Photo by Southernmost Illinois Tourism Bureau
Search Southern Illinois hotels
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Southern Illinois
Cabin
Pet friendly
Check prices for these dates
Our top choices for Southern Illinois hotels
Holiday Inn Express & Suites Effingham by IHG
Holiday Inn Express & Suites Effingham by IHGEffingham
9.4 out of 10, Exceptional, (1,003 reviews)
"Room was clean, staff was very pleasant, breakfast was delicious and plentiful and we were able to enjoy all amenities. "
Laura
The price is NZ$193
includes taxes & fees
28 Feb - 1 Mar
Drury Inn & Suites Marion
Drury Inn & Suites MarionMarion
9.4 out of 10, Exceptional, (1,006 reviews)
"All of the above, enjoyed the evening meal and breakfast, also staff was very friendly.
"
Barbara
The price is NZ$199
includes taxes & fees
13 Mar - 14 Mar
Drury Plaza Hotel Mt. Vernon
Drury Plaza Hotel Mt. VernonMount Vernon
9.6 out of 10, Exceptional, (1,662 reviews)
"Hotel is very clean, nicely furnished and the beds were so comfy!"
Christina
The price is NZ$214
includes taxes & fees
8 Mar - 9 Mar
La Quinta Inn & Suites by Wyndham Effingham
La Quinta Inn & Suites by Wyndham EffinghamEffingham
9.2 out of 10, Wonderful, (1,007 reviews)
"Staff was amazing and the brekfast was good too!"
Kevin
The price is NZ$182
includes taxes & fees
1 Mar - 2 Mar
Hampton Inn & Suites Effingham
Hampton Inn & Suites EffinghamEffingham
9.6 out of 10, Exceptional, (714 reviews)
"Very clean, nice hot breakfast, and kind staff. "
Erin
The price is NZ$256
includes taxes & fees
28 Feb - 1 Mar
Holiday Inn Effingham by IHG
Holiday Inn Effingham by IHGEffingham
9.0 out of 10, Wonderful, (663 reviews)
"Nice place with bar and restaurant on site."
Steve
The price is NZ$171
includes taxes & fees
28 Feb - 1 Mar
Country Hearth Inn & Suites Edwardsville St. Louis
Country Hearth Inn & Suites Edwardsville St. LouisEdwardsville
8.6 out of 10, Excellent, (669 reviews)
"Room was great,staff friendly! All together a great stay."
Zachary
The price is NZ$176
includes taxes & fees
25 Feb - 26 Feb
Best Western U. S. Inn
Best Western U. S. InnNashville
8.6 out of 10, Excellent, (402 reviews)
"Good staff "
Jose Diego
The price is NZ$160
includes taxes & fees
27 Feb - 28 Feb
The Principal Hotel
The Principal HotelColumbia
9.8 out of 10, Exceptional, (206 reviews)
"Great stay and very clean!"
David
The price is NZ$193
includes taxes & fees
3 Mar - 4 Mar
Comfort Suites Mount Vernon
Comfort Suites Mount VernonMount Vernon
9.0 out of 10, Wonderful, (1,008 reviews)
"Very clean and safe stay!"
Dale
The price is NZ$206
includes taxes & fees
8 Mar - 9 Mar
Holiday Inn Express & Suites Mount Vernon by IHG
Holiday Inn Express & Suites Mount Vernon by IHGMount Vernon
9.0 out of 10, Wonderful, (1,001 reviews)
"Breakfast very good staff excellent room clean and comfortable "
Scott
The price is NZ$188
includes taxes & fees
15 Mar - 16 Mar
Country Inn & Suites by Radisson, Effingham, IL
Country Inn & Suites by Radisson, Effingham, ILEffingham
8.8 out of 10, Excellent, (1,002 reviews)
"Clean, friendly staff and good breakfast. Location is excellent. "
Maria
The price is NZ$166
includes taxes & fees
22 Mar - 23 Mar
Home2 Suites By Hilton Effingham
Home2 Suites By Hilton EffinghamEffingham
9.8 out of 10, Exceptional, (38 reviews)
"Very kind staff, very clean, very pleased. "
Erin
The price is NZ$258
includes taxes & fees
28 Feb - 1 Mar
SureStay Hotel by Best Western Whittington Rend Lake
SureStay Hotel by Best Western Whittington Rend LakeWhittington
8.8 out of 10, Excellent, (933 reviews)
"Great place to stay."
Stephen
The price is NZ$142
includes taxes & fees
2 Mar - 3 Mar
Laketree Inn And Suites Marion
Laketree Inn And Suites MarionMarion
8.0 out of 10, Very good, (180 reviews)
"This is a hidden gem. I can’t say enough good things. Peaceful, clean, very nice owners. "
Amy
The price is NZ$126
includes taxes & fees
3 Mar - 4 Mar
Holiday Inn Carbondale-Conference Center by IHG
Holiday Inn Carbondale-Conference Center by IHGCarbondale
8.8 out of 10, Excellent, (657 reviews)
"nice stay! "
James
The price is NZ$199
includes taxes & fees
26 Feb - 27 Feb
Best Western Plus MidAmerica Hotel
Best Western Plus MidAmerica HotelMascoutah
9.0 out of 10, Wonderful, (1,003 reviews)
"Very clean room, friendly staff and wonderful hot breakfast! This was our third stay, Highly recommend!!!!"
