Search O Brien hotels

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
24 Aug - 25 Aug
Tomorrow
25 Aug - 26 Aug
Next weekend
29 Aug - 31 Aug
In two weeks
5 Sept - 7 Sept

Filter by

Guest rating
Guest rating
Property class

Top hotels and accommodation in O Brien

Our top choices for O Brien hotels

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Exterior

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 star property
9.4 out of 10, Exceptional, (1007)
"Very comfortable room and nice breakfast "
The price is NZ$224
includes taxes & fees
14 Sept - 15 Sept
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Hampton Inn & Suites Alachua I-75
Breakfast area

Hampton Inn & Suites Alachua I-75

2.5 star property
9.4 out of 10, Exceptional, (443)
"Friendly staff, bed was comfortable "
The price is NZ$209
includes taxes & fees
21 Sept - 22 Sept
Hampton Inn & Suites Alachua I-75
Americas Best Value Inn Alachua
Desk, blackout curtains, iron/ironing board, rollaway beds

Americas Best Value Inn Alachua

2.0 star property
4.8 out of 10, (576)
"Good people that work there."
The price is NZ$123
includes taxes & fees
25 Aug - 26 Aug
Americas Best Value Inn Alachua
High Springs Country Inn
Double Room, Non Smoking

High Springs Country Inn

2.0 star property
8.0 out of 10, Very good, (6)
"Ive had a stay at this price point with better arrangement such as breakfast included. However, for only one night it wasnt too bad. Room is too dark. Lighter colors in the room luke greish would make it look more cozy."
The price is NZ$124
includes taxes & fees
26 Aug - 27 Aug
High Springs Country Inn
La Quinta Inn & Suite by Wyndham Lake City
Exterior

La Quinta Inn & Suite by Wyndham Lake City

2.5 star property
8.8 out of 10, Excellent, (1000)
"Overall nice place to stay."
The price is NZ$180
includes taxes & fees
25 Aug - 26 Aug
La Quinta Inn & Suite by Wyndham Lake City
Courtyard By Marriott Lake City
Fireplace

Courtyard By Marriott Lake City

3.0 star property
9.6 out of 10, Exceptional, (129)
"Great hotel "
The price is NZ$184
includes taxes & fees
31 Aug - 1 Sept
Courtyard By Marriott Lake City
Comfort Suites Lake City
Lobby

Comfort Suites Lake City

2.5 star property
9.6 out of 10, Exceptional, (1003)
"Amazing place to stay"
The price is NZ$178
includes taxes & fees
31 Aug - 1 Sept
Comfort Suites Lake City
Best Western Plus Lake City
Lobby

Best Western Plus Lake City

2.5 star property
9.2 out of 10, Wonderful, (1001)
"Great property and price."
The price is NZ$154
includes taxes & fees
31 Aug - 1 Sept
Best Western Plus Lake City
Quality Inn Lake City
Outdoor pool, pool loungers

Quality Inn Lake City

2.5 star property
7.8 out of 10, Good, (915)
"Great location right off the interstate"
The price is NZ$144
includes taxes & fees
22 Sept - 23 Sept
Quality Inn Lake City
Baymont by Wyndham Lake City
Outdoor pool

Baymont by Wyndham Lake City

2.5 star property
5.2 out of 10, (1001)
"Easy check-in and friendly front desk staff. The room was very clean and the bed was comfy!"
The price is NZ$111
includes taxes & fees
25 Aug - 26 Aug
Baymont by Wyndham Lake City
Tru by Hilton Lake City
Exterior

Tru by Hilton Lake City

2.5 star property
9.0 out of 10, Wonderful, (1005)
"Staff was friendly, hotel was clean and close to resturants in the area."
The price is NZ$190
includes taxes & fees
25 Aug - 26 Aug
Tru by Hilton Lake City
Days Inn by Wyndham Lake City I-10
Free daily on-the-go breakfast

Days Inn by Wyndham Lake City I-10

2.0 star property
6.8 out of 10, (1001)
"It s a very nice hotel"
The price is NZ$122
includes taxes & fees
25 Aug - 26 Aug
Days Inn by Wyndham Lake City I-10
Hampton Inn & Suites Lake City
Lobby

