A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

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20 Aug - 21 Aug
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21 Aug - 22 Aug
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Our top choices for Defiance hotels

A hotel room with a bed, a sofa, a coffee table, and wall art.
A restaurant with wooden tables and chairs, a blue wall with white floral patterns, and a counter with a coffee machine.
A hotel lobby with a reception desk, seating area, and a large potted plant.
A Sleep Inn & Suites hotel with a modern brick facade, a covered entrance, and a parking lot.

1. Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
O'Fallon
United States
Josh
NZ$156
includes taxes & fees
23 Aug - 24 Aug
Sleep Inn & Suites O'Fallon MO - Technology Drive
A multi-story hotel with a brick facade, multiple windows, and a well-lit entrance.
A buffet with labeled containers of omelets and other dishes.
A lobby with a curved seating area, a reception desk, and a large overhead light fixture.
A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

2. Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
O'Fallon
United States
David
NZ$200
includes taxes & fees
24 Aug - 25 Aug
Holiday Inn Express St. Louis West - O'Fallon by IHG
An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.
A modern kitchen with wooden cabinets, a stainless steel countertop, and various appliances including a coffee maker and a rice cooker.
A hotel room with a large bed, bedside lamps, a TV, a desk, and a bathroom.
A multi-story hotel with a brick facade, a covered outdoor seating area with a fire feature, and a sign indicating it is a Marriott property.

3. TownePlace Suites by Marriott St. Louis Chesterfield

TownePlace Suites by Marriott St. Louis Chesterfield
Chesterfield
United States
Cindy
NZ$253
includes taxes & fees
4 Sept - 5 Sept
TownePlace Suites by Marriott St. Louis Chesterfield
A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.
A spacious living area with a staircase, a large painting, and a chandelier.
A modern bathroom with a large mirror, white vanity, and a bathtub.
A formal dining table set for six with a vase of white flowers, candles, and a view of buildings through large windows.

4. The Wildwood Hotel

The Wildwood Hotel
Wildwood
United States
Hailey
NZ$158
includes taxes & fees
1 Sept - 2 Sept
The Wildwood Hotel
A hotel room with two beds, a desk, a chair, a TV, and a large window.
A spacious lobby with a blue sofa set, a reception desk, and a modern chandelier.
A brick building with a sign reading "Comfort Inn & Suites."
A hotel with a central courtyard, a fountain, and a parking lot with several cars.

5. Comfort Inn & Suites Chesterfield - St. Louis

Comfort Inn & Suites Chesterfield - St. Louis
Chesterfield
United States
Jessica
NZ$171
includes taxes & fees
30 Aug - 31 Aug
Comfort Inn & Suites Chesterfield - St. Louis
A hotel entrance with a covered patio, stone pillars, and a wooden bench.
A buffet area with a variety of fruits and dairy products.
A hotel pool area with a rectangular pool, lounge chairs, and a wooden bench.

6. Staybridge Suites O'Fallon Chesterfield by IHG

Staybridge Suites O'Fallon Chesterfield by IHG
O'Fallon
United States
Norman
NZ$221
includes taxes & fees
31 Aug - 1 Sept
Staybridge Suites O'Fallon Chesterfield by IHG
An outdoor patio area with wicker furniture and a central fire feature.
A hotel room with a bed, a sofa, a desk, and a chair.
A modern hotel lobby with a bar area, seating arrangements, and a reception desk.
A Courtyard Marriott hotel with a parking lot and a green shuttle service.

7. Courtyard by Marriott St. Louis Chesterfield

Courtyard by Marriott St. Louis Chesterfield
Chesterfield
United States
Kelly
NZ$215
includes taxes & fees
29 Aug - 30 Aug
Courtyard by Marriott St. Louis Chesterfield
A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.
A shop with a variety of snacks and beverages, including a refrigerated section with drinks and a display of packaged snacks.
A hotel with a covered entrance, multiple flags, and a well-maintained lawn.
A spacious lobby with a sofa, a coffee station, and a reception desk.

8. Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO
O'Fallon
United States
Kassie
NZ$276
includes taxes & fees
31 Aug - 1 Sept
Hilton Garden Inn St. Louis/O'Fallon MO
A spacious lobby with a stone fireplace, seating area, and a bar with high stools.
A multi-story hotel with a central entrance, large windows, and a well-maintained lawn.
A modern living room with a fireplace, a flat-screen TV, a sofa, a coffee table, and a dining area.
A hotel lobby with a seating area featuring two armchairs, a round coffee table, and a flat-screen TV mounted on a wooden wall.

9. Residence Inn by Marriott O'Fallon

Residence Inn by Marriott O'Fallon
O'Fallon
United States
Gerald
NZ$260
includes taxes & fees
7 Sept - 8 Sept
Residence Inn by Marriott O'Fallon
An indoor swimming pool with lounge chairs, a children's play area, and a restaurant.
A hotel room with a large bed, a desk, a TV, and a view of a pool through the glass door.
A building with a prominent triangular roof and a chimney.
A grand lobby with a stone fireplace, a wooden staircase, and a seating area with sofas and a coffee table.

10. Holiday Inn St. Louis West Six Flags by IHG

Holiday Inn St. Louis West Six Flags by IHG
Eureka
United States
Rob
NZ$186
includes taxes & fees
21 Sept - 22 Sept
Holiday Inn St. Louis West Six Flags by IHG
A hotel room with a bed, two bedside lamps, a chair, a desk with a telephone, and a large cityscape poster on the wall.
A diner-style restaurant with a counter, chairs, a coffee machine, and a wall poster.
A swimming pool with a tiled deck, safety chairs, and a lifeguard sign.
A two-story building with a red roof and white siding, featuring a covered entrance and a small parking area.

11. Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area
O'Fallon
United States
Shelly
NZ$132
includes taxes & fees
31 Aug - 1 Sept
Super 8 by Wyndham O'Fallon MO/St. Louis Area
A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.
An outdoor patio with tables and chairs, a brick building, and a white fence.
A hotel room with two beds, a blue sofa, a lamp, and abstract art on the walls.
A building entrance with glass doors, stone accents, and potted plants.

12. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
Chesterfield
United States
NEBAHAT
NZ$223
includes taxes & fees
20 Sept - 21 Sept
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.
A swimming pool with tiled edges and a hot tub area, surrounded by windows and chairs.
A hotel room with a dining area, a fireplace, and a view of the outdoors.
An outdoor patio with a beige sofa set, two armchairs, and a table.

13. Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
Washington
United States
Michael Macumber
NZ$247
includes taxes & fees
23 Aug - 24 Aug
Best Western Plus Washington Hotel
A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.
A store interior with a 'Treats' sign, snack shelves, and a chalkboard with a welcome message.
A modern hotel room with a large window, a desk with a flat-screen TV, a comfortable seating area, and a decorative wall piece.
A reception desk with a "WELCOME TO THE SHOW ME STATE" sign, a wooden counter, and a Hilton Honors sign.

14. Hampton Inn & Suites St. Louis/Chesterfield

Hampton Inn & Suites St. Louis/Chesterfield
Chesterfield
United States
Karen E
NZ$215
includes taxes & fees
20 Sept - 21 Sept
Hampton Inn & Suites St. Louis/Chesterfield
An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.
A modern hotel room with a grey sofa, a wooden coffee table, a flat-screen TV, a wooden dresser, and a large window with curtains.
A hotel room with two beds, a desk with a TV, a chair, and a lamp.
A modern dining area with yellow and blue chairs, a flat-screen TV, and a kitchen area with appliances.

15. Comfort Inn Near Six Flags St. Louis

Comfort Inn Near Six Flags St. Louis
Pacific
United States
David
NZ$180
includes taxes & fees
20 Sept - 21 Sept
Comfort Inn Near Six Flags St. Louis
A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.
A lobby with a checkered carpet, a marble coffee table, two armchairs with patterned cushions, a sofa, and a dining table with chairs.
A hotel room with a bathroom, a bed, a nightstand, and a window.
An indoor swimming pool with stone flooring, white walls, and a green stripe. There are chairs and a door with a sign.

16. Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
Pacific
United States
Diane
NZ$181
includes taxes & fees
20 Sept - 21 Sept
Quality Inn Near Six Flags St. Louis
A multi-story hotel with a stone facade and a covered entrance.
A compact living space with a kitchenette, a dining area, and a workspace.
A modern living room with a blue accent wall, a gray sofa, a dining table with chairs, and a coffee table.
A compact hotel room with two beds, a desk with a chair, a television, a microwave, and a refrigerator.

17. WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
St. Peters
United States
Ellen
NZ$172
includes taxes & fees
1 Sept - 2 Sept
WoodSpring Suites St Peters-OFallon
A spacious lobby with a central round table, two sofas, and a chandelier.
A hotel room with two beds, a patterned wall, and a view of the city through sheer curtains.
An indoor swimming pool area with clear signage indicating a depth of 3 feet and a no diving warning.
A Drury Plaza hotel with a modern design, featuring a curved facade, large windows, and a Drury Plaza sign on the top.

18. Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
Chesterfield
United States
Andrea T
NZ$254
includes taxes & fees
7 Sept - 8 Sept
Drury Plaza Hotel St. Louis Chesterfield
A spacious lobby with a high ceiling, a dining area, and a seating area with sofas and a coffee table.
An indoor swimming pool with clear blue water, a tiled floor, and a ceiling with square vents.
A spacious lobby with a blue sofa, round coffee table, and blue chairs. There is a reception desk and a seating area with a high ceiling and large windows.
An outdoor patio area with a table and chairs, a glass door entrance, and a visible interior with a dining area.

19. Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
St. Peters
United States
Melanie
NZ$213
includes taxes & fees
30 Aug - 31 Aug
Drury Inn & Suites St. Louis St. Peters
A modern living room with a stone fireplace, a large window, and a seating area with a coffee table.
An outdoor patio with tables and chairs, umbrellas, and a brick building in the background.
An indoor swimming pool with clear glass walls, lounge chairs, and a tiled deck.
A Fairfield Inn & Suites hotel with a modern design, featuring a covered entrance, multiple floors, and a parking lot.

20. Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville
Wentzville
United States
Amanda
NZ$255
includes taxes & fees
27 Aug - 28 Aug
Fairfield Inn & Suites Wentzville
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Stay near popular Defiance attractions

A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)
This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.
See properties
A glass of red wine on a wooden table with a vineyard in the background.
Photo by Pages of Travel

Chandler Hill Vineyards

7.8/10 (7 reviews)
This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
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Historic Daniel Boone Home and Heritage Center

9.6/10 (4 reviews)
Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life.
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Sugar Creek Winery

8.0/10 (1 review)
Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views.
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Yellow Farmhouse Winery

This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views.
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Matson Hill Park Trailhead

Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendour.
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Broemmelsiek Park

This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience.
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Hamburg Trail Trailhead

This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields.
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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Top Defiance Hotel Reviews

Recent Reviews in Defiance

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

10/10 Excellent
"?"
Bill 1-night trip
Posted 4 hours ago
Drury Plaza Hotel St. Louis Chesterfield
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

10/10 Excellent
"Room was a great size for the money. Hotel was clean and quiet and easy to access from the garage. Great pool as well."
Stephanie 2-night trip
Posted 10 hours ago
Ameristar Casino Resort and Spa
Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis

10/10 Excellent
"Nice new hotel"
Dmitrii 1-night trip
Posted 14 hours ago
Drury Inn & Suites Southwest St. Louis
The Wildwood Hotel

The Wildwood Hotel

10/10 Excellent
"This was a very nice property and had a great area for our dogs. The front desk lady was very nice and there were treats for our dogs. We will definitely stay here again when in the St. Louis area. The room was clean and decorated nicely. Two thumbs up!!"
Jack 1-night trip
Posted 16 hours ago
The Wildwood Hotel
Hilton St. Louis Frontenac

Hilton St. Louis Frontenac

10/10 Excellent
"Easy check in. Clean room. Excellent food"
Kelly 1-night trip
Posted 2 days ago
Hilton St. Louis Frontenac
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

