Photo by Cindy Keese

Spa Hotels & Resorts in Seneca from NZ$129

Start date: Check-in selected.
To Date
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Seneca Spa Hotels

Tonight
2 Oct - 3 Oct
Tomorrow
3 Oct - 4 Oct
This weekend
3 Oct - 5 Oct
Next weekend
10 Oct - 12 Oct

Best Seneca Spa Hotels

Lakeside Lodge Clemson
Aerial view

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (1001)
"Very beautiful place to stay"
The price is NZ$233
includes taxes & fees
5 Oct - 6 Oct
Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson
Lobby

Tru by Hilton Seneca Clemson

2.5 star property
9.2 out of 10, Wonderful, (772)
"Very friendly and clean "
The price is NZ$207
includes taxes & fees
12 Oct - 13 Oct
Tru by Hilton Seneca Clemson
Quality Inn Seneca Clemson Area US-123
Free daily on-the-go breakfast

Quality Inn Seneca Clemson Area US-123

2.5 star property
8.0 out of 10, Very good, (645)
"Staff was friendly very clean "
The price is NZ$160
includes taxes & fees
12 Oct - 13 Oct
Quality Inn Seneca Clemson Area US-123
Days Inn by Wyndham Seneca / Clemson Area
Room, 1 King Bed, Non Smoking

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
6.8 out of 10, (701)
"Friendly staff easy check-in. "
The price is NZ$129
includes taxes & fees
5 Oct - 6 Oct
Days Inn by Wyndham Seneca / Clemson Area
Best Western Seneca-Clemson
Lobby

Best Western Seneca-Clemson

2.5 star property
8.4 out of 10, Very good, (620)
"Convenient for Clemson visits."
The price is NZ$169
includes taxes & fees
8 Oct - 9 Oct
Best Western Seneca-Clemson
Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock
Exterior

Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock

10.0 out of 10, Exceptional, (6)
Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
Exterior

5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

10.0 out of 10, Exceptional, (88)
"We had a perfect family vacation on the lake. The layout and design of the property is so thoughtful and well done. There was plenty of space for our large group to spread out, play, and relax. The kitchen is well appointed with everything you need entertain. We could not have had a better time. "
5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!
New to VRBO! Big water views, private dock, pool table, 15 min Clemson!
Terrace/patio

New to VRBO! Big water views, private dock, pool table, 15 min Clemson!

10.0 out of 10, Exceptional, (43)
"Went for Easter holiday with family. Perfect location - nice and quiet. Family all had a good visit. "
New to VRBO! Big water views, private dock, pool table, 15 min Clemson!
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub
Outdoor spa tub

Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

10.0 out of 10, Exceptional, (152)
"Great set up for family Christmas reunion "
Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub
Lakefront Cabin on Lake Keowee. Kayaks, paddle boards, modern & cozy!
Interior

Lakefront Cabin on Lake Keowee. Kayaks, paddle boards, modern & cozy!

10.0 out of 10, Exceptional, (12)
"We had a wonderful 3 night stay! "
The price is NZ$1,168
includes taxes & fees
5 Oct - 6 Oct
Lakefront Cabin on Lake Keowee. Kayaks, paddle boards, modern & cozy!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Seneca Hotel Reviews

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

10/10 Excellent
"Everything was good "
Holly 2-night trip
Posted 1 month ago
Hampton Inn & Suites Seneca-Clemson Area

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Looking for a spa hotel in Seneca?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Discover the lakeside setting in Seneca—worth a picture or two! Make sure you enjoy the coffee shops during your stay. Hotels with spas are the perfect way to take a break from your routine and add a layer of luxury to your weekend away.
What's there to see and do in Seneca?
Take in the sights and attractions that Seneca offers with a visit to Keowee Reservoir, Lake Keowee and Keowee Key Golf Course. If you have extra time while you're in the area, you might want to see Lake Hartwell and Oconee County Library Seneca Branch.
What is a Seneca spa hotel?
Spa hotels in Seneca provide lodging and have an on-site spa offering services such as therapies as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation and relaxation.