jan - 17 Jan 2026
Courtyard Mexico City Airport
Indoor pool, open 6 AM to 8 PM, pool loungers
Barceló México Reforma

Barceló México Reforma

Barceló México Reforma
4.5 star property
11.9 km from Santo Domingo
9.4 out of 10, Exceptional, (5083)
"Beautiful hotel, great location rooms very clean the staff very friendly and helpful."
United States
Khaled
The price is NZ$230
includes taxes & fees
5 Jan - 6 Jan 2026
Barceló México Reforma
Exterior
Galeria Plaza Reforma

Galeria Plaza Reforma

Galeria Plaza Reforma
4.0 star property
Zona Rosa, 10.7 km from Santo Domingo
9.4 out of 10, Exceptional, (3185)
"Great place, centrally located, very walkable."
United States
Jeffrey
The price is NZ$280
includes taxes & fees
22 Dec - 23 Dec
Galeria Plaza Reforma
Exterior
Hampton Inn & Suites Mexico City - Centro Historico

Hampton Inn & Suites Mexico City - Centro Historico

Hampton Inn & Suites Mexico City - Centro Historico
3.0 star property
Historic Center, 11.7 km from Santo Domingo
9.0 out of 10, Wonderful, (1087)
"Always a great place to stay while in CDMX "
United States
Juan
The price is NZ$172
includes taxes & fees
10 Jan - 11 Jan 2026
Hampton Inn & Suites Mexico City - Centro Historico
Outdoor pool, open 8:00 AM to 8:00 PM, pool loungers
Hotel Century Reforma

Hotel Century Reforma

Hotel Century Reforma
3.5 star property
Zona Rosa, 10.6 km from Santo Domingo
8.6 out of 10, Excellent, (1247)
"Great location and accommodations "
United States
Daniel
The price is NZ$202
includes taxes & fees
11 Jan - 12 Jan 2026
Hotel Century Reforma
Exterior
Fiesta Inn Ciudad de Mexico Aeropuerto

Fiesta Inn Ciudad de Mexico Aeropuerto

Fiesta Inn Ciudad de Mexico Aeropuerto
3.5 star property
Venustiano Carranza, 14.3 km from Santo Domingo
8.8 out of 10, Excellent, (3193)
"Breakfast was amazing good room "
United States
Jose
The price is NZ$231
includes taxes & fees
1 Jan - 2 Jan 2026
Fiesta Inn Ciudad de Mexico Aeropuerto
Business Suite with living area and street view
We Hotel Aeropuerto

We Hotel Aeropuerto

We Hotel Aeropuerto
3.5 star property
Venustiano Carranza, 14.1 km from Santo Domingo
8.4 out of 10, Very good, (2144)
"easy to check in, facility clean and staff friendly "
Canada
William
The price is NZ$191
includes taxes & fees
26 Dec - 27 Dec
We Hotel Aeropuerto
Breakfast, lunch, brunch served; Mexican cuisine
Hotel Bellas Artes

Hotel Bellas Artes

Hotel Bellas Artes
4.0 star property
Historic Center, 12.1 km from Santo Domingo
9.6 out of 10, Exceptional, (560)
"Great place to stay in the centro histórico, "
United States
Juan
The price is NZ$185
includes taxes & fees
12 Jan - 13 Jan 2026
Hotel Bellas Artes
Front of property – evening/night
Historico Central Hotel

Historico Central Hotel

Historico Central Hotel
4.0 star property
Historic Center, 12 km from Santo Domingo
9.8 out of 10, Exceptional, (2405)
"Very nice staff, clean rooms, very good breakfast options and close to very city amenities."
United States
Maria
The price is NZ$298
includes taxes & fees
18 Dec - 19 Dec
Historico Central Hotel
Lobby
Hotel PF

Hotel PF

Hotel PF
3.5 star property
Zona Rosa, 10.6 km from Santo Domingo
9.0 out of 10, Wonderful, (2248)
"Clean room, nice amenities in the restroom, friendly and accommodating staff, walkable neighborhood with plenty of restaurants and stores."
United States
Brigette
The price is NZ$156
includes taxes & fees
15 Jan - 16 Jan 2026
Hotel PF
Restaurant
Holiday Inn Express Mexico Basilica by IHG

Holiday Inn Express Mexico Basilica by IHG

Holiday Inn Express Mexico Basilica by IHG
3.0 star property
14.7 km from Santo Domingo
9.2 out of 10, Wonderful, (1046)
"Excellent stay!"
United States
Derek
The price is NZ$142
includes taxes & fees
7 Jan - 8 Jan 2026
Holiday Inn Express Mexico Basilica by IHG
Presidential Suite, 1 King Bed | Bathroom
Hilton Mexico City Reforma

Hilton Mexico City Reforma

Hilton Mexico City Reforma
4.5 star property
Reforma, 12 km from Santo Domingo
9.4 out of 10, Exceptional, (1066)
"Great room and staff. Hotel Bar was also phenomenal!"
United States
Tyneshia Nicole
The price is NZ$371
includes taxes & fees
23 Dec - 24 Dec
Hilton Mexico City Reforma
Terrace/patio
Hotel Punto MX

