A group of men in red uniforms with gold accents, holding rifles and wearing kilts.

Luxury Hotels & Resorts in Southeast Missouri from NZ$171

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Luxury Hotels

Our top choices for Southeast Missouri luxury hotels

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (630 reviews)
The price is NZ$197
includes taxes & fees
4 Aug - 5 Aug
The Riverview

River City Casino & Hotel

River City Casino & Hotel
4.0 star property
St. Louis
9.2 out of 10, Wonderful, (1,665 reviews)
The price is NZ$238
includes taxes & fees
13 Aug - 14 Aug
River City Casino & Hotel

Drury Plaza Hotel St. Louis Brentwood

Drury Plaza Hotel St. Louis Brentwood
4.0 star property
Brentwood
9.6 out of 10, Exceptional, (1,024 reviews)
The price is NZ$276
includes taxes & fees
2 Aug - 3 Aug
Drury Plaza Hotel St. Louis Brentwood

Hilton St. Louis Frontenac

Hilton St. Louis Frontenac
4.0 star property
Frontenac
8.8 out of 10, Excellent, (1,001 reviews)
  • cleanliness
    Upscale St. Louis retreat features pool, concierge, fine dining in prime business district.
The price is NZ$325
includes taxes & fees
31 July - 1 Aug
Hilton St. Louis Frontenac
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Southeast Missouri Hotel Reviews

Explore a world of travel with Expedia