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Check prices for these dates

Tonight
7 Apr - 8 Apr
Tomorrow
8 Apr - 9 Apr
This weekend
10 Apr - 12 Apr
Next weekend
17 Apr - 19 Apr

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Our top choices for Defiance hotels

Reception

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very good, (1,184 reviews)
"Everything was great for overnight stay. "
United States
Regina
The price is NZ$181
includes taxes & fees
15 Apr - 16 Apr
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Indoor pool

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.6 out of 10, Good, (1,000 reviews)
"The room was clean. The parking was easy."
United States
Chris
The price is NZ$148
includes taxes & fees
15 Apr - 16 Apr
Baymont by Wyndham Warrenton
Room, 2 Queen Beds, Non Smoking

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1,187 reviews)
"Great location, comfy and clean rooms "
United States
Nestor
The price is NZ$170
includes taxes & fees
8 Apr - 9 Apr
Wingate by Wyndham St. Louis/Fenton Route 66
Exterior

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
8.8 out of 10, Excellent, (73 reviews)
"Nice hotel with good staff."
United States
Michael
The price is NZ$185
includes taxes & fees
9 Apr - 10 Apr
WoodSpring Suites St Peters-OFallon
Lobby

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (961 reviews)
"Comfy beds, but the trim, doors, and other finishings look pretty rough and in need of replacement. Simple enough breakfast and was just there for a night to sleep so it did the job."
United States
Laura
The price is NZ$175
includes taxes & fees
21 Apr - 22 Apr
Quality Inn Foristell
Property entrance

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,635 reviews)
"Staff was wonderful, location is great for our needs, and it was a quiet stay-which we loved. "
United States
Jessica
The price is NZ$180
includes taxes & fees
12 Apr - 13 Apr
The Wildwood Hotel
Free daily buffet breakfast

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (252 reviews)
"Easy parking, friendly staff, clean and comfy rooms. "
United States
Jan
The price is NZ$199
includes taxes & fees
15 Apr - 16 Apr
Best Western Plus Fenton
Reception

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (685 reviews)
"Very pet friendly. "
United States
Sara
The price is NZ$255
includes taxes & fees
15 Apr - 16 Apr
Hampton Inn St. Louis Wentzville
Lobby

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,009 reviews)
"Great stay! Very clean and staff was very nice. Definitely will be staying there on my return visit to the area!"
United States
Roxanne
The price is NZ$221
includes taxes & fees
19 Apr - 20 Apr
Drury Inn & Suites St. Louis St. Peters
Indoor pool

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,006 reviews)
"Everything was great as always at this location as i have stayed here many times"
United States
Gregory
The price is NZ$214
includes taxes & fees
13 Apr - 14 Apr
Hampton Inn St. Charles St. Peters
Standard Room, 2 Queen Beds

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (639 reviews)
"The parking was easy, the room was verry clean."
United States
Gary
The price is NZ$112
includes taxes & fees
19 Apr - 20 Apr
Super 8 by Wyndham Warrenton
Premium bedding, desk, iron/ironing board, free WiFi

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,000 reviews)
"This was one of our best stays ever nice hot breakfast. Clean room nice staff will stay again "
United States
Lavania
The price is NZ$173
includes taxes & fees
15 Apr - 16 Apr
Sleep Inn & Suites O'Fallon MO - Technology Drive
Exterior

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (890 reviews)
"Great location, clean, modern, killer shower and good bed! I would definitely recommend!"
United States
John
The price is NZ$290
includes taxes & fees
26 Apr - 27 Apr
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Exterior

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very good, (1,004 reviews)
"The breakfast was good. They had two different waffle choices every day. "
United States
Josephine
The price is NZ$179
includes taxes & fees
3 May - 4 May
Comfort Suites St Charles - St Louis
Lobby

Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (369 reviews)
"Breakfast menu is extremely limited. Breakfast does not have bread/ butter."
United States
Arinjay
The price is NZ$218
includes taxes & fees
8 Apr - 9 Apr
Quality Inn Near Six Flags St. Louis
Lobby lounge

Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville
3.0 star property
Wentzville
9.0 out of 10, Wonderful, (667 reviews)
"Property was nice, easy check-in, nice breakfast, room was clean."
United States
Doris
The price is NZ$256
includes taxes & fees
15 Apr - 16 Apr
Fairfield Inn & Suites Wentzville
Front of property – evening/night

Cedar Creek

Cedar Creek
3.0 star property
New Haven
9.0 out of 10, Wonderful, (265 reviews)
"Loved the views and the old west buildings "
United States
Shelly
The price is NZ$271
includes taxes & fees
13 Apr - 14 Apr
Cedar Creek
Lobby

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (671 reviews)
"Great stay and accommodations. The pool was very nice. "
United States
Shane
The price is NZ$257
includes taxes & fees
12 Apr - 13 Apr
Best Western Plus Washington Hotel
Lobby

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
Valley Park
9.6 out of 10, Exceptional, (1,008 reviews)
"Very clean place with great food and friendly staff. "
Canada
Kara
The price is NZ$244
includes taxes & fees
19 Apr - 20 Apr
Drury Inn & Suites Southwest St. Louis
Front of property – evening/night

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis
3.5 star property
Maryland Heights
8.4 out of 10, Very good, (2,195 reviews)
"Great hotel for the hockey tournament... very nice staff... great location. The air quality was poor nearing the casino and awful inside... otherwise a great stay"
United States
Alex
The price is NZ$250
includes taxes & fees
15 Apr - 16 Apr
Hollywood Casino & Hotel St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
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Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.
See properties

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

8/10 Good
"Easy to find"
Sandra 1-night trip
Posted 5 hours ago
Hollywood Casino & Hotel St. Louis

More cheap accommodation in Defiance

Relax Inn Saint Charles

Relax Inn Saint Charles

3800 Harry S Truman Blvd St. Charles MO
The price is NZ$123 per night from 26 Apr to 27 Apr
NZ$123
26 Apr - 27 Apr
includes taxes & fees
6.8/10 (1,001 reviews)

Frequently asked questions

What's the best place to stay in Defiance?
Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and The Wildwood Hotel. See all available top hotels, or vacation rentals in Defiance.
What are some of the best holiday rentals that Defiance has to offer?
St. Charles 1860's Gem - Sleeps 6!: This holiday home rental outside of Defiance is located on a river, and has a garden, a selection of books and air conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Offers an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station, Enterprise Center and Busch Stadium. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at Matson Hill Park Trailhead, August A. Busch Memorial Conservation Area and Missouri River. A couple of additional sights to add to your itinerary are Chandler Hill Vineyards and Historic Daniel Boone Home and Heritage Center. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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