An aerial view of a city with a large stadium, several schools, and a dense residential area.

Downtown South San Francisco Hotels, San Francisco

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Downtown South San Francisco hotels

1. La Quinta Inn & Suites by Wyndham San Francisco Airport N

La Quinta Inn & Suites by Wyndham San Francisco Airport N
3.0 star property
Downtown South San Francisco
8.2 out of 10, Very good, (2,156 reviews)
"Nice, clean hotel with a great breakfast very conveniently located near the airport."
United States
Justin
The price is NZ$276
includes taxes & fees
3 Oct - 4 Oct
La Quinta Inn & Suites by Wyndham San Francisco Airport N

2. Airport Inn

Airport Inn
2.0 star property
Downtown South San Francisco
9.0 out of 10, Wonderful, (1,001 reviews)
"One of the best places I’ve stayed in SF area"
United States
Saikiran
The price is NZ$224
includes taxes & fees
29 Oct - 30 Oct
Airport Inn

3. Inn By The SFO

Inn By The SFO
2.0 star property
Downtown South San Francisco
7.6 out of 10, Good, (1,000 reviews)
"Great Quiet place to rest - has a couch for comfort ."
United States
Antonio
Inn By The SFO

4. Miller Apartments

Miller Apartments
2.0 star property
Downtown South San Francisco
7.2 out of 10, Good, (23 reviews)
"Old house, poorly maintained. I won’t be coming back"
United States
Lou
The price is NZ$224
includes taxes & fees
1 Oct - 2 Oct
Miller Apartments

5. Comfort Inn and Suites San Francisco Airport North

Comfort Inn and Suites San Francisco Airport North
2.5 star property
The East Side, 1.1 km from Downtown South San Francisco
7.8 out of 10, Good, (1,003 reviews)
"Shuttle and breakfast made this worth it"
United States
Sarah
The price is NZ$218
includes taxes & fees
25 Oct - 26 Oct
Comfort Inn and Suites San Francisco Airport North

6. Embassy Suites by Hilton San Francisco Airport Oyster Point

Embassy Suites by Hilton San Francisco Airport Oyster Point
3.5 star property
The East Side, 1.4 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,790 reviews)
"Very clean friendly atmosphere loved it …..❤️❤️❤️"
United States
guadalupe
The price is NZ$289
includes taxes & fees
16 Oct - 17 Oct
Embassy Suites by Hilton San Francisco Airport Oyster Point

7. Hilton Garden Inn San Francisco Arpt North

Hilton Garden Inn San Francisco Arpt North
3.0 star property
The East Side, 1.7 km from Downtown South San Francisco
8.6 out of 10, Excellent, (1,005 reviews)
"Great atmosphere"
United States
Karina
The price is NZ$202
includes taxes & fees
18 Oct - 19 Oct
Hilton Garden Inn San Francisco Arpt North

8. Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel
3.0 star property
1.8 km from Downtown South San Francisco
8.4 out of 10, Very good, (1,929 reviews)
"Clean room, great breakfast."
United States
Larry
The price is NZ$226
includes taxes & fees
16 Oct - 17 Oct
Best Western Plus Grosvenor Airport Hotel

9. Sonesta Select San Francisco Airport Oyster Point Waterfront

Sonesta Select San Francisco Airport Oyster Point Waterfront
3.0 star property
Oyster Point, 2.2 km from Downtown South San Francisco
8.8 out of 10, Excellent, (2,390 reviews)
"Clean and spacious room, Friendly staff."
United States
Sheila Marie
The price is NZ$253
includes taxes & fees
17 Oct - 18 Oct
Sonesta Select San Francisco Airport Oyster Point Waterfront

10. Hotel Nova SFO

Hotel Nova SFO
2.5 star property
1.9 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,019 reviews)
"Clean and super convenient to the airport"
United States
Anne
The price is NZ$260
includes taxes & fees
9 Oct - 10 Oct
Hotel Nova SFO

11. DoubleTree by Hilton San Francisco Airport North Bayfront

DoubleTree by Hilton San Francisco Airport North Bayfront
4.0 star property
3.1 km from Downtown South San Francisco
8.2 out of 10, Very good, (1,775 reviews)
"Great stay!"
United States
Kelcie
The price is NZ$255
includes taxes & fees
2 Oct - 3 Oct
DoubleTree by Hilton San Francisco Airport North Bayfront

12. The Atrium Hotel

The Atrium Hotel
2.5 star property
3 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,029 reviews)
"Very nice place!"
United States
Ramesh
The price is NZ$266
includes taxes & fees
31 Oct - 1 Nov
The Atrium Hotel

13. Hotel Aluxor SFO

Hotel Aluxor SFO
2.5 star property
3.7 km from Downtown South San Francisco
8.6 out of 10, Excellent, (3,029 reviews)
"Had a great overnight stay!"
United States
Kenna
The price is NZ$218
includes taxes & fees
25 Oct - 26 Oct
Hotel Aluxor SFO

