Search O Brien hotels
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in O Brien
Resort
Family friendly
Check prices for these dates
Our top choices for O Brien hotels
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Holiday Inn Express & Suites Alachua - Gainesville Area by IHGAlachua
9.4 out of 10, Exceptional, (1,006 reviews)
"Staff and hotel were wonderful!"
Sandra
The price is NZ$216
includes taxes & fees
9 Mar - 10 Mar
Tru by Hilton Lake City
Tru by Hilton Lake CityLake City
9.2 out of 10, Wonderful, (1,008 reviews)
"Clean and staff was very kind "
Rosemary
The price is NZ$207
includes taxes & fees
22 Feb - 23 Feb
Days Inn by Wyndham Lake City I-10
Days Inn by Wyndham Lake City I-10Lake City
7.0 out of 10, Good, (1,002 reviews)
"Was quite and clean, a little dated but it was a good place to sleep they are pet friendly "
William
The price is NZ$120
includes taxes & fees
22 Feb - 23 Feb
La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake CityLake City
8.8 out of 10, Excellent, (1,082 reviews)
"Excellent place to stay."
Donovan
The price is NZ$197
includes taxes & fees
22 Feb - 23 Feb
Palms Garden Inn
Palms Garden InnLake City
7.4 out of 10, Good, (584 reviews)
"Clean and nice staff "
apollo
The price is NZ$120
includes taxes & fees
25 Feb - 26 Feb
Super 8 by Wyndham Lake City
Super 8 by Wyndham Lake CityLake City
7.2 out of 10, Good, (693 reviews)
"Clean room, friendly staff, fantastic food!"
John
The price is NZ$118
includes taxes & fees
22 Feb - 23 Feb
Hampton Inn & Suites Lake City
Hampton Inn & Suites Lake CityLake City
9.4 out of 10, Exceptional, (1,000 reviews)
"The room was very clean and comfortable. Excellent breakfast and staff was very friendly and helpful."
Kenneth
The price is NZ$233
includes taxes & fees
22 Feb - 23 Feb
Best Western Plus Lake City
Best Western Plus Lake CityLake City
9.0 out of 10, Wonderful, (1,040 reviews)
"Great place to stay"
Jack
The price is NZ$155
includes taxes & fees
8 Mar - 9 Mar
Comfort Suites Lake City
Comfort Suites Lake CityLake City
9.6 out of 10, Exceptional, (1,001 reviews)
"The staff is great"
Tana
The price is NZ$214
includes taxes & fees
1 Mar - 2 Mar
Hampton Inn & Suites Alachua I-75
Hampton Inn & Suites Alachua I-75Alachua
9.4 out of 10, Exceptional, (485 reviews)
"We visited family in the area and stayed here, hotel was clean, quiet, staff was great and room was so comfortable and spacious for our family of 5. Will definitely stay again!"
Libbi
The price is NZ$215
includes taxes & fees
8 Mar - 9 Mar
Motel 6 – Lake City, Fl – Medical Center
Motel 6 – Lake City, Fl – Medical CenterLake City
8.2 out of 10, Very good, (109 reviews)
"Dog friendly and price."
John
The price is NZ$113
includes taxes & fees
1 Mar - 2 Mar
Days Inn by Wyndham Lake City I-75
Days Inn by Wyndham Lake City I-75Lake City
7.6 out of 10, Good, (1,001 reviews)
"The room was clean and comfortable. The parking and surrounding area were good. Staff was friendly. "
Lars
The price is NZ$119
includes taxes & fees
22 Feb - 23 Feb
Quality Inn White Springs Suwanee
Quality Inn White Springs SuwaneeLive Oak
7.2 out of 10, Good, (640 reviews)
"Hotel is an older facility but room was clean and staff were exceptionally friendly and professional."
Wayne
The price is NZ$131
includes taxes & fees
8 Mar - 9 Mar
Americas Best Value Inn Lake City
Americas Best Value Inn Lake CityLake City
8.6 out of 10, Excellent, (1,005 reviews)
"Nice quiet and comfortable hotel a little gem."