Hampton Inn & Suites Lake City

2.5 star property
9.4 out of 10, Exceptional, (1003)
"Nice staff and clean rooms. "
The price is NZ$190
includes taxes & fees
31 Aug - 1 Sept
Hampton Inn & Suites Lake City
Postcard Cabins Gilchrist Springs
Exterior

Postcard Cabins Gilchrist Springs

2.0 star property
10.0 out of 10, Exceptional, (87)
"Beautiful cabin and stay "
The price is NZ$251
includes taxes & fees
25 Aug - 26 Aug
Postcard Cabins Gilchrist Springs
Fairfield Inn & Suites Lake City
Lobby lounge

Fairfield Inn & Suites Lake City

2.5 star property
9.0 out of 10, Wonderful, (121)
"Friendly staff"
The price is NZ$190
includes taxes & fees
27 Aug - 28 Aug
Fairfield Inn & Suites Lake City
Guest Inn
Reception

Guest Inn

2.0 star property
6.0 out of 10, (186)
"Didn't know I had to pay a deposit per day Pet fee and all after booking the room it was almost 200 extra charges witch 125 would be refunded after the manager checks the room ridiculous "
Guest Inn
Quality Inn White Springs Suwanee
Standard Room, 2 Queen Beds, Non Smoking

Quality Inn White Springs Suwanee

2.5 star property
7.2 out of 10, Good, (569)
"Very nice place to stop for the night "
The price is NZ$131
includes taxes & fees
7 Sept - 8 Sept
Quality Inn White Springs Suwanee
Holiday Inn & Suites Lake City by IHG
Exterior

Holiday Inn & Suites Lake City by IHG

3.0 star property
8.6 out of 10, Excellent, (1002)
"Great place to stay friendly staff clean rooms"
The price is NZ$169
includes taxes & fees
31 Aug - 1 Sept
Holiday Inn & Suites Lake City by IHG
Driftwood Inn
1 bedroom, soundproofing, bed sheets

Driftwood Inn

2.0 star property
7.8 out of 10, Good, (742)
"The staff was friendly and helpful. We were very satisfied with the room and the location was convenient to everything (family, chutch, shopping). We would be happy to stay here next time we're in town."
The price is NZ$100
includes taxes & fees
25 Aug - 26 Aug
Driftwood Inn
Days Inn by Wyndham Lake City I-75
Pillow-top beds, in-room safe, desk, blackout curtains

Days Inn by Wyndham Lake City I-75

2.0 star property
7.4 out of 10, Good, (1004)
"The staff was nice and check in was easy"
The price is NZ$129
includes taxes & fees
26 Aug - 27 Aug
Days Inn by Wyndham Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
Photo by Dr__Vlad
Open Photo by Dr__Vlad

Top O Brien Hotel Reviews

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent
"We really like the hotel, it’s very nice. Breakfast could be better, not many healthy selections, but I would definitely recommend the hotel."
Ivon 1-night trip
Posted 1 day ago
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Frequently asked questions

Where is the best place to stay in O Brien?

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG, located 29.9 mi (48.2 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Postcard Cabins Gilchrist Springs and Tru by Hilton Lake City. See all available top hotels, or vacation rentals in O Brien.

What are some of the best holiday rentals that O Brien has to offer?

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY: This highly rated holiday home rental in O Brien offers a fireplace, a patio and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 4 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You can relax into your holiday with a garden and an arcade/games room. See all vacation rentals in O Brien.

If I need to cancel my hotel reservation in O Brien, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.

What are some accommodation options with pools in O Brien?

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG: Provides buffet, an outdoor pool and complimentary high-speed (wired) Internet access. Tru by Hilton Lake City and Holiday Inn & Suites Lake City by IHG are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.

How is it to stay in O Brien?

Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 11 hotels and other accommodation options to choose from. Find out more about O Brien.

What are the top places to visit in O Brien?

Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Troy Spring State Park and Wes Skiles Peacock Springs State Park in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.

What's the seasonal weather in O Brien?

The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.