Photo by Southernmost Illinois Tourism Bureau

Plan, book, travel with confidence
Better together
Save up to NZ$616 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Pet-friendly Southwest Illinois Hotels

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

136 Regency Park O'Fallon IL

3 hours drive from Southern Illinois University

Stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the clean rooms in their reviews. Popular ...

5.8/10 (1,005 reviews)

Walking into the hotel, the first thing I noticed was the smell. The lobby had a weird funk to it. Then after checking in, the room we had was a mess. The curtains were ripped. The chairs and carpets had stains on them. There was hair underneath the mattress. All of the furniture looked like they ...

Reviewed on 13 Apr 2026

Red Roof Inn St Louis - Troy, IL

2030 Formosa Road Troy IL

3 hours drive from Southern Illinois University

Stay at this business-friendly hotel in Troy. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms in their ...

7.8/10 Good! (1,006 reviews)

Did not find anything suitable for my taste for breakfast Lock of counter space in the bathroom Very clean , nice smells in

Reviewed on 14 Apr 2026

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

6 Gateway Dr Collinsville IL

3 hours drive from Southern Illinois University

Stay at this business-friendly hotel in Collinsville. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ...

7.4/10 Good! (1,004 reviews)

Parking adequate. Staff friendly

Reviewed on 14 Apr 2026

See all 752 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.