Photo by Southernmost Illinois Tourism Bureau

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Top Pet-friendly Southwest Illinois Hotels

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

136 Regency Park, O'Fallon, IL

3 hours drive from Southern Illinois University

Stay at this 3-star business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...

6/10 (1,000 reviews)

clean, supper quiet and large room

Reviewed on 31 Oct 2025

Red Roof Inn St Louis - Troy, IL

2030 Formosa Road, Troy, IL

3 hours drive from Southern Illinois University

Book a stay at this business-friendly hotel in Troy. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...

7.6/10 Good! (1,002 reviews)

We were going to a wedding and reception and booked a room to use to change clothes and have a place for everyone in our group to meet. The check in was super-fast and the room was clean. My granddaughter ended up leaving her tablet in the room. When I called to ask if it was found the staff said ...

Reviewed on 31 Oct 2025

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

6 Gateway Dr, Collinsville, IL

3 hours drive from Southern Illinois University

Stay at this 3-star business-friendly hotel in Collinsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

7.2/10 Good! (1,001 reviews)

I was clean

Reviewed on 29 Oct 2025

See all 723 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.