The Mississippi River near Hannibal, Missouri, USA

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Check prices for these dates

This weekend
12 Jun - 14 Jun
Next weekend
19 Jun - 21 Jun

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Our top choices for East Prairie hotels

Indoor pool, outdoor pool

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,008 reviews)
"Breakfast was good,pool hot tub excellent "
United States
Janica
The price is NZ$220
includes taxes & fees
22 June - 23 June
Drury Inn & Suites Sikeston, MO
Exterior

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (574 reviews)
"Very clean hotel with comfortable bedding. Front desk staff was very nice and accommodating as we were traveling with a small dog."
United States
Connie
The price is NZ$206
includes taxes & fees
9 July - 10 July
Hampton Inn Sikeston
Exterior

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (467 reviews)
"Only stayed one night, no complaints"
United States
Zachary
The price is NZ$220
includes taxes & fees
28 June - 29 June
Holiday Inn Express & Suites Sikeston Southwest by IHG
Property amenity

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (84 reviews)
"Great stay, kind staff, very clean property."
United States
Joni
The price is NZ$214
includes taxes & fees
21 June - 22 June
Fairfield Inn & Suites by Marriott Sikeston
Free daily full breakfast

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,007 reviews)
"Very convenient and staff was great."
United States
jeanne
The price is NZ$179
includes taxes & fees
14 June - 15 June
Best Western Plus Sikeston I-55
Lobby

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (397 reviews)
"I slept well! Very clean and comfortable!"
United States
Angela
The price is NZ$162
includes taxes & fees
5 July - 6 July
Sleep Inn at Discovery Park of America
Laptop workspace, blackout curtains, free cots/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (639 reviews)
"Clean rooms,"
United States
Karl
The price is NZ$115
includes taxes & fees
14 June - 15 June
Super 8 by Wyndham Charleston/Sikeston East MO
Premier Room, 1 Bedroom, Non Smoking

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (768 reviews)
"Great stay with Great people, very clean and welcoming"
United States
Mircea
The price is NZ$95
includes taxes & fees
14 June - 15 June
New Orleans Inn Portageville
Room, 1 Queen Bed, Non Smoking

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very good, (64 reviews)
"Great hotel for the price!!! Remodel very nice and modern. "
United States
Amy
The price is NZ$168
includes taxes & fees
13 June - 14 June
Super 8 By Wyndham Marston
Lobby

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (571 reviews)
"Ok place to say the night if you are looking for a place to sleep. "
United States
Paul
The price is NZ$122
includes taxes & fees
15 June - 16 June
Country Hearth Inn & Suites Union City
Lobby sitting area

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (414 reviews)
"It was not at all what I expected. The website showed a very good hotel. It was awful. I would not paid even $40/ night if I knew how awful it is. I felt bad for the ladies working on front desk."
United States
Soheila
The price is NZ$143
includes taxes & fees
10 June - 11 June
The Riverstone Hotel Charleston-Sikeston
Terrace/patio

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (184 reviews)
"The room was clean and comfortable. The staff was courteous during my entire stay."
United States
Alvin
The price is NZ$243
includes taxes & fees
22 June - 23 June
Hampton Inn Union City
Exterior

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (329 reviews)
"Very nice property"
United States
Randy
The price is NZ$225
includes taxes & fees
21 June - 22 June
Holiday Inn Express & Suites Union City by IHG
1 bedroom, desk, laptop workspace, blackout curtains

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,007 reviews)
"When I stay at hotels I like to find hotels like this one for the $$$ value . This hotel was clean and the bed was very comfortable. Room 237 . I didn’t hear any interstate noise . I didn’t eat the breakfast but the coffee was very good . I would stay here again ."
United States
Kurt
The price is NZ$138
includes taxes & fees
21 June - 22 June
Days Inn and Suites by Wyndham Sikeston
Property amenity

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (18 reviews)
"Room was very nice and in very clean condition and hotel staff was very helpful and polite. The breakfast was very delicious and coffee served all day. The hotel smelled very nice and had a very welcoming feeling. Will definitely book with them again"
United States
Joseph
The price is NZ$248
includes taxes & fees
21 June - 22 June
TownePlace Suites by Marriott Sikeston
Free buffet breakfast

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.2 out of 10, Very good, (520 reviews)
"Breakfast was filling and fresh. Short overnight stay which completely met our needs First level room with convenient vehicle parking right outside the door which made moving luggage painless. "
United States
Lisa
The price is NZ$127
includes taxes & fees
30 June - 1 July
Quality Inn Union City US 51
Individually decorated, individually furnished, desk, blackout curtains

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (787 reviews)
"We were very satisfied with our stay. We will make this a regular stay when traveling to or from Iowa."
United States
Carolyn
The price is NZ$119
includes taxes & fees
21 June - 22 June
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Lobby

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (286 reviews)
"the hotel needs updateing poor brekfesr"
United States
DANIEL
The price is NZ$138
includes taxes & fees
10 July - 11 July
Quality Inn Cairo I-57
Room, 1 King Bed, Accessible, Non Smoking

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (642 reviews)
"Staff, A/C, adequate breakfast"
United States
David
The price is NZ$134
includes taxes & fees
17 June - 18 June
Super 8 by Wyndham Sikeston/Miner Area
Standard Room, 2 Double Beds, Non Smoking

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (495 reviews)
"The lake view was beautiful and staff was amazing"
United States
Richard
The price is NZ$129
includes taxes & fees
16 June - 17 June
Reelfoot Lake Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

4.0/5 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
The Mississippi River near Hannibal, Missouri, USA

Top East Prairie Hotel Reviews

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

10/10 Excellent
"The breakfast was really good, as was the coffee. It’s rarely good in hotels, but this coffee was very good. The staff was quite friendly. Thanks"
Kay 1-night trip
Posted 3 hours ago
Best Western Plus Sikeston I-55

More cheap accommodation in East Prairie

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO
The price is NZ$119 per night from 21 June to 22 June
NZ$119
21 June - 22 June
includes taxes & fees
8.4/10 Very Good! (787 reviews)

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay, based on our traveller data. Other good choices for your trip to the area are Hampton Inn Sikeston and Best Western Plus Sikeston I-55. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best holiday rentals that East Prairie has to offer?
The Tackle Box at Reelfoot: This holiday home rental outside of East Prairie has air conditioning and WiFi to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop and a microwave. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
How is it staying in East Prairie?
Visitors will definitely enjoy all that East Prairie has to offer. There are 33 hotels and other accommodation options in the surrounding area. Find out more about East Prairie.
What are the top places to visit in East Prairie?
The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Central Park and Sikeston Depot Museum in the area. Take a look at what more there is to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for East Prairie is 1522 mm.

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