I booked one night at Hotel Florhof on Hotels.com based on reading the reviews, which were generally positive but relatively few in number. When I got to the hotel, I was immediately impressed by the "family-run" feel of the place. The reception was very nice and friendly. When I got to my room, I was immediately struck by how absolutely clean the room was. The floors, instead of being gross carpet, are very nice blonde oak hardwood. The linens were spotless and the entire place just looked clean. The bathroom is stocked with very nice Kiehl's products. In terms of location, the hotel is a little outside the old city, but very convenient to the city center where I was going. My colleague and I ate in the hotel's restaurant that evening, and it was excellent. I enjoyed the venison, which was cooked perfectly. They also have a small but nice selection of Swiss wines.
The only drawback was the internet. The internet was, at least during my stay, painfully slow and would often drop entirely. No doubt this was an irritation.
Overall, however, I enjoyed my stay so much I booked two more nights for my upcoming return visit to Zurich. Highly recommended.