East Prairie Hotel & Accommodation Deals 2026 from NZ$104 - Fully Refundable Options

Our top choices for East Prairie hotels

Breakfast included

1. Drury Inn & Suites Sikeston, MO

Sikeston

Sally

includes taxes & fees

16 Aug - 17 Aug

2. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

theresa

includes taxes & fees

23 Aug - 24 Aug

3. Best Western Plus Sikeston I-55

Sikeston

Carl

includes taxes & fees

9 Aug - 10 Aug

4. Hampton Inn Sikeston

Sikeston

Brandi

includes taxes & fees

16 Aug - 17 Aug

5. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Dwain

includes taxes & fees

9 Aug - 10 Aug

6. The Riverstone Hotel Charleston-Sikeston

Charleston

Emily

includes taxes & fees

27 July - 28 July

Laptop workspace, blackout curtains, free cots/infant beds, free WiFi

7. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

Karl

includes taxes & fees

2 Aug - 3 Aug

8. Comfort Inn & Suites Sikeston I-55

Sikeston

Starlette

includes taxes & fees

21 Aug - 22 Aug

Desk, blackout curtains, iron/ironing board (on request), free WiFi

9. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Sharika West

includes taxes & fees

30 July - 31 July

10. TownePlace Suites by Marriott Sikeston

Sikeston

Jason

includes taxes & fees

16 Aug - 17 Aug

1 bedroom, desk, laptop workspace, blackout curtains

11. Days Inn and Suites by Wyndham Sikeston

Sikeston

"The hotel looked very good from the outside. And when you first went into the lobby was very nice. But the rooms were very basic. They was absolutely no pictures hung from the walls. The kitchen area just had a small refrigerator and a microwave setting on top of it. I had to ask for a coffee maker, and it was a single cup coffee maker. The free breakfast was very minimal. But at least everything was clean."

Robert S

includes taxes & fees

18 Aug - 19 Aug

Iron/ironing board (on request), free WiFi, bed sheets

12. Country Yard Inn and Suite

Sikeston

Sheryl

includes taxes & fees

29 July - 30 July

Room, 1 King Bed, Non Smoking | View from room

13. Eagle Inn Charleston

Charleston

Jackson

includes taxes & fees

1 Aug - 2 Aug

14. Super 8 By Wyndham Marston

Marston

Temera

includes taxes & fees

26 July - 27 July

15. Quality Inn Cairo I-57

Cairo

Susan

includes taxes & fees

14 Aug - 15 Aug

16. Sleep Inn at Discovery Park of America

Union City

David

includes taxes & fees

24 Aug - 25 Aug

Room, 1 King Bed, Accessible, Non Smoking

17. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

James

includes taxes & fees

26 July - 27 July

18. Country Hearth Inn & Suites Union City

Union City

Jade

includes taxes & fees

1 Aug - 2 Aug

19. Travel Inn Marston I-55 by Hotel O

Marston

Bosup

includes taxes & fees

26 July - 27 July

20. New Orleans Inn Portageville

Portageville

Rachel

includes taxes & fees

2 Aug - 3 Aug

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Sign in

Sign up, it's free

Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.

See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie

A tree-lined landscape with a river and fields.

Top East Prairie Hotel Reviews

Recent Reviews in East Prairie

Sleep Inn at Discovery Park of America

10/10 Excellent

"Everything thing was perfect! I would highly recommend this property!"

Super 8 by Wyndham Charleston/Sikeston East MO

8/10 Good

"For the price, the room was acceptable. There had been some attempts to update the rooms. There was no carpet in the room we were in. The bed was hard and on a squeaky platform. The air-conditioning was set to 78 when we arrived at 11pm so it was warm in the room as we were trying to go to sleep. We left early in the morning so we did not check out the breakfast. My main complaint would be the person who checked us in was on her cell phone the whole time and nearly checked me in under someone else's reservation."

Hampton Inn Sikeston

8/10 Good

"Fast checking in and out. Very friendly staff and abundant complimentary breakfast. Spacious room and we liked having a walk in shower. There was plenty of green space to walk our small dog. The only complaint we had is that when we sat on the sofa, the cushion covers came off. They did not zip securely over the cushion anymore."

More cheap accommodation in East Prairie

New Orleans Inn Portageville

600 US-61 Portageville MO

NZ$104

2 Aug - 3 Aug

includes taxes & fees

8/10 Very good! (792 reviews)

Frequently asked questions

What is the best area to stay in East Prairie?

The best area to stay in East Prairie is near Main Street, particularly around the intersection with Washington Street.

This central part of East Prairie offers the most convenience for visitors. It's where you'll find the majority of local businesses, including eateries and shops. The area is quite walkable, allowing you to easily explore the town's core.

For travellers looking for a straightforward and practical base, staying near Main Street is ideal.

When is the best time to go to East Prairie?

The best time to visit East Prairie, Missouri, is typically during the spring (April to May) and autumn (September to October) months.

These seasons offer the most pleasant weather, with mild temperatures and less humidity, making it ideal for exploring the town and its surrounding natural areas. Spring brings blooming flowers and lush greenery, while autumn showcases beautiful fall foliage, particularly along the nearby Mississippi River.

For those interested in local festivities, visiting in September allows you to experience the annual Sweet Corn Festival, a significant event for the town.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, although it depends on the cancellation policy of your booking. Most bookings are refundable if cancelled within 24 to 48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to 'My Trips' and selecting your reservation. To find flexible deals, filter your search by 'Fully refundable property' for hotels in East Prairie.

How can I save on a hotel booking in East Prairie with Expedia?

One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on East Prairie hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

How much is the nightly rate for a hotel in East Prairie?

Prices for hotels in East Prairie often vary, but you can find a great deal from NZ$104 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by 'Price: low to high' for our cheapest rates.

Explore a world of travel with Expedia

Book Hotels in East Prairie on Expedia.com

Search East Prairie hotels

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in East Prairie

Check prices for these dates

Filter by

Our top choices for East Prairie hotels

1. Drury Inn & Suites Sikeston, MO

2. Holiday Inn Express & Suites Sikeston Southwest by IHG

3. Best Western Plus Sikeston I-55

4. Hampton Inn Sikeston

5. Fairfield Inn & Suites by Marriott Sikeston

6. The Riverstone Hotel Charleston-Sikeston

7. Super 8 by Wyndham Charleston/Sikeston East MO

8. Comfort Inn & Suites Sikeston I-55

9. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10. TownePlace Suites by Marriott Sikeston

11. Days Inn and Suites by Wyndham Sikeston

12. Country Yard Inn and Suite

13. Eagle Inn Charleston

14. Super 8 By Wyndham Marston

15. Quality Inn Cairo I-57

16. Sleep Inn at Discovery Park of America

17. Super 8 by Wyndham Sikeston/Miner Area

18. Country Hearth Inn & Suites Union City

19. Travel Inn Marston I-55 by Hotel O

20. New Orleans Inn Portageville

Stay near popular East Prairie attractions

Big Oak Tree State Park

Learn more about East Prairie

Top East Prairie Hotel Reviews

Recent Reviews in East Prairie

Sleep Inn at Discovery Park of America

More cheap accommodation in East Prairie

New Orleans Inn Portageville

Frequently asked questions

Explore a world of travel with Expedia

Go further with the Expedia app