A gazebo with columns, a large tree with hanging roots, and a building in the background.

Santa Ana Hotels, Panama City

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santa Ana hotels

1. Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (100 reviews)
"Always an amazing stay"
United States
chris
The price is NZ$215
includes taxes & fees
21 July - 22 July
Casco View Apartments

2. Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (73 reviews)
"Excellent staff, close to metro and embassies. A good location, good room for a great price. I would stay again. "
United Kingdom
Mark
The price is NZ$47
includes taxes & fees
20 July - 21 July
Hostal La Cigarra

3. Hotel República

Hotel República
2.0 star property
Santa Ana
6.8 out of 10, (195 reviews)
"Very good ."
United States
Denice
The price is NZ$158
includes taxes & fees
20 July - 21 July
Hotel República

4. Hotel Riazor

Hotel Riazor
3.0 star property
Santa Ana
3.8 out of 10, (11 reviews)
"Rough neighborhood "
Canada
Del
The price is NZ$48
includes taxes & fees
20 July - 21 July
Hotel Riazor

5. La Manzana Barrio Vivo by Wynwood

La Manzana Barrio Vivo by Wynwood
3.0 star property
Santa Ana
7.6 out of 10, Good, (18 reviews)
"Very clean and safe property"
United States
Javier Alberto Lindauer
The price is NZ$188
includes taxes & fees
20 July - 21 July
La Manzana Barrio Vivo by Wynwood

6. ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
6.0 out of 10, (11 reviews)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
The price is NZ$69
includes taxes & fees
20 July - 21 July
ART CASCO The Hotel

7. Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
4.0 star property
San Felipe, 0.9 km from Santa Ana
9.2 out of 10, Wonderful, (1,000 reviews)
"Love the breakfast and the rooms were amazing"
United States
querube
The price is NZ$311
includes taxes & fees
17 Aug - 18 Aug
Central Hotel Panama Casco Viejo

8. Hotel Magnolia Boutique

Hotel Magnolia Boutique
2.0 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (489 reviews)
"Hotel located near shops and restaurants. Great for exploring Casco Viejo."
United States
ivania e
The price is NZ$157
includes taxes & fees
20 July - 21 July
Hotel Magnolia Boutique

9. American Trade Hotel

American Trade Hotel
4.5 star property
San Felipe, 0.7 km from Santa Ana
9.4 out of 10, Exceptional, (772 reviews)
"Everybody was so nice and attentive ! Location is great. It was our first time in Panama and it was just great !"
United States
Lourdes
The price is NZ$410
includes taxes & fees
16 Aug - 17 Aug
American Trade Hotel

10. Hotel Casa Panamá

Hotel Casa Panamá
4.0 star property
San Felipe, 0.6 km from Santa Ana
7.6 out of 10, Good, (719 reviews)
"Great property will definitely come back"
United States
Robert
The price is NZ$118
includes taxes & fees
4 Aug - 5 Aug
Hotel Casa Panamá

11. Tantalo Hotel

Tantalo Hotel
3.5 star property
San Felipe, 0.7 km from Santa Ana
8.8 out of 10, Excellent, (310 reviews)
"Great location, staff was helpful and friendly. Food was delicious. Rooftop and views were great! "
United States
Krista
The price is NZ$165
includes taxes & fees
9 Aug - 10 Aug
Tantalo Hotel

12. Oasis Hotel

Oasis Hotel
3.0 star property
San Felipe, 0.6 km from Santa Ana
8.4 out of 10, Very good, (144 reviews)
"Great stay! Highly recommend"
United States
Gregg
The price is NZ$109
includes taxes & fees
25 July - 26 July
Oasis Hotel

13. Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo
4.5 star property
San Felipe, 0.9 km from Santa Ana
9.8 out of 10, Exceptional, (327 reviews)
"Property is well-appointed with flashes of history sprinkled throughout. Food is fantastic."
United States
Stephanie
The price is NZ$511
includes taxes & fees
20 July - 21 July
Hotel La Compañía Casco Antiguo

14. Hotel San Felipe

Hotel San Felipe
4.0 star property
San Felipe, 0.7 km from Santa Ana
9.4 out of 10, Exceptional, (419 reviews)
"Great location with wonderful restaurants and parks and museum within walking distance"
United States
stephen
The price is NZ$302
includes taxes & fees
20 July - 21 July
Hotel San Felipe

15. Amarla Boutique Hotel Casco Viejo Adults Only

Amarla Boutique Hotel Casco Viejo Adults Only
3.0 star property
San Felipe, 1 km from Santa Ana
9.6 out of 10, Exceptional, (137 reviews)
"The location was great & staff was cool too!"
United States
Kennedi
The price is NZ$364
includes taxes & fees
28 July - 29 July
Amarla Boutique Hotel Casco Viejo Adults Only

