Photo by Isa

Santa Ana Hotels, Panama City

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
11 Nov - 12 Nov
Tomorrow
12 Nov - 13 Nov
This weekend
14 Nov - 16 Nov
Next weekend
21 Nov - 23 Nov

Filter by

Guest rating
Guest rating
Star rating

1368 Cheap Hotels in Santa Ana - Specials, Reviews, & Last Minute Deals

Luxury Apartment | Balcony
Casco View Apartments

Casco View Apartments

3.5 star property
Santa Ana
9.2 out of 10, Wonderful, (50)
"Room was clean large and great to have kitchen and laundry in the unit. The pool is small and not really a lounging area. Overall it was super loud, dogs barking, alarms going off and immediate area a little sketch "
United States
Christine
Casco View Apartments
Balcony
Hotel República

Hotel República

2.0 star property
Santa Ana
6.6 out of 10, (180)
"Good value. "
United States
Matthew
Hotel República
Front of property
ART CASCO The Hotel

ART CASCO The Hotel

2.0 star property
Santa Ana
6.4 out of 10, (9)
"Highly recommend "
United States
Treveon
ART CASCO The Hotel
Bar (on property)
Hostal La Cigarra

Hostal La Cigarra

2.0 star property
Santa Ana
7.6 out of 10, Good, (54)
"Great location to walk around the casco! Street parking available for free! Prices are really affordable! Staff was really helpful "
United States
Eldris
The price is NZ$43
includes taxes & fees
12 Nov - 13 Nov
Hostal La Cigarra
Apartment (20)
La Manzana by Wynwood House

La Manzana by Wynwood House

3.0 star property
Santa Ana
7.2 out of 10, Good, (15)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is NZ$141
includes taxes & fees
12 Nov - 13 Nov
La Manzana by Wynwood House
Room, Multiple Bedrooms, Accessible, Smoking | Pool
Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A

2.0 star property
Santa Ana
2.0 out of 10, (1)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is NZ$285
includes taxes & fees
20 Nov - 21 Nov
Room-sofa Bed Stay Rooftop Pool & Gym, A
Outdoor pool, pool umbrellas, pool loungers
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4.0 star property
21.1 km from Santa Ana
8.4 out of 10, Very good, (2263)
"Great location near airport updated hotel "
Canada
Joe
The price is NZ$239
includes taxes & fees
28 Nov - 29 Nov
Crowne Plaza Panama Airport by IHG
47-inch flat-screen TV with cable channels, TV
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4.0 star property
San Felipe, 0.9 km from Santa Ana
9.0 out of 10, Wonderful, (1003)
"This Hotel is amazing! From the greetings at check in to the good bye at check out the staff were very attentive and amazing. The hotel has 4 restaurants each one with a different theme and food selection; we tried all and the food, prices, and staff were beyond of amazing. Hotel is in the center of Casco Viejo, very close to all attractions. Thank you the staff and I will definitely will recommend."
United States
Joel
The price is NZ$437
includes taxes & fees
17 Nov - 18 Nov
Central Hotel Panama Casco Viejo
Living area
ORHO HOTEL BOUTIQUE PANAMA Airport

ORHO HOTEL BOUTIQUE PANAMA Airport

2.0 star property
20.5 km from Santa Ana
9.0 out of 10, Wonderful, (25)
"Everything was EXCELLENT from the initial communication right after I made my reservation at the airport. Transportation from and to the airport and warm reception at the beautiful hotel. The beautiful, clean and very comfortable room. You can't ask for more. When I revisit Panamá I will definitely be staying here."
United States
Orlando
The price is NZ$234
includes taxes & fees
12 Nov - 13 Nov
ORHO HOTEL BOUTIQUE PANAMA Airport
Front of property
La Concordia Boutique Hotel

La Concordia Boutique Hotel

4.0 star property
San Felipe, 0.5 km from Santa Ana
9.4 out of 10, Exceptional, (190)
"Clean, safety, nice staff, decoration and quite building "
United States
Claudia
The price is NZ$427
includes taxes & fees
16 Nov - 17 Nov
La Concordia Boutique Hotel
Reception
Hotel Coral Suites

