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Top hotels and accommodation in East Prairie

1 bedroom, desk, laptop workspace, blackout curtains
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2.0 star property
Sikeston
7.2 out of 10, Good, (1003)
"Clean and comfortable "
United States
Jim
The price is NZ$127
includes taxes & fees
10 Nov - 11 Nov
Days Inn and Suites by Wyndham Sikeston
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 star property
Sikeston
9.0 out of 10, Wonderful, (419)
"Nice property and friendly staff."
United States
Nancy
The price is NZ$191
includes taxes & fees
16 Nov - 17 Nov
Hampton Inn Sikeston
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 star property
Sikeston
8.6 out of 10, Excellent, (436)
"staff was friendly nothing to crazy about this hotel "
United States
Isaac
The price is NZ$203
includes taxes & fees
14 Nov - 15 Nov
Holiday Inn Express & Suites Sikeston Southwest by IHG
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 star property
Sikeston
8.4 out of 10, Very good, (1019)
"Very convenient and great breakfast "
United States
Duwaine
The price is NZ$170
includes taxes & fees
16 Nov - 17 Nov
Best Western Plus Sikeston
Exterior
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
Sikeston
8.4 out of 10, Very good, (703)
"Very quiet and comfortable "
United States
Lana
The price is NZ$115
includes taxes & fees
12 Nov - 13 Nov
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Lobby
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

2.5 star property
Union City
9.0 out of 10, Wonderful, (297)
"Awesome room wonderful breakfast great staff"
United States
Thomas
The price is NZ$171
includes taxes & fees
16 Nov - 17 Nov
Sleep Inn at Discovery Park of America
Front of property – evening/night
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
Charleston
6.6 out of 10, (603)
"Staff was great! Room was nice. "
United States
Lana
The price is NZ$109
includes taxes & fees
11 Nov - 12 Nov
Super 8 by Wyndham Charleston/Sikeston East MO
Room, 1 King Bed, Accessible, Non Smoking
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2.0 star property
Sikeston
6.6 out of 10, (558)
"Staff is always so nice and rooms are always clean. I have stayed here several times over the years and always come back to it when traveling through. "
United States
Laura
The price is NZ$127
includes taxes & fees
16 Nov - 17 Nov
Super 8 by Wyndham Sikeston/Miner Area
Lobby
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1002)
"Friendly staff and clean rooms "
United States
LENA M
The price is NZ$157
includes taxes & fees
15 Nov - 16 Nov
Pear Tree Inn Sikeston
Exterior
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

2.5 star property
Sikeston
8.4 out of 10, Very good, (275)
"It was a very nice stay. The pool was clean and enjoying!"
United States
Lisa
The price is NZ$170
includes taxes & fees
7 Dec - 8 Dec
Comfort Inn & Suites Sikeston I-55
Seasonal outdoor pool
Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51

2.5 star property
Union City
6.8 out of 10, (353)
"I found the staff to be great. My room was large, clean and in good repair. Parking plentiful. I will definitely stay here again when in the area."
United States
Donna
The price is NZ$115
includes taxes & fees
6 Dec - 7 Dec
Hospitality House Union City I 69 / US 51
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1002)
"Clean room, great location and friendly staff"
United States
Mark
The price is NZ$192
includes taxes & fees
18 Nov - 19 Nov
Drury Inn & Suites Sikeston, MO
Lobby
Quality Inn Union City US 51

Quality Inn Union City US 51

2.5 star property
Union City
8.4 out of 10, Very good, (479)
"Very nice staff"
United States
Jonathan
The price is NZ$142
includes taxes & fees
30 Nov - 1 Dec
Quality Inn Union City US 51
Bar (on property)
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

2.5 star property
Sikeston
9.2 out of 10, Wonderful, (29)
"Very clean and comfortable room. "
United States
Roxanne
The price is NZ$203
includes taxes & fees
16 Nov - 17 Nov
Fairfield Inn & Suites by Marriott Sikeston
Reception
Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City

2.5 star property
Union City
8.6 out of 10, Excellent, (543)
"Clean rooms, helpful and polite staff"
United States
Jennifer
The price is NZ$152
includes taxes & fees
9 Nov - 10 Nov
Country Hearth Inn & Suites Union City
Lobby
Quality Inn Cairo I-57

Quality Inn Cairo I-57

2.5 star property
Cairo
6.6 out of 10, (271)
"We had a quiet and convenient one night stay. "
United States
Cindy
The price is NZ$136
includes taxes & fees
16 Nov - 17 Nov
Quality Inn Cairo I-57
Terrace/patio
Hampton Inn Union City

Hampton Inn Union City

2.5 star property
Union City
9.4 out of 10, Exceptional, (158)
"It was peaceful and quiet"
United States
Erin
The price is NZ$211
includes taxes & fees
16 Nov - 17 Nov
Hampton Inn Union City
Gazebo
Travel Inn

Travel Inn

2.5 star property
Marston
5.8 out of 10, (114)
"Had a great time loved it "
United States
Shyianne
Travel Inn
Bar (on property)
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

3.0 star property
Sikeston
8.4 out of 10, Very good, (5)
"I loved all of what this property had to offer "
United States
Christian
The price is NZ$243
includes taxes & fees
16 Nov - 17 Nov
TownePlace Suites by Marriott Sikeston
Premier Room, 1 Bedroom, Non Smoking
New Orleans Inn Portageville

New Orleans Inn Portageville

2.5 star property
Portageville
8.0 out of 10, Very good, (716)
"Very friendly staff "
United States
Rachel
New Orleans Inn Portageville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

3.8/5 (8 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
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Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Clean room, great location and friendly staff"
Mark 1-night trip
Posted 5 days ago
Drury Inn & Suites Sikeston, MO

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Hampton Inn Sikeston and Sleep Inn at Discovery Park of America. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best holiday rentals that East Prairie has to offer?
Duck Hunting, Fishing or Relaxing Family Vacation: This holiday home rental outside of East Prairie is located on a lake, and has a patio, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 31 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Central Park and New Madrid Historical Museum in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

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