Photo by Meredith Breckner

Defiance Holiday Rentals

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Holiday Rentals in Defiance

The Lofts of North Main Street
9.6 out of 10, Exceptional, (90)
"Photos don't do it justice. This was the perfect place to stay for me and my family during my college graduation weekend. The accommodations are a perfect balance between chic, cozy, and modern. There was plenty of space for all 5 of us to spread out and relax. We never felt like we were crowded or had too little privacy. The upstairs loft is a neat spot to chill or to sleep, and in the living room/dining room/kitchen area we could visit while watching TV, eating, and cooking/cleaning in the...
The price is NZ$409
per night
5 Jun - 6 Jun
The Lofts of North Main Street
☆BackYard BBQ Hidden Gem☆Perfect Location~Groups /Pets Welcome
9.0 out of 10, Wonderful, (41)
"My friends had a good time on our weekend stay. The neighborhood and neighbors were really nice. The outdoor area was a bonus, we liked the patio and yard space for outdoor activities. The house had everything we needed and were even provided extra toiletries. My only complaint would be the sleeping arrangements, the pull out bed wasn’t comfortable but we doubled up on mattresses and it worked out fine."
☆BackYard BBQ Hidden Gem☆Perfect Location~Groups /Pets Welcome
Craigshire Suites
3.0 star property
7.0 out of 10, Good, (1110)
"Great customer service "
The price is NZ$494
per night
5 Jun - 6 Jun
Craigshire Suites
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Cozy Cottage, we're told it's heavenly!
10.0 out of 10, Exceptional, (150)
"The host goes the extra mile in making sure that everything is provided for! We enjoyed the experience."
Cozy Cottage, we're told it's heavenly!
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
10.0 out of 10, Exceptional, (185)
"We could walk to the riverfront, walking paths, shops and restaurants!"
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟
10.0 out of 10, Exceptional, (38)
"We enjoyed our stay and loved the close proximity to Main Street. The downstairs shower could use an upgrade but other than that the house was warm and cozy."
🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟
Residence on the Roundabout
9.6 out of 10, Exceptional, (106)
"Close to all St. Charles shopping. Close to St. Louis , the loop. We have stayed here twice . And will be back . Cute place for 4 adults or a family . Fenced yard , close to a park ."
Residence on the Roundabout
1790's Renovated Barn, Main Street St. Charles, Hot Tub in private backyard!
10.0 out of 10, Exceptional, (186)
"Forty family members gathered in the St. Louis area for my mom's 93rd birthday. Many of us were minutes away from each other along Main Street in St. Charles. It was a perfect location for us since we are all walkers and foodies. The Red Barn Guesthouse was a perfect fit for the 6 of us!"
1790's Renovated Barn, Main Street St. Charles, Hot Tub in private backyard!
Historic headquarters of city founder! Gated parking!
10.0 out of 10, Exceptional, (14)
"This historic home was perfect for our stay. Historic St. Charles is right out the front door. Very comfortable bed and two patios….. one in front and one in the back. We will be back."
Historic headquarters of city founder! Gated parking!
Charming Cottage on Main St. in Historic St. Charles! Jetted Tub, 2 Fireplaces!!
10.0 out of 10, Exceptional, (220)
"We felt like we stepped back in time staying in a small cottage in the cobblestone street of Old St Charles."
Charming Cottage on Main St. in Historic St. Charles! Jetted Tub, 2 Fireplaces!!
The St. Charles Guest House, lovely historic home, fun for families and groups
10.0 out of 10, Exceptional, (107)
"This house was perfect for our family to hang out and hit Main Street in St. Charles. The house itself has an updated kitchen and bathrooms and has enough space for a big family chill and watch movies or play video games. It is within walking distance of all the attractions on Main Street and if you are up to it, the Ameristar casino."
The St. Charles Guest House, lovely historic home, fun for families and groups
Cute spacious Ranch - very safe area - 4 BR 2B- big fenced yard -1800 sft
9.6 out of 10, Exceptional, (7)
"Nice property. Excellent host. Very accommodating"
The price is NZ$507
per night
10 Jun - 11 Jun
Cute spacious Ranch - very safe area - 4 BR 2B- big fenced yard -1800 sft
Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort
10.0 out of 10, Exceptional, (52)
"So much outdoor lake fun. Hot tub, paddle boards, kayaks, fire pit, beach and multiple decks and seating areas. Lake life!"
The price is NZ$1,219
per night
24 Jun - 25 Jun
Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort
Escape the city to quiet and picturesque Golden Eagle, IL..
10.0 out of 10, Exceptional, (312)
"This was our second stay. We love the peacefulness and beauty of this area. The home was so comfortable! Such warm and generous hosts!"
Escape the city to quiet and picturesque Golden Eagle, IL..
1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo.
10.0 out of 10, Exceptional, (238)
"We loved theguesthouse it was such a nice place and clise to everything"
1870's Luxury Guest Cottage, Historic Downtown St. Charles, Mo.
Gorgeous Lakefront Getaway - Innsbrook Chalet with Outdoor Spa!
10.0 out of 10, Exceptional, (68)
"The house was in a remote quiet location on a pretty lake. Very very clean and well appointed. Wonderful firepit and firewood provided. But the second bedroom is actually a loft open to below! Very surprised as the listing called it a 2 bedroom! Overall a great house at Innsbrook!"
Gorgeous Lakefront Getaway - Innsbrook Chalet with Outdoor Spa!
Authentic Log cabin with something for everyone!
9.6 out of 10, Exceptional, (316)
"We liked the cabin and my grandkids like feeding the fish and playing in the water.There where just 2 things that bothered me.The black ants where bad and the kitchen oven was really dirty.Other than that we enjoyed our stay very much."
Authentic Log cabin with something for everyone!
Remodeled Kirkwood Guest house
10.0 out of 10, Exceptional, (56)
"Ryan was extremely helpful before checking in, during our stay and follow up afterwards. The apartment was clean, questions were answered promptly and we felt extremely comfortable. Location is a residential neighborhood, which adds to the feeling of coming home after enjoying all the city has to offer. Great restaurants nearby!"
Remodeled Kirkwood Guest house
Cowboy cabin, March availability, look for discounted weekly rates!
10.0 out of 10, Exceptional, (164)
"We love it here! We’ve been coming here for 10 years and the property and grounds have just grew and became more and more beautiful!"
Cowboy cabin, March availability, look for discounted weekly rates!
Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!
10.0 out of 10, Exceptional, (8)
"Refreshing retreat for our small church. Relaxing. Everything we needed was there. Open floor plan made time together better. The fireplace and views are amazing."
The price is NZ$1,688
per night
9 Jun - 10 Jun
Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!
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See all available properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other types of properties in Defiance you may be interested in

