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The best area to stay in Uxbridge is generally along the main thoroughfares of Route 16 (Douglas Street/Mendon Street) and Route 146A (Quaker Highway), as these offer the most convenient access to local amenities and attractions.For visitors looking for a central and well-connected base, the area around the intersection of Route 16 and Route 146A is ideal. This part of Uxbridge provides easy access to the town's few local businesses, including eateries and shops. It's a practical choice for anyone wanting to explore the Blackstone Valley National Historical Park, as several of its key sites are a short drive away.Couples or solo explorers interested in the region's history and natural beauty will appreciate staying near the southern end of Uxbridge, closer to the historic village of Linwood and the Blackstone River. This area offers a more tranquil setting, with opportunities for walks along the river or visits to the historic mills.

The best time to visit Uxbridge, Massachusetts is during the late spring, summer, and early autumn months, specifically from May to October, when the weather is most agreeable for outdoor activities.During these months, the weather is typically warm and pleasant, with lower humidity than peak summer. This makes it ideal for exploring the historic Blackstone River Valley National Historical Park, which runs through Uxbridge. You can enjoy walking or cycling along the Blackstone River Greenway or visiting local farms and orchards.Travellers interested in outdoor pursuits will find May, June, September, and October particularly appealing. The milder temperatures are great for hiking the various trails, such as those found at the Southern New England Trunkline Trail.