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Business Hotels & Resorts in Southeast Missouri

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Check availability on Southeast Missouri Business Hotels

Tonight
7 Aug - 8 Aug
Tomorrow
8 Aug - 9 Aug
This weekend
7 Aug - 9 Aug
Next weekend
14 Aug - 16 Aug

Our top choices for Southeast Missouri business-friendly hotels

1. Shepherd Mountain Inn

Shepherd Mountain Inn
Ironton
United States
Katie
NZ$229
includes taxes & fees
27 Aug - 28 Aug
Shepherd Mountain Inn

2. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Christine
NZ$162
includes taxes & fees
14 Aug - 15 Aug
Madison Inn Lodge

3. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
United States
Kellie
NZ$107
includes taxes & fees
15 Aug - 16 Aug
Baymont Inn and Suites by Wyndham Farmington, MO

4. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Jamie
NZ$146
includes taxes & fees
16 Aug - 17 Aug
Drury Inn & Suites Jackson MO

5. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
Farmington
United States
Sarah
NZ$110
includes taxes & fees
13 Aug - 14 Aug
Super 8 by Wyndham Farmington

6. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
Farmington
United States
Louise
NZ$196
includes taxes & fees
16 Aug - 17 Aug
Crown Pointe Lodge, BW Signature Collection

7. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
United States
Heather
NZ$178
includes taxes & fees
3 Sept - 4 Sept
Fairfield Inn & Suites by Marriott Cape Girardeau

8. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
Poplar Bluff
United States
Elaine
NZ$181
includes taxes & fees
16 Aug - 17 Aug
Drury Inn & Suites Poplar Bluff

9. The Riverview

The Riverview
Cape Girardeau
United States
James
NZ$202
includes taxes & fees
16 Aug - 17 Aug
The Riverview

10. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
Farmington
United States
Tara
NZ$195
includes taxes & fees
23 Aug - 24 Aug
Holiday Inn Express & Suites Farmington by IHG
View all properties

Top Southeast Missouri Hotel Reviews

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent
"The manager and staff are excellent"
Robbie 2-night trip
Posted 19 hours ago
Days Inn and Suites by Wyndham Sikeston
Baymont by Wyndham Festus

Baymont by Wyndham Festus

10/10 Excellent
"The staff and everything was wonderful."
Zakkary 10-night trip
Posted 1 day ago
Baymont by Wyndham Festus
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent
"I enjoyed the walk out room to the pool area"
BRANDON 1-night trip
Posted 1 day ago
Baymont Inn and Suites by Wyndham Farmington, MO
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Loved the hotel! Super clean, friendly staff, large rooms"
Tracy 1-night trip
Posted 2 days ago
Drury Plaza Hotel Cape Girardeau Conference Center
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"Had a great time staying here. Would recommend to anyone coming that direction."
Kelly 1-night trip
Posted 2 days ago
Pear Tree Inn Cape Girardeau West
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

8/10 Good
"Great place to stay in the area and a good value for the money spent. Just South of St. Louis and plenty of places to shop, eat and go on adventures. The water pressure in the shower was weak but we got by."
Jeff 2-night trip
Posted 4 days ago
Comfort Inn Festus - St Louis South

Frequently asked questions

How much do business-friendly hotels in Southeast Missouri cost?
Prices for business hotels in Southeast Missouri range between and per night. Whatever your budget, Expedia is here to help you find the best place to get your work done. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business-friendly hotels are there in Southeast Missouri?
When work takes you on the road in Southeast Missouri, there are business-friendly hotels to select from.
What is there to do in Southeast Missouri near my business-friendly hotel?
Whether you're passionate about arts, culture, shopping or dining, Southeast Missouri has something to suit all tastes! The popular city of Cape Girardeau has plenty of things to do, including Isle Casino Cape Girardeau, Cape Rock Park and Fort D Historic Site. If you're planning a business trip to Ste Genevieve, Sainte Genevieve Winery, Bolduc House Museum and Felix Valle House State Historic Site have to be on your itinerary.

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