The best areas to stay in Biloxi are along Beach Boulevard (Highway 90) for direct beach access and close proximity to attractions, or in the downtown district for a more urban feel.Beach Boulevard is the main artery running along the Gulf Coast. Here, you'll find most of the larger resorts and hotels directly across from the beaches. It's a very convenient area for visitors who want to enjoy the sand and sea, with many dining options and entertainment venues within easy reach. The Biloxi Lighthouse is a prominent landmark along this stretch.For families, staying along Beach Boulevard is ideal. The hotels often feature large swimming pools and are just a short walk across the road to the calm waters of the Gulf. Many family-friendly restaurants are also scattered along this route, making it easy to find meals that suit everyone.Downtown Biloxi offers a different experience, with a focus on historic sites, local shops, and a growing culinary scene. It's a more walkable area with a mix of older buildings and newer developments. The Ohr-O'Keefe Museum of Art is a top cultural attraction here, and you'll find various local eateries and boutiques.Couples looking for a blend of history and good food might prefer downtown.