Hotel Coral Suites

3.5 star property
El Cangrejo, 3.7 km from Santa Ana
9.0 out of 10, Wonderful, (1002)
"Great place for the price. "
United States
Ryan
The price is NZ$135
includes taxes & fees
12 Nov - 13 Nov
Hotel Coral Suites
Outdoor spa tub
TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro

3.5 star property
El Cangrejo, 3.5 km from Santa Ana
9.2 out of 10, Wonderful, (1002)
"Staff was helpful, room was clean and I enjoyed my stay. "
United States
Lystra
The price is NZ$153
includes taxes & fees
12 Nov - 13 Nov
TRYP by Wyndham Panamá Centro
Outdoor pool, open 9:00 AM to 9:00 PM, pool loungers
Hospedium Princess Hotel Panama

Hospedium Princess Hotel Panama

3.5 star property
Obarrio, 3.6 km from Santa Ana
7.6 out of 10, Good, (666)
"The breakfast was great, I love the pool."
United States
Estefani
The price is NZ$101
includes taxes & fees
12 Nov - 13 Nov
Hospedium Princess Hotel Panama
View from property
Waldorf Astoria Panama

Waldorf Astoria Panama

5.0 star property
Bella Vista, 2.9 km from Santa Ana
9.0 out of 10, Wonderful, (1002)
"Very beautiful room was spotless, and staff was very good with customer service"
United States
Anthony
The price is NZ$335
includes taxes & fees
6 Dec - 7 Dec
Waldorf Astoria Panama
Outdoor pool, pool loungers
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (4491)
"Lovely breakfast and area"
United States
ASANTEE-WAA
The price is NZ$231
includes taxes & fees
17 Nov - 18 Nov
Hotel Riu Plaza Panama
Front of property – evening/night
Principe Hotel and Suites

Principe Hotel and Suites

3.0 star property
El Cangrejo, 3.9 km from Santa Ana
9.0 out of 10, Wonderful, (1557)
"Clean from affordable pleasant staff was very nice stay "
United States
Iris
The price is NZ$97
includes taxes & fees
29 Nov - 30 Nov
Principe Hotel and Suites
View from property
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 star property
Punta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2126)
"Very nice hotel, all amenities met our needs. "
Canada
gordon
The price is NZ$308
includes taxes & fees
12 Nov - 13 Nov
Plaza Paitilla Inn Hotel
Front of property
Novotel Panama City

Novotel Panama City

4.0 star property
El Cangrejo, 4.3 km from Santa Ana
9.2 out of 10, Wonderful, (1003)
"Room very clean, nice staffs and good location "
United States
Hayden
The price is NZ$179
includes taxes & fees
8 Dec - 9 Dec
Novotel Panama City
Suite, 1 Bedroom, Non Smoking, Golf View (Terrace)
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5.0 star property
Juan Diaz, 12.7 km from Santa Ana
9.6 out of 10, Exceptional, (624)
"great service"
United States
Gianluca
The price is NZ$365
includes taxes & fees
6 Dec - 7 Dec
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Aerial view
Gamboa Rainforest Reserve

Gamboa Rainforest Reserve

3.5 star property
24.7 km from Santa Ana
7.8 out of 10, Good, (654)
"Great customer service. Food delicious"
United States
Stephanie Lezcano
The price is NZ$208
includes taxes & fees
27 Nov - 28 Nov
Gamboa Rainforest Reserve
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Our guide on where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

San Felipe

While visiting San Felipe, you might make a stop by sights like Interoceanic Canal Museum and National Theater.

Top Santa Ana Hotel Reviews

W Panama

W Panama

10/10 Excellent
"Clean hotel "
Karisse Letoya Onica 7-night trip
Posted 3 days ago
W Panama

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Cinta Costera and Avenida Balboa while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Based on Expedia customer reviews, Hotel República is the highest ranked property in Santa Ana. This hotel is a short 4-minute walk from Avenida Balboa, and it offers a rooftop terrace and free WiFi. Another top choice in the area is Hostal La Cigarra.
How many hotels can I expect to find in Santa Ana?
Expedia has 96 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighbourhood. Albrook Shopping Mall, Amador Theater and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.