Santa Maria Hotels, Guayaquil

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Check prices for these dates

Tonight
16 Dec - 17 Dec
Tomorrow
17 Dec - 18 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

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Our top choices for Santa Maria hotels

2 bars/lounges, lobby lounge
Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana, 7.5 km from Santa Maria
9.2 out of 10, Wonderful, (1002)
"The hotel and service were great!"
United States
Rolando
The price is NZ$213
16 Jan - 17 Jan 2026
Wyndham Guayaquil Puerto Santa Ana
Food and drink
Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 7.5 km from Santa Maria
8.6 out of 10, Excellent, (134)
"Was good "
United States
Jephson G
Hotel Patrimonial by Greenfield
Economy Double Room
Malecon Guesthouse

Malecon Guesthouse

Malecon Guesthouse
3.0 star property
7.9 km from Santa Maria
The price is NZ$43
2 Jan - 3 Jan 2026
Malecon Guesthouse
Free daily buffet breakfast
Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels
4.0 star property
Rocafuerte, 8 km from Santa Maria
9.2 out of 10, Wonderful, (1003)
"Very good staff, every one was very nice and the room very clean and very convenient to travel everywhere."
United States
Leticia
The price is NZ$134
16 Jan - 17 Jan 2026
Unipark by Oro Verde Hotels
Outdoor pool, open 8:00 AM to 9:00 PM, pool loungers
Grand Hotel Guayaquil, an Ascend Collection Hotel

Grand Hotel Guayaquil, an Ascend Collection Hotel

Grand Hotel Guayaquil, an Ascend Collection Hotel
4.0 star property
Rocafuerte, 7.9 km from Santa Maria
9.2 out of 10, Wonderful, (989)
"Great place to Stay.!"
United States
Erwin
The price is NZ$164
20 Dec - 21 Dec
Grand Hotel Guayaquil, an Ascend Collection Hotel
Lobby lounge
Mansión del Río

Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 7.8 km from Santa Maria
8.8 out of 10, Excellent, (134)
"Breakfast was good. I enjoyed my scrambled eggs and toast "
United States
Caitlin
The price is NZ$114
17 Dec - 18 Dec
Mansión del Río
Terrace/patio
Harmonie

Harmonie

Harmonie
2.0 star property
Simón Bolívar, 4.8 km from Santa Maria
9.0 out of 10, Wonderful, (80)
"Great staff very friendly Good spot"
Canada
Chelsea
The price is NZ$52
2 Jan - 3 Jan 2026
Harmonie
Property entrance
DC Suites Aeropuerto

DC Suites Aeropuerto

DC Suites Aeropuerto
3.0 star property
Simón Bolívar, 5.2 km from Santa Maria
9.0 out of 10, Wonderful, (580)
"Great location and clean hotel"
United States
Elvin
DC Suites Aeropuerto
Restaurant
Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 7.9 km from Santa Maria
10.0 out of 10, Exceptional, (2)
"The staff was very friendly and helpful. The hotel is new and modern, it is a good place to relax and work. "
United States
Richard
The price is NZ$500
17 Dec - 18 Dec
Hotel Río Guayas by Art Hotels Ecuador
Outdoor spa tub
Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE
3.5 star property
Puerto Santa Ana, 7.5 km from Santa Maria
9.4 out of 10, Exceptional, (100)
"The apartment was in a great location and very clean and well maintained."
United States
Rolando
The price is NZ$193
26 Dec - 27 Dec
Luxury Suites Riverfront GYE
Reception
TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport
4.5 star property
Simón Bolívar, 4.9 km from Santa Maria
9.0 out of 10, Wonderful, (1000)
"💯"
United States
Sreenidhi
The price is NZ$185
21 Dec - 22 Dec
TRYP by Wyndham Guayaquil Airport
Property grounds
Hostal Macaw

Hostal Macaw

Hostal Macaw
3.0 star property
Kennedy, 4.6 km from Santa Maria
10.0 out of 10, Exceptional, (9)
"Wonderful hosts and felt like home "
United States
Tina
The price is NZ$122
2 Jan - 3 Jan 2026
Hostal Macaw
Lobby
Hilton Colon Guayaquil

