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Top Fishing Eastern South Dakota Hotels

Lewis and Clark Resort

43496 Shore Drive Yankton SD

2 hours drive from Denny Sanford Premier Center

Stay at this beach hotel in Yankton. Enjoy free Wi-Fi, free parking and an outdoor pool. Popular attractions Lewis and Clark Recreation Area and Midway Recreation ...

8.8/10 Excellent! (283 reviews)

We were upgraded to a 3 bedroom cabin for the same price.

Reviewed on 24 Nov 2025

Cabin on bluff of Big Sioux River with rushing waters of the Klondike Dam below.

Larchwood IA

44 min drive from Denny Sanford Premier Center

Stay at this holiday home in Larchwood. Enjoy free Wi-Fi, a garden and laundry facilities. Popular attractions Lake Alvin Recreation Area and Lake Alvin Beach ...

9.8/10 Exceptional! (184 reviews)

Lovely cabin by the river. Great for taking wedding pictures and getting ready with the girls.

Reviewed on 29 Aug 2025

Comfort Inn Yankton SD

611 W 23rd Street Yankton SD

2 hours drive from Denny Sanford Premier Center

Stay at this business-friendly hotel in Yankton. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular ...

8.8/10 Excellent! (662 reviews)

I was working 7p - 7a at Springfield. When I got to my room in the morning after work, the hotel was very quiet and I was never bothered by housekeeping. I was able to sleep pretty well, even though it was during the day.

Reviewed on 29 Nov 2025

See all 888 properties in Eastern South Dakota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.