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1 Oct - 2 Oct
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2 Oct - 3 Oct
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2 Oct - 4 Oct
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Our top choices for Southeast Missouri hotels

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.
A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.
A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.
A hotel room with two beds, a lamp, and a painting on the wall.

1. Shepherd Mountain Inn

Shepherd Mountain Inn
Ironton
United States
Michael
NZ$239
includes taxes & fees
2 Oct - 3 Oct
Shepherd Mountain Inn
A motel with a covered entrance, a flag, and a phone number.
A hotel room with two beds, a desk, a chair, a TV, and a bathroom.
A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.
A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

2. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Bawan
NZ$170
includes taxes & fees
11 Oct - 12 Oct
Madison Inn Lodge
A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

3. Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus
Festus
United States
Abram
NZ$181
includes taxes & fees
29 Oct - 30 Oct
Hampton Inn & Suites By Hilton Festus
A modern kitchen with a coffee machine, a refrigerator, and a microwave.
A laundry room with a front-loading washer and dryer, a door, and a light fixture.
A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.
A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.

4. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
Farmington
United States
Marisa
NZ$115
includes taxes & fees
11 Oct - 12 Oct
Super 8 by Wyndham Farmington
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.
A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.
A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.
A gym with cardio equipment, a bench press, and a squat rack.

5. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
United States
Joseph
NZ$110
includes taxes & fees
1 Nov - 2 Nov
Baymont Inn and Suites by Wyndham Farmington, MO
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

6. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Sandra
NZ$200
includes taxes & fees
6 Oct - 7 Oct
Drury Plaza Hotel Cape Girardeau Conference Center
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
A restaurant with a brick wall, a flat-screen TV, and a bar area.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.
A hotel room with two beds, a brick wall, and a wooden headboard.

7. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Thomas
NZ$154
includes taxes & fees
1 Nov - 2 Nov
Drury Inn & Suites Jackson MO
A hotel room with a bed, a sofa, a desk, and a chair.
A modern living room with a sofa, armchairs, a coffee table, and a painting on the wall.
A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.
A coffee station with two coffee machines, a coffee press, and various coffee-related items on a wooden counter.

8. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
Farmington
United States
Sheila
NZ$225
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Express & Suites Farmington by IHG
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.
A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

9. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
United States
Carlos
NZ$203
includes taxes & fees
8 Oct - 9 Oct
Fairfield Inn & Suites by Marriott Cape Girardeau
A hotel room with two beds, a desk, a chair, a TV, and a lamp.
An outdoor pool area with lounge chairs and an umbrella.
A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".
A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.

10. Fort Davidson Hotel

Fort Davidson Hotel
Ironton
United States
richard
NZ$233
includes taxes & fees
27 Oct - 28 Oct
Fort Davidson Hotel
An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.
A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.
A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.
A spacious hotel lobby with a dining area, kitchen, and large windows.

11. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
Farmington
United States
Stephanie
NZ$212
includes taxes & fees
14 Oct - 15 Oct
Crown Pointe Lodge, BW Signature Collection
An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.
A hotel room with a wooden desk, a chair, a television, a microwave, and a minibar.
A reception desk with a wooden panel design, a bicycle mounted on the wall, and a sign reading "Hilton Honors".
A hotel room with two beds, a flat-screen TV, a desk, and a window with blinds.

12. Hampton Inn Farmington

Hampton Inn Farmington
Farmington
United States
Charlie
NZ$209
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn Farmington
A living room with a blue wall, a fireplace, a sofa, and a chair.
A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.
A brick building with a sign reading "Mercantile & Hotel".
A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

13. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
United States
JANEEN
NZ$203
includes taxes & fees
4 Oct - 5 Oct
EC Reed's Mercantile and Hotel
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
An outdoor patio with tables and chairs, a stone wall, and large windows.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.
A hotel room with two beds, a nightstand, a lamp, and a chair.

14. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
United States
Elaine
NZ$155
includes taxes & fees
1 Nov - 2 Nov
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A hotel room with two beds, a desk, a chair, and a view of the city.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

15. The Riverview

The Riverview
Cape Girardeau
United States
Alyssa
NZ$206
includes taxes & fees
6 Oct - 7 Oct
The Riverview
A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.
A modern kitchen with a stone backsplash, a dining area with red chairs, and a red accent wall with a framed picture.
A room with a brown leather sofa, a red chair, and a cityscape painting on the wall.
A hotel with a central entrance, multiple parking spaces, and a well-lit facade.

16. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
Marston
United States
Brenda
NZ$113
includes taxes & fees
2 Oct - 3 Oct
Super 8 By Wyndham Marston
A spacious lobby with a reception desk, seating area, and large windows.
An indoor swimming pool with a clear view of the outside through large windows.
A spacious lobby with a high ceiling, a mezzanine level, and a seating area with a sofa and chairs.
A spacious conference room with brick walls, multiple tables and chairs, a large window, and a mounted TV.

17. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
Poplar Bluff
United States
Dean
NZ$189
includes taxes & fees
18 Oct - 19 Oct
Drury Inn & Suites Poplar Bluff
A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.
A hotel lobby with a seating area, a reception desk, and a bar.
A swimming pool with a diving board, pool rules signs, and lounge chairs.
A kitchen counter with a coffee machine, a kettle, and storage boxes.

18. Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
Perryville
United States
David
NZ$209
includes taxes & fees
31 Oct - 1 Nov
Holiday Inn Express & Suites Perryville by IHG
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.
A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.
An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.
A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

19. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
Sikeston
United States
Allen
NZ$203
includes taxes & fees
11 Oct - 12 Oct
Fairfield Inn & Suites by Marriott Sikeston
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.
A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

20. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
United States
Elizabeth
NZ$144
includes taxes & fees
11 Oct - 12 Oct
Pear Tree Inn Cape Girardeau West
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Holiday Rentals in Southeast Missouri

Cabin
A rustic log cabin with a stone foundation, surrounded by trees and a wooden fence.
A compact kitchen with wooden cabinets, a dishwasher, a refrigerator, and a coffee maker.
A park entrance with a sign for Sam A. Baker State Park and Mudlick Mountain Store and Grill.
A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

Sam A Baker State Park

Sam A Baker State Park
Patterson
"Pet friendly, great staff. "
Sam A Baker State Park
Cottage
A dining area with a checkered tablecloth, wooden chairs, and a red rug.
A two-story house with a red exterior, a front porch, and a well-maintained lawn.
A swimming pool with a wooden deck, surrounded by a white picket fence, and featuring colorful umbrellas.
An outdoor patio with a table and chairs, a grill, and a large umbrella.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Ironton
"Stroller, pack n play and high chair. This was amazing "
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
Aparthotel
A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.
A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.
A building with a sign that reads "The Atrium Boutique Hotel".
A building with a dark exterior, a large window, and a sign that reads "The Atrium."

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
Perryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
The Atrium - A Boutique Hotel
Cabin
A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.
Private kitchen
A rustic cabin with a wooden exterior, a small deck, and a picnic table.
A cabin with two Adirondack chairs outside, a picnic table, and a small black structure with a window and a sign.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
French Village
"I really enjoyed my time at the stay !"
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Aparthotel
A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.
A hallway with exposed brick walls, wooden flooring, and a white door.
A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.
A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

Urban Lofts

Urban Lofts
Perryville
"Beautiful place and staff was amazing!"
Urban Lofts
Cabin
A rustic cabin with a metal roof, surrounded by a wooden deck and picnic tables, set in a forested area.
A calm lake with a wooden dock and a forested island in the distance.
A bedroom with a wooden bed, a bench, and a window.
A wooden deck with a railing leading to a building with a metal roof and a brown door.

Lake Wappapello

Lake Wappapello
Williamsville
"Pet friendly. Family-friendly "
Lake Wappapello
Holiday Home
A wooden deck with two Adirondack chairs and a hammock.
A spacious living room with wooden floors, a stone fireplace, and a mounted television.
A bedroom with a large bed, wooden ceiling, and a view of the outdoors.
A spacious living room with a wooden ceiling, a fireplace, and a television.

