Southeast Missouri Travel Guide

Name: Drury Inn & Suites Sikeston, MO
Rating: 9.4

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Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff ...

9.6/10 Exceptional! (1,000 reviews)

Parking was available for my handicap son ,breakfast was great,very clean room and friendly staff

Reviewed on 31 Mar 2026

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The Riverview

777 Main St Cape Girardeau MO

Stay at this business-friendly hotel in Cape Girardeau. Enjoy free Wi-Fi, free parking and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and ...

9.4/10 Exceptional! (538 reviews)

Really nice rooms

Reviewed on 31 Mar 2026

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Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ...

9.4/10 Exceptional! (1,000 reviews)

Our first visit to a Drury Inn — what an amazing place. Not only was there an excellent breakfast with many choices, but there was also a light dinner served. This was all included for a very reasonable price. Our room was very clean and comfortable. We will definitely be looking for more Drury Inns ...

Reviewed on 30 Mar 2026

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See all 640 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

7555 State Hwy Y French Village MO

Stay at this cabin in French Village. Enjoy free parking, patios and climate control.

9.8/10 Exceptional! (57 reviews)

Beautiful , comfortable!!

Reviewed on 21 Mar 2026

St Francis River: The Blue Yurt and Hot Tub

Fredericktown MO

Stay at this cabin in Fredericktown. Enjoy air conditioning.

8.8/10 Excellent! (21 reviews)

Absolutely loved the location. Once we found it. One bummer was the hot tub doesn’t get hot and that was the biggest thing we were looking forward to. Other than that, everything was pretty functional. Dishes weren’t clean, but we hand washed them ourselves. Nice little get away.

Reviewed on 14 Mar 2026

Johnson's Shut-ins State Park

148 Taum Sauk Trail Middle Brook MO

Stay at this cabin in Middle Brook. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Popular attractions Johnson's Shut-ins State Park and Taum Sauk ...

10/10 Exceptional! (1 review)

These newer cabins are clean and have everything you need. Highly recommend!

Reviewed on 5 Nov 2025

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Lake Wappapello

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Current River State Park

Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.