A coastal resort with beachfront villas and a clear blue sky.

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Check prices for these dates

Tonight
5 Oct - 6 Oct
Tomorrow
6 Oct - 7 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

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Our top choices for Panacea hotels

1. The Panacea Motel

The Panacea Motel
Panacea
United States
Dashawn
NZ$222
includes taxes & fees
6 Oct - 7 Oct
The Panacea Motel

2. Best Western Wakulla Inn & Suites

Best Western Wakulla Inn & Suites
Crawfordville
United States
James
NZ$230
includes taxes & fees
18 Oct - 19 Oct
Best Western Wakulla Inn & Suites

3. Wildwood Inn

Wildwood Inn
Crawfordville
United States
Shane
NZ$238
includes taxes & fees
22 Oct - 23 Oct
Wildwood Inn

4. The Lodge at Wakulla Springs

The Lodge at Wakulla Springs
Crawfordville
United States
Joy
NZ$167
includes taxes & fees
6 Oct - 7 Oct
The Lodge at Wakulla Springs

5. St James Bay Golf & Pickleball Resort

St James Bay Golf & Pickleball Resort
Carrabelle
United States
Richard
NZ$255
includes taxes & fees
6 Oct - 7 Oct
St James Bay Golf & Pickleball Resort

6. The Moorings Hotel and Marina

The Moorings Hotel and Marina
Carrabelle
United States
Tina
NZ$253
includes taxes & fees
12 Oct - 13 Oct
The Moorings Hotel and Marina

7. The Old Carrabelle Hotel

The Old Carrabelle Hotel
Carrabelle
United States
Christy
NZ$207
includes taxes & fees
18 Oct - 19 Oct
The Old Carrabelle Hotel

8. Franklin Inn

Franklin Inn
Carrabelle
United States
Nathan
NZ$185
includes taxes & fees
6 Oct - 7 Oct
Franklin Inn
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Stay near popular Panacea attractions

Alligator Point Beach

8.8/10 (10 reviews)
Escape to this pristine stretch of old coastal Florida with white sands and shallow, clear waters. Spot dolphins and sea turtles while enjoying the serenity of an undeveloped shoreline.
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Bald Point State Park

8.6/10 (20 reviews)
Where Ochlockonee Bay meets Apalachee Bay, this coastal park showcases diverse ecosystems from beaches to pine flatwoods. Spot migrating raptors and monarch butterflies while hiking through pristine natural habitats.
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Mashes Sand Beach

8.8/10 (3 reviews)
Mashes Sands Beach offers serene shallow waters and expansive sandbars perfect for peaceful exploration. Wade through the tea-colored Gulf waters while spotting hermit crabs and enjoying spectacular sunset views.
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Wilson Beach

Wilson Beach offers a serene Gulf Coast escape with pristine shores and gentle waves far from tourist crowds. Bring supplies and enjoy peaceful beachcombing along this unspoiled natural sanctuary.
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Public Beach Access

Mashes Sands Beach features tranquil white-sand shores and shallow waters ideal for families. Wade in the gentle surf, cast a fishing line, or enjoy a peaceful picnic away from tourist crowds.
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Panacea Springs

Once a popular health resort, these historic mineral springs were believed to possess healing properties in the early 1900s. Explore the remnants of spa structures while imagining the therapeutic rituals of a bygone era.
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Silver Lake

Swim in crystal-clear waters along a pristine 250-foot white sand beach surrounded by longleaf pines. The mile-long interpretive trail offers peaceful wildlife encounters with bald eagles and turtles.
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Gulf Specimen Public Aquarum

Take the children to visit the sea life you'll find at Gulf Specimen Public Aquarum during your holiday to Panacea. Stroll along the beaches in this relaxing area or seek out the fishing spots.
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Learn more about Panacea

Kayak through pristine coastal marshes at Panacea's Woolley Park, where fishing piers and boardwalks offer prime spots for catching redfish. Nearby St. Marks National Wildlife Refuge invites visitors to spot migratory birds and explore the historic lighthouse along scenic hiking trails.

See all hotels in Panacea
A coastal resort with beachfront villas and a clear blue sky.

Top Panacea Hotel Reviews

Recent Reviews in Panacea

Tiki House is a Unique Beach Front gathering spot for family, friends and pups.

Tiki House is a Unique Beach Front gathering spot for family, friends and pups.

10/10 Excellent
"The house was very nice, and as advertised. Right on the beach."
Donna A. 7-night trip
Posted 8 hours ago
Tiki House is a Unique Beach Front gathering spot for family, friends and pups.
5 Bedroom Beach House Slps 12 - Private Beach - Shells - Fishing -Screened porch

5 Bedroom Beach House Slps 12 - Private Beach - Shells - Fishing -Screened porch

10/10 Excellent
"Great place to stay very peaceful and relaxing."
David H. 7-night trip
Posted 6 days ago
5 Bedroom Beach House Slps 12 - Private Beach - Shells - Fishing -Screened porch
Great sunrise view from dining area and decks. Easy beach access.