16. La Concordia Boutique Hotel

La Concordia Boutique Hotel
4.0 star property
San Felipe, 0.5 km from Santa Ana
9.6 out of 10, Exceptional, (226 reviews)
"Charming boutique hotel, super comfortable with big spacious rooms, and the location in the old part of town was perfect. The staff was very nice."
United States
Monica
The price is NZ$379
includes taxes & fees
21 July - 22 July
La Concordia Boutique Hotel

17. Marriott Panama Hotel

Marriott Panama Hotel
4.0 star property
2.1 km from Santa Ana
9.0 out of 10, Wonderful, (1,002 reviews)
"The room was clean, the staff was nice and the breakfast had gluten free options, the gf bread was great and a really good buffet."
United States
Mara L
The price is NZ$318
includes taxes & fees
7 Aug - 8 Aug
Marriott Panama Hotel

18. Radisson Hotel Panama Canal

Radisson Hotel Panama Canal
4.5 star property
Amador, 2.3 km from Santa Ana
8.6 out of 10, Excellent, (1,002 reviews)
"The hotel is good, love the quiet atmosphere it have some times."
United States
Carol
The price is NZ$161
includes taxes & fees
30 July - 31 July
Radisson Hotel Panama Canal

19. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
San Felipe, 1.1 km from Santa Ana
9.8 out of 10, Exceptional, (691 reviews)
"It was an amazing stay! The only place we would stay in Panama City."
United States
Josh
The price is NZ$890
includes taxes & fees
15 Aug - 16 Aug
Sofitel Legend Casco Viejo, Panama City

20. The Executive Hotel

The Executive Hotel
3.5 star property
Campo Alegre, 3.2 km from Santa Ana
9.2 out of 10, Wonderful, (1,183 reviews)
"Will definitely stay there again"
United States
Carleen
The price is NZ$167
includes taxes & fees
11 Aug - 12 Aug
The Executive Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas, pool loungers
Casco View Apartments
3.5 star property
9.0
Wonderful
100 reviews
View
Bar (on property)
Hostal La Cigarra
2.0 star property
7.6
Good
73 reviews
View
Front of property
ART CASCO The Hotel
2.0 star property
6.0
11 reviews
View
Beach shuttle
Hotel República
2.0 star property
6.8
195 reviews
View
Bar (on property)
Hotel Riazor
3.0 star property
3.8
11 reviews
View

Our guide on where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Calidonia

Calidonia is a destination travellers like for its shopping, and you might hop aboard the metro at Estación Lotería or Santo Tomas Station to explore sights like Via Espana.

Top Santa Ana Hotel Reviews

Recent Reviews in Santa Ana

Find out more about Santa Ana

Top reasons to visit Santa Ana

  • Vibrant Atmosphere: Santa Ana boasts a lively ambiance filled with friendly locals and a true Panamanian vibe, perfect for immersing yourself in the culture.
  • Cultural Attractions: Visit notable sites like the Santa Ana Church and explore the rich heritage through local history museums.
  • Guided Tours: Engage in guided experiences, including neighbourhood and walking tours that reveal the charm of Panama City.
  • Diverse Accommodation: Enjoy a variety of accommodation options, from pet-friendly hotels to unique city apartments.
  • Outdoor Adventures: Discover scenic hills and outdoor activities that provide a refreshing escape amidst the urban setting.

Find great hotels near Santa Ana

Explore a variety of accommodation options in Santa Ana, Panama City, where you'll find both hotels and apartments tailored for every type of traveller. Whether you're seeking a pet-friendly stay, a business-friendly environment, or a unique city experience, Santa Ana has it all. Consider options like Hotel El Panama and various Panama vacation rentals to ensure a memorable visit to this vibrant area of Panamá Province.

