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Business Hotels & Resorts in Southeast Missouri from NZ$109

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Check availability on Southeast Missouri Business Hotels

Tonight
28 Sept - 29 Sept
Tomorrow
29 Sept - 30 Sept
This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

Our top choices for Southeast Missouri business-friendly hotels

A motel with a covered entrance, a flag, and a phone number.
A hotel room with two beds, a desk, a chair, a TV, and a bathroom.
A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.
A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

1. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Bawan
NZ$169
includes taxes & fees
22 Oct - 23 Oct
Madison Inn Lodge
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.
A hotel room with two beds, a lamp, and a painting on the wall.
A building with a red awning labeled "Shepherd Mountain Inn."
A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.

2. Shepherd Mountain Inn

Shepherd Mountain Inn
Ironton
United States
Michael
NZ$238
includes taxes & fees
21 Oct - 22 Oct
Shepherd Mountain Inn
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.
A restaurant with a brick wall, a flat-screen TV, and a bar area.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

3. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Thomas
NZ$157
includes taxes & fees
11 Oct - 12 Oct
Drury Inn & Suites Jackson MO
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.
A gym with cardio equipment, a bench press, and a squat rack.
A hotel reception area with a glass partition, a reception desk, and a digital kiosk.
A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

4. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
United States
Joseph
NZ$109
includes taxes & fees
25 Oct - 26 Oct
Baymont Inn and Suites by Wyndham Farmington, MO
A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.
Snack bar
Terrace/patio
Exterior

5. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
Poplar Bluff
United States
Rhonda
NZ$173
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn Poplar Bluff
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

6. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Sandra
NZ$199
includes taxes & fees
6 Oct - 7 Oct
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
An outdoor patio with tables and chairs, a stone wall, and large windows.
A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.
A hotel room with two beds, a nightstand, a lamp, and a chair.

7. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
United States
Elaine
NZ$161
includes taxes & fees
7 Oct - 8 Oct
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A hotel room with a bed, a sofa, a desk, and a chair.
An indoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.
A coffee station with two coffee machines, a coffee press, and various coffee-related items on a wooden counter.
A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.

8. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
Farmington
United States
Sheila
NZ$227
includes taxes & fees
4 Oct - 5 Oct
Holiday Inn Express & Suites Farmington by IHG
An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.
A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.
A spacious hotel lobby with a dining area, kitchen, and large windows.

9. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
Farmington
United States
Susan
NZ$211
includes taxes & fees
25 Oct - 26 Oct
Crown Pointe Lodge, BW Signature Collection
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.
A hotel room with two beds, a desk, a chair, and a view of the city.

10. The Riverview

The Riverview
Cape Girardeau
United States
Alyssa
NZ$203
includes taxes & fees
6 Oct - 7 Oct
The Riverview
View all properties

Top Southeast Missouri Hotel Reviews

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

8/10 Good
"Staff was friendly, especially in the dining area. Breakfast included was good, but limited selection. Central location with easy access and parking."
Raymond 4-night trip
Posted 2 hours ago
Pear Tree Inn Cape Girardeau West
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent
"Staff were helpful."
Joseph 1-night trip
Posted 1 day ago
Baymont Inn and Suites by Wyndham Farmington, MO
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

10/10 Excellent
"Difficult to communicate with person setting up and maintaining breakfast area as they did not speak English"
Terry 1-night trip
Posted 1 day ago
Comfort Inn Festus - St Louis South
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent
"Great experience. Staff was welcoming. Rooms were clean."
yolanda 2-night trip
Posted 1 day ago
Drury Inn & Suites Hayti Caruthersville
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

10/10 Excellent
"Debbie at the desk was super nice and helpful."
Nancy 1-night trip
Posted 2 days ago
Holiday Inn Poplar Bluff by IHG
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

8/10 Good
"Definitely worth it, clean"
Joy 1-night trip
Posted 3 days ago
Motel 6 Poplar Bluff, MO
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Clean room and perfect stay. We have come to consistently appreciate Drury brand for a quality stay. We would definitely recommend this location for clean comfortable accommodations."
Hiram 1-night trip
Posted 6 days ago
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

10/10 Excellent
"Clean room, staff"
Lavonne 2-night trip
Posted 6 days ago
Drury Inn & Suites Poplar Bluff
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent
"This was a very good value. It has been the best hotel I've stayed at in awhile."
David 1-night trip
Posted 7 days ago
Days Inn and Suites by Wyndham Sikeston

Frequently asked questions

How much do business-friendly hotels in Southeast Missouri cost?
Prices for business hotels in Southeast Missouri range between NZ$109 and NZ$238 per night. Whatever your budget, Expedia is here to help you find the best place to get your work done. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business-friendly hotels are there in Southeast Missouri?
When work takes you on the road in Southeast Missouri, there are 50 business-friendly hotels to select from.
What is there to do in Southeast Missouri near my business-friendly hotel?
Whether you're passionate about arts, culture, shopping or dining, Southeast Missouri has something to suit all tastes! The popular city of Cape Girardeau has plenty of things to do, including Isle Casino Cape Girardeau, Cape Rock Park and Fort D Historic Site. If you're planning a business trip to Ste Genevieve, Sainte Genevieve Winery, Bolduc House Museum and Felix Valle House State Historic Site have to be on your itinerary.

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