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Comfort Inn & Suites Sikeston I-55

2.5 star property
Hotel in Sikeston with fitness centre and 24-hour front desk

Choose dates to view prices

Just off I-55, Comfort Inn & Suites Sikeston I-55 provides a practical base for travelers. Guests can swim in the indoor pool, use the laundry facilities, connect with in-room WiFi, maintain fitness routines at the gym, or handle work matters in the business center.

Reviews

8.4 out of 10
Very good

Popular amenities

  • Pet-friendly
  • Gym
  • Laundry
  • Parking included
  • Free WiFi
The current price is NZ$169
includes taxes & fees
7 Dec - 8 Dec

Room options

Available filters for rooms
Showing 5 of 5 rooms

View all photos for Standard Room, 2 Queen Beds, Non Smoking

Standard Room, 2 Queen Beds, Non Smoking

Standard Room, 2 Queen Beds, Non Smoking

8.0 out of 10
Very good
(11 reviews)

Highlights

Air conditioning
Fridge
Separate bedroom
Private bathroom
Coffee/tea maker
Cable/satellite channels
Desk
  • Sleeps 4
  • 2 Queen Beds

View all photos for Suite, 1 King Bed with Sofa bed, Non Smoking

Suite, 1 King Bed with Sofa bed, Non Smoking

Suite, 1 King Bed with Sofa bed, Non Smoking

Highlights

Air conditioning
Fridge
Sofa bed
Separate bedroom
Private bathroom
Coffee/tea maker
Cable/satellite channels
Desk
  • 1 bedroom
  • Sleeps 4
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Room, 1 King Bed, Accessible, Non Smoking

Room, 1 King Bed, Accessible, Non Smoking

Room, 1 King Bed, Accessible, Non Smoking

9.0 out of 10
Wonderful
(2 reviews)

Highlights

Air conditioning
Separate bedroom
Private bathroom
Coffee/tea maker
Cable/satellite channels
Desk
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 2 Queen Beds, Accessible, Non Smoking

Room, 2 Queen Beds, Accessible, Non Smoking

Room, 2 Queen Beds, Accessible, Non Smoking

10.0 out of 10
Exceptional
(4 reviews)

Highlights

Air conditioning
Separate bedroom
Private bathroom
Coffee/tea maker
Cable/satellite channels
Desk
  • Sleeps 4
  • 2 Queen Beds

View all photos for Standard Room, 1 King Bed, Non Smoking

Standard Room, 1 King Bed, Non Smoking

Standard Room, 1 King Bed, Non Smoking

8.0 out of 10
Very good
(14 reviews)

Highlights

Air conditioning
Fridge
Separate bedroom
Private bathroom
Coffee/tea maker
Cable/satellite channels
Desk
  • Sleeps 2
  • 1 King Bed

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8.4 out of 10, Very good, 1,003 reviews
The price is NZ$169
includes taxes & fees
30 Nov - 1 Dec
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About the area

Map
109 Matthews Ln, Sikeston, MO, 63801

What's nearby

  • City of Miner Convention Center - 5 min walk - 0.4 km
  • Saint Francis Medical Center - 28 min drive - 57.8 km
  • Isle Casino Cape Girardeau - 33 min drive - 61.2 km
  • Southeast Missouri State University - 33 min drive - 62.0 km
  • Show Me Center - 34 min drive - 62.9 km

Getting around

  • Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 29 min drive

Restaurants

  • ‪Lambert's Cafe - ‬17 min walk
  • ‪Buffalo Wild Wings - ‬5 min drive
  • ‪Pizza Inn - ‬2 min drive
  • ‪Burger King - ‬4 min drive
  • ‪McDonald's - ‬2 min walk

