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Check prices for these dates

This weekend
22 May - 24 May
Next weekend
29 May - 31 May

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Our top choices for Defiance hotels

Lobby

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very good, (998 reviews)
"Great breakfast, clean room..."
United States
George
The price is NZ$162
includes taxes & fees
14 June - 15 June
Quality Inn Foristell
Indoor pool

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.6 out of 10, Good, (1,002 reviews)
"Excellent place to stay!"
United States
Steven
The price is NZ$144
includes taxes & fees
3 June - 4 June
Baymont by Wyndham Warrenton
Reception

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
7.8 out of 10, Good, (1,291 reviews)
"Would stay here again."
United States
Randy
The price is NZ$195
includes taxes & fees
26 May - 27 May
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Exterior

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
8.8 out of 10, Excellent, (122 reviews)
"Overall a good stay. Would stay there again."
United States
Roxanne
The price is NZ$148
includes taxes & fees
8 June - 9 June
WoodSpring Suites St Peters-OFallon
Premium bedding, desk, iron/ironing board, free WiFi

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,006 reviews)
"Everything was excellent, location amenities, food.."
United States
FERNANDO
The price is NZ$163
includes taxes & fees
25 May - 26 May
Sleep Inn & Suites O'Fallon MO - Technology Drive
Room, 2 Queen Beds, Non Smoking

Super 8 by Wyndham Washington

Super 8 by Wyndham Washington
2.0 star property
Washington
8.4 out of 10, Very good, (729 reviews)
"This was a very good place to stay with our dogs. Clean, comfortable, accessible, with friendly staff."
United States
Lisa
The price is NZ$167
includes taxes & fees
3 June - 4 June
Super 8 by Wyndham Washington
Property entrance

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,645 reviews)
"Great place to stay, met my needs. "
United States
kathy
The price is NZ$164
includes taxes & fees
25 May - 26 May
The Wildwood Hotel
Exterior

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very good, (1,002 reviews)
"Good nice place"
United States
Cathy
The price is NZ$193
includes taxes & fees
31 May - 1 June
Comfort Suites St Charles - St Louis
Lobby

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
Valley Park
9.6 out of 10, Exceptional, (1,031 reviews)
"Excellent breakfast and pet friendly is a huge plus "
United States
Elleigh
The price is NZ$257
includes taxes & fees
14 June - 15 June
Drury Inn & Suites Southwest St. Louis
Room, 2 Queen Beds, Non Smoking

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1,228 reviews)
"Lots of food choices and gas stations near by also very easy highway access"
United States
Daquana
The price is NZ$167
includes taxes & fees
25 May - 26 May
Wingate by Wyndham St. Louis/Fenton Route 66
Free daily buffet breakfast

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (298 reviews)
"Staff and breakfast were amazing!"
United States
Shilo
The price is NZ$195
includes taxes & fees
26 May - 27 May
Best Western Plus Fenton
Lobby

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (686 reviews)
"Very clean and staff were friendly. Breakfast was good and will definitely stay here again. "
United States
Rod
The price is NZ$250
includes taxes & fees
26 May - 27 May
Best Western Plus Washington Hotel
Exterior

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (913 reviews)
"Very nice place to stay. Staff was super friendly. Clean, nice breakfast. "
United States
Patty
The price is NZ$274
includes taxes & fees
24 May - 25 May
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Lobby

Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (380 reviews)
"Great last minute booking when we needed to get off the road after a long day."
United States
Brent
The price is NZ$202
includes taxes & fees
25 May - 26 May
Quality Inn Near Six Flags St. Louis
Indoor pool

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,000 reviews)
"Friendly staff. Comfy bed. Good breakfast. "
United States
Melanie
The price is NZ$208
includes taxes & fees
31 May - 1 June
Hampton Inn St. Charles St. Peters
Premium bedding, desk, iron/ironing board, free cots/infant beds

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
St. Charles
8.0 out of 10, Very good, (1,000 reviews)
"Only needed a place to stay for the night and this was the perfect place. Very convenient from everywhere we wanted to go with a clean and comfortable room!"
United States
Kenzie
The price is NZ$157
includes taxes & fees
31 May - 1 June
Super 8 by Wyndham St Charles
Lobby lounge

Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville
3.0 star property
Wentzville
9.0 out of 10, Wonderful, (674 reviews)
"Property was nice, easy check-in, nice breakfast, room was clean."
United States
Doris
The price is NZ$258
includes taxes & fees
7 June - 8 June
Fairfield Inn & Suites Wentzville
43-inch LED TV with digital channels, TV

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1,000 reviews)
"Quiet and wood's surroundings nice place"
United States
Matthew
The price is NZ$167
includes taxes & fees
9 June - 10 June
Comfort Inn & Suites St. Louis - O'Fallon
Lobby

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,003 reviews)
"Great location and clean hotel!"
United States
Admir
The price is NZ$216
includes taxes & fees
31 May - 1 June
Drury Inn & Suites St. Louis St. Peters
Reception

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (704 reviews)
"Good location, clean and friendly staff. "
United States
Michelle
The price is NZ$263
includes taxes & fees
7 June - 8 June
Hampton Inn St. Louis Wentzville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

3.9/5 (7 reviews)
This elegant Missouri winery showcases local and California wines from its hillside setting. Savour varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
See properties

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

10/10 Excellent
"Complimentary breakfast, dinner and drink options were very nice."
Adam 3-night trip
Posted 6 hours ago
Drury Plaza Hotel St. Louis Chesterfield

More cheap accommodation in Defiance

Motel 6 Maryland Heights, MO

Motel 6 Maryland Heights, MO

12330 Dorsett Rd Maryland Heights MO
The price is NZ$118 per night from 24 May to 25 May
NZ$118
24 May - 25 May
includes taxes & fees
6.2/10 (1,000 reviews)

Frequently asked questions

What's the best place to stay in Defiance?
Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and The Wildwood Hotel. See all available top hotels, or vacation rentals in Defiance.
What are some of the best holiday rentals that Defiance has to offer?
🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟: This holiday home rental outside of Defiance offers a patio, a garden and air conditioning to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
What are some accommodation options with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Offers an indoor pool, an outdoor pool and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels with an on-site pool. View all hotels with pools in Defiance.
How is it staying in Defiance?
Visitors can enjoy all that Defiance has to offer, including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium and Gateway Arch. In Defiance, there are 19 hotels and other accommodation options to choose from. Find out more about Defiance.
What should I do while I'm visiting Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River and Matson Hill Park Trailhead. A couple of additional sights to add to your itinerary are Chandler Hill Vineyards and Sugar Creek Winery. Take a look at what more there is to see and do in Expedia's Defiance guide.
What's the weather like in Defiance?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

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