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Our top choices for East Prairie hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
Located just off the highway near Sikeston dining and shopping, this hotel offers both indoor and outdoor pools for year-round swimming. Guests praise the peaceful atmosphere, helpful staff, and complimentary breakfast, parking, and WiFi.

"This our favorite place to stop for a good night sleep. "
United States
Eileen
The price is NZ$177
includes taxes & fees
29 Dec - 30 Dec
Drury Inn & Suites Sikeston, MO

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very good, (1009)
Located in Sikeston, this hotel offers an indoor pool for relaxing swims after a day of exploring. Near Central Park and the Sikeston Depot Museum, guests praise the delicious free breakfast and attentive service.

"Great stay, everything was clean and comfortable. "
United States
Charles
The price is NZ$148
includes taxes & fees
28 Dec - 29 Dec
Best Western Plus Sikeston

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (722)
Enjoy tranquil accommodation at this welcoming Sikeston hotel where helpful staff receive consistent praise. Located near Central Park and Sikeston Depot Museum, guests appreciate the quiet atmosphere, clean rooms, and daily continental breakfast.

"Room was good as usual. This is 4th stay over past 5 years. Only issue I had on this stay was the orange juice from breakfast options. "
United States
Todd
The price is NZ$108
includes taxes & fees
25 Dec - 26 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (310)
Experience comfort in the entertainment district of Union City at this welcoming hotel. Start your day with free breakfast before exploring nearby Discovery Park of America. After sightseeing, unwind in the indoor pool or maintain your routine at the 24-hour fitness centre.

"Rooms were spotless and comfortable. The bathroom had all the amenities. Great view. Awesome buffet breakfast to wake up to. "
United States
Rickey Smith
The price is NZ$193
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express & Suites Union City by IHG

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (320)
Located in Union City, this hotel offers convenient access to Discovery Park of America. Enjoy free breakfast, WiFi, and parking. Jump into the indoor pool or get active in the 24-hour fitness centre, making your Tennessee adventure complete.

"Wonderful breakfast, awesome room"
United States
Kimberly
The price is NZ$164
includes taxes & fees
2 Jan - 3 Jan 2026
Sleep Inn at Discovery Park of America

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
Escape to this serene retreat with both indoor and outdoor pools for year-round enjoyment. The fitness centre keeps your routine intact while complimentary breakfast energises your day exploring nearby Central Park and Sikeston Depot Museum.

"Everything was clean, staff was friendly "
United States
Matthew
The price is NZ$148
includes taxes & fees
29 Dec - 30 Dec
Pear Tree Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (450)
Take a refreshing dip in the indoor pool or maintain your routine at the fitness centre. Free breakfast, WiFi, and parking enhance your stay. Central Park and Sikeston Depot Museum are just moments away from this welcoming retreat.

"clean room, comfy bedding, nice staff, convenient location "
United States
Alexa
The price is NZ$189
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn Sikeston

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (548)
Discover convenience at this friendly Union City motel, where free breakfast and parking enhance every stay. Explore County Market Place and Reelfoot Shopping Centre nearby. Guests consistently praise the clean rooms and helpful staff.

"Clean rooms, helpful and polite staff"
United States
Jennifer
The price is NZ$146
includes taxes & fees
25 Dec - 26 Dec
Country Hearth Inn & Suites Union City

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (613)
This Charleston motel offers complimentary on-the-go breakfast and WiFi for a hassle-free stay. Guests appreciate the helpful staff and free parking. Located within driving distance of Cape Girardeau Municipal Airport for easy regional access.

"Staff was great! Room was nice. "
United States
Lana
The price is NZ$118
includes taxes & fees
25 Dec - 26 Dec
Super 8 by Wyndham Charleston/Sikeston East MO

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very good, (488)
Unwind at this Union City hotel offering a seasonal outdoor pool and spa pool for relaxation. Just a short distance from County Market Place and Reelfoot Shopping Centre, guests enjoy free breakfast, WiFi, and parking.

