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Top Fishing Eastern South Dakota Hotels

Lewis and Clark Resort

43496 Shore Drive Yankton SD

2 hours drive from Denny Sanford Premier Center

Stay at this beach hotel in Yankton. Enjoy free Wi-Fi, free parking and an outdoor pool. Popular attractions Lewis and Clark Recreation Area and Midway Recreation ...

8.8/10 Excellent! (287 reviews)

Clean, full kitchen

Reviewed on 25 Dec 2025

Cabin on bluff of Big Sioux River with rushing waters of the Klondike Dam below.

Larchwood IA

44 min drive from Denny Sanford Premier Center

Stay at this holiday home in Larchwood. Enjoy free Wi-Fi, a garden and laundry facilities. Popular attractions Lake Alvin Recreation Area and Lake Alvin Beach ...

9.8/10 Exceptional! (185 reviews)

This place was honestly perfect for my family and me. We spent so much quality time together, which is really important to us, and when we needed our own space, the rooms were laid out perfectly for that too. Everything was clean and well cared for, and one of our favorite things was that the property ...

Reviewed on 27 Dec 2025

Comfort Inn Yankton SD

611 W 23rd Street Yankton SD

2 hours drive from Denny Sanford Premier Center

Stay at this business-friendly hotel in Yankton. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular ...

8.8/10 Excellent! (683 reviews)

It was good

Reviewed on 16 Jan 2026

See all 936 properties in Eastern South Dakota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.