Tim
The price is NZ$126
includes taxes & fees
24 Feb - 25 Feb
BlueGem Motel
BlueGem MotelHigh Springs
9.2 out of 10, Wonderful, (408 reviews)
"Beautiful room, very clean and the bed was incredibly soft and comfortable to sleep in! "
Julians
The price is NZ$139
includes taxes & fees
23 Feb - 24 Feb
Home2 Suites by Hilton Lake City
Home2 Suites by Hilton Lake CityLake City
9.4 out of 10, Exceptional, (764 reviews)
"This is an excellent hotel while you roadtrip:)"
Desiree Moreno
The price is NZ$250
includes taxes & fees
1 Mar - 2 Mar
Quality Inn Lake City
Quality Inn Lake CityLake City
8.0 out of 10, Very good, (982 reviews)
"Staff were great and room was clean and comfortable "
Ethan
The price is NZ$152
includes taxes & fees
22 Mar - 23 Mar
Baymont by Wyndham Lake City I-75
Baymont by Wyndham Lake City I-75Lake City
5.0 out of 10, (1,003 reviews)
"Excelente"
Eduardo
The price is NZ$109
includes taxes & fees
24 Feb - 25 Feb
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Learn more about O Brien
Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.
Top O Brien Hotel Reviews
La Quinta Inn & Suite by Wyndham Lake City
10/10 Excellent
More cheap accommodation in O Brien
Motel 6 – Lake City, Fl – Medical Center
3340 W US Highway 90 Lake City FL
The price is NZ$113 per night from 1 Mar to 2 Mar
NZ$113
1 Mar - 2 Mar
includes taxes & fees
8/10 Very Good! (107 reviews)
Frequently asked questions
Explore a world of travel with Expedia
- Beach Hotels in Central West Coast Florida
- Historic Hotels in Northern Florida
- All Inclusive Hotels in Northern Florida
- Cheap Hotels in Trenton
- Motels in Mayo
- Caravan Parks in Lake Butler
- Resort in Northern Florida
- Motels in Northern Florida
- Condo Rentals in Steinhatchee
- Cabin Rentals in Jasper
- Cabin Rentals in Live Oak
- Caravan Parks in Central West Coast Florida
- Lodges in Central West Coast Florida
- Resort in Central West Coast Florida
- B&B in Central West Coast Florida
- Ranches in Central West Coast Florida
- Apartments in Archer
- Cabin Rentals in Archer
- Holiday Homes in Perry
- Holiday Homes in Lake City
- Caravan Parks in Lulu
- Cabin Rentals in White Springs
- Cabin Rentals in High Springs
- Cottages in Madison
- Cross City Hotels
- High Springs Hotels
- Fort White Hotels
- Hotels near Ginnie Spring
- Hotels near Chiefland Farmers Flea Market
- Steinhatchee Hotels
- Newberry Hotels
- Lake City Hotels
- Athena Hotels
- Lake Butler Hotels
- Alachua Hotels
- Day Hotels
- Mayo Hotels
- Branford Hotels
- Trenton Hotels
- Hotels near Sante Fe College
- Alton Hotels
- Jennings Hotels
- Hotels near Ichetucknee Springs State Park
- Jena Hotels
- Hotels near Ruth B. Kirby Gilchrist Blue Springs State Park
- Perry Hotels
- Lulu Hotels
- Jasper Hotels
- Live Oak Hotels
- Brooker Hotels
- Bell Hotels
- Old Town Hotels
- Wellborn Hotels
- Mcalpin Hotels
- Flights to Bronson
- Flights to Central West Coast Florida
- Flights to Gainesville
- Flights to Northern Florida
- Flights to Chiefland
- Flights from Gainesville
- Flights from Chiefland
- Flights from Fort White
- Flights from Perry
- Flights from Live Oak
- Flights from Central West Coast Florida
- Flights from Lulu
- Flights from Jasper
- Flights from O Brien
- Lulu Holidays
- Brooker Holidays
- Chiefland Farmers Flea Market
- Gibson Park
- Southside Sports Complex
- Devil's Milhopper Geological State Park
- Epiphany Catholic Church
- Ichetucknee Springs State Park
- Visit High Springs
- Visit Pinetta
- Visit Gainesville
- Visit Hampton Springs
- Visit Central West Coast Florida
- Visit Northern Florida
- Visit Sanderson
- Visit Fowlers Bluff
- Visit Archer
- Visit Lulu
- Visit Jennings
- Visit Fanning Springs
