Photo by Southernmost Illinois Tourism Bureau

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Top Pet-friendly Southwest Illinois Hotels

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

136 Regency Park O'Fallon IL

3 hours drive from Southern Illinois University

Stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the clean rooms in their reviews. Popular ...

6/10 (1,000 reviews)

Nice for price

Reviewed on 4 Feb 2026

Red Roof Inn St Louis - Troy, IL

2030 Formosa Road Troy IL

3 hours drive from Southern Illinois University

Stay at this business-friendly hotel in Troy. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms in their ...

7.8/10 Good! (1,003 reviews)

Very nice room and very clean, very very comfortable bed, slept amazing, great amenities and bathroom, great rate as well and nice location! Staff were very helpful and friendly as well for our night here!

Reviewed on 16 Feb 2026

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

6 Gateway Dr Collinsville IL

3 hours drive from Southern Illinois University

Stay at this business-friendly hotel in Collinsville. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

7.2/10 Good! (1,012 reviews)

I’ve been at La Quinta’s staying there for a long time. I don’t believe $100 deposit. I can’t trust people. I don’t know what to tell you, but I will never say that again

Reviewed on 21 Feb 2026

See all 745 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.