Southeast Jacksonville Luxury Holidays 2026

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Top Luxury Southeast Jacksonville Hotels

Tricove Inn & Suites

4300 Salisbury Rd Jacksonville FL

11 min drive from Mayo Clinic Florida

Stay at this business-friendly motel in Jacksonville. Enjoy free Wi-Fi, free parking and a fitness centre. Our guests praise the helpful staff and the clean ...

7.4/10 Good! (1,000 reviews)

"Great facility and location. Except key had some glitches which was inconvenient"

Reviewed on 13 Sept 2026

Red Roof Inn PLUS+ Jacksonville - Southpoint

6969 Lenoir Avenue E Jacksonville FL

11 min drive from Mayo Clinic Florida

Stay at this business-friendly hotel in Jacksonville. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff and the clean ...

Wyndham Garden Jacksonville

4660 Salisbury Road Jacksonville FL

10 min drive from Mayo Clinic Florida

Stay at this business-friendly hotel in Jacksonville. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff and the clean ...

See all 603 properties in Southeast Jacksonville

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.