South Main Hotels, Houston

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
1 Jan - 2 Jan
Tomorrow
2 Jan - 3 Jan
This weekend
2 Jan - 4 Jan
Next weekend
9 Jan - 11 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for South Main hotels

Lobby
Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1199)
"This place is great if you want an overnight stay for a Texans game."
United States
Jeremy
The price is NZ$180
includes taxes & fees
1 Feb - 2 Feb
Wyndham Houston near NRG Park/Medical Center
Lobby
Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1005)
"Staff friendly, room clean, breakfast good but a few more items to choose from would help "
United States
ERIC
The price is NZ$193
includes taxes & fees
25 Jan - 26 Jan
Comfort Suites Houston near Medical Center- NRG Stadium
Gazebo
Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (993)
"Easy access to stadium "
United States
Richard
The price is NZ$139
includes taxes & fees
1 Feb - 2 Feb
Wingate Houston near NRG Park/Medical Center
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1000)
"Clean rooms, quiet property. We will be back again. "
United States
Javier
The price is NZ$110
includes taxes & fees
1 Feb - 2 Feb
Quality Inn & Suites NRG Park - Medical Center
Exterior
Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (826)
"This is a safe, friendly hotel close to MDA Cancer Center"
United States
Myra
The price is NZ$150
includes taxes & fees
29 Jan - 30 Jan
Candlewood Suites Houston Medical Center by IHG
Lobby
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Houston Central Business District, 10.9 km from South Main
8.4 out of 10, Very good, (3983)
"Rooms were great and the staff was absolutely amazing. "
United States
Elmer
The price is NZ$163
includes taxes & fees
4 Jan - 5 Jan
Club Quarters Hotel Downtown, Houston
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, pool loungers
Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria
4.0 star property
The Galleria, 8.7 km from South Main
9.0 out of 10, Wonderful, (1192)
"Clean rooms great location helpful front desk staff "
United States
Kim
The price is NZ$335
includes taxes & fees
2 Jan - 3 Jan
Hyatt Regency Houston/Galleria
Exterior
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
3.0 star property
31.8 km from South Main
8.8 out of 10, Excellent, (1727)
"All staff were super friendly, hospitable and informative. "
United States
Bradley
The price is NZ$165
includes taxes & fees
23 Jan - 24 Jan
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Terrace/patio
SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1617)
"Great place to stay "
United States
Andrea
The price is NZ$188
includes taxes & fees
30 Jan - 31 Jan
SpringHill Suites by Marriott Houston Intercontinental Arprt
Lobby sitting area
Hyatt Place Houston Downtown

Hyatt Place Houston Downtown

Hyatt Place Houston Downtown
3.0 star property
Houston Central Business District, 11 km from South Main
9.0 out of 10, Wonderful, (1588)
"Great stay. Room was spacious and great location close to a lot. "
United States
Kristina
The price is NZ$198
includes taxes & fees
4 Jan - 5 Jan
Hyatt Place Houston Downtown
Exterior
Hilton Americas-Houston

Hilton Americas-Houston

Hilton Americas-Houston
4.0 star property
10.4 km from South Main
9.4 out of 10, Exceptional, (1628)
"Great hotel. Lively bar, great breakfast, friendly staff, nice room, close to everything. "
United States
Thomas
The price is NZ$346
includes taxes & fees
17 Jan - 18 Jan
Hilton Americas-Houston
Cocktail bar
Le Meridien Houston Downtown

Le Meridien Houston Downtown

Le Meridien Houston Downtown
4.0 star property
Houston Central Business District, 10.7 km from South Main
8.8 out of 10, Excellent, (1002)
"Great hotel staff. "
United States
Camille
The price is NZ$275
includes taxes & fees
4 Jan - 5 Jan
Le Meridien Houston Downtown
Terrace/patio
Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1096)
"Courteous staff, clean rooms, excellent location."
United States
Rebecca
The price is NZ$204
includes taxes & fees
31 Jan - 1 Feb
Courtyard by Marriott Houston Intercontinental Airport
Lobby
Houston Marriott South at Hobby Airport

Houston Marriott South at Hobby Airport

Houston Marriott South at Hobby Airport
3.5 star property
Southeast Houston, 15.7 km from South Main
8.8 out of 10, Excellent, (1345)
"Great option in the area "
United States
German
The price is NZ$190
includes taxes & fees
2 Jan - 3 Jan
Houston Marriott South at Hobby Airport
Exterior detail
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4.0 star property
8.9 km from South Main
8.2 out of 10, Very good, (3192)
"Great hotel, great rooms! "
United States
Javier
The price is NZ$263
includes taxes & fees
31 Jan - 1 Feb
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Standard Room, 2 Queen Beds
Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG
3.5 star property
6.5 km from South Main
7.8 out of 10, Good, (1287)
"The staff were very friendly and helpful! The overall stay was amazing! "
United States
Timothy
The price is NZ$131
includes taxes & fees
1 Feb - 2 Feb
Crowne Plaza Houston Med Ctr-Galleria Area by IHG
City view
Hyatt Regency Houston Downtown

Hyatt Regency Houston Downtown

Hyatt Regency Houston Downtown
4.0 star property
Houston Central Business District, 10.5 km from South Main
9.2 out of 10, Wonderful, (1088)
"Great staff and nice room. "
United States
Nikiesha
The price is NZ$354
includes taxes & fees
2 Jan - 3 Jan
Hyatt Regency Houston Downtown
50-inch Smart TV with cable channels, TV, Netflix
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3636)
"Great Hotel! "
United States
Delilah
The price is NZ$263
includes taxes & fees
18 Jan - 19 Jan
Blossom Hotel Houston, Curio Collection by Hilton
Pillow-top beds, desk, iron/ironing board, WiFi
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd

La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd

La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
3.5 star property
32 km from South Main
9.2 out of 10, Wonderful, (1005)
"Great Hotel"
United States
Jessica
The price is NZ$140
includes taxes & fees
1 Feb - 2 Feb
La Quinta Inn & Suites by Wyndham Houston East at Sheldon Rd
Restaurant
Hyatt Place Houston/Galleria

Hyatt Place Houston/Galleria

Hyatt Place Houston/Galleria
3.0 star property
8.7 km from South Main
8.8 out of 10, Excellent, (1302)
"It's a lovely place. Excellent staff & rooms. I could stay there again. "
United States
Ayieta
The price is NZ$227
includes taxes & fees
16 Jan - 17 Jan
Hyatt Place Houston/Galleria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Our guide on where to stay in South Main

Find the best South Main areas for the activities you enjoy most.
Discovery Green which includes a high-rise building, a square or plaza and a city

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Houston showing a high-rise building and a city

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Main Street Square Station.

Menil Collection showing interior views and art

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Top South Main Hotel Reviews

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

10/10 Excellent
"All good"
Nora H 1-night trip
Posted 14 hours ago
Hilton Houston Plaza/Medical Center

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness centre. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.

Explore a world of travel with Expedia