South Main Hotels, Houston

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for South Main hotels

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (835 reviews)
"This is a safe, friendly hotel close to MDA Cancer Center"
United States
Myra
The price is NZ$186
includes taxes & fees
18 Feb - 19 Feb
Candlewood Suites Houston Medical Center by IHG

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,002 reviews)
"Clean room, helpful staff and good location to hospital."
United States
George
The price is NZ$209
includes taxes & fees
21 Feb - 22 Feb
Comfort Suites Houston near Medical Center- NRG Stadium

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,002 reviews)
"Room was clean, bed was comfortable, breakfast was good. Perfect place to stay for going to NRG Stadium as it’s an easy walk"
United Kingdom
Daniel
The price is NZ$160
includes taxes & fees
18 Feb - 19 Feb
Quality Inn & Suites NRG Park - Medical Center

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,000 reviews)
"Easy access to stadium "
United States
Richard
The price is NZ$172
includes taxes & fees
22 Feb - 23 Feb
Wingate Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1,218 reviews)
"Front desk staff was very professional and kind."
United States
MARINA
The price is NZ$194
includes taxes & fees
17 Feb - 18 Feb
Wyndham Houston near NRG Park/Medical Center

Fairfield Inn & Suites Houston Intercontinental Airport

Fairfield Inn & Suites Houston Intercontinental Airport
3.0 star property
30.6 km from South Main
8.6 out of 10, Excellent, (1,002 reviews)
"Great place, nice room"
United States
Lester
The price is NZ$169
includes taxes & fees
22 Feb - 23 Feb
Fairfield Inn & Suites Houston Intercontinental Airport

Baymont by Wyndham Houston Hobby Airport

Baymont by Wyndham Houston Hobby Airport
2.5 star property
18.4 km from South Main
8.6 out of 10, Excellent, (895 reviews)
"Very clean !! every thing is new. breakfast also very good, we will comeback to stay again."
United States
LEI
The price is NZ$124
includes taxes & fees
23 Feb - 24 Feb
Baymont by Wyndham Houston Hobby Airport

Four Points by Sheraton Houston Intercontinental Airport

Four Points by Sheraton Houston Intercontinental Airport
3.0 star property
29.9 km from South Main
8.4 out of 10, Very good, (1,007 reviews)
"The staff was friendly and the hotel was clean"
United States
Lisa
The price is NZ$171
includes taxes & fees
20 Feb - 21 Feb
Four Points by Sheraton Houston Intercontinental Airport

Holiday Inn Express & Suites Houston SW - Galleria Area by IHG

Holiday Inn Express & Suites Houston SW - Galleria Area by IHG
2.5 star property
9.6 km from South Main
8.0 out of 10, Very good, (1,000 reviews)
"Clean room, friendly and responsive staff"
United States
Clara
The price is NZ$200
includes taxes & fees
19 Feb - 20 Feb
Holiday Inn Express & Suites Houston SW - Galleria Area by IHG

Comfort Suites Houston West at Clay Road

Comfort Suites Houston West at Clay Road
2.5 star property
22.8 km from South Main
8.4 out of 10, Very good, (1,003 reviews)
"Friendly staff, breakfast excellent perfect location! Will definitely stay here again"
Canada
wanda
The price is NZ$150
includes taxes & fees
22 Feb - 23 Feb
Comfort Suites Houston West at Clay Road

Hilton Garden Inn Houston NW America Plaza

Hilton Garden Inn Houston NW America Plaza
3.5 star property
25 km from South Main
8.6 out of 10, Excellent, (1,000 reviews)
"It was very relaxing and the staff are very friendly and helpful. "
United States
Chantel
The price is NZ$179
includes taxes & fees
22 Feb - 23 Feb
Hilton Garden Inn Houston NW America Plaza

Hampton Inn Houston-Brookhollow

Hampton Inn Houston-Brookhollow
2.5 star property
20.4 km from South Main
8.2 out of 10, Very good, (1,002 reviews)
"The staff is awesome! What a great place to stay! "
United States
Cynthia
The price is NZ$166
includes taxes & fees
23 Feb - 24 Feb
Hampton Inn Houston-Brookhollow