  • Central Hotel Panama Casco Viejo: Nestled 805m away from Santa Ana, Central Hotel Panama Casco Viejo is a charming 4-star establishment that exudes romance and relaxation. With a guest rating of 9.2 out of 10, this hotel is ideal for those seeking a tranquil getaway or a romantic escape. The property boasts an array of pampering amenities, including an outdoor pool, a full-service spa, and packages designed for romantic experiences. Guests can indulge in delightful dining options via 24-hour room service and enjoy unique features like champagne service. Whether you’re unwinding with a body treatment or enjoying a steam room session, this hotel is perfect for couples looking to relax and reconnect.
  • American Trade Hotel: Situated 644m from Santa Ana, the 4.5-star American Trade Hotel offers a dynamic blend of adventure and romance, earning a guest rating of 9.4 out of 10. Families and couples alike will appreciate the range of activities available, from nearby bike rentals to hiking excursions. The hotel features amenities for children, ensuring a family-friendly atmosphere. Guests can savour garden views while dining and enjoy limited-hour room service along with romantic packages. Outdoor pools, sun loungers, and massage services provide ample opportunities for relaxation after a day of adventure.
  • Sofitel Legend Casco Viejo, Panama City: A luxurious 5-star hotel located 1.1km from Santa Ana, Sofitel Legend Casco Viejo boasts an impressive guest rating of 9.8 out of 10. This establishment is designed for discerning travellers seeking a sophisticated retreat, combining luxury with business-friendly amenities. The hotel features a full-service spa with aromatherapy treatments and a swim-up bar, promising an indulgent experience. With elegant accommodations and a focus on relaxation, this hotel is an exceptional choice for those looking to blend business with leisure in a refined setting.

Where to stay near Santa Ana

Santa Ana, a vibrant neighbourhood in Panama City, offers a unique blend of family-friendly and business-themed experiences. Visitors can soak in the lively atmosphere filled with friendly locals while exploring nearby attractions that showcase the true Panamanian vibe. Don't miss the chance to wander through the best parts of Panama, where relaxation and luxury await. Whether you're dining at local eateries or enjoying the urban scenery, Santa Ana promises an unforgettable vacation experience.

  • Panama City: As the vibrant capital of Panama, Panama City is a bustling metropolis where modernity meets history. Nestled beside the Pacific Ocean, it boasts an impressive skyline alongside the iconic Panama Canal. Visitors flock to experience a mix of cultural attractions, business opportunities, and family-friendly activities. The city offers numerous shopping centres and parks to explore, making it an ideal destination for all types of travellers. Don't miss the chance to indulge in local cuisine at street vendors or enjoy a leisurely day at one of its beautiful beaches.
  • Casco Viejo: A mere 644m from Santa Ana, Casco Viejo is a UNESCO World Heritage site that showcases Panama's colonial past. This charming neighbourhood is known for its cobbled streets, colourful buildings, and vibrant atmosphere. With a rich blend of cafes, shops, and cultural sites, it’s perfect for leisurely strolls and family outings. Visitors are drawn to its historical landmarks, relaxing parks, and enticing shopping areas. The lively ambiance is especially vibrant during peak seasons like January and March to April, making it an inviting spot to soak up local culture.
  • Barrio Chino: Just 322m from Santa Ana, Barrio Chino is Panama City's bustling Chinatown, where you can immerse yourself in the rich blend of Chinese and Panamanian cultures. This lively neighbourhood is filled with shops, restaurants, and markets, making it a fantastic place for a culinary adventure. Travellers can explore fascinating museums and research facilities that highlight the area's unique history. The neighbourhood comes alive during peak travel months like February and December, making it a vibrant area to experience both cultural and family-friendly activities.

Things to do near Santa Ana

Shopping

In Santa Ana, visit the Albrook Mall for a variety of shops, from clothing to electronics. For a more local experience, check out the nearby Mercado de Santa Ana, where you can find unique handicrafts and souvenirs reflecting Panamanian culture.

Recreation

Explore the serene atmosphere of the Santa Ana Wellness Centre, where you can indulge in yoga classes and holistic therapies. Afterwards, enjoy a leisurely stroll in Parque de Santa Ana, surrounded by lush greenery, perfect for relaxation and unwinding amidst nature.

Adventure

Gatun Eco Adventures offers an exhilarating zipline and ropes course experience, located 48.3km from Santa Ana. Feel the rush as you soar through lush canopies and navigate exciting aerial challenges, all while embracing the vibrant outdoor atmosphere that this adventure venue provides.

Nightlife

The vibrant nightlife in Santa Ana features lively bars and local music venues. Check out the popular Casa Jaguar for a laid-back vibe and cocktails, or visit the bustling La Tana for a taste of Panama's craft beers and a friendly atmosphere.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions near Santa Ana

Santa Ana in Panama City offers a delightful mix of family-friendly, business, and city-themed experiences. Visitors can explore captivating attractions like the Santa Ana Church, Iglesia Santa Ana, and the San Miguel area. With its rich cultural heritage, scenic hills, and history museums, Santa Ana promises an enriching getaway for those seeking outdoor adventures and a taste of local culture.