Amber
The price is NZ$190
includes taxes & fees
25 Feb - 26 Feb
Best Western Delta Inn
Best Western Delta InnEffingham
9.2 out of 10, Wonderful, (1,011 reviews)
"Staff very friendly!"
C. Mark
The price is NZ$159
includes taxes & fees
1 Mar - 2 Mar
Clarion Pointe Mattoon near University
Clarion Pointe Mattoon near UniversityMattoon
8.4 out of 10, Very good, (878 reviews)
"The staff provided really good service and room was really clean."
YESENIA
The price is NZ$166
includes taxes & fees
7 Mar - 8 Mar
Holiday Inn Express Metropolis by IHG
Holiday Inn Express Metropolis by IHGMetropolis
8.6 out of 10, Excellent, (1,003 reviews)
"Clean - updated room
Breakfast was excellent "
Lee
The price is NZ$177
includes taxes & fees
26 Feb - 27 Feb
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southern Illinois
Cottage
Pet-friendly Home w/ Fenced Yard: 'cozy in Casey'
Pet-friendly Home w/ Fenced Yard: 'cozy in Casey'Casey
10.0 out of 10, Exceptional, (1 review)
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Southern Illinois attractions
Learn more about Southern Illinois
Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.
Photo by Southernmost Illinois Tourism Bureau
Open Photo by Southernmost Illinois Tourism Bureau
Top Southern Illinois Hotel Reviews
More cheap accommodation in Southern Illinois
Super 8 by Wyndham O'Fallon
1100 Eastgate Dr O'Fallon IL
The price is NZ$97 per night from 3 Mar to 4 Mar
NZ$97
3 Mar - 4 Mar
includes taxes & fees
7/10 Good! (1,000 reviews)
Explore a world of travel with Expedia
- Cheap Hotels in Grayville
- Spa Hotels in Carbondale
- Luxury Hotels in Marion
- Luxury Hotels in Southeast Illinois
- Pet Friendly Hotels in Mount Vernon
- Hilton Hotels in Whittington
- Marriott Hotels & Resorts in Carterville
- Dix Hotels
- Marion County Hotels
- Christopher Hotels
- Flora Hotels
- Sims Hotels
- Odin Hotels
- Cisne Hotels
- Tamaroa Hotels
- Centralia Hotels
- Bonnie Hotels
- Elkville Hotels
- Carlyle Hotels
- Ina Hotels
- Johnston City Hotels
- Belle Rive Hotels
- Nashville Hotels
- Enfield Hotels
- Benton Hotels
- Galatia Hotels
- Buckner Hotels
- Hotels near Bell Tower Park
- Whittington Hotels
- Sesser Hotels
- Mount Vernon Hotels
- Fairfield Hotels
- West Frankfort Hotels
- Patoka Hotels
- Herrin Hotels
- Du Quoin Hotels
- Hoyleton Hotels
- Farmstay in Southeast Illinois
- Caravan Parks in Du Quoin
- Motels in Southern Illinois
- Cabin Rentals in Southern Illinois
- Resort in Southern Illinois
- Motels in Sparta
- Lodges in Pomona
- Apartments in Ava
- Motels in Dix
- Cabin Rentals in Wolf Creek
- Cottages in Cobden
- Motels in Marion
- Cabin Rentals in Benton
- Bremen Holidays
- Ferne Clyffe State Park
- Herald Holidays
- William Jennings Bryan Boyhood Home and Museum
- Walsh Holidays
- Pomona Winery
- Herrin Holidays
- Carmi Holidays
- Sih Medical Group
- Heartland Regional Medical Center
- Lake of Egypt
- Christopher Holidays
- Marissa Holidays
- Du Quoin Holidays
- Sparta Country Club
- King City Square Shopping Center
- Ken Gray Presidential Hall of Fame
- Salem Fairgrounds
- Opdyke Holidays
- Visit West Frankfort
- Visit Ozark
- Visit Tunnel Hill
- Visit Makanda
- Visit Johnston City
- Visit Mount Vernon
- Visit West Salem
- Visit Goreville
- Visit Maunie
- Visit Sesser
- Visit Cisne
- Visit Herrin
- Visit Wertenberg
- Visit Wamac
- Pet-Friendly Holiday Packages Southeast Illinois
- Car hire in Avis Fort Lauderdale Cruiseport Shuttle-2520 Miami Rd
- Car hire Mount Vernon
- Car hire Carmi
- Hertz Rental Cars in Southern Illinois
- Global Rent a Car Rental Cars in Southern Illinois
- Dollar Rental Cars in Southern Illinois
- Enterprise Rental Cars in Benton
- Hertz Rental Cars in Southwest Illinois
