South Main Hotels, Houston

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

6607 Cheap Hotels in South Main - Specials, Reviews, & Last Minute Deals

Comfort Suites Houston near Medical Center- NRG Stadium

2.5 star property
South Main
8.6 out of 10, Excellent, (1000)
"Loved staying at the Comfort Suites ."
United States
Linda
The price is NZ$191
includes taxes & fees
30 Nov - 1 Dec
Comfort Suites Houston near Medical Center- NRG Stadium

Wyndham Houston near NRG Park/Medical Center

3.5 star property
South Main
7.2 out of 10, Good, (1191)
"Perfect "
United States
Maria
The price is NZ$204
includes taxes & fees
30 Nov - 1 Dec
Wyndham Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

3.0 star property
South Main
6.6 out of 10, (970)
"Great staff, excellent service and convenient to the area we were wanting to be. Room was clean and bed was very comfortable."
United States
Roy
The price is NZ$258
includes taxes & fees
16 Nov - 17 Nov
Wingate Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
South Main
6.4 out of 10, (1001)
"Everything was great"
United States
Yeimi
The price is NZ$126
includes taxes & fees
16 Dec - 17 Dec
Quality Inn & Suites NRG Park - Medical Center

Candlewood Suites Houston Medical Center by IHG

2.5 star property
South Main
7.4 out of 10, Good, (813)
"Yes the where"
United States
Robert
The price is NZ$161
includes taxes & fees
24 Nov - 25 Nov
Candlewood Suites Houston Medical Center by IHG

Hyatt Place Houston Medical Center

3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2124)
"Great stay"
United States
Vallie
The price is NZ$267
includes taxes & fees
23 Nov - 24 Nov
Hyatt Place Houston Medical Center

Hyatt Regency Houston/Galleria

4.0 star property
The Galleria, 8.7 km from South Main
9.0 out of 10, Wonderful, (1140)
"Confortable bed, quiet ron and nice breakfast!"
United States
Juan
The price is NZ$309
includes taxes & fees
23 Nov - 24 Nov
Hyatt Regency Houston/Galleria

Hyatt House Houston Medical Center

3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1160)
"I had a great stay! I travel to Houston several times a year and this is one of my favorite places to stay."
United States
Star
The price is NZ$267
includes taxes & fees
22 Nov - 23 Nov
Hyatt House Houston Medical Center

Blossom Hotel Houston, Curio Collection by Hilton

4.0 star property
Texas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3555)
"The best hotel in this area. "
United States
Paula Porreca
The price is NZ$271
includes taxes & fees
14 Dec - 15 Dec
Blossom Hotel Houston, Curio Collection by Hilton

The Whitehall Houston

4.0 star property
Houston Central Business District, 10 km from South Main
8.6 out of 10, Excellent, (1859)
"Great stay."
United States
Anita
The price is NZ$278
includes taxes & fees
21 Nov - 22 Nov
The Whitehall Houston

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4.0 star property
8.9 km from South Main
8.2 out of 10, Very good, (2892)
"Great location nice beds staff was amazing and good breakfast "
United States
Canyelle
The price is NZ$241
includes taxes & fees
27 Nov - 28 Nov
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

The Royal Sonesta Houston Galleria

4.0 star property
The Galleria, 8.8 km from South Main
8.4 out of 10, Very good, (1366)
"Great stay "
United States
Jennifer
The price is NZ$238
includes taxes & fees
16 Nov - 17 Nov
The Royal Sonesta Houston Galleria

Hilton Garden Inn Houston Medical Center, TX

3.0 star property
Texas Medical Center, 4.7 km from South Main
9.4 out of 10, Exceptional, (1003)
"Great hotel and location!"
United States
Gonzalo
The price is NZ$206
includes taxes & fees
23 Nov - 24 Nov
Hilton Garden Inn Houston Medical Center, TX

Hyatt Regency Houston West

3.5 star property
23.2 km from South Main
8.6 out of 10, Excellent, (1233)
"Great room and staff."
United States
Brad
The price is NZ$266
includes taxes & fees
21 Nov - 22 Nov
Hyatt Regency Houston West

InterContinental Houston by IHG

4.0 star property
Texas Medical Center, 4.1 km from South Main
9.2 out of 10, Wonderful, (1005)
"Very well maintenance property, beautiful lobby and friendly staff."
United States
Viji
The price is NZ$321
includes taxes & fees
28 Nov - 29 Nov
InterContinental Houston by IHG

Holiday Inn Express & Suites Houston - Memorial City Centre by IHG

2.5 star property
Memorial City, 18.4 km from South Main
8.8 out of 10, Excellent, (1003)
"Clean, friendly staff, good breakfast, and all around great stay! "
United States
Rebecca
The price is NZ$240
includes taxes & fees
21 Nov - 22 Nov
Holiday Inn Express & Suites Houston - Memorial City Centre by IHG

Haven Inn & Suites Downtown Houston

2.5 star property
North Houston, 18.8 km from South Main
9.4 out of 10, Exceptional, (1005)
"Very clean and safe, would stay again"
United States
Krimson
Haven Inn & Suites Downtown Houston

Club Quarters Hotel Downtown, Houston

4.0 star property
Houston Central Business District, 10.9 km from South Main
8.4 out of 10, Very good, (3891)
"Hotel was beautiful, room was great for the price"
United States
Sonya
The price is NZ$192
includes taxes & fees
17 Nov - 18 Nov
Club Quarters Hotel Downtown, Houston

Home2 Suites by Hilton at the Galleria

3.0 star property
Greater Uptown, 8 km from South Main
8.8 out of 10, Excellent, (961)
" Clean room , comfortable Good breakfast "
United States
Yelyzaveta
The price is NZ$212
includes taxes & fees
21 Nov - 22 Nov
Home2 Suites by Hilton at the Galleria

Holiday Inn Express Houston - Galleria Area by IHG

2.5 star property
The Galleria, 8.6 km from South Main
9.4 out of 10, Exceptional, (1001)
"Very nice place to stay"
United States
Jose
The price is NZ$206
includes taxes & fees
23 Nov - 24 Nov
Holiday Inn Express Houston - Galleria Area by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in South Main with free breakfast

Hotels in South Main with a pool

Top guest rated hotels in South Main

Our guide on where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Gerald D. Hines Waterwall Park.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

Northside

While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more of the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

Top South Main Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.