Photo by RVLuckyorWhat
Search Upstate South Carolina hotels
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Upstate South Carolina
Family friendly
Check prices for these dates
Our top choices for Upstate South Carolina hotels
Clemson University's James F. Martin Inn
Clemson University's James F. Martin InnClemson
9.4 out of 10, Exceptional, (1,002 reviews)
"This was such a great hotel! The staff were so nice and friendly, the hotel and room were clean and comfy. I would definitely stay again and recommend to others. "
Melissa
The price is NZ$270
includes taxes & fees
7 July - 8 July
The Inn at Patrick Square
The Inn at Patrick SquareClemson
9.8 out of 10, Exceptional, (873 reviews)
"We have stayed here many times and always have a wonderful experience."
Karyn
The price is NZ$290
includes taxes & fees
7 July - 8 July
Holiday Inn Express Gaffney by IHG
Holiday Inn Express Gaffney by IHGGaffney
8.8 out of 10, Excellent, (515 reviews)
"Room very clean staff was great breakfast was really good with lots of options "
melvin
The price is NZ$183
includes taxes & fees
18 July - 19 July
Hampton Inn Greer Greenville, SC
Hampton Inn Greer Greenville, SCGreer
9.6 out of 10, Exceptional, (473 reviews)
"Parking is very convenient to the hotel. The room was clean and the beds were very comfortable. Breakfast was good and there was a large variety of choices. Excellent stay!"
Trina
The price is NZ$265
includes taxes & fees
9 July - 10 July
Hampton Inn & Suites Clinton - I-26
Hampton Inn & Suites Clinton - I-26Clinton
9.0 out of 10, Wonderful, (754 reviews)
"The breakfast was very good and the set up was excellent. "
Sarah
The price is NZ$224
includes taxes & fees
1 Aug - 2 Aug
Fairfield Inn & Suites by Marriott Greenville Simpsonville
Fairfield Inn & Suites by Marriott Greenville SimpsonvilleSimpsonville
9.0 out of 10, Wonderful, (740 reviews)
"Great stay!"
Nayeli
The price is NZ$178
includes taxes & fees
12 July - 13 July
Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & SuitesGreenville
9.2 out of 10, Wonderful, (1,535 reviews)
"Location was very convenient and the breakfast was nice."
Shabana
The price is NZ$183
includes taxes & fees
12 July - 13 July
Tru by Hilton Seneca Clemson
Tru by Hilton Seneca ClemsonSeneca
9.2 out of 10, Wonderful, (860 reviews)
"Room was clean staff was great breakfast was good"
Jason
The price is NZ$198
includes taxes & fees
19 July - 20 July
Best Western Spartanburg I-26
Best Western Spartanburg I-26Spartanburg
5.6 out of 10, (355 reviews)
"Convenient and close to everything rooms are nice and staff is friendly "
Daniel
The price is NZ$186
includes taxes & fees
12 July - 13 July
Carolina Inn Anderson Clemson Area
Carolina Inn Anderson Clemson AreaAnderson
7.6 out of 10, Good, (16 reviews)
"The staff is great "
Luis Fernando
The price is NZ$117
includes taxes & fees
7 July - 8 July
Fairfield Inn & Suites by Marriott Anderson Clemson
Fairfield Inn & Suites by Marriott Anderson ClemsonAnderson
9.0 out of 10, Wonderful, (582 reviews)
"The breakfast was amazing, and I had the best sleep ever. I would definitely come.back "
Salaeka
The price is NZ$180
includes taxes & fees
12 July - 13 July
Four Points by Sheraton Spartanburg
Four Points by Sheraton SpartanburgSpartanburg
9.4 out of 10, Exceptional, (508 reviews)
"Great stay"
Susan
The price is NZ$197
includes taxes & fees
19 July - 20 July
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHGAnderson
9.2 out of 10, Wonderful, (632 reviews)
"Room was clean and customer service was excellent, check in was smooth "
Gina
The price is NZ$214
includes taxes & fees
26 July - 27 July
AC Hotel by Marriott Spartanburg
AC Hotel by Marriott SpartanburgSpartanburg
9.4 out of 10, Exceptional, (640 reviews)
"Very clean and friendly staff"
Carla
The price is NZ$309
includes taxes & fees
12 July - 13 July
Hampton Inn Gaffney
Hampton Inn GaffneyGaffney
8.8 out of 10, Excellent, (741 reviews)
"Everything was great!"
Cristen
The price is NZ$165
includes taxes & fees
2 Aug - 3 Aug
Lakeside Lodge Clemson
Lakeside Lodge ClemsonSeneca
9.0 out of 10, Wonderful, (1,003 reviews)
"We loved it and we will visit again."
Kelly
The price is NZ$237
includes taxes & fees
8 July - 9 July
Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference CenterClemson
8.2 out of 10, Very good, (1,004 reviews)
"Nice location."
Nancy
The price is NZ$185
includes taxes & fees
7 July - 8 July
Tru by Hilton Spartanburg
Tru by Hilton SpartanburgSpartanburg
9.2 out of 10, Wonderful, (933 reviews)
"Wonderful rooms, helpful staff, and probably the best breakfast I have seen anywhere"
Hester L.