Hilton Colon Guayaquil

Hilton Colon Guayaquil
4.5 star property
Kennedy, 4.2 km from Santa Maria
8.6 out of 10, Excellent, (816)
"Great room"
United States
Trevor
The price is NZ$184
27 Dec - 28 Dec
Hilton Colon Guayaquil
Children’s activities
Oro Verde Guayaquil

Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 6.9 km from Santa Maria
9.4 out of 10, Exceptional, (1006)
"Staff, room cleanliness, bkfast and of course, the renovations look wonderful! "
United States
Iam
The price is NZ$166
21 Dec - 22 Dec
Oro Verde Guayaquil
Reception
Hostal California Inn

Hostal California Inn

Hostal California Inn
3.0 star property
7.4 km from Santa Maria
8.6 out of 10, Excellent, (8)
"Me encantó, es muy cómoda, la habitación super amplia y limpia Si duda volveré "
Mexico
Anita
Hostal California Inn
Front of property
Hotel The Royalty Inn

Hotel The Royalty Inn

Hotel The Royalty Inn
4.0 star property
Simón Bolívar, 5.1 km from Santa Maria
8.6 out of 10, Excellent, (10)
"Good for a single night stay , close to the airport and mall "
United States
Jonathan
Hotel The Royalty Inn
Terrace/patio
Hotel del Parque

Hotel del Parque

Hotel del Parque
4.5 star property
7 km from Santa Maria
9.8 out of 10, Exceptional, (108)
"I love"
United States
Maria
The price is NZ$855
4 Jan - 5 Jan 2026
Hotel del Parque
Executive Suite, Kitchenette, City View | Private kitchen
Suitesecu Rentals Guayaquil

Suitesecu Rentals Guayaquil

Suitesecu Rentals Guayaquil
4.5 star property
Simón Bolívar, 4.9 km from Santa Maria
9.4 out of 10, Exceptional, (8)
"You can walk to the airport."
United States
Digna
The price is NZ$57
22 Dec - 23 Dec
Suitesecu Rentals Guayaquil
Indoor pool, open 8:00 AM to 10 PM, pool loungers
Hotel Ramada

Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 7.9 km from Santa Maria
8.0 out of 10, Very good, (382)
"Great customer service, very kind staff, amazing location"
Canada
Maria Lorena
Hotel Ramada
Outdoor pool
River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana, 7.6 km from Santa Maria
8.6 out of 10, Excellent, (42)
"The staff were soo nice with me and my family !! I really enjoy my stay :)"
United States
Maria
The price is NZ$114
29 Dec - 30 Dec
River View suites Puerto Santa Ana gye
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our guide on where to stay in Santa Maria

Find the best Santa Maria areas for the activities you enjoy most.

Ecuador

Ecuador might not have many top sights, but C.C. Riocentro Sur and Mall del Sur are two attractions nearby that you can check out.

Downtown Guayaquil

Travellers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like San Francisco Square and Central Market while you're in town.

Puerto Santa Ana

Restaurants and river views are some things travellers note about Puerto Santa Ana. Check out Santa Ana Hill or Botanical Garden while you're familiarising yourself with the larger area.

Urdesa

Urdesa is well liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to World Trade Center or San Marino Mall.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

Top Santa Maria Hotel Reviews

DC Suites Aeropuerto

DC Suites Aeropuerto

10/10 Excellent
"Everything "
Marco 2-night trip
Posted 2 days ago
DC Suites Aeropuerto

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Frequently asked questions

What is Santa Maria like?
Travellers are sure to enjoy a stay in Guayaquil's Santa Maria neighbourhood.
If I need to cancel my hotel reservation in Santa Maria, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to view the best deals in Santa Maria.
What can I see and do in this Guayaquil neighbourhood?
Salón de Eventos Rubi, City Mall and Guayaquil Parrot are just a few of the places to visit in and around Santa Maria. La Rotonda Shopping Center and Santa Ana Port are also worth a visit when you're out sightseeing in Guayaquil.