Our top choices for Upstate South Carolina hotels

Holiday Inn Express Gaffney by IHG

Gaffney

melvin

includes taxes & fees

17 July - 18 July

Hampton Inn Greer Greenville, SC

Greer

Trina

includes taxes & fees

9 July - 10 July

Hampton Inn Gaffney

Gaffney

Cristen

includes taxes & fees

2 Aug - 3 Aug

Best Western Plus Clemson Hotel & Conference Center

Clemson

Nancy

includes taxes & fees

22 July - 23 July

Lakeside Lodge Clemson

Seneca

Kelly

includes taxes & fees

12 July - 13 July

Tru by Hilton Seneca Clemson

Seneca

Jason

includes taxes & fees

15 July - 16 July

Best Western Travelers Rest Greenville

Travelers Rest

Trisha

includes taxes & fees

12 July - 13 July

Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

Nayeli

includes taxes & fees

12 July - 13 July

Clemson University's James F. Martin Inn

Clemson

Melissa

includes taxes & fees

19 July - 20 July

The Inn at Patrick Square

Clemson

Karyn

includes taxes & fees

12 July - 13 July

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Anderson

Gina

includes taxes & fees

26 July - 27 July

Best Western Spartanburg Northwest

Spartanburg

Shatima

includes taxes & fees

12 July - 13 July

Hampton Inn & Suites Clinton - I-26

Clinton

Sarah

includes taxes & fees

26 July - 27 July

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Shabana

includes taxes & fees

12 July - 13 July

SpringHill Suites by Marriott Greenville Downtown

Greenville Downtown

Samir

includes taxes & fees

26 July - 27 July

Tru by Hilton Spartanburg

Spartanburg

Hester L.

includes taxes & fees

22 July - 23 July

Carolina Inn Anderson Clemson Area

Anderson

Luis Fernando

includes taxes & fees

8 July - 9 July

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Janet

includes taxes & fees

2 Aug - 3 Aug

Spartanburg Marriott

Spartanburg

Katherine

includes taxes & fees

3 Aug - 4 Aug

Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Spartanburg

Ralph

includes taxes & fees

19 July - 20 July

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Holiday Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Awesome place "

Apartment

Landing Apartments Greer - Sugar Creek

Greer

"The apartment was clean. Excellent value for stay. Amenities were great. Will book again!"

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great deal for the location. Apartment needed a little bit of love/attention."

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Aparthotel

Full-sized fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!

Seneca

"Beautiful and quaint cabin! Highly recommend, great view of the lake."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

Greer Guest House < 1 Mi to Park & Downtown Area!

Greer

"Nice place en Greenville area "

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Enjoy the student vibe around Clemson University, a top university in Clemson. Experience the area's theatre scene or attend a football match.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

Recent Reviews in Upstate South Carolina

Hyatt Place Greenville Downtown

10/10 Excellent

"We like Hyatt Place wherever we go!"

Best Western Plus Greenville I-385 Inn & Suites

10/10 Excellent

"We were just passing through and stayed one night. We were very impressed. Staff was great, easy check-in, room was clean and spacious. We loved that it was a huge shower only. Dining places nearby. Not noisy despite being in a busy area on the interstate. The breakfast area was nice and clean and the breakfast was really good with a great variety of food options."

Hotel Hartness

10/10 Excellent

"Hotel Hartness delivered exactly the kind of refined, quietly confident hospitality my wife and I look for — especially on a birthday stay. We visited June 25–26, and the experience felt thoughtfully elevated without ever drifting into pretense. The property itself has that rare balance of architectural clarity and warmth: clean lines, beautiful natural light, and a sense of calm that feels intentional rather than manufactured. As someone who spent years at Michelin North America helping launch the Michelin Guide in the U.S., I’m attuned to the small signals of a well-run hotel — staff cadence, service pacing, environmental detail, and the ability to make a stay feel personal without being intrusive. Hartness hits those notes. Our room was immaculate, quiet, and genuinely comfortable, with the kind of finishing touches that show someone cared about the guest experience rather than just the design brief. My wife’s birthday was acknowledged with sincerity, not script — a detail that matters more than any amenity. Patterson Kitchen + Bar Dinner at Patterson Kitchen + Bar was the highlight. The kitchen cooks with confidence: balanced seasoning, clean execution, and a sense of place in the ingredients. Hotel Hartness is a property that understands modern Southern hospitality: understated luxury, genuine warmth, and a culinary program that stands on its own. For a birthday getaway, it was exactly right."