About this property

Comfort Inn & Suites Sikeston I-55

Property highlights
Take advantage of laundry facilities, a gym and a business centre at Comfort Inn & Suites Sikeston I-55. Stay connected with free in-room WiFi.
Other perks include:
  • An indoor pool
  • Free self-parking
  • A 24-hour front desk, a front desk safe and laundry services
  • A lift
  • Guest reviews speak highly of the helpful staff
Room features
All 64 rooms offer comforts such as air conditioning, in addition to amenities such as free WiFi.
Extra amenities include:
  • Bathrooms with baths or showers
  • Cable channels, coffee/tea makers and desks

Similar properties

Property amenity
Drury Inn & Suites Sikeston, MO
  • Pool
  • Breakfast included
  • Pet-friendly
  • Parking included
9.4 out of 10, Exceptional, 1,005 reviews
The price is NZ$195
includes taxes & fees
23 Nov - 24 Nov
Drury Inn & Suites Sikeston, MO

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transport

  • Free self parking on site
  • Wheelchair-accessible parking available

Things to do

  • Gym
  • Indoor pool

Family friendly

  • Indoor pool
  • Laundry facilities

Conveniences

  • 24-hour front desk
  • Laundry facilities
  • Safe at front desk

Business services

  • Business centre

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Lift
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible registration desk

More

  • 3 floors
  • Smoke-free property

Room amenities

Bedroom

  • Bedsheets provided

Bathroom

  • Bathtub or shower
  • Private bathroom
  • Towels provided

Entertainment

  • Cable/satellite channels

Food and drink

  • Coffee/tea maker

More

  • Air conditioning
  • Desk
  • Phone

Policies

Check-in

Check-in start time: 2:00 PM; check-in end time: anytime
Minimum check-in age - 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

Pets are allowed for an extra charge of USD 20 per pet, per night
Service animals are welcome, and are exempt from fees
Welcoming dogs and cats only
2 total (up to 9 kg per pet)
Specific rooms only; pet-friendly rooms can be requested by contacting the property on the number on the booking confirmation

Children and extra beds

Children are welcome
Rollaway/extra beds are not available.
Cots (infant beds) are not available

Payment types

Important information

Optional extras

  • Pet fee: USD 20 per pet, per night
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
This property affirms that it follows the cleaning and disinfection practices of Commitment to Clean (Choice)

Property is also known as

Comfort Inn Sikeston Hotel
Comfort Inn Sikeston

Frequently asked questions

Does Comfort Inn & Suites Sikeston I-55 have a pool?

Yes, this property has an indoor pool.

How much does it cost to stay at Comfort Inn & Suites Sikeston I-55?

As of 18 Nov 2025, prices found for a 1-night stay for 2 adults at Comfort Inn & Suites Sikeston I-55 on 7 Dec 2025 start from NZ$168.79, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Is Comfort Inn & Suites Sikeston I-55 pet-friendly?

Yes, Comfort Inn & Suites Sikeston I-55 allows cats and dogs (limit 2 total) with a maximum weight of up to 9 kg per pet. There's a fee of USD 20 per pet, per night. Service animals are exempt from fees.

How much is parking at Comfort Inn & Suites Sikeston I-55?

Self-parking is free at this property.

What time is check-in at Comfort Inn & Suites Sikeston I-55?

Check-in start time: 2:00 PM; check-in end time: anytime.

What time is check-out at Comfort Inn & Suites Sikeston I-55?

Checkout is at 11:00 AM.

Where is Comfort Inn & Suites Sikeston I-55 located?

Situated in Sikeston, this hotel is 0.4 mi (0.6 km) from City of Miner Convention Center and within 6 miles (10 km) of Sikeston Depot Museum and Central Park. Front Street Studio & Art Gallery is 9 mi (14.5 km) away.

