Adults Only & Resorts in Southeast Missouri from NZ$96

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Adults Only

No exact matches found, but these alternatives could be just right

Recommended hotels in Southeast Missouri

Lobby

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,019 reviews)
"The breakfast and nightly gathering makes this location a fantastic value and will be our choice of stops when heading south again!"
United States
William
The price is NZ$145
includes taxes & fees
28 June - 29 June
Drury Inn & Suites Jackson MO
View from property

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
9.8 out of 10, Exceptional, (78 reviews)
"The Experience was amazing and we enjoyed the views and the firepit!"
United States
Kenzia
The price is NZ$245
includes taxes & fees
22 June - 23 June
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Free toiletries, hair dryer, towels

Deerfield Inn & Suites Steele Near Blytheville I 55

Deerfield Inn & Suites Steele Near Blytheville I 55
2.5 star property
Steele
The price is NZ$96
includes taxes & fees
18 June - 19 June
Deerfield Inn & Suites Steele Near Blytheville I 55
Lobby lounge

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (201 reviews)
"The room was clean, the staff was extremely helpful with our check in!"
United States
Travis
The price is NZ$179
includes taxes & fees
2 July - 3 July
Fairfield Inn & Suites by Marriott Cape Girardeau
Snack bar

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (135 reviews)
"This is a clean, quiet, well designed hotel."
United States
Kendra
The price is NZ$174
includes taxes & fees
1 July - 2 July
Tru By Hilton Cape Girardeau
Lobby

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,000 reviews)
"Wonderful room and food offerings were extra thoughtful."
United States
Jonna
The price is NZ$194
includes taxes & fees
28 June - 29 June
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby sitting area

EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (99 reviews)
"It was a very neat experience! Highly recommend you stop here and get away from big chain hotels for a night. The staff were super friendly and the restaurant/store was so nostalgic!"
United States
DANIELLE
The price is NZ$173
includes taxes & fees
21 June - 22 June
EC Reed's Mercantile and Hotel
Free daily buffet breakfast

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (875 reviews)
"Nice quiet overnight stay."
United States
Tammy
The price is NZ$180
includes taxes & fees
12 July - 13 July
Hampton Inn Poplar Bluff
Exterior

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (594 reviews)
"Beautiful new hotel didn’t disappoint! Rey comfortable beds. Great breakfast and attentive staff keeping things filed for the best guest experience. I would definitely stop there again on my next trip through Perryville!"
United States
Cheryl
The price is NZ$198
includes taxes & fees
22 June - 23 June
Holiday Inn Express & Suites Perryville by IHG
Lobby

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (1,017 reviews)
"Great place to stay. Clean, great staff and the food is good. Would stay again."
United States
Stephanie
The price is NZ$186
includes taxes & fees
28 June - 29 June
Drury Inn & Suites Poplar Bluff
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southeast Missouri Hotel Reviews

Frequently asked questions

What is there to do in Southeast Missouri near my adults-only hotel?
There are many things to see and do in Southeast Missouri. If you're heading to Cape Girardeau, swing by Isle Casino Cape Girardeau, Cape Rock Park and Fort D Historic Site. Planning to stay in Ste Genevieve? Sainte Genevieve Winery, Bolduc House Museum and Felix Valle House State Historic Site are top attractions here.
From what age can you stay in an adult-only hotel in Southeast Missouri?
Generally, it's 16  18 or 21. The adult-only resorts and hotels in Southeast Missouri can have different age requirements, so read the rules of the property you have your eye on before reserving your stay. Whether you're planning a romantic trip or a bachelorette party, Expedia's adult-only hotels have everything you need for a fun-filled grown-up getaway.
Are all adult-only resorts all-inclusive in Southeast Missouri?
If you just want to stay at a resort or hotel where most of what you need is covered by the room rate, use our handy "all-inclusive" filter. This will display the available adult-only all-inclusive properties in Southeast Missouri that normally include food, drinks and the room, a selection of on-site activities and entertainment. Click on the resort you have your eye on to find out what you get for your money.
When is the best time to stay at an adult-only all-inclusive resort in Southeast Missouri?
Almost any time is a good time to stay at an adult-only all-inclusive resort in Southeast Missouri, but there are a few factors worth considering. Start with the time of the year you'd like to travel. Peak season has its own special buzz, but there's a higher demand for both flights and accommodation. Low season is not as hectic and easier on the purse strings. Of course, the weather plays a big part in making or breaking your getaway, so do some research before locking in your adult-only resort or hotel.
Can I cancel or change my adult-only resort booking?
You can. And there may be no charge depending on the kind of adult-only resort or hotel booking you have. Check the details in your itinerary or go to Expedia's Trips portal for help. Haven't found your accommodation yet? You can look for Southeast Missouri adult-only hotels that allow full refunds — just in case. Reserve your getaway with the guarantee that wherever you stay, you'll always be A-OK!

Explore a world of travel with Expedia