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Check prices for these dates

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28 Mar - 29 Mar
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29 Mar - 30 Mar
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3 Apr - 5 Apr
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10 Apr - 12 Apr

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Our top choices for East Prairie hotels

Exterior

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (515 reviews)
"Very nice property. Staff friendly, check in easy, room clean well appointed. Price was very reasonable."
United States
Steve
The price is NZ$201
includes taxes & fees
11 Apr - 12 Apr
Hampton Inn Sikeston
Lobby

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (368 reviews)
"Great stay. "
United States
Paul
The price is NZ$164
includes taxes & fees
19 Apr - 20 Apr
Sleep Inn at Discovery Park of America
Indoor pool, outdoor pool

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1,001 reviews)
"Bedding needs to be updated. Pillows smelled and carpet could be cleaned. Bathroom was clean. Staff was friendly and helpful. "
United States
Belinda
The price is NZ$206
includes taxes & fees
3 Apr - 4 Apr
Drury Inn & Suites Sikeston, MO
Free daily continental breakfast

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (451 reviews)
"Clean rooms, friendly staff and convenient location."
United States
Mark
The price is NZ$183
includes taxes & fees
12 Apr - 13 Apr
Holiday Inn Express & Suites Sikeston Southwest by IHG
Room, 1 Queen Bed, Non Smoking

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.2 out of 10, Very good, (53 reviews)
"The property is beautiful! The rooms are terrific! Staff is amazing! Totally recommend!! "
United States
Sue
The price is NZ$128
includes taxes & fees
9 Apr - 10 Apr
Super 8 By Wyndham Marston
Lobby sitting area

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (410 reviews)
"Clean "
United States
Chris
The price is NZ$111
includes taxes & fees
29 Mar - 30 Mar
The Riverstone Hotel Charleston-Sikeston
Free buffet breakfast

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very good, (500 reviews)
"Overall, a decent stay. No fancy bells or whistles, exactly what was advertised and delivered. Only issue of note was that the room smelled of body odder when we stayed. "
United States
John
The price is NZ$141
includes taxes & fees
19 Apr - 20 Apr
Quality Inn Union City US 51
Free daily full breakfast

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,000 reviews)
"nice and covenant have stay here a few times, staff always has a smile. "
United States
Roger
The price is NZ$184
includes taxes & fees
2 Apr - 3 Apr
Best Western Plus Sikeston I-55
Lobby

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (557 reviews)
"Very clean nice staff and well run "
United States
zach
The price is NZ$130
includes taxes & fees
30 Mar - 31 Mar
Country Hearth Inn & Suites Union City
Laptop workspace, blackout curtains, free cots/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (627 reviews)
"Affordable for a quick one night stay. Restaurant and gas station next to hotel."
United States
Annette
The price is NZ$120
includes taxes & fees
31 Mar - 1 Apr
Super 8 by Wyndham Charleston/Sikeston East MO
Individually decorated, individually furnished, desk, blackout curtains

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (754 reviews)
"Very nice place, very nice stay! They were out of cream cheese for the bagels at breakfast though.:-)"
United States
Mark
The price is NZ$130
includes taxes & fees
2 Apr - 3 Apr
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Property amenity

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (65 reviews)
"Nice quiet hotel "
United States
Steven
The price is NZ$199
includes taxes & fees
4 Apr - 5 Apr
Fairfield Inn & Suites by Marriott Sikeston
1 bedroom, desk, laptop workspace, blackout curtains

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,000 reviews)
"Business friendly, clean room staff very friendly, accommodating."
United States
Janice
The price is NZ$134
includes taxes & fees
5 Apr - 6 Apr
Days Inn and Suites by Wyndham Sikeston
Premier Room, 1 Bedroom, Non Smoking

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (754 reviews)
"The staff was great very helpful and friendly "
United States
Javier
The price is NZ$95
includes taxes & fees
29 Mar - 30 Mar
New Orleans Inn Portageville
Exterior

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (317 reviews)
"The room was spacious & clean. The complimentary breakfast was nice. Very quiet place and next to a unique tourist attraction."
United States
Angela
The price is NZ$227
includes taxes & fees
12 Apr - 13 Apr
Holiday Inn Express & Suites Union City by IHG
Lobby

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (282 reviews)
"Amenities, microwave, refrigerator,iron and iron board,Shower soap options "
United States
Maurice
The price is NZ$154
includes taxes & fees
29 Mar - 30 Mar
Quality Inn Cairo I-57
Lobby

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (388 reviews)
"Easy to check in.. Clean Room..Lots of food options near by.. "
United States
Pooran
The price is NZ$125
includes taxes & fees
30 Mar - 31 Mar
Hospitality House Union City I 69 / US 51
Standard Room, 2 Double Beds, Non Smoking

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (476 reviews)
"Ok one night stay."
United States
David
The price is NZ$139
includes taxes & fees
31 Mar - 1 Apr
Reelfoot Lake Inn
Desk, free WiFi, bed sheets, alarm clocks

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (290 reviews)
"nice room, clean. breakfast was great and lady keeping it full, hot, and clean!"
United States
Fred
The price is NZ$184
includes taxes & fees
26 Apr - 27 Apr
Comfort Inn & Suites Sikeston I-55
Room, 1 King Bed, Accessible, Non Smoking

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (603 reviews)
"The room was spotless, the staff was very good and helpful. I loved my stay. I recommend Drury Inn to all my family and friends. "
United States
Kandy
The price is NZ$125
includes taxes & fees
9 Apr - 10 Apr
Super 8 by Wyndham Sikeston/Miner Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

3.8/5 (8 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
The Mississippi River near Hannibal, Missouri, USA

Top East Prairie Hotel Reviews

Reelfoot Lake Inn

Reelfoot Lake Inn

10/10 Excellent
"The view of the lake is beautiful. It's right across the road. The manager and staff were very kind and set me up in the kind of room I requested. It had a microwave, refrigerator and coffee pot with the coffee. The bed was very comfortable and the air worked great. I would stay there again. "
Tina 4-night trip
Posted 12 hours ago
Reelfoot Lake Inn

More cheap accommodation in East Prairie

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO
The price is NZ$130 per night from 2 Apr to 3 Apr
NZ$130
2 Apr - 3 Apr
includes taxes & fees
8.4/10 Very Good! (754 reviews)

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Hampton Inn Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best holiday rentals that East Prairie has to offer?
Duck Hunting, Fishing or Relaxing Family Vacation: This holiday home rental outside of East Prairie is located on a lake, and has a patio, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 32 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Central Park and Sikeston Depot Museum in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

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