The price is NZ$178
includes taxes & fees
26 July - 27 July
Best Western Travelers Rest Greenville
Best Western Travelers Rest GreenvilleTravelers Rest
7.6 out of 10, Good, (1,004 reviews)
"Friendly staff at check-in, clean rooms, safe area. Great breakfast. "
Trisha
The price is NZ$169
includes taxes & fees
12 July - 13 July
Hilton Garden Inn Anderson
Hilton Garden Inn AndersonAnderson
9.0 out of 10, Wonderful, (753 reviews)
"Great place to stay"
Maureen
The price is NZ$193
includes taxes & fees
12 July - 13 July
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Upstate South Carolina
Cabin
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott BonvoySeneca
9.8 out of 10, Exceptional, (87 reviews)
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Upstate South Carolina attractions
Learn more about Upstate South Carolina
Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.
Photo by Visit Greenville, South Carolina
Open Photo by Visit Greenville, South Carolina
Top Upstate South Carolina Hotel Reviews
Recent Reviews in Upstate South Carolina
Hotel Hartness
10/10 Excellent
More cheap accommodation in Upstate South Carolina
Days Inn by Wyndham Greenville
60 Roper Mountain Rd Greenville SC
The price is NZ$129 per night from 26 July to 27 July
NZ$129
26 July - 27 July
includes taxes & fees
5.6/10 (1,007 reviews)
Explore a world of travel with Expedia
- Motels in Greenville - Spartanburg
- Resort in Greenville - Spartanburg
- Cabin Rentals in Upstate South Carolina
- Serviced Apartments in Greenville
- Apartments in Greenville
- Farmstay in Greenville
- Condo Rentals in Greenville
- Motels in Greenville
- B&B in Greenville
- Holiday Homes in Greenville
- Cabin Rentals in Taylors
- Romantic Hotels in Greenville - Spartanburg
- Lgbt Welcoming Hotels in Greenville Downtown
- Lgbt Welcoming Hotels in Wade Hampton
- Ski Hotels in Upstate South Carolina
- Romantic Hotels in Greenville
- Pet Friendly Hotels in Greenville
- Spa Hotels in Greenville
- Motel 6 Hotels in Greenville
- Drury Inn & Suites Hotels in Upstate South Carolina
- Belton Hotels
- West End Hotels
- Gray Court Hotels
- Williamston Hotels
- Mauldin Hotels
- Hotels near Bob Jones University
- Duncan Hotels
- Moore Hotels
- Woodside Cotton Mill Village Historic District Hotels
- Travelers Rest Hotels
- Liberty Hotels
- Fountain Inn Hotels
- Hotels near Golden Lanes and Golden Skate
- Greer Hotels
- Hotels near Happy Cow Dairy
- Hotels near Donaldson Center
- Greenville Downtown Hotels
- Wade Hampton Hotels
- Hotels near Haywood Mall
- Pelzer Hotels
- Piedmont Hotels
- Greenville Hotels
- Taylors Hotels
- Easley Hotels
- Hotels near Tyger River Park
- Sans Souci Hotels
- Five Forks Hotels
- Woodruff Hotels
- Hotels near Pebble Creek Golf Course
- Flights to Greenville
- Flights to Simpsonville
- Flights from Welcome
- Flights from Donaldson Center
- Flights from Greenville-Spartanburg Intl.
- Flights from Charlotte (CLT) to Greenville (GMU)
- Flights from Miami (MIA) to Greenville (GMU)
- Flights from Burlington (BTV) to Greenville (GSP)
- Flights from Bartow (BOW) to Greenville (GSP)
- Flights from Rota (ROP) to Greenville (GSP)
- Flights from Wellington (WLG) to Greenville (GSP)
- Flights from Los Angeles (LAX) to Greenville (GSP)
- Flights from Wyndham (WYN) to Greenville (GSP)
- Flights from Mason City (MCW) to Greenville (GSP)
- Flights from Atlanta (ATL) to Greenville (GSP)
- Flights from Houston (IAH) to Greenville (GSP)
- Flights from Philadelphia (PHL) to Greenville (GSP)
- Flights from Fort Lauderdale (FLL) to Greenville (GSP)
- Flights from Bari (BRI) to Greenville (GSP)
- Flights from Islamabad (ISB) to Greenville (GSP)
- Flights from Foggia (FOG) to Greenville (GSP)
- Flights from Roi Et (ROI) to Greenville (GSP)
- Flights from Casablanca (CMN) to Greenville (GDC)
- Flights from Clemson (CEU) to Greenville (GDC)
- Flights from Rome (FCO) to Greenville (GDC)
- Flights from Geneva (GVA) to Greenville (GDC)
- Flights from Pickens (LQK) to Greenville (GDC)
- Visit Pelzer
- Visit Hampton-Pinckney Historic District
- Visit Greenville
- Visit Greenville - Spartanburg
- Visit Greenville Downtown
- Visit Five Forks
- Greenville Little Theater
- Butler Springs Park
- Prisma Health Greenville Memorial Hospital
- Heritage Green
- Greenville Holidays
- Bob Jones University
- Gravitopia Trampoline Arena
