South Main Hotels, Houston
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Our top choices for South Main hotels
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.0 out of 10, Good, (1,275 reviews)
"Hotel clean and convenient "
Mitzi
The price is NZ$187
includes taxes & fees
26 Apr - 27 Apr
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,007 reviews)
"Close and convenient to NRG."
Cynthia
The price is NZ$200
includes taxes & fees
26 Apr - 27 Apr
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (847 reviews)
"Room was clean. It had a musty smell though. "
Ryan
The price is NZ$159
includes taxes & fees
5 Apr - 6 Apr
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,001 reviews)
"Great location"
Jeremy
The price is NZ$161
includes taxes & fees
6 Apr - 7 Apr
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
"Courteous staff, clean room, quite property"
Javier
The price is NZ$129
includes taxes & fees
19 Apr - 20 Apr
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (163 reviews)
"Nice place to stay"
Bella
The price is NZ$197
includes taxes & fees
27 Apr - 28 Apr
Hotel Royale
Hotel Royale20.9 km from South Main
9.2 out of 10, Wonderful, (22 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
Jerome
The price is NZ$148
includes taxes & fees
27 Apr - 28 Apr
Palace Inn Blue 290 W 43rd & Bingle Rd
Palace Inn Blue 290 W 43rd & Bingle Rd19.4 km from South Main
9.4 out of 10, Exceptional, (26 reviews)
"loveeeee. so cute came here for spring break. comfy little spot definitely recommend!"
Danielle
The price is NZ$172
includes taxes & fees
26 Apr - 27 Apr
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.2 out of 10, Wonderful, (197 reviews)
"Yes very great place"
Lloyd
The price is NZ$182
includes taxes & fees
4 May - 5 May
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,192 reviews)
"Enjoyed my stay!"
Chelsea Renee
The price is NZ$258
includes taxes & fees
19 Apr - 20 Apr
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Hampton Inn & Suites Houston-Bush Intercontinental Aprt31.8 km from South Main
8.8 out of 10, Excellent, (1,818 reviews)
"Clean room and courteous staff. "
Sarah
The price is NZ$194
includes taxes & fees
25 Apr - 26 Apr
Best Western Plus Manvel Inn & Suites
Best Western Plus Manvel Inn & Suites22.6 km from South Main
8.8 out of 10, Excellent, (774 reviews)
"Everything about this place was awesome. Will definitely be staying there again on my next trip!!!!!"
Penny
The price is NZ$157
includes taxes & fees
15 Apr - 16 Apr
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,002 reviews)
"Clean and courteous staff."
chris
The price is NZ$166
includes taxes & fees
4 May - 5 May
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,006 reviews)
"Great short stay!!!"
BriAnna
The price is NZ$187
includes taxes & fees
19 Apr - 20 Apr
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.2 out of 10, Very good, (1,749 reviews)
"The staff was very helpful and made our stay enjoyable."
cynthia
The price is NZ$179
includes taxes & fees
4 May - 5 May
Crystal Inn - NorthWest - 290
Crystal Inn - NorthWest - 29024.8 km from South Main
9.8 out of 10, Exceptional, (47 reviews)
"The staff were very nice everything was clean inside and out. "
Tyisha
The price is NZ$214
includes taxes & fees
7 Apr - 8 Apr
Magnolia Hotel Houston, A Tribute Portfolio Hotel
Magnolia Hotel Houston, A Tribute Portfolio HotelHouston Central Business District, 11 km from South Main
9.2 out of 10, Wonderful, (1,469 reviews)
"Great location, great hotel and staff. Will stay here again. "
larry
The price is NZ$276
includes taxes & fees
11 Apr - 12 Apr
SpringHill Suites by Marriott Houston Intercontinental Arprt
SpringHill Suites by Marriott Houston Intercontinental Arprt31.8 km from South Main
9.0 out of 10, Wonderful, (1,703 reviews)
"wonderful stay "
Stepfan
The price is NZ$223
includes taxes & fees
19 Apr - 20 Apr
Hilton Houston North
Hilton Houston North30.5 km from South Main
8.4 out of 10, Very good, (1,016 reviews)
"Very convenient location, clean, and staff was exceptional "
Shatoria
The price is NZ$258
includes taxes & fees
26 Apr - 27 Apr
Home2 Suites by Hilton Houston Pasadena
Home2 Suites by Hilton Houston Pasadena24.3 km from South Main
9.4 out of 10, Exceptional, (851 reviews)
"Breakfast offerings were limited, but overall, the stay was great. Beds were comfortable, room was clean, staff was friendly. Felt safe in our hotel and would gladly stay again."
Travis
The price is NZ$202
includes taxes & fees
26 Apr - 27 Apr
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,007 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 847 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.0 Good 1,275 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,001 reviews | View | ||||||
 Quality Inn & Suites NRG Park - Medical Center | 6.6 1,000 reviews | View |
Our guide on where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
Hotel Zaza Houston Museum District
10/10 Excellent
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- Visit Bellaire
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- Visit The Galleria
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- Visit Greenway Plaza-Upper Kirby
- Hobby Center for the Performing Arts
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- Carl Lewis International Track and Field Complex
- Lakewood Church Central Campus
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- Jesse H. Jones Hall
- Richmond Avenue
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- Conrad Hilton Archives
- Memorial Hermann Southwest Hospital
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