Business Hotels & Resorts in Southeast Missouri from NZ$108

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Business Hotels

Best Southeast Missouri Business Hotels

Drury Inn & Suites Jackson MO
Lobby

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1002)
"We had a last minute reservation here. The staff was very pleasant, helpful and wonderful overall!!"
The price is NZ$161
includes taxes & fees
24 Aug - 25 Aug
Drury Inn & Suites Jackson MO
Drury Inn & Suites Sikeston, MO
Property amenity

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1001)
"Great location "
The price is NZ$175
includes taxes & fees
24 Aug - 25 Aug
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Hayti Caruthersville
Lobby

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1000)
"We enjoyed our stay."
The price is NZ$181
includes taxes & fees
22 Aug - 23 Aug
Drury Inn & Suites Hayti Caruthersville
Microtel Inn & Suites by Wyndham Sainte Genevieve
Room, 2 Queen Beds, Non Smoking

Microtel Inn & Suites by Wyndham Sainte Genevieve

2.5 star property
8.8 out of 10, Excellent, (588)
"It was a great stay. Only thimg maybe more variety or hot breakfast."
The price is NZ$159
includes taxes & fees
7 Sept - 8 Sept
Microtel Inn & Suites by Wyndham Sainte Genevieve
Super 8 by Wyndham Cuba
In-room safe, desk, blackout curtains, free cots/infant beds

Super 8 by Wyndham Cuba

2.0 star property
8.8 out of 10, Excellent, (951)
"Good comfortable stay for the money"
The price is NZ$139
includes taxes & fees
1 Sept - 2 Sept
Super 8 by Wyndham Cuba
Comfort Inn Willow Springs US 60 and US 63
Suite, Non Smoking

Comfort Inn Willow Springs US 60 and US 63

2.5 star property
9.2 out of 10, Wonderful, (499)
"Quiet, safe, and clean. Good breakfast. Great parking for trailers or RVs. Nice area. Wonderful staff."
The price is NZ$200
includes taxes & fees
24 Aug - 25 Aug
Comfort Inn Willow Springs US 60 and US 63
Pear Tree Inn St. Louis Arnold
Lobby

Pear Tree Inn St. Louis Arnold

2.5 star property
9.2 out of 10, Wonderful, (1001)
"Location is excellent "
The price is NZ$176
includes taxes & fees
22 Aug - 23 Aug
Pear Tree Inn St. Louis Arnold
Holiday Inn Express & Suites Perryville by IHG
Exterior

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
9.4 out of 10, Exceptional, (496)
"I thought that this property had just been constructed as everything was brilliant. Staff was super nice and knowledgeable about the area. 100% would recommend to anyone needing to visit the area or passing through."
The price is NZ$184
includes taxes & fees
24 Aug - 25 Aug
Holiday Inn Express & Suites Perryville by IHG
Pear Tree Inn Sikeston
Lobby

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1007)
"Very nice property Friendly helpful staff"
The price is NZ$155
includes taxes & fees
22 Aug - 23 Aug
Pear Tree Inn Sikeston
The Riverview
Grand Riverview Two Queen Room

The Riverview

2.0 star property
9.4 out of 10, Exceptional, (389)
"Nice place to stay! everything was fun and clean."
The price is NZ$201
includes taxes & fees
18 Aug - 19 Aug
The Riverview
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Southeast Missouri Hotel Reviews

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

10/10 Excellent
"Very nice property Friendly helpful staff"
Michael 1-night trip
Posted 1 day ago
Pear Tree Inn Sikeston

Frequently asked questions

How much do business-friendly hotels in Southeast Missouri cost?
Prices for business hotels in Southeast Missouri range between NZ$108 and NZ$181 per night. Whatever your budget, Expedia is here to help you find the best place to get your work done. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business-friendly hotels are there in Southeast Missouri?
When work takes you on the road in Southeast Missouri, there are 50 business-friendly hotels to select from.
What is there to do in Southeast Missouri near my business-friendly hotel?
Whether you're passionate about arts, culture, shopping or dining, Southeast Missouri has something to suit all tastes! The popular city of Cape Girardeau has plenty of things to do, including Isle Casino Cape Girardeau, Cape Rock Park and Fort D Historic Site. If you're planning a business trip to Ste Genevieve, Sainte Genevieve Winery, Bolduc House Museum and Felix Valle House State Historic Site have to be on your itinerary.