14. Hotel Skye SFO

Hotel Skye SFO
3.0 star property
3.9 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2,028 reviews)
"The location was perfect for a one night stay at the SF area."
United States
Eduviges
The price is NZ$263
includes taxes & fees
4 Oct - 5 Oct
Hotel Skye SFO

15. Gateway Inn & Suites San Francisco SFO Airport

Gateway Inn & Suites San Francisco SFO Airport
2.0 star property
3.7 km from Downtown South San Francisco
8.6 out of 10, Excellent, (1,101 reviews)
"Nice and close to airport very clean rooms a great little dive"
United States
Julian
The price is NZ$167
includes taxes & fees
18 Oct - 19 Oct
Gateway Inn & Suites San Francisco SFO Airport

16. Hotel Aura SFO

Hotel Aura SFO
3.0 star property
4.4 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2,648 reviews)
"Great airport stay"
United States
Charles
The price is NZ$220
includes taxes & fees
4 Oct - 5 Oct
Hotel Aura SFO

17. Aloft by Marriott San Francisco Airport

Aloft by Marriott San Francisco Airport
3.0 star property
6.9 km from Downtown South San Francisco
9.0 out of 10, Wonderful, (2,275 reviews)
"Great location for the airport"
Australia
ross
The price is NZ$274
includes taxes & fees
25 Oct - 26 Oct
Aloft by Marriott San Francisco Airport

18. La Quinta Inn & Suites by Wyndham San Francisco Airport West

La Quinta Inn & Suites by Wyndham San Francisco Airport West
3.0 star property
5.4 km from Downtown South San Francisco
8.6 out of 10, Excellent, (1,874 reviews)
"Very nice hotel, very reasonable wth a great breakfast! Huge pool, very pretty courtyard and staff is superb!"
United States
Joy
The price is NZ$282
includes taxes & fees
31 Oct - 1 Nov
La Quinta Inn & Suites by Wyndham San Francisco Airport West

19. Hotel 1550 - SFO Airport

Hotel 1550 - SFO Airport
3.5 star property
5.1 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,025 reviews)
"Convenient to airport with shuttle service and easy in and accommodations."
United States
Larry
The price is NZ$278
includes taxes & fees
18 Oct - 19 Oct
Hotel 1550 - SFO Airport

20. The Westin San Francisco Airport

The Westin San Francisco Airport
4.0 star property
6.9 km from Downtown South San Francisco
8.8 out of 10, Excellent, (1,803 reviews)
"We were only there the one night as lay-over but from the amenities we saw (pool/hot tub area, exercise facilities, restaurant) and hotel location on the bay it would have been good for an extended stay as well."
United States
Douglas
The price is NZ$303
includes taxes & fees
25 Oct - 26 Oct
The Westin San Francisco Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our guide on where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.

Fisherman's Wharf

Taste some of the city’s freshest sea food and catch some fabulous views in this waterfront neighbourhood dating back to the time of the gold rush.

Union Square

Fashion puts its best foot forward in one of America’s largest shopping plazas.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and Chase Center are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

Nob Hill

Examine architecturally significant buildings, visit the Cable Car Museum and enjoy magnificent views of greater San Francisco in this affluent district.

Top Downtown South San Francisco Hotel Reviews

Recent Reviews in Downtown South San Francisco

Frequently asked questions

What other neighbourhoods are similar to Downtown South San Francisco?
While Downtown South San Francisco has its own distinct character, the most similar neighbourhoods in the Bay Area are Burlingame and San Mateo.

Burlingame, located just south of Downtown South San Francisco, offers a comparable experience with its vibrant high street, Burlingame Avenue. This area is known for its upmarket boutiques, diverse restaurants, and independent coffee shops. It's a very walkable neighbourhood, making it convenient for those who enjoy strolling and discovering local businesses.

San Mateo, further south from Burlingame, also shares many characteristics with Downtown South San Francisco. Its downtown area, particularly around 3rd and 4th Avenues, features a variety of dining options, from casual eateries to fine dining establishments, as well as a selection of shops. It's a slightly larger city centre but maintains a similar approachable feel.

Both Burlingame and San Mateo are excellent choices for business travellers or those seeking a convenient base with good transport links to San Francisco and Silicon Valley, much like Downtown South San Francisco.
What are the best hotels in Downtown South San Francisco that travellers recommend?
Two of the best hotels in Downtown South San Francisco that receive consistently high recommendations from travellers are the Airport Inn and the 3-star La Quinta Inn & Suites by Wyndham San Francisco Airport N.

The Airport Inn, with an 8.8 rating, is praised for its clean and spacious rooms and comfortable beds. Guests also frequently mention the great location and the friendly staff. It offers convenient amenities like free covered self-parking and a terrace.

