Photo by Bill Dillard

Spa Hotels & Resorts in Southeast Missouri

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Spa Hotels

Best Southeast Missouri Spa Hotels

Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1004)
"It was right off the interstate with lots of restaurant options "
United States
Kelly
The price is NZ$182
includes taxes & fees
30 Nov - 1 Dec
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southeast Missouri Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Clean room and amenities were great"
Crystal 2-night trip
Posted 9 days ago
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Clean and friendly staff!!!"
Edward 1-night trip
Posted 9 days ago
Drury Inn & Suites Cape Girardeau

Explore a world of travel with Expedia