South Main Hotels, Houston

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6627 Cheap Hotels in South Main - Specials, Reviews, & Last Minute Deals

Comfort Suites Houston near Medical Center- NRG Stadium

2.5 star property
South Main
8.6 out of 10, Excellent, (1007)
"Loved staying at the Comfort Suites ."
United States
Linda
The price is NZ$193
includes taxes & fees
30 Nov - 1 Dec
Comfort Suites Houston near Medical Center- NRG Stadium

Wyndham Houston near NRG Park/Medical Center

3.5 star property
South Main
7.2 out of 10, Good, (1191)
"Perfect "
United States
Maria
The price is NZ$206
includes taxes & fees
14 Nov - 15 Nov
Wyndham Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

3.0 star property
South Main
6.6 out of 10, (968)
"Low water pressure and barely over warm water temperatures. Room was clean and staff were very nice. "
United States
ReDenia
The price is NZ$164
includes taxes & fees
11 Nov - 12 Nov
Wingate Houston near NRG Park/Medical Center

Quality Inn & Suites NRG Park - Medical Center

2.5 star property
South Main
6.4 out of 10, (1005)
"Everything was great"
United States
Yeimi
The price is NZ$126
includes taxes & fees
11 Dec - 12 Dec
Quality Inn & Suites NRG Park - Medical Center

Candlewood Suites Houston Medical Center by IHG

2.5 star property
South Main
7.4 out of 10, Good, (809)
"Room was clean and roomy. The toilet height was too low. Staff was friendly and professional."
United States
Willie
The price is NZ$154
includes taxes & fees
16 Nov - 17 Nov
Candlewood Suites Houston Medical Center by IHG

Hyatt Place Houston Medical Center

3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2112)
"Great stay"
United States
Vallie
The price is NZ$229
includes taxes & fees
24 Nov - 25 Nov
Hyatt Place Houston Medical Center

Hyatt Regency Houston/Galleria

4.0 star property
The Galleria, 8.7 km from South Main
9.0 out of 10, Wonderful, (1131)
"Very clean room and good breakfast"
United States
Nils
The price is NZ$283
includes taxes & fees
23 Nov - 24 Nov
Hyatt Regency Houston/Galleria

Hyatt House Houston Medical Center

3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1155)
"Great stay"
United States
Kurt
The price is NZ$247
includes taxes & fees
23 Nov - 24 Nov
Hyatt House Houston Medical Center

Blossom Hotel Houston, Curio Collection by Hilton

4.0 star property
Texas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3558)
"Always stay here when in the area. "
United States
Kevin
The price is NZ$289
includes taxes & fees
11 Dec - 12 Dec
Blossom Hotel Houston, Curio Collection by Hilton

The Whitehall Houston

4.0 star property
Houston Central Business District, 10 km from South Main
8.6 out of 10, Excellent, (1850)
"Amazing place to stay with family"
United States
Mohamed
The price is NZ$264
includes taxes & fees
21 Nov - 22 Nov
The Whitehall Houston

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4.0 star property
8.9 km from South Main
8.2 out of 10, Very good, (2868)
"This hotel was excellent i will definitely stay here again "
United States
Genia
The price is NZ$244
includes taxes & fees
27 Nov - 28 Nov
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

The Royal Sonesta Houston Galleria

4.0 star property
The Galleria, 8.8 km from South Main
8.4 out of 10, Very good, (1355)
"Great stay "
United States
Jennifer
The price is NZ$248
includes taxes & fees
16 Nov - 17 Nov
The Royal Sonesta Houston Galleria

Hilton Garden Inn Houston Medical Center, TX

3.0 star property
Texas Medical Center, 4.7 km from South Main
9.4 out of 10, Exceptional, (1002)
"Great hotel and location!"
United States
Gonzalo
The price is NZ$208
includes taxes & fees
23 Nov - 24 Nov
Hilton Garden Inn Houston Medical Center, TX

Hyatt Regency Houston West

3.5 star property
23.2 km from South Main
8.6 out of 10, Excellent, (1229)
"Great room and staff."
United States
Brad
The price is NZ$241
includes taxes & fees
23 Nov - 24 Nov
Hyatt Regency Houston West

InterContinental Houston by IHG

4.0 star property
Texas Medical Center, 4.1 km from South Main
9.2 out of 10, Wonderful, (1003)
"Very well maintenance property, beautiful lobby and friendly staff."
United States
Viji
The price is NZ$325
includes taxes & fees
28 Nov - 29 Nov
InterContinental Houston by IHG

Haven Inn & Suites Downtown Houston

2.5 star property
North Houston, 18.8 km from South Main
9.4 out of 10, Exceptional, (1004)
"Very clean and safe, would stay again"
United States
Krimson
Haven Inn & Suites Downtown Houston

Holiday Inn Express & Suites Houston - Memorial City Centre by IHG

2.5 star property
Memorial City, 18.4 km from South Main
8.8 out of 10, Excellent, (1005)
"Clean, friendly staff, good breakfast, and all around great stay! "
United States
Rebecca
The price is NZ$240
includes taxes & fees
13 Nov - 14 Nov
Holiday Inn Express & Suites Houston - Memorial City Centre by IHG

Club Quarters Hotel Downtown, Houston

4.0 star property
Houston Central Business District, 10.9 km from South Main
8.4 out of 10, Very good, (3891)
"Hotel was beautiful, room was great for the price"
United States
Sonya
The price is NZ$237
includes taxes & fees
17 Nov - 18 Nov
Club Quarters Hotel Downtown, Houston

Holiday Inn Express Houston - Galleria Area by IHG

2.5 star property
The Galleria, 8.6 km from South Main
9.4 out of 10, Exceptional, (1007)
"Very nice place to stay"
United States
Jose
The price is NZ$241
includes taxes & fees
23 Nov - 24 Nov
Holiday Inn Express Houston - Galleria Area by IHG

Home2 Suites by Hilton at the Galleria

3.0 star property
Greater Uptown, 8 km from South Main
8.8 out of 10, Excellent, (956)
" Clean room , comfortable Good breakfast "
United States
Yelyzaveta
The price is NZ$215
includes taxes & fees
17 Nov - 18 Nov
Home2 Suites by Hilton at the Galleria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in South Main with free breakfast

Hotels in South Main with a pool

Top guest rated hotels in South Main

Our guide on where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Gerald D. Hines Waterwall Park.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.

Northside

While you're in Northside, take in top sights like The Heights Theater or Greenspoint Mall, and hop on the metro to see more of the city at Northline Transit Center/HCC Station or Melbourne/North Lindale Station.

Top South Main Hotel Reviews

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Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and free parking. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.