Defiance Holiday Rentals

    calendar shield illustration
    Change your mind
    Book hotels with free cancellation
    deals illustration
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    bed illustration
    Be picky
    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Holiday Rentals in Defiance

Lots of Space! Central to St Charles and STL. Newly Remodeled. Large Backyard!

8.6 out of 10, Excellent, (23)
"This was a great experience. Communication was great and I felt safe to have my family there for a small get together. I really appreciate the experience!!"
Lots of Space! Central to St Charles and STL. Newly Remodeled. Large Backyard!

AK's STL Pearl Grey House - Game Room

9.0 out of 10, Wonderful, (4)
"Quiet neighborhood, comfortable house, well-stocked kitchen. We would stay here again."
The price is NZ$783
includes taxes & fees
8 July - 9 July
AK's STL Pearl Grey House - Game Room

Huge yard - 10 min walk to shops & restaurants

The price is NZ$846
includes taxes & fees
6 July - 7 July
Huge yard - 10 min walk to shops & restaurants

Charming 3-bedroom house with AC, WiFi in amazing St. Louis

9.0 out of 10, Wonderful, (2)
"Clean and comfortable property close to everywhere we needed to go while there. "
The price is NZ$785
includes taxes & fees
26 June - 27 June
Charming 3-bedroom house with AC, WiFi in amazing St. Louis

Cozy & Safe - 6 beds - mins from shopping &stores

9.4 out of 10, Exceptional, (25)
"House was clean, beds were nice. Close to everything yet far enough away to be from the craziness that can happen close to a big city. "
The price is NZ$618
includes taxes & fees
8 July - 9 July
Cozy & Safe - 6 beds - mins from shopping &stores

Maison Champignon by StayLage

The price is NZ$613
includes taxes & fees
8 July - 9 July
Maison Champignon by StayLage

Downtown St. Charles • Cozy Historic Home

9.8 out of 10, Exceptional, (9)
"It was in a great location, beds are comfortable, just overall very, very comfortable home"
The price is NZ$1,074
includes taxes & fees
30 June - 1 July
Downtown St. Charles • Cozy Historic Home

Adorable 2 Bedroom Home

10.0 out of 10, Exceptional, (9)
"Very nice and clean and nice location.Would definitely stay again!"
The price is NZ$494
includes taxes & fees
9 July - 10 July
Adorable 2 Bedroom Home

St. Charles, MO house with Private Patio

8.8 out of 10, Excellent, (15)
"Perfect spot for exploring the historic district or the Lindenwood campus. Easy parking. Charming older home."
The price is NZ$572
includes taxes & fees
7 July - 8 July
St. Charles, MO house with Private Patio

The Original Custom House!

9.8 out of 10, Exceptional, (29)
"Perfect little property to stay and visit Main Street! "
The price is NZ$648
includes taxes & fees
7 July - 8 July
The Original Custom House!

Fenton Oasis - private pool and garden

The price is NZ$545
includes taxes & fees
30 June - 1 July
Fenton Oasis - private pool and garden

St. Charles Victorian Gem | Steps to Main Street

9.8 out of 10, Exceptional, (15)
"The house was great. Comfortable, well-equipped, and very roomy."
The price is NZ$1,100
includes taxes & fees
30 June - 1 July
St. Charles Victorian Gem | Steps to Main Street

Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

9.6 out of 10, Exceptional, (42)
"My family and I had a wonderful time. The home was clean and just enough space for us all. Would definitely book again. "
The price is NZ$550
includes taxes & fees
29 June - 30 June
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

Stunning 1890's Home - Sleeps 8!

10.0 out of 10, Exceptional, (63)
"There was plenty of room to sit with friends in the living room/kitchen. Everything was clean. It was a nice convenient spot to stay! "
The price is NZ$672
includes taxes & fees
6 July - 7 July
Stunning 1890's Home - Sleeps 8!

St. Charles 1860's Gem - Sleeps 6!

9.8 out of 10, Exceptional, (102)
"Travel for work and like quiet neighborhoods with outside space and long hot bath before bedtime. This place had all of above plus antique house was awesome and beautifully furnished with comfy bed.A great stay!"
The price is NZ$405
includes taxes & fees
7 July - 8 July
St. Charles 1860's Gem - Sleeps 6!

Spacious 2 Bedroom Townhome by StayLage

8.0 out of 10, Very good, (5)
"2 bedroom w comfortable, king size beds. Lovely space very nicely decorated. But stairs are very steep, in from entry and up to second floor & we have some mobility issues."
The price is NZ$537
includes taxes & fees
8 July - 9 July
Spacious 2 Bedroom Townhome by StayLage

2 Bed Townhome w/ Backyard and Laundry by StayLage

8.8 out of 10, Excellent, (14)
"Overall, the location was perfect. There’s so much around that area so convenience was top notch! The owner was extremely accommodating and quick to respond! I would definitely stay at this location again!!"
The price is NZ$525
includes taxes & fees
7 July - 8 July
2 Bed Townhome w/ Backyard and Laundry by StayLage

Charming open 4bd and screen-in porch! Sleeps 10!

9.4 out of 10, Exceptional, (29)
"House and yard were great! Loved the location."
The price is NZ$830
includes taxes & fees
30 June - 1 July
Charming open 4bd and screen-in porch! Sleeps 10!

JUNE SALE,Cozy 2BR Chalet, W/ Hot Tub on 1.2 Private Acres!

6.0 out of 10, (1)
"The house was clean and cute but smaller than we expected. The 2nd bedroom was very small and while it technically could sleep two, with the bottom mattress pulled out, it just wasn't the best experience. The master bedroom was spacious and bed was comfortable."
The price is NZ$830
includes taxes & fees
7 July - 8 July
JUNE SALE,Cozy 2BR Chalet, W/ Hot Tub on 1.2 Private Acres!

Fragrance free - spacious Ranch -safe &quiet- 4 br 2 bath

9.6 out of 10, Exceptional, (21)
"This is a neat little property with all you need for a pleasant stay."
The price is NZ$606
includes taxes & fees
22 July - 23 July
Fragrance free - spacious Ranch -safe &quiet- 4 br 2 bath
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Frequently asked questions

Can I find holiday rentals in Defiance?

Yes, there are holiday rentals close to the most popular sights in Defiance, or you can select a more secluded option if you're looking for a relaxing stay. Defiance is known for its wineries and parks.

What are some of the best holiday rentals that Defiance has to offer?

St. Charles 1860's Gem - Sleeps 6!: This holiday home rental outside of Defiance is located on a river, and has a garden, a selection of books and air conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop.

How many holiday rentals will I find in Defiance?

With 4 Expedia holiday rentals, you're guaranteed to find just the right place for your Defiance stay.

What’s there to see and do in Defiance?

August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Yellow Farmhouse Winery and Chandler Hill Vineyards.

What’s a holiday rental in Defiance like?

Holiday rentals are private properties where you can stay for a few weeks, or just a few days, in Defiance. Holiday rentals feature amenities such as hot tubs, fire pits and patios so you'll have everything you want. If you're concerned about a sanitised environment, holiday rentals can offer a sense of security away from shared hotel lifts and lobbies bustling with people while still allowing you the enjoyment of travel. You'll also have more space in a holiday rental than in a traditional hotel, which makes a holiday rental an attractive option for families.