"The Staff for sure is what keeps me coming back! Plus the rooms are very clean!"
United States
Walter
The price is NZ$136
includes taxes & fees
18 Jan - 19 Jan 2026
Quality Inn Union City US 51

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (732)
This welcoming motel offers clean rooms praised by guests, plus convenient amenities including free WiFi and parking. The 24-hour front desk ensures assistance anytime during your stay in charming Portageville.

"Friendly sta"
United States
Melissa
New Orleans Inn Portageville

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (282)
Experience refreshing comfort at this Sikeston hotel with an indoor swimming pool and fitness centre. Near Central Park and Sikeston Depot Museum, travellers appreciate the helpful staff, complimentary WiFi, and free parking for a convenient, stress-free stay.

"Room was clean, breakfast was very good. "
United States
Connie
The price is NZ$172
includes taxes & fees
28 Dec - 29 Dec
Comfort Inn & Suites Sikeston I-55

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
7.8 out of 10, Good, (39)
This hotel in Marston offers complimentary perks including daily full breakfast served between 6:00 AM and 9:00 AM, WiFi, and self parking. Conveniently located for travellers exploring the area.

"Great hotel, great staff"
United States
Dmitry
The price is NZ$113
includes taxes & fees
28 Dec - 29 Dec
Super 8 By Wyndham Marston

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
Discover comfort at this Sikeston hotel with an indoor pool and fitness centre. Enjoy complimentary breakfast, WiFi, and parking while exploring nearby Central Park and Sikeston Depot Museum. Guests consistently praise the helpful staff and immaculate rooms.

"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is NZ$182
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
Sikeston
9.2 out of 10, Wonderful, (41)
This business-friendly hotel offers an indoor pool, restaurant, and complimentary breakfast. Located near Sikeston Depot Museum, guests enjoy free WiFi and parking while exploring local attractions.

"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is NZ$196
includes taxes & fees
1 Jan - 2 Jan 2026
Fairfield Inn & Suites by Marriott Sikeston

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (461)
"Bed bugs in two separate rooms, wouldn’t refund my room"
United States
Jacquelynn
The price is NZ$137
includes taxes & fees
25 Dec - 26 Dec
Reelfoot Lake Inn

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (165)
Located near County Market Place and Reelfoot Shopping Centre, this welcoming hotel offers a free breakfast and convenient parking. Take a morning swim in the indoor pool after enjoying the complimentary meal. The helpful staff earns consistent praise from guests.

"Clean room, nice breakfast"
United States
STUART
The price is NZ$210
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn Union City

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (274)
Start your day with complimentary full breakfast before exploring nearby attractions. This hotel provides free WiFi and parking, making it an ideal base for visiting Fort Defiance State Park and Ballard Wildlife Management Area.

"Break fast was excellent "
United States
Uma
The price is NZ$135
includes taxes & fees
24 Jan - 25 Jan 2026
Quality Inn Cairo I-57

MainStay Suites Union City, TN

MainStay Suites Union City, TN
2.5 star property
Union City
8.6 out of 10, Excellent, (42)
Hiking trails surround this welcoming hotel with free breakfast and parking. The 24-hour fitness centre and health club keep exercise routines on track, while in-room refrigerators and microwaves add convenience for extended stays.

"Perfect, staff was very helpful."
United States
Marcos
The price is NZ$182
includes taxes & fees
29 Dec - 30 Dec
MainStay Suites Union City, TN

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (568)
Start your day with complimentary breakfast at this Sikeston hotel. Enjoy free WiFi and parking while staying minutes from Central Park and the Sikeston Depot Museum. Cape Girardeau Municipal Airport is just a 29-minute drive away.

"Awesomeness "
United States
Rick
The price is NZ$116
includes taxes & fees
8 Jan - 9 Jan 2026
Super 8 by Wyndham Sikeston/Miner Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

More cheap accommodation in East Prairie

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Hampton Inn Sikeston and Sleep Inn at Discovery Park of America. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best holiday rentals that East Prairie has to offer?
3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters: This holiday home rental outside of East Prairie is located on a lake, and has a fireplace, a patio and a BBQ to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 33 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Mississippi River and Big Oak Tree State Park exemplify the area's natural beauty. You'll also find Central Park and River Ridge Winery in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

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