Lake Nona Medical City Hotels, Orlando

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
9 Dec - 10 Dec
Tomorrow
10 Dec - 11 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Lake Nona Medical City hotels

Lounge
Aloft Orlando Lake Nona

Aloft Orlando Lake Nona

3.0 star property
Lake Nona Medical City
9.8 out of 10, Exceptional, (259)
"Beautiful hotel and excellent location. "
United States
Samue
The price is NZ$222
includes taxes & fees
22 Dec - 23 Dec
Aloft Orlando Lake Nona
Outdoor pool
Courtyard Orlando Lake Nona

Courtyard Orlando Lake Nona

3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (590)
"Great stay"
United States
Romulo
The price is NZ$283
includes taxes & fees
21 Dec - 22 Dec
Courtyard Orlando Lake Nona
Outdoor pool
Residence Inn Orlando Lake Nona

Residence Inn Orlando Lake Nona

3.0 star property
Lake Nona Medical City
9.6 out of 10, Exceptional, (325)
"Very clean hotel and spacious room with comfortable seating and kitchen area. The location was great for me as I was there visiting someone in an area hospital. There are also restaurants and coffee shops right outside the entrance. "
United States
Sharon
The price is NZ$334
includes taxes & fees
21 Dec - 22 Dec
Residence Inn Orlando Lake Nona
Lobby
La Quinta Inn & Suites by Wyndham Orlando UCF

La Quinta Inn & Suites by Wyndham Orlando UCF

3.0 star property
25.4 km from Lake Nona Medical City
8.6 out of 10, Excellent, (2685)
"Great location and friendly staff!"
United States
Loren
The price is NZ$171
includes taxes & fees
21 Dec - 22 Dec
La Quinta Inn & Suites by Wyndham Orlando UCF
Terrace/patio
The Delaney Hotel

The Delaney Hotel

3.5 star property
South Orange, 20.2 km from Lake Nona Medical City
9.6 out of 10, Exceptional, (1014)
"The Hotel is wonderful had a great restaurant and bar the staff was very friendly and the room looked like the photos "
United States
Michael
The Delaney Hotel
Premium bedding, in-room safe, desk, blackout curtains
Ramada by Wyndham Suites Orlando Airport

Ramada by Wyndham Suites Orlando Airport

3.0 star property
Airport North, 10.4 km from Lake Nona Medical City
8.2 out of 10, Very good, (5171)
"Great place to stay close to airport "
United States
Rebekah
The price is NZ$174
includes taxes & fees
10 Dec - 11 Dec
Ramada by Wyndham Suites Orlando Airport
Pillow-top beds, in-room safe, desk, blackout curtains
Wingate by Wyndham - Orlando International Airport

Wingate by Wyndham - Orlando International Airport

3.0 star property
Airport North, 11 km from Lake Nona Medical City
8.8 out of 10, Excellent, (3727)
"Good room, good breakfast and convenient to the airport."
United States
Mark
The price is NZ$167
includes taxes & fees
10 Dec - 11 Dec
Wingate by Wyndham - Orlando International Airport
5 outdoor pools, free pool cabanas, pool umbrellas
Sheraton Vistana Villages Resort Villas, I-Drive/Orlando

Sheraton Vistana Villages Resort Villas, I-Drive/Orlando

4.0 star property
International Drive District, 20 km from Lake Nona Medical City
9.2 out of 10, Wonderful, (2714)
"Stayed here before always enjoyed it "
United States
Margaret
The price is NZ$187
includes taxes & fees
4 Jan - 5 Jan 2026
Sheraton Vistana Villages Resort Villas, I-Drive/Orlando
Outdoor pool, pool loungers
Wyndham Garden Orlando Airport

Wyndham Garden Orlando Airport

3.0 star property
Belle Isle, 11.9 km from Lake Nona Medical City
9.0 out of 10, Wonderful, (4010)
"Very clean hotel and easy experience checking in and out "
United States
Arielle
The price is NZ$170
includes taxes & fees
15 Dec - 16 Dec
Wyndham Garden Orlando Airport
Free daily continental breakfast
La Quinta Inn & Suites by Wyndham Orlando Airport North

La Quinta Inn & Suites by Wyndham Orlando Airport North

3.0 star property
Airport North, 10.9 km from Lake Nona Medical City
7.4 out of 10, Good, (815)
"Near the beach , very nice people at the reception. "
United States
Leonie
The price is NZ$154
includes taxes & fees
17 Dec - 18 Dec
La Quinta Inn & Suites by Wyndham Orlando Airport North
6 outdoor pools, free pool cabanas, pool umbrellas
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

4.0 star property
22.5 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (4069)
"Very clean best resort "
United States
Shatira
The price is NZ$217
includes taxes & fees
5 Jan - 6 Jan 2026
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
Property grounds
SPOT X Hotel Orlando/Intl Dr by The Red Collection

SPOT X Hotel Orlando/Intl Dr by The Red Collection

3.0 star property
21 km from Lake Nona Medical City
8.6 out of 10, Excellent, (2936)
"Clean room, close to Disney and good breakfast at a reasonable price"
United States
pamela
The price is NZ$178
includes taxes & fees
14 Dec - 15 Dec
SPOT X Hotel Orlando/Intl Dr by The Red Collection
Lobby lounge
Aloft Orlando Lake Buena Vista