  • Metropolitan Cathedral of Panama: Located a mere 805m from Santa Ana, this stunning cathedral showcases a blend of architectural styles, reflecting the rich cultural heritage of Panama. Visitors can admire its intricate details and peaceful atmosphere, making it a perfect spot for quiet reflection.
  • Interoceanic Canal Museum: Just 805m away, the Interoceanic Canal Museum offers insights into the remarkable history of the Panama Canal. Through engaging exhibits, you can explore the engineering marvel that transformed global trade routes and learn about the cultural impact on Panama.
  • Independence Square: Also located 805m from Santa Ana, this vibrant square is a hub of activity and history. Surrounded by significant buildings, it's an ideal place to soak up the local culture and enjoy the lively atmosphere of the city.

Best time to go to Santa Ana

The best time to visit Santa Ana is dependent on what kind of holiday you are seeking. April is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. November is its coolest month on average. At this time, visitor numbers are average and weather is mostly cloudy with frequent rain.

calendar iconCalendar Monthtemperature iconTemperaturerain iconPrecipitationmostly cloudy iconCloudinessoccupation rate iconOccupancyprice iconPricing
January78.8°F (26.0°C)No RainMostly SunnyAverageSlightly High
February79.2°F (26.2°C)No RainMostly SunnySlightly HighAverage
March79.7°F (26.5°C)No RainMostly SunnySlightly HighSlightly High
April80.4°F (26.9°C)Light RainMostly SunnyAverageSlightly High
May80.2°F (26.8°C)Frequent RainMostly CloudySlightly LowAverage
June79.9°F (26.6°C)Frequent RainMostly CloudySlightly LowAverage
July79.3°F (26.3°C)Frequent RainMostly CloudyAverageAverage
August79.2°F (26.2°C)Frequent RainMostly CloudyAverageAverage
September79.3°F (26.3°C)Frequent RainMostly CloudySlightly LowSlightly Low
October78.6°F (25.9°C)Frequent RainMostly CloudyAverageSlightly Low
November78.3°F (25.7°C)Frequent RainMostly CloudyAverageSlightly Low
December78.6°F (25.9°C)Light RainMostly CloudySlightly HighAverage

The nearest major airports for your trip to Santa Ana

Flying into Santa Ana, Panama is convenient with three major airports nearby. Balboa (BLB-Panama Pacifico Intl.) is located 6.4km away, with excellent hotels such as The Westin Playa Bonita Panama and Sofitel Legend Casco Viejo, both offering airport shuttle services. Panama City (PAC-Marcos A. Gelabert Intl.) is the closest, at 3.2km, with luxury options like Waldorf Astoria Panama and American Trade Hotel, providing 24-hour shuttle access. Tocumen Intl. (PTY) is 20.9km away, featuring hotels like The Santa Maria, A Luxury Collection Hotel, which is easily accessible from the airport. Enjoy a smooth journey to your stay in Santa Ana.

Frequently asked questions

What are the best hotels in Santa Ana that travellers recommend?
For a popular hotel in Santa Ana, consider Hostal La Cigarra.

Hostal La Cigarra, with a rating of 7.6, is particularly noted by guests for its convenient location and comfortable rooms. This property features a traditional design and is situated within a historical district, close to a shopping district. It is also very convenient for visiting local attractions, being only 0.6 km from the Museum of History Panama and the Mola Museum. Other nearby points of interest include Cinta Costera, 1.6 km away, and Avenida Balboa, 3.6 km away.
What are the top pet-friendly hotels in Santa Ana?
For a top pet-friendly hotel in Santa Ana, you should consider Hostal La Cigarra.

Hostal La Cigarra, with a 7.6 rating, is a pet-friendly accommodation that permits pets and charges a cleaning amount for them. It is located in a historical district, making it convenient for exploring sites like the Museum of History Panama and the Mola Museum, both just 0.6 km away. Guests have frequently commented on its convenient location and comfortable rooms.
What are the best budget hotels in Santa Ana?
For budget-friendly accommodation in Santa Ana, you might consider Hostal La Cigarra, Hotel República, or ART CASCO The Hotel.

Hostal La Cigarra, with a rating of 7.6, provides free WiFi and is located in a historical district, close to the Amador Theater and the Museum of History Panama. Guests often comment on its convenient location and comfortable rooms.

Hotel República offers free WiFi and a lovely terrace, including a rooftop terrace, for guests to enjoy. It is also situated within a historical district.

ART CASCO The Hotel provides free WiFi and is conveniently located near museums and a historical district. It also offers nearby offsite parking with a discount.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline − this is often within 24 to 48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our 'Fully refundable property' filter during your search to find the right Santa Ana hotel for you.
How can I save on a hotel booking in Santa Ana with Expedia?
One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on Santa Ana hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
How much is the nightly rate for a hotel in Santa Ana?
Hotel prices in Santa Ana often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates and sort search results by 'Price: low to high' for our cheapest rates.

Explore a world of travel with Expedia