Tiny Houses of French Village

Tiny Houses of French Village
French Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Tiny Houses of French Village
Cottage
A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.
A covered porch with yellow chairs, a bench, and a small table.
A spacious living area with a kitchen island, dining table, and a television.
A kitchen with wooden cabinets, a central island, and a dining area with a table set for four.

Walk to Dtwn: Ironton Home in Historic District

Walk to Dtwn: Ironton Home in Historic District
Ironton
"Clean and comfortable "
Walk to Dtwn: Ironton Home in Historic District
Cottage
Interior
A wooden deck leading to a house with a wooden door and a small porch area.
A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.
Interior

Walk to Current River: Ozarks Adventure Home!

Walk to Current River: Ozarks Adventure Home!
Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
Walk to Current River: Ozarks Adventure Home!
Cottage
A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.
A red house with a wooden deck and stone steps leading to a porch.
A dining area with a glass table and chairs, wooden flooring, and large windows.
A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Cozy Belgrade Cottage w/ Wood-burning Stove!
Belgrade
Cozy Belgrade Cottage w/ Wood-burning Stove!
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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
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A sunset over a lake with boats and ducks.
Photo by JG Morris

Lake Wappapello

8.8/10 (54 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.
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Century Casino Caruthersville

7.0/10 (57 reviews)
Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

Recent Reviews in Southeast Missouri

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

8/10 Good
"Nice clean room and helpful staff."
Stacy 1-night trip
Posted 11 hours ago
Holiday Inn Poplar Bluff by IHG
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"EVERYONE was EXTREMELY FRIENDLY"
Rex 1-night trip
Posted 23 hours ago
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

8/10 Good
"At breakfast they ran out of milk! And no coffee creamer except the powdered nondairy packet stuff."
Jeff 1-night trip
Posted 2 days ago
Drury Inn & Suites Hayti Caruthersville
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

10/10 Excellent
"trodo estubo excelente gracias por sus servicios"
Julio 1-night trip
Posted 3 days ago
Candlewood Suites Cape Girardeau by IHG
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent
"Clean rooms. Nice breakfast. Very nice staff."
Teresa 1-night trip
Posted 3 days ago
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

10/10 Excellent
"Difficult to communicate with person setting up and maintaining breakfast area as they did not speak English"
Terry 1-night trip
Posted 4 days ago
Comfort Inn Festus - St Louis South
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"I loved everything about this cabin and I was on a high from this experience."
Paris 1-night trip
Posted 5 days ago
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent
"This was a very good value. It has been the best hotel I've stayed at in awhile."
David 1-night trip
Posted 10 days ago
Days Inn and Suites by Wyndham Sikeston
Silo Farm Haus- located in the heart of wine country!

Silo Farm Haus- located in the heart of wine country!

10/10 Excellent
"We were quite impressed with what has been done with the silo! Everything was clean and comfortable upon our arrival. The area was nice and quiet – just what we were looking for away from the city. Sunsets and star gazing were amazing. We would definitely love to come back to the area in the fall when the leaves have turned."
Becky D. 2-night trip
Posted 1 month ago
Silo Farm Haus- located in the heart of wine country!

More cheap accommodation in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
NZ$110
1 Nov - 2 Nov
includes taxes & fees
Baymont Inn and Suites by Wyndham Farmington, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
NZ$134
1 Nov - 2 Nov
includes taxes & fees
Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO
NZ$144
11 Oct - 12 Oct
includes taxes & fees
Pear Tree Inn Cape Girardeau West
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO
NZ$148
25 Oct - 26 Oct
includes taxes & fees
7.8/10 Good! (1,000 reviews)
Comfort Inn Festus - St Louis South
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
NZ$157
3 Oct - 4 Oct
includes taxes & fees
Motel 6 Poplar Bluff, MO
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO
NZ$181
18 Oct - 19 Oct
includes taxes & fees
Hampton Inn Poplar Bluff

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