Great sunrise view from dining area and decks. Easy beach access.

10/10 Excellent
"Property is clean and in a great location for peace and quiet. We enjoyed meeting the host and I'm sure will book with them again."
Jennifer W. 3-night trip
Posted 7 days ago
Great sunrise view from dining area and decks. Easy beach access.
Lighthouse- enjoy the water, bask in the view

Lighthouse- enjoy the water, bask in the view

10/10 Excellent
"A very remote location, laid back small community and very natural beaches."
Neal D. 7-night trip
Posted 8 days ago
Lighthouse- enjoy the water, bask in the view
Hideaway Beach Cottage on waterfront with amazing views.

Hideaway Beach Cottage on waterfront with amazing views.

10/10 Excellent
"Booking this stay was incredibly easy. Hosts are responsive and very accommodating. Price was great, especially considering that we thought the property was even better in person. Pictures truly don’t do it justice. The small town of Panacea is a breath of fresh air. Not your typical touristy beach town. We wanted to have a slow, low stim vacation with our young kids and that’s exactly what we got. There are still enough restaurants to choose from if you want to eat out every night in the town and even more within a 20 minute drive. If you want to stay in and cook, the kitchen has plenty of room and is stocked well. Large dining table with more than enough room. The living area large and comfy. We didn’t use the second bedroom beds because our kids are still in pack and plays. Two fit in the room just fine. The master bedroom mattress was genuinely one of the most comfortable beds I’ve slept in. Screened in porch was amazing to relax in and let in 0 bugs somehow. So impressed. Our absolute favorite part though was the yard and little beach on the bay. Our kids can’t stand to be inside and they played for HOURS in the good sized yard. We watched stingrays, fish, and birds in the bay. The only thing I’d tell people to consider is that the beach can be a drive. The closest beach, Mashes Sands, had almost no shoreline so you’ll need to drive \- 20 minutes for a beach. This didn’t bother us at all. There is virtually no traffic and tons of options."
Dean D. 4-night trip
Posted 11 days ago
Hideaway Beach Cottage on waterfront with amazing views.
Private Beachfront w/ Sauna, Hottub, Golf Cart, Kayaks, Paddle Boards & Bikes +

Private Beachfront w/ Sauna, Hottub, Golf Cart, Kayaks, Paddle Boards & Bikes +

10/10 Excellent
"This was our third trip to this house for a week. Enjoyed everything.. you don't need anything."
Kim H. 7-night trip
Posted 13 days ago
Private Beachfront w/ Sauna, Hottub, Golf Cart, Kayaks, Paddle Boards & Bikes +
Coastal Getaway on canal-steps to the beach

Coastal Getaway on canal-steps to the beach

10/10 Excellent
"Awesome weekend staying at this location. We was within walking distance to the beach and fishing. Loved that it had a complete bathroom downstairs when we came in from fishing all day and night. Great communication with the host. Very prompt responding to questions. Will recommend to family and friends!!"
Allyson G. 2-night trip
Posted 3 weeks ago
Coastal Getaway on canal-steps to the beach
"Somewhere In The Sun"  Beachfront Cottage - Old Florida Style Hideaway

"Somewhere In The Sun" Beachfront Cottage - Old Florida Style Hideaway

10/10 Excellent
"Great beach bungalow. Pictures don’t do it justice. Much more spacious than we anticipated. Had everything we needed. Very cute and wonderful views of the beach. Area was great for us, quiet, private, not touristy at all. We saw so many stars at night, even saw the Milky Way the first night there. Definitely recommend if you are looking for that old school small Florida beach house vibe."
Melissa D. 7-night trip
Posted 3 weeks ago
"Somewhere In The Sun" Beachfront Cottage - Old Florida Style Hideaway
Waterfront, Pool, Private Hot Tub, Golf Cart, Kayaks, Bikes, Tennis, 🐶 friendly

Waterfront, Pool, Private Hot Tub, Golf Cart, Kayaks, Bikes, Tennis, 🐶 friendly

10/10 Excellent
"House was perfict if your looking for a quit place and relaxing time this is your place"
Joshua J. 7-night trip
Posted 1 month ago
Waterfront, Pool, Private Hot Tub, Golf Cart, Kayaks, Bikes, Tennis, 🐶 friendly

More cheap accommodation in Panacea

Franklin Inn

Franklin Inn

1589 US-98 Carrabelle FL
NZ$185
6 Oct - 7 Oct
includes taxes & fees
Franklin Inn
The Old Carrabelle Hotel

The Old Carrabelle Hotel

201 Tallahassee St Carrabelle FL
NZ$207
18 Oct - 19 Oct
includes taxes & fees
The Old Carrabelle Hotel
The Panacea Motel

The Panacea Motel

1545 Coastal Hwy Panacea FL
NZ$222
6 Oct - 7 Oct
includes taxes & fees
The Panacea Motel
Best Western Wakulla Inn & Suites

Best Western Wakulla Inn & Suites

3292 Coastal Hwy 98 Crawfordville FL
NZ$230
18 Oct - 19 Oct
includes taxes & fees
8.8/10 Excellent! (1,001 reviews)
Best Western Wakulla Inn & Suites
The Moorings Hotel and Marina

The Moorings Hotel and Marina

1000 Hwy 98 Carrabelle FL
NZ$253
12 Oct - 13 Oct
includes taxes & fees
8.6/10 Excellent! (54 reviews)
The Moorings Hotel and Marina
Cozy Waterfront 'island House' on Live Oak Island!

