Photo by Southernmost Illinois Tourism Bureau

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Top Pet-friendly Southwest Illinois Hotels

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

136 Regency Park O'Fallon IL

3 hours drive from Southern Illinois University

Stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the clean rooms in their reviews. Popular ...

5.8/10 (1,001 reviews)

"Room was clean. Staff was friendly at check-in. Convenient location to a lot of restaurants! Breakfast items were ok, for a quick bite. They offered eggs, sausage patties, cereal, bagels, toast, waffles, yogurt and apples. Drink choices were apple and orange juice, coffee and tea. Fitness center ..."

Reviewed on 27 May 2026

Red Roof Inn St Louis - Troy, IL

2030 Formosa Road Troy IL

3 hours drive from Southern Illinois University

Stay at this business-friendly hotel in Troy. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms in their ...

7.8/10 Good! (1,001 reviews)

"This was the best red red roof inn, I ever seen or been in so friendly and it was like home being away from home. I truly recommend this hotel while traveling or passing through. Thank you, Red Roof Inn"

Reviewed on 4 June 2026

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

6 Gateway Dr Collinsville IL

3 hours drive from Southern Illinois University

Stay at this business-friendly hotel in Collinsville. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

7.4/10 Good! (1,003 reviews)

"Exceeded my expectations! Thank you"

Reviewed on 2 June 2026

See all 776 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.