Beginning of main content

Search over 1,000,000 properties worldwide and 550 airlines worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Top Holiday Rentals Destinations in South Carolina

Estimated price for 1 night/2 adults

Ocean Enclave by Hilton Grand Vacations
Ocean Enclave by Hilton Grand Vacations
3.5 out of 5.0 1600 Ocean Blvd, Myrtle Beach, SC
NZ$209
4.8/5 (106 reviews)

Brand New Condo like hotel rooms. It was like living in a luxury apartment.

Reviewed on 7 Nov. 2019
Located in Downtown Myrtle Beach, this beachfront aparthotel is in the city centre and within a 5-minute walk of Myrtle Beach Boardwalk and SkyWheel Myrtle Beach. ...
Hyatt House Mount Pleasant-Midtown
Hyatt House Mount Pleasant-Midtown
3.5 out of 5.0 1430 Midtown Avenue, Mount Pleasant, SC
NZ$194
4.5/5 (190 reviews)

The people that worked at front desk and in the breakfast area.

Reviewed on 7 Nov. 2019
Situated in the shopping district, this aparthotel is within 9 mi (15 km) of Patriots Point, USS Yorktown and South Carolina Aquarium. Charleston Music Hall ...
TownePlace Suites by Marriott Charleston-North Charleston
TownePlace Suites by Marriott Charleston-North Charleston
2.5 out of 5.0 7535 Northside Drive, North Charleston, SC
NZ$133
4.5/5 (340 reviews)

Great staff! Clean rooms! Appreciated the kitchenette!

Reviewed on 15 Nov. 2019
Situated near the airport, this aparthotel is 1.6 mi (2.6 km) from Northwoods Mall and within 6 miles (10 km) of Charleston Tanger Outlets and Frankie's Fun ...
Hawthorn Suites by Wyndham Charleston/West Ashley
Hawthorn Suites by Wyndham Charleston/West Ashley
2.5 out of 5.0 2455 Savannah Hwy, Charleston, SC
NZ$135
3.7/5 (1548 reviews)

The managers checked in on everyone during breakfast and tried to make sure everyone was happy.

Reviewed on 1 Nov. 2019
Situated in Charleston, this aparthotel is 1.5 mi (2.5 km) from Citadel Mall and within 6 miles (10 km) of Charles Towne Landing State Historic Site and Charleston ...
Oceans One Resort
Oceans One Resort
3.0 out of 5.0 102 South Ocean Boulevard, Myrtle Beach, SC
4.1/5 (743 reviews)

I fell in love I would definitely book again ! Everything is ocean view , nice condos , great customer service . Thank you for the stay , you’ll be seeing me again .

Reviewed on 25 Oct. 2019
Located in Downtown Myrtle Beach, this beachfront condo is in the city centre and within 1 mi (2 km) of Family Kingdom Amusement Park, Mount Atlanticus Miniature ...
Home2 Suites by Hilton Columbia Harbison
Home2 Suites by Hilton Columbia Harbison
2.5 out of 5.0 550 Columbiana Dr, Columbia, Irmo, SC
NZ$145
4.5/5 (98 reviews)

Great place to stay! Great outdoor sitting area with fireplace. Free laundry and pool. Kitchen in the room saves money on eating out. Will stay here again.

Reviewed on 10 Nov. 2019
Situated in Irmo, this aparthotel is within a 15-minute walk of Harbison Theatre and Irmo Community Park. Columbiana Centre and Frankie's Fun Park are also within ...
Suburban Extended Stay Hotel at the University
Suburban Extended Stay Hotel at the University
2376 East highway 501, Building A, Conway, SC
NZ$67
4.1/5 (7 reviews)

Beds, small kitchen area, washroom. Not much else in rooms but if you just need a place to sleep it was nice and cheap. Only issue was that the ac fan made my cold susceptible asthma act up but with a shirt on it wasn't too bad.

Reviewed on 6 Nov. 2019
Situated in Conway, this aparthotel is within 1 mi (2 km) of Horry Georgetown Technical College, Conway Medical Center, and Coastal Carolina University. Wild ...
Home2 Suites by Hilton Charleston Airport/Convention Center
Home2 Suites by Hilton Charleston Airport/Convention Center
2.5 out of 5.0 3401 W. Montague Avenue, North Charleston, SC
NZ$180
4.4/5 (657 reviews)

Staff were amazing - friendly and really helpful. They go above and beyond to make your stay great. Would highly recommend

Reviewed on 13 Nov. 2019
Situated near the airport, this aparthotel is within 1 mile (2 km) of Charleston Area Convention Center, North Charleston Coliseum and Performing Arts Center ...
Home2 Suites by Hilton Summerville
Home2 Suites by Hilton Summerville
2.5 out of 5.0 221 Holiday Drive, Summerville, SC
NZ$148
4.4/5 (154 reviews)

Loved all the colorful areas of the hotel. Large room. Very dark in the room at night which allowed for an excellent nights sleep. The room at first seemed clean but as we looked closer throughout the stay it was obvious that some areas don’t get cleaned as well as others. That’s a typical hotel ...

Reviewed on 27 Oct. 2019
Situated in Summerville, this aparthotel is within 3 miles (5 km) of Summerville Dorchester Museum, White Gables and Azalea Park. Wassamassaw Community Park ...

You always said you would go on a dream holiday someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannonball into the deep end. Go ahead, unplug and unwind in style. When you book one of our South Carolina holiday rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your holiday just got upgraded.

As much as you love your vacation rental, it’s always good to get out and explore to soak up South Carolina. Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in South Carolina. Seeing all the best attractions is bound to make you fall in love with South Carolina. Who knows, you may even be tempted to extend your stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true. 

It’s your escape so why share it? You deserve your own slice of paradise. Booking your holiday rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in South Carolina short-term rentals, that won’t be hard to do.