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Top Luxury Panhandle Plains Hotels

Studio 6 Amarillo, TX – West Medical Center

6801 W Interstate 40, Amarillo, TX

4 hours drive from Texas Tech University

Book a stay at this business-friendly hotel in Amarillo. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the breakfast and the pool ...

7.4/10 Good! (1,000 reviews)

"It was right off the interstate highway"

Reviewed on 21 Jul. 2025

Spark by Hilton Amarillo East

2301 East I40, Amarillo, TX

4 hours drive from Texas Tech University

Book a stay at this business-friendly hotel in Amarillo. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

8.2/10 Very Good! (76 reviews)

"Everything was great."

Reviewed on 30 Jul. 2025

Hawthorn Suites by Wyndham Lubbock

4435 Marsha Sharp Fwy, Lubbock, TX

25 min walk from Texas Tech University

Stay at this 3-star business-friendly hotel in Lubbock. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the clean ...

7.8/10 Good! (1,003 reviews)

"We are greatly enjoying our stay with this property, during our in-limbo in town move. The staff is friendly, and courteous and always willing to go the extra mile. Thru a very stressful week in life, this is the one space I’ve found some peace and quiet to regroup. Our family is very grateful for ..."

Reviewed on 4 Aug. 2025

See all 2,039 properties in Panhandle Plains

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.