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South Main Hotels, Houston

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Our top choices for South Main hotels

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.8 out of 10, Excellent, (1,001 reviews)
"Clean & comfortable, super nice staff, good breakfast options, convenient to MDA."
United States
Cleota
The price is NZ$195
includes taxes & fees
5 July - 6 July
Comfort Suites Houston near Medical Center- NRG Stadium

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.0 out of 10, Good, (1,324 reviews)
"Would stay again!"
United States
Austin
The price is NZ$186
includes taxes & fees
2 Aug - 3 Aug
Wyndham Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,001 reviews)
"Good parking"
United States
joseph
The price is NZ$155
includes taxes & fees
6 July - 7 July
Wingate Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,002 reviews)
"Very clean rooms and excellent staff"
United States
Efrain
The price is NZ$120
includes taxes & fees
2 Aug - 3 Aug
Quality Inn & Suites NRG Park - Medical Center

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (881 reviews)
"My stay was perfect "
United States
Fredrick
The price is NZ$152
includes taxes & fees
2 Aug - 3 Aug
Candlewood Suites Houston Medical Center by IHG

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (323 reviews)
"Great experience with friendly staff."
United States
Maria
The price is NZ$162
includes taxes & fees
19 July - 20 July
Best Western Plus Pearland/Houston Medical Center Hotel

Home2 Suites by Hilton Houston Pasadena

Home2 Suites by Hilton Houston Pasadena
3.0 star property
24.3 km from South Main
9.4 out of 10, Exceptional, (883 reviews)
"Excellent stay. The room was very nice and spacious and the staff was great."
United States
Dannie
The price is NZ$235
includes taxes & fees
25 July - 26 July
Home2 Suites by Hilton Houston Pasadena

SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,817 reviews)
"I had a great stay"
United States
Datroynard
The price is NZ$259
includes taxes & fees
18 July - 19 July
SpringHill Suites by Marriott Houston Intercontinental Arprt

Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,245 reviews)
"Great hotel, convenient for travel Very clean"
United States
Elisabel
The price is NZ$242
includes taxes & fees
23 July - 24 July
Courtyard by Marriott Houston Intercontinental Airport

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
3.0 star property
31.8 km from South Main
8.8 out of 10, Excellent, (1,917 reviews)
"Close to the airport and near many restaurants."
United States
Lori
The price is NZ$176
includes taxes & fees
11 July - 12 July
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
3.0 star property
31.2 km from South Main
8.0 out of 10, Very good, (2,253 reviews)
"Great Hotel!"
United States
Alexa
The price is NZ$173
includes taxes & fees
12 July - 13 July
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.7 km from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
"Definitely will stay here again. Great location near Great Wolf Lodge."
United States
Deanndra
The price is NZ$174
includes taxes & fees
3 Aug - 4 Aug
Tru by Hilton Houston Webster NASA

Doubletree by Hilton Houston Hobby Airport

Doubletree by Hilton Houston Hobby Airport
4.0 star property
Southeast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,003 reviews)
"The breakfast was exceptional"
United States
Loren
The price is NZ$210
includes taxes & fees
27 July - 28 July
Doubletree by Hilton Houston Hobby Airport

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
3.0 star property
18.5 km from South Main
8.8 out of 10, Excellent, (1,250 reviews)
The price is NZ$169
includes taxes & fees
13 July - 14 July
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Studio 6 Houston, TX – Pearland/Medical Center

Studio 6 Houston, TX – Pearland/Medical Center
2.0 star property
Southeast Houston, 12.9 km from South Main
9.4 out of 10, Exceptional, (141 reviews)
"Awesome staff, clean rooms and love the free parking! Thanks a lot for a great stay!"
United States
Rorie
The price is NZ$126
includes taxes & fees
13 July - 14 July
Studio 6 Houston, TX – Pearland/Medical Center

Hotel Royale

Hotel Royale
2.0 star property
20.9 km from South Main
9.2 out of 10, Wonderful, (44 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
United States
Jerome
The price is NZ$136
includes taxes & fees
5 July - 6 July
Hotel Royale

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
2.5 star property
30.8 km from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
"Wonderful enjoyed the stay and breakfast clean rooms"
United States
Albert
The price is NZ$188
includes taxes & fees
19 July - 20 July
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

