South Main Hotels, Houston
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Our top choices for South Main hotels
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,302 reviews)
"Would stay again!"
Austin
The price is NZ$179
includes taxes & fees
20 May - 21 May
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,017 reviews)
"Clean & comfortable, super nice staff, good breakfast options, convenient to MDA."
Cleota
The price is NZ$178
includes taxes & fees
31 May - 1 June
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,005 reviews)
"Excellent Service"
Ryan
The price is NZ$150
includes taxes & fees
25 May - 26 May
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (864 reviews)
"My stay was perfect "
Fredrick
The price is NZ$156
includes taxes & fees
2 June - 3 June
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,003 reviews)
"Very clean rooms and excellent staff"
Efrain
The price is NZ$126
includes taxes & fees
2 June - 3 June
Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.6 out of 10, Exceptional, (73 reviews)
"The property was very clean and the staff was great. I would stay here again when back in town."
Cruz
The price is NZ$123
includes taxes & fees
28 May - 29 May
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (247 reviews)
"Simply amazing stay "
Jesus
The price is NZ$177
includes taxes & fees
21 May - 22 May
Hotel Royale
Hotel Royale20.9 km from South Main
9.2 out of 10, Wonderful, (36 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
Jerome
The price is NZ$148
includes taxes & fees
22 May - 23 May
Palace Inn Blue 290 W 43rd & Bingle Rd
Palace Inn Blue 290 W 43rd & Bingle Rd19.4 km from South Main
9.2 out of 10, Wonderful, (62 reviews)
"We loved it, very nice employees and very clean."
Jorge
The price is NZ$163
includes taxes & fees
1 June - 2 June
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,008 reviews)
"Parking was easy."
Chris
The price is NZ$187
includes taxes & fees
31 May - 1 June
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Hampton Inn & Suites Houston-Bush Intercontinental Aprt31.8 km from South Main
8.8 out of 10, Excellent, (1,897 reviews)
"Nice overnight stay. Great for close to airport!!!"
Jaime
The price is NZ$187
includes taxes & fees
1 June - 2 June
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (172 reviews)
"It was very clean"
Jesus
The price is NZ$163
includes taxes & fees
24 May - 25 May
Best Western Plus Manvel Inn & Suites
Best Western Plus Manvel Inn & Suites22.6 km from South Main
8.8 out of 10, Excellent, (786 reviews)
"Everything about this place was awesome. Will definitely be staying there again on my next trip!!!!!"
Penny
The price is NZ$155
includes taxes & fees
1 June - 2 June
SpringHill Suites by Marriott Houston Intercontinental Arprt
SpringHill Suites by Marriott Houston Intercontinental Arprt31.8 km from South Main
9.0 out of 10, Wonderful, (1,768 reviews)
"Gorgeous, perfect location, super comfy beds"
Caitlin
The price is NZ$241
includes taxes & fees
1 June - 2 June
La Quinta Inn & Suites by Wyndham Richmond-Sugarland
La Quinta Inn & Suites by Wyndham Richmond-Sugarland30.3 km from South Main
8.6 out of 10, Excellent, (1,003 reviews)
"Close proximity to plenty of restaurants and to Brazos Bend State Park!"
Katie
The price is NZ$162
includes taxes & fees
1 June - 2 June
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham18.5 km from South Main
8.8 out of 10, Excellent, (1,171 reviews)
"Room very clean and spacious
Good choice for breakfast and staffs very polite"
Kofoworola
The price is NZ$165
includes taxes & fees
27 May - 28 May
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,214 reviews)
"Wonderful place to stay!"
Lisa
The price is NZ$252
includes taxes & fees
25 May - 26 May
Grand Tuscany Hotel
Grand Tuscany Hotel20.3 km from South Main
7.6 out of 10, Good, (50 reviews)
" Exactly what we needed, perfect location, perfect atmosphere friendly staff very clean facility"
Sonya
The price is NZ$197
includes taxes & fees
31 May - 1 June
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
"Great location and the staff was great. Very comfortable beds and rooms were very clean. I always come back to this hotel."
Matthew
The price is NZ$187
includes taxes & fees
31 May - 1 June
Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 4.4 km from South Main
8.4 out of 10, Very good, (1,921 reviews)
"Breakfast was wonderful and the front desk staff were very helpful."
Reta
The price is NZ$200
includes taxes & fees
31 May - 1 June
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,017 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 864 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,005 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,003 reviews | View | ||||||
 Comfort Suites Houston Near Medical Center- NRG Stadium | 8.8 Excellent 11 reviews | View |
Our guide on where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
Magnolia Hotel Houston, A Tribute Portfolio Hotel
10/10 Excellent
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- Visit Bellaire
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- Visit Greenway Plaza-Upper Kirby
- Hobby Center for the Performing Arts
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- Jesse H. Jones Hall
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