Adults Only & Resorts in Southeast Missouri

Start date: Check-in selected.
To Date
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Adults Only

Tonight
3 Oct - 4 Oct
Tomorrow
4 Oct - 5 Oct
This weekend
3 Oct - 5 Oct
Next weekend
10 Oct - 12 Oct

Best Southeast Missouri Adults Only

We don't have any properties that match your exact search
See all properties in Southeast Missouri

Recommended hotels in Southeast Missouri

Drury Inn & Suites Jackson MO
Lobby

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1003)
"Was a clean room, nice staff, good parking "
The price is NZ$164
includes taxes & fees
14 Oct - 15 Oct
Drury Inn & Suites Jackson MO
Pear Tree Inn Sikeston
Lobby

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1004)
"I love this hotel! Have stayed several times and will definitely stay again. The rooms are always very clean and the staff is so friendly and helpful. I highly recommend this hotel!"
The price is NZ$152
includes taxes & fees
18 Oct - 19 Oct
Pear Tree Inn Sikeston
Drury Inn & Suites Hayti Caruthersville
Lobby

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1000)
"Nice place for a over night stay would recamend."
The price is NZ$184
includes taxes & fees
19 Oct - 20 Oct
Drury Inn & Suites Hayti Caruthersville
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1005)
"Very nice hotel"
The price is NZ$175
includes taxes & fees
12 Oct - 13 Oct
Drury Plaza Hotel Cape Girardeau Conference Center
Microtel Inn & Suites by Wyndham Sainte Genevieve
Room, 2 Queen Beds, Non Smoking

Microtel Inn & Suites by Wyndham Sainte Genevieve

2.5 star property
8.8 out of 10, Excellent, (597)
"Clean, friendly, and safe."
The price is NZ$164
includes taxes & fees
19 Oct - 20 Oct
Microtel Inn & Suites by Wyndham Sainte Genevieve
Fairfield Inn & Suites by Marriott Poplar Bluff
Lobby lounge

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (816)
"Very nice hotel! We had a great stay"
The price is NZ$198
includes taxes & fees
5 Oct - 6 Oct
Fairfield Inn & Suites by Marriott Poplar Bluff
Drury Inn & Suites Poplar Bluff
Lobby

Drury Inn & Suites Poplar Bluff

3.0 star property
9.2 out of 10, Wonderful, (916)
"Always a good stay"
The price is NZ$192
includes taxes & fees
9 Oct - 10 Oct
Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Sikeston, MO
Property amenity

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1000)
"Very nice and quiet "
The price is NZ$178
includes taxes & fees
19 Oct - 20 Oct
Drury Inn & Suites Sikeston, MO
Crown Pointe Lodge, BW Signature Collection
Lobby

Crown Pointe Lodge, BW Signature Collection

2.5 star property
9.0 out of 10, Wonderful, (551)
"We'd stay here again."
The price is NZ$210
includes taxes & fees
2 Nov - 3 Nov
Crown Pointe Lodge, BW Signature Collection
Hampton Inn By Hilton Dexter
Reception

Hampton Inn By Hilton Dexter

2.5 star property
The price is NZ$228
includes taxes & fees
23 Oct - 24 Oct
Hampton Inn By Hilton Dexter
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southeast Missouri Hotel Reviews

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What is there to do in Southeast Missouri near my adults-only hotel?
There are many things to see and do in Southeast Missouri. If you're heading to Cape Girardeau, swing by Isle Casino Cape Girardeau, Cape Rock Park and Fort D Historic Site. Planning to stay in Ste Genevieve? Sainte Genevieve Winery, Bolduc House Museum and Felix Valle House State Historic Site are top attractions here.
From what age can you stay in an adult-only hotel in Southeast Missouri?
Generally, it's 16  18 or 21. The adult-only resorts and hotels in Southeast Missouri can have different age requirements, so read the rules of the property you have your eye on before reserving your stay. Whether you're planning a romantic trip or a bachelorette party, Expedia's adult-only hotels have everything you need for a fun-filled grown-up getaway.
Are all adult-only resorts all-inclusive in Southeast Missouri?
If you just want to stay at a resort or hotel where most of what you need is covered by the room rate, use our handy "all-inclusive" filter. This will display the available adult-only all-inclusive properties in Southeast Missouri that normally include food, drinks and the room, a selection of on-site activities and entertainment. Click on the resort you have your eye on to find out what you get for your money.
When is the best time to stay at an adult-only all-inclusive resort in Southeast Missouri?
Almost any time is a good time to stay at an adult-only all-inclusive resort in Southeast Missouri, but there are a few factors worth considering. Start with the time of the year you'd like to travel. Peak season has its own special buzz, but there's a higher demand for both flights and accommodation. Low season is not as hectic and easier on the purse strings. Of course, the weather plays a big part in making or breaking your getaway, so do some research before locking in your adult-only resort or hotel.
Can I cancel or change my adult-only resort booking?
You can. And there may be no charge depending on the kind of adult-only resort or hotel booking you have. Check the details in your itinerary or go to Expedia's Trips portal for help. Haven't found your accommodation yet? You can look for Southeast Missouri adult-only hotels that allow full refunds — just in case. Reserve your getaway with the guarantee that wherever you stay, you'll always be A-OK!