A calm lake surrounded by trees and vegetation.

Business Hotels & Resorts in Southwest Illinois from NZ$134

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Check availability on Southwest Illinois Business Hotels

Our top choices for Southwest Illinois business-friendly hotels

Lobby lounge

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.5 star property
Mount Vernon
9.8 out of 10, Exceptional, (1,736 reviews)
"Convenient to interstate, clean room, and breakfast was great."
United States
Rachid
The price is NZ$217
includes taxes & fees
26 July - 27 July
Drury Plaza Hotel Mt. Vernon
Exterior

Holiday Inn Express & Suites Vandalia by IHG

Holiday Inn Express & Suites Vandalia by IHG
2.5 star property
Vandalia
8.8 out of 10, Excellent, (841 reviews)
"Yummy breakfast, accommodating staff, clean rooms! I do wish our bathroom had a fan to help with humidity during/after showers."
United States
Rebecca
The price is NZ$193
includes taxes & fees
26 July - 27 July
Holiday Inn Express & Suites Vandalia by IHG
Exterior

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
2.5 star property
Murphysboro
9.4 out of 10, Exceptional, (573 reviews)
"Great place to stay! New, comfortable. Friendly and knowledgeable staff, nice decor, convenient breakfast."
United States
David
The price is NZ$205
includes taxes & fees
2 Aug - 3 Aug
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Lobby

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1,013 reviews)
"The staff at this location go above and beyond to ensure a wonderful stay"
United States
Tracie
The price is NZ$258
includes taxes & fees
9 Aug - 10 Aug
Drury Inn & Suites Marion
Lobby

SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
2.5 star property
Whittington
8.8 out of 10, Excellent, (995 reviews)
"Very clean, helpful staff, comfortable beds, but be careful exiting the shower, the floors are slick"
United States
Emily
The price is NZ$163
includes taxes & fees
23 July - 24 July
SureStay Hotel by Best Western Whittington Rend Lake
Suite, 1 King Bed, Non Smoking (One-Bedroom, Honeymoon) | Jetted bathtub

Seasons Inn & Suites Highland

Seasons Inn & Suites Highland
2.5 star property
Highland
8.0 out of 10, Very good, (668 reviews)
"The staff is very friendly and accommodating they took care of us very well. "
United States
Philip
The price is NZ$155
includes taxes & fees
9 Aug - 10 Aug
Seasons Inn & Suites Highland
In-room safe, desk, iron/ironing board, cots/infant beds

Quality Inn & Suites Vandalia near I-70 and Hwy 51

Quality Inn & Suites Vandalia near I-70 and Hwy 51
2.5 star property
Vandalia
8.4 out of 10, Very good, (1,000 reviews)
"Great staff"
United States
Jason
The price is NZ$134
includes taxes & fees
20 July - 21 July
Quality Inn & Suites Vandalia near I-70 and Hwy 51
Lobby

Comfort Inn & Suites Greenville I-70

Comfort Inn & Suites Greenville I-70
2.5 star property
Greenville
8.4 out of 10, Very good, (452 reviews)
"Property was ok Breakfast was good "
United States
Alan
The price is NZ$198
includes taxes & fees
19 July - 20 July
Comfort Inn & Suites Greenville I-70
Exterior

Holiday Inn Express & Suites Mount Vernon by IHG

Holiday Inn Express & Suites Mount Vernon by IHG
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1,000 reviews)
"Front desk ladies were great, as well as hotel"
United States
Cecil
The price is NZ$207
includes taxes & fees
26 July - 27 July
Holiday Inn Express & Suites Mount Vernon by IHG
Front of property – evening/night

Hampton Inn Carbondale

Hampton Inn Carbondale
2.5 star property
Carbondale
8.4 out of 10, Very good, (656 reviews)
"My stay was great all staff was helpful and very friendly and attentive."
United States
Brenda
The price is NZ$193
includes taxes & fees
21 July - 22 July
Hampton Inn Carbondale
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southwest Illinois Hotel Reviews

Best Western St. Louis Fairview Heights

Best Western St. Louis Fairview Heights

8/10 Good
"The staff were very nice and helpful. The property itself looks to be going through a remodel but overall was nice. I did notice some spots in our room that seemed like they could have been swept better, and the overall smell of fresh paint was overwhelming. Shower worked good, but the vent in the bathroom was extremely loud and sounded like it was very old. Also upsetting that the pool is closed due to permit issues, as we had a toddler who was very excited to swim."
Gracie Dawn 2-night trip
Posted 4 hours ago
Best Western St. Louis Fairview Heights

Frequently asked questions

How much do business-friendly hotels in Southwest Illinois cost?
Rates for business hotels in Southwest Illinois range between NZ$134 and NZ$258 per night. No matter your budget, Expedia is here to help you find the perfect place for a successful work trip. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business-friendly hotels are there in Southwest Illinois?
When you need to travel for work in Southwest Illinois, you'll have 105 business-friendly hotels to pick from.
What is there to do in Southwest Illinois near my business-friendly hotel?
You'll find many exciting attractions to explore when travelling through Southwest Illinois. If you're planning a few nights in Murphysboro, Lake Murphysboro State Park is a hit with visitors.

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