Another highly recommended option is the 3-star La Quinta Inn & Suites by Wyndham San Francisco Airport N, which has an 8.0 rating. Guests often highlight the comfortable and clean rooms, the great complimentary breakfast, and the friendly and helpful staff. This hotel also provides a free scheduled airport shuttle and 24-hour fitness facilities, making it very convenient for travellers. It is located near points of interest such as the SFO Museum and The Shops at Tanforan.
What are the best family hotels in Downtown South San Francisco?
For family-friendly accommodation in Downtown South San Francisco, you might consider the La Quinta Inn & Suites by Wyndham San Francisco Airport N or the Inn By The SFO.

The 3-star La Quinta Inn & Suites by Wyndham San Francisco Airport N, with a rating of 8.0, is a great choice for families. Guests often mention the comfortable and clean rooms, along with the great breakfast, which is complimentary. The hotel also offers a free continental breakfast, a pool, and both cots and sofa beds are available for families. It is conveniently located near the SFO Museum and The Shops at Tanforan, both within 1.8 km.

Another good option is the Inn By The SFO, which has a rating of 7.8. This hotel is praised for its quiet neighbourhood and clean rooms. It provides cots and rollaway extra beds, suiting families. Guests also appreciate the free parking and excellent customer service.
What hotels in Downtown South San Francisco offer free breakfast?
For hotels in Downtown South San Francisco that offer complimentary breakfast, consider the La Quinta Inn & Suites by Wyndham San Francisco Airport N.

The 3-star La Quinta Inn & Suites by Wyndham San Francisco Airport N, with a solid 8.0 rating, provides a free continental breakfast to start your day. Guests frequently mention the comfortable and clean rooms, as well as the friendly and helpful staff. This hotel also offers free WiFi and complimentary airport transportation. It is conveniently located near the SFO Museum, which is just 1.8 kilometres away.
What are the top pet-friendly hotels in Downtown South San Francisco?
For a highly-rated pet-friendly hotel in Downtown South San Francisco, consider the La Quinta Inn & Suites by Wyndham San Francisco Airport N.

This 3-star hotel boasts an 8.0 rating and is popular for its comfortable and clean rooms, as well as its friendly and helpful staff. Guests frequently praise the great breakfast and convenient location. The hotel permits both dogs and cats, making it an excellent choice for travellers with pets. It is also conveniently located near attractions such as the SFO Museum and The Shops at Tanforan.
What are the best budget hotels in Downtown South San Francisco?
For highly-rated budget hotels in Downtown South San Francisco, consider the La Quinta Inn & Suites by Wyndham San Francisco Airport N, the Inn By The SFO, and Airport Inn.

The 3-star La Quinta Inn & Suites by Wyndham San Francisco Airport N, with an 8.0 rating, offers guests comfortable and clean rooms along with a great complimentary breakfast. Its convenient location is often praised, and it provides free WiFi, free toiletries, and free airport transportation. It is also just 1.8 km from the SFO Museum.

Another excellent option is the Inn By The SFO, rated 7.8. Guests appreciate the comfortable beds, clean rooms, and the quiet neighbourhood. It offers free WiFi, free toiletries, and free self-parking. San Bruno Point Park is just 1.8 km away.

Airport Inn, with an 8.8 rating, is top for its clean and spacious rooms, friendly staff, and great location. This hotel provides free WiFi, free toiletries, and free self-parking, including accessible and covered options. It is also close to San Bruno Point Park, which is 1.7 km away.
What are the best hotels in Downtown South San Francisco near San Francisco Bay?
For a hotel in Downtown South San Francisco near San Francisco Bay, consider the Inn By The SFO.

The Inn By The SFO, with a 7.8 rating, is a good option for families travelling with children. Guests appreciate the availability of rollaway extra beds and cribs. The hotel also offers early check-in for an additional charge, which can be useful after a long journey. Guests have frequently commented on the free parking, comfortable beds, and clean rooms. San Bruno Point Park is a short 1.8 km away, and San Francisco Bay is 11.1 km from the hotel. The hotel is situated in a quiet neighbourhood.
When is the best time to go to Downtown South San Francisco?
Downtown South San Francisco is a year-round destination, but the best time to visit is during the late spring and early autumn months, specifically from May to June and September to October.

These periods offer the most pleasant weather conditions, with less fog and generally warmer temperatures compared to the summer. You'll find it comfortable for exploring the local shops and eateries along Grand Avenue or enjoying a stroll in one of the city's parks.

For travellers looking to avoid the busiest tourist seasons and potentially find better value on accommodation, visiting in May or October is ideal. The crowds are typically thinner, and the weather remains agreeable for outdoor activities and day trips to nearby San Francisco or the wine country.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline − this is often within 24 to 48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our 'Fully refundable property' filter during your search to find the right Downtown South San Francisco hotel for you.
How can I save on a hotel booking in Downtown South San Francisco with Expedia?
One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on Downtown South San Francisco hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
How much is the nightly rate for a hotel in Downtown South San Francisco?
Hotel prices in Downtown South San Francisco often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates and sort search results by 'Price: low to high' for our cheapest rates.

Explore a world of travel with Expedia