South Main Hotels, Houston
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Our top choices for South Main hotels
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (835 reviews)
"This is a safe, friendly hotel close to MDA Cancer Center"
Myra
The price is NZ$186
includes taxes & fees
18 Feb - 19 Feb
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,002 reviews)
"Clean room, helpful staff and good location to hospital."
George
The price is NZ$209
includes taxes & fees
21 Feb - 22 Feb
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,002 reviews)
"Room was clean, bed was comfortable, breakfast was good. Perfect place to stay for going to NRG Stadium as it’s an easy walk"
Daniel
The price is NZ$160
includes taxes & fees
18 Feb - 19 Feb
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
"Easy access to stadium "
Richard
The price is NZ$172
includes taxes & fees
22 Feb - 23 Feb
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,218 reviews)
"Front desk staff was very professional and kind."
MARINA
The price is NZ$194
includes taxes & fees
17 Feb - 18 Feb
Fairfield Inn & Suites Houston Intercontinental Airport
Fairfield Inn & Suites Houston Intercontinental Airport30.6 km from South Main
8.6 out of 10, Excellent, (1,002 reviews)
"Great place, nice room"
Lester
The price is NZ$169
includes taxes & fees
22 Feb - 23 Feb
Baymont by Wyndham Houston Hobby Airport
Baymont by Wyndham Houston Hobby Airport18.4 km from South Main
8.6 out of 10, Excellent, (895 reviews)
"Very clean !! every thing is new. breakfast also very good, we will comeback to stay again."
LEI
The price is NZ$124
includes taxes & fees
23 Feb - 24 Feb
Four Points by Sheraton Houston Intercontinental Airport
Four Points by Sheraton Houston Intercontinental Airport29.9 km from South Main
8.4 out of 10, Very good, (1,007 reviews)
"The staff was friendly and the hotel was clean"
Lisa
The price is NZ$171
includes taxes & fees
20 Feb - 21 Feb
Holiday Inn Express & Suites Houston SW - Galleria Area by IHG
Holiday Inn Express & Suites Houston SW - Galleria Area by IHG9.6 km from South Main
8.0 out of 10, Very good, (1,000 reviews)
"Clean room, friendly and responsive staff"
Clara
The price is NZ$200
includes taxes & fees
19 Feb - 20 Feb
Comfort Suites Houston West at Clay Road
Comfort Suites Houston West at Clay Road22.8 km from South Main
8.4 out of 10, Very good, (1,003 reviews)
"Friendly staff, breakfast excellent perfect location! Will definitely stay here again"
wanda
The price is NZ$150
includes taxes & fees
22 Feb - 23 Feb
Hilton Garden Inn Houston NW America Plaza
Hilton Garden Inn Houston NW America Plaza25 km from South Main
8.6 out of 10, Excellent, (1,000 reviews)
"It was very relaxing and the staff are very friendly and helpful. "
Chantel
The price is NZ$179
includes taxes & fees
22 Feb - 23 Feb
Hampton Inn Houston-Brookhollow
Hampton Inn Houston-Brookhollow20.4 km from South Main
8.2 out of 10, Very good, (1,002 reviews)
"The staff is awesome! What a great place to stay! "
Cynthia
The price is NZ$166
includes taxes & fees
23 Feb - 24 Feb
GreenTree Inn Houston IAH Airport
GreenTree Inn Houston IAH Airport31.4 km from South Main
6.6 out of 10, (1,007 reviews)
"Staff was very friendly , room was very clean "
Charlette
The price is NZ$105
includes taxes & fees
17 Feb - 18 Feb
Sleep Inn & Suites Near Downtown North
Sleep Inn & Suites Near Downtown NorthGreater Heights, 14.2 km from South Main
8.4 out of 10, Very good, (798 reviews)
"Great place to stay at "
Audrey
The price is NZ$173
includes taxes & fees
22 Feb - 23 Feb
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD28.7 km from South Main
9.0 out of 10, Wonderful, (990 reviews)
"The hotel was very clean the staff was amazing. We enjoyed our stay"
Teanna
The price is NZ$157
includes taxes & fees
22 Feb - 23 Feb
Home2 Suites by Hilton Houston IAH Airport Beltway 8
Home2 Suites by Hilton Houston IAH Airport Beltway 829.9 km from South Main
8.4 out of 10, Very good, (813 reviews)
"Great room close to airport "
Kelli
The price is NZ$154
includes taxes & fees
22 Feb - 23 Feb
Hampton Inn & Suites Houston I-10 West Park Row
Hampton Inn & Suites Houston I-10 West Park Row29.4 km from South Main
8.8 out of 10, Excellent, (686 reviews)
"Room was very clean and front desk staff were great!"
Bobby
The price is NZ$156
includes taxes & fees
22 Feb - 23 Feb
Hilton Houston North
Hilton Houston North30.5 km from South Main
8.4 out of 10, Very good, (1,002 reviews)
"I had a great stay at this hotel. The room was clean and comfortable."
Victor
The price is NZ$253
includes taxes & fees
22 Feb - 23 Feb
Doubletree by Hilton Houston Hobby Airport
Doubletree by Hilton Houston Hobby AirportSoutheast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,006 reviews)
"Excellent stay! The room was very clean and comfortable, and the staff went above and beyond to be friendly and helpful. Check-in was smooth, the amenities were great, and the overall atmosphere made it a relaxing experience. I’d definitely stay here again!"
Wayne
The price is NZ$207
includes taxes & fees
23 Feb - 24 Feb
Holiday Inn Express Houston - Galleria Area by IHG
Holiday Inn Express Houston - Galleria Area by IHGThe Galleria, 8.6 km from South Main
9.4 out of 10, Exceptional, (1,004 reviews)
"Clean room, great staff, great breakfast, comfortable bed. "
Sabine
The price is NZ$275
includes taxes & fees
22 Feb - 23 Feb
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 835 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.2 Good 1,218 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,000 reviews | View | ||||||
 Comfort Suites Near Texas Medical Center - NRG Stadium | 9.0 Wonderful 6 reviews | View | ||||||
 Motel 6 Houston Medical Center Reliant Park | 5.6 471 reviews | View |
Our guide on where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Top South Main Hotel Reviews
DoubleTree by Hilton Hotel Houston - Greenway Plaza
10/10 Excellent
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- Visit Bellaire
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- Visit Greenway Plaza-Upper Kirby
- Hobby Center for the Performing Arts
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- Carl Lewis International Track and Field Complex
- Lakewood Church Central Campus
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- Jesse H. Jones Hall
- Richmond Avenue
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- Conrad Hilton Archives
- Memorial Hermann Southwest Hospital
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