The Moran CITYCENTRE

The Moran CITYCENTRE
4.0 star property
18.3 km from South Main
9.0 out of 10, Wonderful, (1,086 reviews)
"Very relaxing place."
United States
CLINTON
The price is NZ$382
includes taxes & fees
12 July - 13 July
The Moran CITYCENTRE

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
Texas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,147 reviews)
"The best hotel! Location/ pool/ fitness/ comfortable beds: beautiful views"
United States
Jennifer Noel
The price is NZ$312
includes taxes & fees
12 July - 13 July
The Westin Houston Medical Center/Museum District

Hampton Inn Houston Downtown Convention Center

Hampton Inn Houston Downtown Convention Center
2.5 star property
10.9 km from South Main
8.8 out of 10, Excellent, (1,002 reviews)
"Great stay! Nice staff & clean rooms!"
United States
Brandon
The price is NZ$251
includes taxes & fees
15 July - 16 July
Hampton Inn Houston Downtown Convention Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.8
Excellent
1,001 reviews
View
Exterior
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
881 reviews
View
Premium bedding, pillow-top beds, in-room safe, individually decorated
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.0
Good
1,324 reviews
View
Lobby
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6
1,001 reviews
View
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,002 reviews
View

Our guide on where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Recent Reviews in South Main

Frequently asked questions

What are the best hotels in South Main that travellers recommend?
For highly recommended hotels in South Main, consider the Wyndham Houston near NRG Park/Medical Center, Wingate Houston near NRG Park/Medical Center, Quality Inn & Suites NRG Park - Medical Center, and Comfort Suites Houston near Medical Centre- NRG Stadium.

The 3.5-star Wyndham Houston near NRG Park/Medical Center, with a 7.2 rating, is often praised by guests for its amazing staff, comfortable beds, and clean, big rooms. It also features an outdoor pool with sun loungers and is conveniently located close to NRG Astrodome (0.9 km), NRG Park (0.7 km), and NRG Arena (0.8 km).

The 3-star Wingate Houston near NRG Park/Medical Center is another great option. Guests frequently highlight the friendly and extremely polite staff, the free continental breakfast, and the comfortable, clean rooms. It is very close to NRG Astrodome (0.7 km), NRG Park (0.5 km), and NRG Arena (0.7 km).

The Quality Inn & Suites NRG Park - Medical Center is top for its excellent customer service and hospitality, along with clean rooms and a convenient location. This hotel offers free to-go breakfast and some rooms feature a balcony. It is situated near NRG Astrodome (1.0 km), NRG Park (0.8 km), and NRG Arena (0.9 km).

Finally, the Comfort Suites Houston near Medical Centre- NRG Stadium, with an excellent 8.6 rating, is known for its friendly and helpful staff, comfortable and clean rooms, and a great complimentary full breakfast. It also provides fitness facilities and is conveniently located near NRG Astrodome (1.0 km), NRG Park (0.8 km), and NRG Arena (1.4 km).
What are the best family hotels in South Main?
For family hotels in South Main, consider the Wingate Houston near NRG Park/Medical Center, the Wyndham Houston near NRG Park/Medical Center, and the Comfort Suites Houston near Medical Centre- NRG Stadium.

The 3-star Wingate Houston near NRG Park/Medical Center is a great option, located just 0.5 km from NRG Park. Guests appreciate the friendly and extremely polite staff, as well as the free and good breakfast. The comfortable and clean rooms with good beds contribute to a pleasant stay, and it also features a pool for family enjoyment.

Another excellent choice is the 3.5-star Wyndham Houston near NRG Park/Medical Center, rated 7.2. Situated only 0.7 km from NRG Park, this hotel offers child-friendly window design and free cribs, making it suitable for families with young children. Guests frequently mention the great and amazing staff, the superb location, and the clean, big rooms with comfortable beds.

The Comfort Suites Houston near Medical Centre- NRG Stadium, with an 8.6 rating, is also highly recommended. This hotel is conveniently located 0.8 km from NRG Park and features child-friendly window design. Guests consistently praise the comfortable and clean rooms, the friendly and helpful staff, and the great breakfast.
What are the top pet-friendly hotels in South Main?
For highly-rated pet-friendly hotels in South Main, consider the Wingate Houston near NRG Park/Medical Center, the Wyndham Houston near NRG Park/Medical Center, Candlewood Suites Houston Medical Center by IHG, and the Quality Inn & Suites NRG Park - Medical Center.