GreenTree Inn Houston IAH Airport

GreenTree Inn Houston IAH Airport
2.0 star property
31.4 km from South Main
6.6 out of 10, (1,007 reviews)
"Staff was very friendly , room was very clean "
Canada
Charlette
The price is NZ$105
includes taxes & fees
17 Feb - 18 Feb
GreenTree Inn Houston IAH Airport

Sleep Inn & Suites Near Downtown North

Sleep Inn & Suites Near Downtown North
2.5 star property
Greater Heights, 14.2 km from South Main
8.4 out of 10, Very good, (798 reviews)
"Great place to stay at "
United States
Audrey
The price is NZ$173
includes taxes & fees
22 Feb - 23 Feb
Sleep Inn & Suites Near Downtown North

La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD

La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD
3.0 star property
28.7 km from South Main
9.0 out of 10, Wonderful, (990 reviews)
"The hotel was very clean the staff was amazing. We enjoyed our stay"
United States
Teanna
The price is NZ$157
includes taxes & fees
22 Feb - 23 Feb
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD

Home2 Suites by Hilton Houston IAH Airport Beltway 8

Home2 Suites by Hilton Houston IAH Airport Beltway 8
3.0 star property
29.9 km from South Main
8.4 out of 10, Very good, (813 reviews)
"Great room close to airport "
United States
Kelli
The price is NZ$154
includes taxes & fees
22 Feb - 23 Feb
Home2 Suites by Hilton Houston IAH Airport Beltway 8

Hampton Inn & Suites Houston I-10 West Park Row

Hampton Inn & Suites Houston I-10 West Park Row
2.5 star property
29.4 km from South Main
8.8 out of 10, Excellent, (686 reviews)
"Room was very clean and front desk staff were great!"
United States
Bobby
The price is NZ$156
includes taxes & fees
22 Feb - 23 Feb
Hampton Inn & Suites Houston I-10 West Park Row

Hilton Houston North

Hilton Houston North
3.5 star property
30.5 km from South Main
8.4 out of 10, Very good, (1,002 reviews)
"I had a great stay at this hotel. The room was clean and comfortable."
United States
Victor
The price is NZ$253
includes taxes & fees
22 Feb - 23 Feb
Hilton Houston North

Doubletree by Hilton Houston Hobby Airport

Doubletree by Hilton Houston Hobby Airport
4.0 star property
Southeast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,006 reviews)
"Excellent stay! The room was very clean and comfortable, and the staff went above and beyond to be friendly and helpful. Check-in was smooth, the amenities were great, and the overall atmosphere made it a relaxing experience. I’d definitely stay here again!"
United States
Wayne
The price is NZ$207
includes taxes & fees
23 Feb - 24 Feb
Doubletree by Hilton Houston Hobby Airport

Holiday Inn Express Houston - Galleria Area by IHG

Holiday Inn Express Houston - Galleria Area by IHG
2.5 star property
The Galleria, 8.6 km from South Main
9.4 out of 10, Exceptional, (1,004 reviews)
"Clean room, great staff, great breakfast, comfortable bed. "
United States
Sabine
The price is NZ$275
includes taxes & fees
22 Feb - 23 Feb
Holiday Inn Express Houston - Galleria Area by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Exterior
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
835 reviews
View
Premium bedding, pillow-top beds, in-room safe, individually decorated
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.2
Good
1,218 reviews
View
Lobby
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6
1,000 reviews
View
Room
Comfort Suites Near Texas Medical Center - NRG Stadium
2.0 star property
9.0
Wonderful
6 reviews
View
Desk, cots/infant beds, rollaway beds, free WiFi
Motel 6 Houston Medical Center Reliant Park
2.5 star property
5.6
471 reviews
View

Our guide on where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness centre. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 63 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

Explore a world of travel with Expedia