Independent in Southeast Missouri
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
Tonight
7 Sept - 8 SeptTomorrow
8 Sept - 9 SeptThis weekend
11 Sept - 13 SeptNext weekend
18 Sept - 20 Sept
Save an average of 15% on thousands of hotels when you're signed in
Top Southeast Missouri Hotel Reviews
Pear Tree Inn Cape Girardeau West
10/10 Excellent
"Was overall great place to stay"
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
10/10 Excellent
"This was my first time camping and I will say that I will definitely return. It was an amazing experience and the workers were soooooooo amazingly nice and accommodating. I will be telling everyone about these hidden gem."
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
10/10 Excellent
"This place was awesome hands down! The staff was extremely accommodating and friendly. Thank you Madison for a great check in experience. Of all the hotels we stayed at over our road trip this weekend this was the best deal and the nicest establishment by far. The receptionist even gave my children little toys out the treasure chest as we were checking out. Thank y'all again! Will def be back if I am ever in the area."
The Riverview
8/10 Good
"Clean room"
Motel 6 Poplar Bluff, MO
8/10 Good
"Clean quiet property. Basic room with practical design. Could improve the quality of the coffee."
Best Western Plus Sikeston I-55
8/10 Good
"Great location, nice, clean and well maintained, Hotel employees were very helpful great customer service,"
Drury Inn & Suites Sikeston, MO
10/10 Excellent
"This was my second time staying at Drury hotel. I will most definitely book another stay."
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
10/10 Excellent
"Comfortable and convenient"
Drury Inn & Suites Cape Girardeau
10/10 Excellent
"Nice place! Breakfast was amazing!"
Explore a world of travel with Expedia
- Motels in Belleview
- Cabin Rentals in Jackson
- Holiday Homes in Ste Genevieve
- Cabin Rentals in Cherryville
- Motels in Ellington
- Villas in Tiff
- Holiday Homes in Poplar Bluff
- Motels in Pilot Knob
- New Offenburg Hotels
- Bonne Terre Hotels
- Caledonia Hotels
- Bloomsdale Hotels
- Benton Hotels
- Ellsinore Hotels
- Potosi Hotels
- Poplar Bluff Hotels
- Cape Girardeau Hotels
- Annapolis Hotels
- Greenville Hotels
- Tiff Hotels
- Fredericktown Hotels
- Hotels near Mark Twain National Forest
- Hotels near Millstream Gardens Conservation Area
- Desloge Hotels
- Bloomfield Hotels
- Qulin Hotels
- Bismarck Hotels
- Ellington Hotels
- Advance Hotels
- Jackson Hotels
- French Village Hotels
- Pilot Knob Hotels
- Bernie Hotels
- St Mary Hotels
- Fruitland Hotels
- Dexter Hotels
- Arcadia Hotels
- Bunker Hotels
- Farmington Hotels
- De Soto Hotels
- Park Hills Hotels
- Doniphan Hotels
- Oran Hotels
- Leadwood Hotels
- Black Hotels
- Eminence Hotels
- Marble Hill Hotels
- Des Arc Hotels
- Hotels near Malden Regional
- Doe Run Hotels
- Van Buren Hotels
- Patterson Hotels
- Lesterville Hotels
- Ironton Hotels
- Piedmont Hotels
- Flights to Cape Girardeau
- Flights to Ironton
- Flights to Van Buren
- Flights from Poplar Bluff Municipal
- Flights from Winona
- Flights from Black
- Flights from London (LON) to Poplar Bluff (POF)
- Flights from San Antonio (SAT) to Poplar Bluff (POF)
- Flights from Chattanooga (CHA) to Poplar Bluff (POF)
- Flights from Jackson (MKL) to Poplar Bluff (POF)
- Flights from Nashville (BNA) to Poplar Bluff (POF)
- Flights from Raleigh (RDU) to Poplar Bluff (POF)
- Flights from Edmonton (YEG) to Cape Girardeau (CGI)
- Flights from Rolla (RLA) to Cape Girardeau (CGI)
- Flights from Monterrey (MTY) to Cape Girardeau (CGI)
- Flights from Manila (MNL) to Cape Girardeau (CGI)