Visit South Main
Popular places to visit
George R. Brown Convention Center
During your trip, find out what's happening in George R. Brown Convention Center, a top convention centre in Houston. Experience the great live music and acclaimed art galleries in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the acclaimed theatre scene and entertainment choices in this vibrant area.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed art galleries and lively festivals in this vibrant area.
Rice University
Walk around the campus of Rice University, a top university in Houston. Experience the area's acclaimed art galleries and lively festivals.
University of Houston
Walk around the campus of University of Houston, a top university in Houston. Experience the great live music and acclaimed art galleries in this vibrant area.
Activities
Houston Museum of Natural Sciences: Planetarium Ticket
Houston: Houston Botanic Garden Entry Ticket
Houston City Tour and Downtown Aquarium All Rides Pass
Our pick of the best South Main Hotel Deals
Wyndham Houston near NRG Park/Medical Center
Reviewed on 7 Aug. 2025
The Whitehall Houston
Reviewed on 11 Aug. 2025
Hilton Houston Plaza/Medical Center
Reviewed on 12 Aug. 2025
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Reviewed on 13 Aug. 2025
Club Quarters Hotel Downtown, Houston
Reviewed on 13 Aug. 2025
Holiday Inn Houston Downtown by IHG
Reviewed on 10 Aug. 2025
Other neighbourhoods around South Main
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Houston Museum District
Known for its abundant dining options and interesting museums, there's plenty to explore in Houston Museum District. Top attractions like Houston Zoo and Children's Museum of Houston are major draws, and you can catch the metro at M. D. Anderson Station or Museum District Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Houston Zoo or Continental Club and hop on the metro to see more of the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Westheimer Rd while you're exploring the area.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Gerald D. Hines Waterwall Park.
Midtown
Midtown is well liked for its restaurants and live music. If you're hoping to get in some sightseeing, Continental Club and Midtown Arts and Theater Center Houston are top spots, and you can jump on the metro at McGowen Station or Ensemble/HCC Station to get around.