Hollywood Casino & Hotel St. Louis
3.5 star property
8.2 out of 10, Very good, (1219)
"Na"
The price is NZ$207
per night
17 Jun - 18 Jun
Hollywood Casino & Hotel St. Louis
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
2.5 star property
4.6 out of 10, (1013)
"Good"
The price is NZ$118
per night
5 Jun - 6 Jun
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
La Quinta Inn & Suites by Wyndham St. Louis Westport
2.5 star property
7.6 out of 10, Good, (1016)
"Room was just fine, had all the conveniences i look for - coffee maker, fridge, and microwave. Food nearby. Room was clean. Hotel was much better than i thought it would be after seeing some reviews. I thought it was pretty nice and i am picky. Though i forget to tell them the hairdryer didn't work."
The price is NZ$147
per night
23 Jun - 24 Jun
La Quinta Inn & Suites by Wyndham St. Louis Westport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

You always said you would go on a dream holiday someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannonball into the deep end. Go ahead, unplug and unwind in style. When you book one of our Defiance holiday rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your holiday just got upgraded.

As much as you love your vacation rental, it’s always good to get out and explore to soak up Defiance. Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in Defiance. Seeing all the best attractions is bound to make you fall in love with Defiance. Who knows, you may even be tempted to extend your stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true. 

It’s your escape so why share it? You deserve your own slice of paradise. Booking your holiday rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in Defiance short-term rentals, that won’t be hard to do.

Frequently asked questions

Can I find holiday rentals in Defiance?

Yes, we have holiday rentals where you'll be just 9.8 mi (15.8 km) from Six Flags St. Louis, giving you a more secluded option if you want peace and quiet. Defiance is known for its wineries and parks.

What are some of the best holiday rentals that Defiance has to offer?

The St. Charles Guest House, lovely historic home, fun for families and groups: This holiday home rental outside of Defiance is located on a river, and offers a fireplace, air conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family.

What’s there to see and do in Defiance?

Missouri River and August A. Busch Memorial Conservation Area are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Chandler Hill Vineyards and Sugar Creek Winery.

What’s a holiday rental in Defiance like?

Holiday rentals are private properties where you can stay for a few weeks, or just a few days, in Defiance. Holiday rentals feature amenities such as hot tubs, fire pits and patios so you'll have everything you want. If you're concerned about a sanitised environment, holiday rentals can offer a sense of security away from shared hotel lifts and lobbies bustling with people while still allowing you the enjoyment of travel. You'll also have more space in a holiday rental than in a traditional hotel, which makes a holiday rental an attractive option for families.

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