Southeast Missouri Travel Guide

Tourist Guide

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
A historic building named 'Poplar Bluff' with a red-tiled roof and brick facade.
A river flowing through a rocky landscape with dense green forest in the background.
A brick building with a sign that reads "Welcome to Historic Downtown Poplar Bluff."
A river surrounded by dense green forest.
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
The price is NZ$204 per night from 19 Nov to 20 Nov
NZ$204
19 Nov - 20 Nov
includes taxes & fees
Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff ...
Drury Plaza Hotel Cape Girardeau Conference Center
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2.5 out of 5
2420 Crestwood Dr Poplar Bluff MO
The price is NZ$181 per night from 6 Dec to 7 Dec
NZ$181
6 Dec - 7 Dec
includes taxes & fees
Stay at this hotel in Poplar Bluff. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in their reviews. ...
9.4/10 Exceptional! (1,000 reviews)
"Breakfast very good!"

Reviewed on 13 Nov 2026

Hampton Inn Poplar Bluff
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
The price is NZ$113 per night from 22 Nov to 23 Nov
NZ$113
22 Nov - 23 Nov
includes taxes & fees
Stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking and an outdoor pool. Our guests praise the helpful staff and the clean ...
8/10 Very good! (1,004 reviews)
"The room was comfortable. The breakfast was well prepared and well stocked. The parking lot could use more adequate security lighting."

Reviewed on 14 Nov 2026

Baymont Inn and Suites by Wyndham Farmington, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios and climate control.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Silo Farm Haus- located in the heart of wine country!

Silo Farm Haus- located in the heart of wine country!

Ste. Genevieve MO
Stay at this holiday home in Ste Genevieve. Enjoy laundry facilities. Popular attractions Crown Valley Winery and Hawn State Park are located nearby.
10/10 Exceptional! (160 reviews)
"Visited for the weekend with my wife to celebrate our anniversary. The Silo Farm Haus was absolutely perfect! The views of the rolling farmland were gorgeous. Inside was cozy and beautifully decorated. We had a wonderful time and would highly recommend staying here if you get the chance."

Reviewed on 19 Oct 2026

Silo Farm Haus- located in the heart of wine country!
Lake Wappapello

Lake Wappapello

2 out of 5
8005 Missouri 172 Williamsville MO
Stay at this cabin in Williamsville. Enjoy free parking. Popular attractions Poplar Bluff History Museum and North Main Street Historic District are located ...
Lake Wappapello
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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