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Comfort Inn & Suites Sikeston I-55 Reviews

Reviews

8.4

Very good

Rating 10 - Excellent. 130 out of 277 reviews
Rating 8 - Good. 91 out of 277 reviews
Rating 6 - Okay. 29 out of 277 reviews
Rating 4 - Poor. 18 out of 277 reviews
Rating 2 - Terrible. 9 out of 277 reviews

8.6/10

Cleanliness

8.8/10

Staff & service

8.2/10

Amenities

8.2/10

Property conditions & facilities

8.2/10

Eco-friendliness

Reviews

10/10 Excellent

Connie

Liked: Cleanliness, property conditions & facilities
Room was clean, breakfast was very good.
Stayed 1 night in Nov 2025

10/10 Excellent

Shonta'

Liked: Cleanliness, staff & service, property conditions & facilities
Love Everything
Stayed 4 nights in Oct 2025

10/10 Excellent

Shonta'

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The Jacuzzi was the Best!!! 👏
Stayed 6 nights in Oct 2025

10/10 Excellent

Lisa

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
It was a very nice stay. The pool was clean and enjoying!
Stayed 1 night in Jul 2025

10/10 Excellent

Peggy

Liked: Cleanliness, staff & service, property conditions & facilities
The facility was very nice.
Stayed 2 nights in May 2025

2/10 Terrible

samuel

Disliked: Cleanliness, property conditions & facilities
Not a very good hotel will not stay there again
Stayed 1 night in Jul 2025

8/10 Good

Amanda

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice hotel with great staff. Room was fine, breakfast could be better but overall a good stay for this area.

10/10 Excellent

Kimberly

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We were in town for a pit-stop to sleep and the staff was very nice. Comfy beds and nice location
Stayed 1 night in Mar 2025

8/10 Good

John

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Good stay

It was decent…slept well The room was clean
Stayed 1 night in May 2025

8/10 Good

Denise

hotel was fine clean and convient
Stayed 1 night in Feb 2025

6/10 Okay

Wendy

Liked: Cleanliness, staff & service, property conditions & facilities
Everything was good. The beds were too hard and pillows were too soft.
Stayed 1 night in Jun 2025

8/10 Good

George

Liked: Cleanliness, amenities, property conditions & facilities
Clean
Stayed 1 night in Jun 2025

10/10 Excellent

Mike

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean, and available rooms when we needed it most due to storms
Stayed 1 night in Feb 2025

10/10 Excellent

Corinthian

Liked: Cleanliness, amenities, property conditions & facilities
It was cool
Stayed 3 nights in May 2025

10/10 Excellent

Marsha

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
It was okay, quiet and helpful.
Stayed 1 night in Apr 2025

10/10 Excellent

Sasha

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We were happy with our stay
Stayed 1 night in Oct 2024

10/10 Excellent

Sharon

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice
Stayed 1 night in Apr 2025

10/10 Excellent

Margaret

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Thank you

Great stay, quiet, friendly and just what we expected!
Stayed 1 night in Feb 2025

6/10 Okay

Juanita

Liked: Cleanliness, amenities, property conditions & facilities
The check in guy threw my id at me and was rude
Stayed 3 nights in Jun 2025

10/10 Excellent

Michael

Liked: Cleanliness, staff & service, property conditions & facilities
Conveniant to I55, clean, and comfortable,
Stayed 1 night in Dec 2024

10/10 Excellent

Timothy

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean & friendly service. Easy access from the highway. Bed is comfortable. Breakfast area looks very nice. A good selection of food choices. Would recommend this property. The ice machine wasn’t working on our floor, but could get ice near the lobby, so not a huge issue.
Stayed 1 night in May 2025

10/10 Excellent

Roger

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice spacious rooms. Beds were very comfortable. Quiet place.
Stayed 1 night in Jan 2025

10/10 Excellent

Cindy

Place was great
Stayed 1 night in May 2024

10/10 Excellent

John

Liked: Cleanliness, staff & service, property conditions & facilities
Great for overnights, staff friendly and attentive
Stayed 1 night in Apr 2024

8/10 Good

Dylan

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Right off the main drag, huge complimentary breakfast area
Stayed 1 night in May 2024