Aloft Orlando Lake Buena Vista

3.0 star property
21.7 km from Lake Nona Medical City
8.8 out of 10, Excellent, (1905)
"Great rooms, staff, and property!"
United States
Cindy
The price is NZ$144
includes taxes & fees
14 Dec - 15 Dec
Aloft Orlando Lake Buena Vista
Outdoor pool, pool umbrellas, pool loungers
Kompose Boutique Resort at Theme Parks

Kompose Boutique Resort at Theme Parks

3.0 star property
30.8 km from Lake Nona Medical City
9.4 out of 10, Exceptional, (1942)
"Beautiful resort with very friendly staff. "
United States
kristie
The price is NZ$140
includes taxes & fees
11 Dec - 12 Dec
Kompose Boutique Resort at Theme Parks
Outdoor pool
DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando

4.0 star property
Florida Center, 21.7 km from Lake Nona Medical City
8.4 out of 10, Very good, (6884)
"Wonderful stay. Great location!"
United States
Charmaine
The price is NZ$174
includes taxes & fees
15 Dec - 16 Dec
DoubleTree by Hilton at the Entrance to Universal Orlando
Outdoor pool, open 9 AM to 10 PM, pool loungers
Orlando Palms Hotel

Orlando Palms Hotel

2.5 star property
14.9 km from Lake Nona Medical City
7.6 out of 10, Good, (2228)
"Very friendly staff."
United States
Lynn
The price is NZ$105
includes taxes & fees
15 Dec - 16 Dec
Orlando Palms Hotel
View from property
Avanti International Resort

Avanti International Resort

4.0 star property
International Drive District, 20.8 km from Lake Nona Medical City
7.8 out of 10, Good, (4289)
"Enjoyed our stay "
United States
Sheltra
The price is NZ$170
includes taxes & fees
14 Dec - 15 Dec
Avanti International Resort
Meeting facility
Hampton Inn & Suites Orlando Intl Dr N

Hampton Inn & Suites Orlando Intl Dr N

2.5 star property
International Drive District, 21.6 km from Lake Nona Medical City
9.2 out of 10, Wonderful, (1073)
"Second time staying at this hotel and loved it great hotel for family and close to the main attractions "
United States
Kadeisha
The price is NZ$175
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn & Suites Orlando Intl Dr N
Property amenity
Courtyard by Marriott Orlando Downtown

Courtyard by Marriott Orlando Downtown

3.0 star property
23.1 km from Lake Nona Medical City
9.6 out of 10, Exceptional, (1005)
"Beautiful hotel & convenient location"
United States
John
The price is NZ$201
includes taxes & fees
21 Dec - 22 Dec
Courtyard by Marriott Orlando Downtown
7 outdoor pools, pool cabanas (surcharge), pool umbrellas
Westgate Lakes Resort & Spa Universal Studios Area

Westgate Lakes Resort & Spa Universal Studios Area

4.0 star property
20.7 km from Lake Nona Medical City
8.2 out of 10, Very good, (5553)
"Great resort 10 out 10 I recommend and will visit again thank you ☺️😊"
United States
SOPHIA
The price is NZ$249
includes taxes & fees
5 Jan - 6 Jan 2026
Westgate Lakes Resort & Spa Universal Studios Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Our guide on where to stay in Lake Nona Medical City

Find the best Lake Nona Medical City areas for the activities you enjoy most.

International Drive District

Adventure activities, iconic attractions, shopping and world-class dining destinations make this famous street one of Orlando’s most popular tourist attractions.

Magic Kingdom® Theme Park featuring rides and interior views as well as a couple
Photo by ©Disney
Open Photo by ©Disney

Bay Lake

Exciting theme parks plentiful wildlife and top sights from Epcot® to Walt Disney World® Resort – discover Bay Lake, a destination also famous for its entertainment.

Downtown Orlando

One of the most popular neighborhoods in Florida, this bustling area is full of art galleries, shops, bars and restaurants.

Universal Studios Florida® which includes a city, night scenes and signage

Florida Center

If you're spending some time in Florida Center, Universal Orlando Resort and Universal Studios Florida are top sights worth seeing.

Champions Gate

Ample dining options and top golf courses are well-reviewed features of Champions Gate. Make a stop by top sights like ChampionsGate Golf Club while you're exploring the area.

Top Lake Nona Medical City Hotel Reviews

DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando

10/10 Excellent
"Great staff"
Thomas 5-night trip
Posted 2 days ago
DoubleTree by Hilton at the Entrance to Universal Orlando

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Lake Nona Medical City?
Lake Nona Medical City is a neighbourhood that travellers like for its restaurants.
What's the best accommodation in Lake Nona Medical City?
Based on Expedia customer reviews, Aloft Orlando Lake Nona is the highest ranked property in Lake Nona Medical City. This hotel offers a restaurant and an outdoor pool. Other favourite options in the area include Residence Inn Orlando Lake Nona and Courtyard Orlando Lake Nona.
How many hotels will I find in Lake Nona Medical City?
Expedia has 5 Lake Nona Medical City hotels and other accommodation options, and one might make a good home base for venturing out into the greater Orlando area.
If I need to cancel my hotel reservation in Lake Nona Medical City, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and get a refund within a 24-hour period of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Lake Nona Medical City.
What is there to do around this Orlando neighbourhood?
Eagle Creek Golf Club, USTA National Campus and Austin-Tindall Regional Park are just a few of the places to visit in and around Lake Nona Medical City. When you're sightseeing around the area, Lake Hart and Kissimmee Bay Country Club are a couple of other sights to visit.