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Business Hotels & Resorts in Southeast Missouri from NZ$112

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Check availability on Southeast Missouri Business Hotels

Our top choices for Southeast Missouri business-friendly hotels

A motel with a covered entrance, a flag, and a phone number.

1. Madison Inn Lodge

Madison Inn Lodge
2.5 star property
Fredericktown
7.6 out of 10, Good, (314 reviews)
"Nice and clean friendly staff"
United States
Bawan
The price is NZ$171
includes taxes & fees
15 Nov - 16 Nov
Madison Inn Lodge
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

2. Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.2 out of 10, Wonderful, (339 reviews)
"Clean room, wifi easy to connect to, parking right in front."
United States
Jonathan
The price is NZ$243
includes taxes & fees
15 Dec - 16 Dec
Shepherd Mountain Inn
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

3. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very good, (1,004 reviews)
"Our room was spacious, clean and the bed was super comfortable!"
Canada
Kim
The price is NZ$112
includes taxes & fees
22 Nov - 23 Nov
Baymont Inn and Suites by Wyndham Farmington, MO
A reception area with a modern design, featuring a decorative wall piece, a small table with a bowl, and a patterned partition.

4. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
2.5 star property
Farmington
8.6 out of 10, Excellent, (445 reviews)
"We stayed one night and it was great! Breakfast was delicious."
United States
January
The price is NZ$230
includes taxes & fees
13 Dec - 14 Dec
Holiday Inn Express & Suites Farmington by IHG
A modern kitchen with a coffee machine, a refrigerator, and a microwave.

5. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
2.0 star property
Farmington
8.0 out of 10, Very good, (691 reviews)
"Clean nice staff are great"
United States
Marisa
The price is NZ$123
includes taxes & fees
20 Nov - 21 Nov
Super 8 by Wyndham Farmington
A spacious lobby with a reception desk, seating area, and large windows.

6. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,002 reviews)
"I like how clean they were, and the food was excellent and the hot tub was great"
United States
Alan
The price is NZ$192
includes taxes & fees
19 Nov - 20 Nov
Drury Inn & Suites Poplar Bluff
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

7. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,005 reviews)
"Easy check in and room was very clean. The food for breakfast and dinner is the bomb."
United States
Melody
The price is NZ$203
includes taxes & fees
15 Nov - 16 Nov
Drury Plaza Hotel Cape Girardeau Conference Center
A bed with white bedding, a wooden headboard, a nightstand with a drawer, and a wall-mounted light fixture.

8. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
2.5 star property
Farmington
8.8 out of 10, Excellent, (704 reviews)
"Tucked away gem."
United States
christopher
The price is NZ$209
includes taxes & fees
20 Nov - 21 Nov
Crown Pointe Lodge, BW Signature Collection
An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

9. Hampton Inn Farmington

Hampton Inn Farmington
2.5 star property
Farmington
8.8 out of 10, Excellent, (584 reviews)
"The staff were so friendly & housekeeping came in each day to take care of our room. The breakfast was one of the best we have had. We had a great stay. Thank you to the staff!"
United States
Charlie
The price is NZ$215
includes taxes & fees
13 Dec - 14 Dec
Hampton Inn Farmington
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

10. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (118 reviews)
"Friendly staff, great breakfast, nice amenities"
United States
Roslyn
The price is NZ$226
includes taxes & fees
26 Nov - 27 Nov
Fairfield Inn & Suites by Marriott Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotel Reviews

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

8/10 Good
"The room was comfortable. The breakfast was well prepared and well stocked. The parking lot could use more adequate security lighting."
Richard 2-night trip
Posted 16 hours ago
Baymont Inn and Suites by Wyndham Farmington, MO

Frequently asked questions

How much do business-friendly hotels in Southeast Missouri cost?
Prices for business hotels in Southeast Missouri range between NZ$112 and NZ$243 per night. Whatever your budget, Expedia is here to help you find the best place to get your work done. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business-friendly hotels are there in Southeast Missouri?
When work takes you on the road in Southeast Missouri, there are 50 business-friendly hotels to select from.
What is there to do in Southeast Missouri near my business-friendly hotel?
Whether you're passionate about arts, culture, shopping or dining, Southeast Missouri has something to suit all tastes! The popular city of Cape Girardeau has plenty of things to do, including Isle Casino Cape Girardeau, Cape Rock Park and Fort D Historic Site. If you're planning a business trip to Ste Genevieve, Sainte Genevieve Winery, Bolduc House Museum and Felix Valle House State Historic Site have to be on your itinerary.

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