10/10 Excellent
"Perfect place"
Adam 1-night trip
Posted 4 days ago
Hampton Inn St. Charles St. Peters
Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

10/10 Excellent
"There was plenty of parking, AC worked like a dream, the beds were super comfy, and the staff was so kind, patient, and helpful. The only thing we were sad about was the pool. It wasn't dirty, it just looked a little too green and we don't know why. We didn't ask or press the issue because honestly we were out of the hotel for most of the time we were there. It may have been perfectly fine. We saw someone else getting ready to get into it. We were going to be checking in really late and they accommodated us. We got down to breakfast late one day, and they patiently waited for us to finish. We stayed for two nights. We had one bedroom with two queen size beds and it did not feel like the four of us were on top of each other, there was so much space! Overall good experience!!"
Felicia 2-night trip
Posted 8 days ago
Days Inn and Suites by Wyndham St. Louis/Westport Plaza

More cheap accommodation in Defiance

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

1970 Craig Rd Maryland Heights MO
NZ$133
23 Aug - 24 Aug
includes taxes & fees
4.4/10 (1,004 reviews)
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

1147 Technology Drive O'Fallon MO
NZ$156
23 Aug - 24 Aug
includes taxes & fees
Sleep Inn & Suites O'Fallon MO - Technology Drive
Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport

12220 Dorsett Rd Maryland Heights MO
NZ$181
6 Sept - 7 Sept
includes taxes & fees
8/10 Very good! (1,091 reviews)
Best Western Plus St. Louis West-Westport
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO
NZ$189
30 Aug - 31 Aug
includes taxes & fees
Hampton Inn St. Charles St. Peters
Best Western Plus Fenton

Best Western Plus Fenton

1680 Fenton Business Park Ct Fenton MO
NZ$193
21 Sept - 22 Sept
includes taxes & fees
9/10 Wonderful! (437 reviews)
Best Western Plus Fenton
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

11 Arnage Boulevard Chesterfield MO
NZ$223
20 Sept - 21 Sept
includes taxes & fees
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Frequently asked questions

What is the best area to stay in Defiance?
The best area to stay in Defiance is directly within the village centre, particularly near the intersection of Highway F and Femme Osage Creek Road.This area is the heart of Defiance, offering a collection of local businesses, dining options, and access to the Katy Trail. It's a small, walkable village with a relaxed pace, surrounded by scenic vineyards and rolling hills. The historic Defiance Roadhouse is a popular landmark here.For couples looking for a romantic getaway, the village centre is ideal. You'll find boutique accommodation options, often with a focus on local wines and cuisine. It's great for enjoying leisurely meals, exploring the nearby wineries, and taking peaceful walks along the Katy Trail.Solo travellers seeking a peaceful retreat and outdoor activities will also find the village centre appealing.
When is the best time to go to Defiance?
The best times to go to Defiance are during the spring (late April to early June) and autumn (September to October) when the weather is pleasant and the natural beauty of the area is at its peak.Spring offers mild temperatures, making it ideal for outdoor activities like cycling and hiking along the Katy Trail. The vineyards begin to bud, and the countryside is lush and green. This period is particularly good for couples who enjoy scenic walks and wine tasting without the summer crowds.Autumn brings cooler, crisp air and the stunning transformation of the leaves, creating a picturesque backdrop for exploring the region. Many local wineries also host harvest festivals during this time. For those who appreciate outdoor beauty and a relaxed pace, this season provides an excellent experience.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, although it depends on the cancellation policy of your booking. Most bookings are refundable if cancelled within 24 to 48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to 'My Trips' and selecting your reservation. To find flexible deals, filter your search by 'Fully refundable property' for hotels in Defiance.
How can I save on a hotel booking in Defiance with Expedia?
One Key™—Expedia's free travel rewards program—gives you instant access to discounts with Member Prices on Defiance hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
How much is the nightly rate for a hotel in Defiance?
Prices for hotels in Defiance often vary, but you can find a great deal from NZ$132 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by 'Price: low to high' for our cheapest rates.

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