Hotel Punto MX

Hotel Punto MX
3.5 star property
Historic Center, 11.7 km from Santo Domingo
9.0 out of 10, Wonderful, (1436)
"Loved everything about this hotel will definitely be back! "
United States
Andrea
The price is NZ$117
includes taxes & fees
13 Jan - 14 Jan 2026
Hotel Punto MX
Breakfast, lunch, dinner served; Mexican cuisine
Zocalo Central & Rooftop Mexico City

Zocalo Central & Rooftop Mexico City

Zocalo Central & Rooftop Mexico City
4.0 star property
Historic Center, 12.2 km from Santo Domingo
9.8 out of 10, Exceptional, (2656)
"Great place to stay! "
United States
Guadalupe
The price is NZ$382
includes taxes & fees
12 Jan - 13 Jan 2026
Zocalo Central & Rooftop Mexico City
Outdoor pool
Holiday Inn Zona Centro by IHG

Holiday Inn Zona Centro by IHG

Holiday Inn Zona Centro by IHG
3.5 star property
12.7 km from Santo Domingo
9.2 out of 10, Wonderful, (1001)
"Todo excelente "
Mexico
Gabriela
The price is NZ$199
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Zona Centro by IHG
Lobby
Fiesta Inn Periferico Sur

Fiesta Inn Periferico Sur

Fiesta Inn Periferico Sur
3.5 star property
Coyoacan, 2.9 km from Santo Domingo
8.8 out of 10, Excellent, (1106)
"Nice hotel"
Canada
Yan
The price is NZ$191
includes taxes & fees
18 Dec - 19 Dec
Fiesta Inn Periferico Sur
Bar (on property)
Camino Real Polanco Mexico

Camino Real Polanco Mexico

Camino Real Polanco Mexico
4.5 star property
11.1 km from Santo Domingo
9.2 out of 10, Wonderful, (3142)
"Clean, great staff, delicious restaurants inside, beautiful room and views"
United States
Aurora
The price is NZ$231
includes taxes & fees
4 Jan - 5 Jan 2026
Camino Real Polanco Mexico
Terrace/patio
Hotel Brasilia

Hotel Brasilia

Hotel Brasilia
3.0 star property
16.5 km from Santo Domingo
9.0 out of 10, Wonderful, (1013)
"Super clean hotel and the staff very pleasant and friendly."
United States
Emanuel
The price is NZ$125
includes taxes & fees
25 Dec - 26 Dec
Hotel Brasilia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Our guide on where to stay in Santo Domingo

Find the best Santo Domingo areas for the activities you enjoy most.

Roma Norte

Known for its fascinating museums and popular shops, there's plenty to explore in Roma Norte. Check out top attractions like MUCA Roma and Centro Cultural El Punto, and jump on the metro at Insurgentes Station or Sevilla Station to see more of the city.

Polanco showing heritage architecture, a church or cathedral and a garden

Polanco

Visit the most diverse section of Mexico City for sophisticated shopping, dining, accommodations and sightseeing.

La Condesa showing café scenes

La Condesa

Enjoy 20th-century history in these two sections of Mexico City, with interesting art and architecture reflecting European influences.

Metropolitan Cathedral showing heritage elements, a church or cathedral and heritage architecture

Historic Center

Consider a visit to Zócalo and take some time to enjoy the interesting museums during your time in Historic Center. If you want to see more of the city, jump on the metro at Allende Station or Bellas Artes Station.

Reforma featuring a city, central business district and night scenes

Reforma

Consider a visit to Paseo de la Reforma and take some time to enjoy the important monuments during your time in Reforma. If you want to see more of the city, jump on the metro at Insurgentes Station or Cuauhtemoc Station.

Top Santo Domingo Hotel Reviews

Hotel Catedral

Hotel Catedral

10/10 Excellent
"Good price. Excellent breakfast"
Rongfu 2-night trip
Posted 2 days ago
Hotel Catedral

Explore a world of travel with Expedia

Frequently asked questions

What is Santo Domingo like?
Travellers to Mexico City's Santo Domingo neighbourhood will be sure to enjoy a stay here.
How many hotels will I find in the Santo Domingo area?
Book one of Expedia's 5 hotels and other accommodation options in Santo Domingo and start exploring everything Mexico City has to offer.
If I need to cancel my hotel reservation in Santo Domingo, will I receive a refund?
Yes, most room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then use the "fully refundable" filter to review the best deals available in Santo Domingo.
What are the top things to see and do in Santo Domingo?
Parroquia de San Juan Bautista, Casa del Teatro and Museo Diego Rivera Anahuacalli are just a few of the places to visit in and around Santo Domingo. While you're out sightseeing, Museo de la Ciudad and Hidalgo Plaza are a couple of additional sights to visit in Mexico City.