All hotels in Southern Illinois, Illinois
Plan, book, stay with confidence
Be picky
Search almost a million properties worldwide
Change your mind
Book hotels with free cancellation
All hotels in Southern Illinois, Illinois
We have found 994 Southern Illinois Hotels
- Giant City Lodge
- Traveler's Inn Motel
- Hampton Inn Mt. Vernon
- Hart Estate Bed and Breakfast
- Budget Inn Du Quoin
- Baymont by Wyndham Mattoon
- Econo Lodge
- Quality Inn Grayville, IL
- Hollywood Casino & Hotel St. Louis
- Drury Plaza Hotel St. Louis at the Arch
- Pear Tree Inn St. Louis Near Union Station
- Hampton Inn St. Louis-Downtown (At the Gateway Arch)
- Casino Queen Hotel
- Best Western St. Louis-Kirkwood Route 66
- Hilton St. Louis at the Ballpark
Let Expedia take you to the best Hotels in Southern Illinois. You'll find the largest selection of hotel deals, discount prices, and cheap hotel rates on reservations anywhere in the world. Expedia, the leader in world travel, gives you customer reviews, maps, and the best selection of hotels near landmarks and attractions.