The 3-star Wingate Houston near NRG Park/Medical Center is a great option, allowing dogs and other pets. Guests frequently highlight the friendly and polite staff, the comfortable and clean rooms, and the good complimentary breakfast. It is conveniently located near NRG Park, NRG Astrodome, and NRG Arena.

Another excellent choice is the 3.5-star Wyndham Houston near NRG Park/Medical Center, which permits pets. This hotel, rated 7.2, is praised for its great and amazing staff, superb location, and clean, big rooms with comfortable beds. It offers free WiFi and is also close to NRG Park, NRG Astrodome, and NRG Arena.

The Candlewood Suites Houston Medical Center by IHG also permits pets and has a review rating of 7.4. This hotel provides free WiFi and free self-parking. It is situated near NRG Park, NRG Astrodome, and NRG Arena.

Finally, the Quality Inn & Suites NRG Park - Medical Center welcomes pets. This hotel offers free breakfast, including a to-go option, free self-parking, and a complimentary area shuttle. Guests often compliment the excellent and clean rooms, the convenient location, and the excellent customer service and hospitality. It is also very close to NRG Park, NRG Astrodome, and NRG Arena.
What are the most romantic hotels in South Main for couples?
For a romantic stay in South Main, the Quality Inn & Suites NRG Park - Medical Center is a good choice for couples.

The Quality Inn & Suites NRG Park - Medical Center offers suites that provide extra space and comfort. Guests have consistently praised the excellent and clean rooms, as well as the convenient location of the hotel. It provides complimentary breakfast and free toiletries, adding to the convenience of your stay. The hotel also offers free self-parking and a free area shuttle, making it easy to explore the surroundings. With NRG Astrodome just 1.0 km away and NRG Arena 0.9 km away, there's plenty to see and do nearby.
What are the best hotels in South Main near NRG Park?
When looking for hotels in South Main near NRG Park, the Wyndham Houston near NRG Park/Medical Center and the Wingate Houston near NRG Park/Medical Center are excellent options, particularly for families.

The 3.5-star Wyndham Houston near NRG Park/Medical Center, with a rating of 7.2, boasts a superb location, being just 0.7 km from NRG Park. Guests frequently praise the amazing staff, the clean and spacious rooms, and the comfortable beds. It also offers child-friendly window designs and free cribs, making it a great choice for those travelling with children.

Another highly-rated option is the 3-star Wingate Houston near NRG Park/Medical Center. While its rating is not provided, it is consistently praised for its good location, just 0.5 km from NRG Park. This hotel offers a pool, connecting rooms, and complimentary continental breakfast, which guests often describe as good. The staff are noted for being friendly and extremely polite, and the rooms are comfortable and clean.
When is the best time to go to South Main?
The best time to go to South Main is during the spring (March to May) and autumn (September to November) months.

These seasons offer pleasant weather, with comfortable temperatures that are ideal for exploring the area's outdoor attractions and walking around. Spring brings blooming flowers and a refreshing atmosphere, while autumn provides cooler temperatures and often clear skies, superb for enjoying the local parks and open-air markets.

For those planning a romantic getaway, spring is particularly lovely. The milder weather allows for leisurely strolls along the riverwalk and enjoying al fresco dining without the intense summer heat. The natural beauty of the area is at its peak, creating a beautiful backdrop for couples.

Families travelling with children might find autumn more appealing. The slightly cooler temperatures are more comfortable for kids, especially when visiting attractions like the local nature centres or attending outdoor festivals.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline − this is often within 24 to 48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our 'Fully refundable property' filter during your search to find the right South Main hotel for you.
How can I save on a hotel booking in South Main with Expedia?
One Key™ – Expedia's free travel rewards programme – gives you instant access to perks and Member Prices on South Main hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
How much is the nightly rate for a hotel in South Main?
Hotel prices in South Main often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates and sort search results by 'Price: low to high' for our cheapest rates.

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