Our top choices for South Carolina Midlands hotels

Hampton Inn & Suites Lexington Columbia

Lexington

Vlad

includes taxes & fees

6 June - 7 June

Fairfield Inn & Suites by Marriott Santee

Santee

Michael

includes taxes & fees

7 June - 8 June

Holiday Inn Express & Suites Latta by IHG

Latta

Graziamaria

includes taxes & fees

31 May - 1 June

Hampton Inn Santee-I-95

Santee

Preston

includes taxes & fees

7 June - 8 June

Crowne Plaza North Augusta by IHG

North Augusta

Nicole

includes taxes & fees

24 May - 25 May

Carriage House Inn

Aiken

Melissa

includes taxes & fees

24 May - 25 May

Desk, laptop workspace, iron/ironing board, free WiFi

Aiken Midtown Hotel

Aiken

Brenda

includes taxes & fees

16 June - 17 June

Best Western Plus Lexington Inn

Downtown Lexington

Laura

includes taxes & fees

21 June - 22 June

Lexington Expo Hotel by IHG

Lexington

Richard

includes taxes & fees

7 June - 8 June

Tru By Hilton Fort Mill, SC

Fort Mill

Robin

includes taxes & fees

14 June - 15 June

Hampton Inn & Suites Columbia Killian Road

Columbia

Anthony

includes taxes & fees

7 June - 8 June

Tru By Hilton Santee

Santee

June

includes taxes & fees

7 June - 8 June

Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG

Florence

Dawson

includes taxes & fees

21 June - 22 June

Hampton Inn & Suites Orangeburg

Orangeburg

Toy

includes taxes & fees

21 June - 22 June

Staybridge Suites Florence - Civic Center by IHG

Florence

David

includes taxes & fees

21 June - 22 June

Comfort Inn & Suites Florence Center Area

Florence

Robert

includes taxes & fees

14 June - 15 June

Country Inn & Suites by Radisson, Columbia Airport, SC

Cayce

Allan

includes taxes & fees

21 June - 22 June

Springhill Suites by Marriott Columbia near Fort Jackson

Columbia

Mary

includes taxes & fees

7 June - 8 June

Best Western Plus Santee Inn

Santee

Nicole

includes taxes & fees

2 June - 3 June

Park Inn by Radisson Florence, SC

Florence

Shamar

includes taxes & fees

25 May - 26 May

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Holiday Rentals in South Carolina Midlands

Aparthotel

stayAPT Suites Columbia-Irmo Harbison

Irmo

"The room was very nice. Everything was clean. I loved the security of the building. The rooms couldn't be accessed without a keycard. I will definitely stay again."

Cottage

Lake Access & Boat Slip: Greenwood Cottage!

Greenwood

"Outstanding little cottage for my mom and daughter weekend! Super clean and comfortable. "

Apartment

Easy Access to I-77 & I-20: Columbia Duplex!

Columbia

"It was very nice and pleasant. Quiet neighborhood."

Cottage

Columbia Vacation Rental < 2 Mi to University

Downtown Columbia

"House was very welcoming, with a cottage vibe, the older home renovations mixed with the floor and trim work over the doors was beautiful and unique. Very updated home nicely done. "

Cottage

Stunning Lakefront Retreat w/ Dock Access!

Greenwood

Cottage

Prosperity Vacation Rental ~ 1 Mi to Lake Murray!

Hollands Landing

"The property had a lot of land. It was a peaceful, beautiful scenery. They had games in the house, ax throwing, corn hole outside & bonfire. Seeing the neighbors horses walk by was amazing. "

Apartment

Aiken Apt w/ Garden-view Balcony: Half-mi to Dtwn!

Aiken

"Absolutely LOVED our stay at this property! Everything was perfect from the location, cleanliness, decor, and owner! I would definitely stay here again and recommend to anyone! Thanks for being an amazing host especially after returning from Jamaica! ❤️❤️❤️❤️❤️❤️"

Cottage

Peaceful Camden Vacation Rental ~ 3 Mi to Town!

Camden

"Location was perfect for us. Very cozy, and clean. Hadn't been modernized, but it was in great shape. Nasolgic; felt like I was visiting my grandparents! Only having one bathroom was a bit challenging, but we made it work!"

Cottage

10 Mi to Augusta: Quiet Home w/ Patio & Yard!

Graniteville

"Love this place "

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Stay near popular South Carolina Midlands attractions

Carowinds Theme Park

4.4/5 (962 reviews)

Choose from 13 roller coasters, chase your friends in a bumper car, enjoy the water slides and beaches of Boomerang Bay, and walk with dinosaurs.

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Learn more about South Carolina Midlands

With Revolutionary War sites, a charming capital city and lots of kayaking opportunities, this southern region is sure to delight.

See all hotels in South Carolina Midlands

Top South Carolina Midlands Hotel Reviews

Park Inn by Radisson Florence, SC

2/10 Terrible

"Pool was closed. Gym was a closet. Rooms were not cleaned properly. There was pubic hair all on shower walls. Ottoman had spilled drink on it and one of the beds had a dirty fitted sheet with new stains and not worn in stains. Breakfast was really lacking options coffee was watery. Gave motel vibes.need higher standards for cleaning. I was extremely tired from the road and just chucked it up. It sucks because hotel has a lot of potential but cleanliness is not something to slack especially with bed and bath."

Courtyard by Marriott Columbia Downtown at USC

4/10 Poor

"The entire staff was amazing with the exception of one man behind the counter (and I think he was tge manager). He seemed to have a chip on his shoulder because I booked through "a third party" and was canceling one night of our 2 night reservation. I didn't realize how hilly the area was which was quite difficult getting around with a wheelchair. I've been charged for both nights and now need to fight that."

The Lantern Columbia

10/10 Excellent

"Outstanding hotel! Super nice staff, wonderful sleek design and lots of amenities (gym 24/7, water and coffee machines, mini fridge, restaurant and bar). Such a pleasant stay, we couldn't wish for anything better! We are travelling with a toddler and they had a nice place in the back to offload a car and you can then either do valet ($30) or do street parking (free 7pm-9am). Also walking distance to so many bars and restaurants!"