Cozy Waterfront 'island House' on Live Oak Island!

Crawfordville FL
Get ratesCozy Waterfront 'island House' on Live Oak Island!

Frequently asked questions

What is the best area to stay in Panacea?
The best area to stay in Panacea is right along the waterfront, particularly around the main highway, US-98.This area is the heart of Panacea, offering direct access to the Gulf of Mexico's tranquil waters. You'll find most of the local seafood restaurants and shops concentrated along US-98, making it very convenient. It's a relaxed, coastal community known for its fishing and natural beauty.Families often find this area ideal due to its proximity to the water-based activities. Many accommodations here offer easy access to fishing charters, boat rentals, and paddleboarding opportunities in the bay. The educational exhibits at the Gulf Specimen Marine Lab are also a short walk away, providing an engaging experience for children and adults alike.Couples looking for a quiet escape will appreciate the peaceful atmosphere and scenic views. The waterfront properties often provide lovely spots to relax and enjoy the sunset over the bay, with several local eateries offering fresh seafood right on the water.
What are the best hotels in Panacea that travellers recommend?
For a highly recommended hotel in Panacea, consider The Panacea Motel.The Panacea Motel, with a 9.0 rating, offers excellent value and is praised by guests for its comfortable beds and nice towels. It provides free self-parking and early check-in is often available. The motel is conveniently located near local attractions such as Woolley Park, just 1.0 km away, Gulf Specimen Public Aquarium, 1.5 km away, and Panacea Park, which is 1.2 km from the property.
What are the top pet-friendly hotels in Panacea?
For a top pet-friendly hotel in Panacea, consider The Panacea Motel.The Panacea Motel, with a very good 9.0 rating, is an excellent choice for travellers with pets as both dogs and cats are permitted. Guests frequently mention the good beds and the nice towels, alongside the good value for the price. The hotel also offers early check-in, which can be very convenient. It is well-located near local attractions such as Woolley Park, just 1.0 km away, Gulf Specimen Public Aquarium, 1.5 km away, and Panacea Park, 1.2 km away.
What are the best budget hotels in Panacea?
For a top budget hotel in Panacea, consider The Panacea Motel.This motel, with a 9.0 rating, is frequently praised by guests for its good value and comfortable beds, with many noting the nice towels provided. It offers free WiFi and complimentary self-parking. Early check-in is also available, which can be very convenient. The Panacea Motel is handily located near local attractions, being only 0.3 km from Panacea Springs, 1.0 km from Woolley Park, and 1.2 km from Panacea Park.
What are the best hotels in Panacea near Woolley Park?
For a highly-rated hotel in Panacea near Woolley Park, consider The Panacea Motel.The Panacea Motel, with a 9.0 rating, is conveniently located just 1.0 km from Woolley Park. Guests often mention the comfortable beds and the good value for money. The motel also offers free WiFi and complimentary self-parking, and early check-in is available. It is also only 1.5 km from the Gulf Specimen Public Aquarum and 1.2 km from Panacea Park.
When is the best time to go to Panacea?
The best time to go to Panacea, Florida, is typically during the spring (March to May) and autumn (September to November) months.During these periods, the weather is pleasantly warm, with comfortable temperatures ranging from the low 20s to high 20s Celsius. You'll find fewer crowds compared to the peak summer season, making it ideal for a relaxing and unhurried experience. It's superb for enjoying outdoor activities like kayaking, fishing, or exploring the nature trails without the intense heat and humidity of summer.Travellers looking for a tranquil escape will appreciate the calm waters and the opportunity to spot local wildlife, such as manatees and various bird species. The mild weather makes it a great time for couples to enjoy romantic walks along the coastline or explore the local seafood restaurants.Conversely, while summer (June to August) offers very warm weather for swimming, it also brings higher humidity, more frequent thunderstorms, and larger crowds.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, although it depends on the cancellation policy of your booking. Most bookings are refundable if cancelled within 24 to 48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to 'My Trips' and selecting your reservation. To find flexible deals, filter your search by 'Fully refundable property' for hotels in Panacea.
How can I save on a hotel booking in Panacea with Expedia?
One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on Panacea hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
How much is the nightly rate for a hotel in Panacea?
Prices for hotels in Panacea often vary, but you can find a great deal from NZ$167 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by 'Price: low to high' for our cheapest rates.

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