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Top Luxury Panhandle Plains Hotels

Studio 6 Amarillo, TX – West Medical Center

6801 W Interstate 40 Amarillo TX

4 hours drive from Texas Tech University

Stay at this business-friendly hotel in Amarillo. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the breakfast and the pool in their ...

7.4/10 Good! (1,000 reviews)

Was given the wrong room and walked in on some random man! When we did get to our right room it was literally crawling with cockroaches me and my boyfriend were doing a long road trip we had stay at multiple motels this one was by far the WORST stay somewhere else

Reviewed on 10 Feb 2026

Spark by Hilton Amarillo East

2301 East I40 Amarillo TX

4 hours drive from Texas Tech University

Stay at this business-friendly hotel in Amarillo. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

9/10 Wonderful! (319 reviews)

Get a waffle machine!

Reviewed on 12 Mar 2026

Hawthorn Suites by Wyndham Lubbock

4435 Marsha Sharp Fwy Lubbock TX

25 min walk from Texas Tech University

Stay at this business-friendly hotel in Lubbock. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms in ...

8/10 Very Good! (1,004 reviews)

The room was ok. Beds were a little high, had my elderly mother with me and getting in and out of bed was a challenge. Looked like maybe rooms were updated but not very well. Chunk of wood missing next to fridge.

Reviewed on 10 Mar 2026

See all 2,295 properties in Panhandle Plains

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.