Photo by Southernmost Illinois Tourism Bureau
Search Southern Illinois hotels
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Southern Illinois
Check prices for these dates
Our top choices for Southern Illinois hotels
Drury Plaza Hotel Mt. Vernon
Drury Plaza Hotel Mt. VernonMount Vernon
9.6 out of 10, Exceptional, (1,691 reviews)
"Wonderful stay! Great hotel and convenient location off the highway. We loved the evening meal and happy hour."
Judy
The price is NZ$213
includes taxes & fees
14 June - 15 June
Holiday Inn Express & Suites Effingham by IHG
Holiday Inn Express & Suites Effingham by IHGEffingham
9.4 out of 10, Exceptional, (1,004 reviews)
"Breakfast was great!"
Carol
The price is NZ$253
includes taxes & fees
21 June - 22 June
Comfort Suites Mount Vernon
Comfort Suites Mount VernonMount Vernon
9.0 out of 10, Wonderful, (1,047 reviews)
"Great, place to stay."
Daniel
The price is NZ$217
includes taxes & fees
31 May - 1 June
Hampton Inn & Suites Effingham
Hampton Inn & Suites EffinghamEffingham
9.6 out of 10, Exceptional, (737 reviews)
"Great location, nice-dog friendly hotel. This is right off the freeway, has many places to eat nearby. We highly recommend trying The Firefly grill one block away
Everyone on staff was very nice."
Debra
The price is NZ$295
includes taxes & fees
31 May - 1 June
La Quinta Inn & Suites by Wyndham Effingham
La Quinta Inn & Suites by Wyndham EffinghamEffingham
9.2 out of 10, Wonderful, (1,004 reviews)
"Clean hotel, excellent staff, good breakfast"
Alexis
The price is NZ$228
includes taxes & fees
14 June - 15 June
Quality Inn Effingham North
Quality Inn Effingham NorthEffingham
8.4 out of 10, Very good, (1,003 reviews)
"staff was friendly, and the sausage and eggs were really good in the morning."
Jeffery
The price is NZ$172
includes taxes & fees
6 June - 7 June
Country Inn & Suites by Radisson, Effingham, IL
Country Inn & Suites by Radisson, Effingham, ILEffingham
8.8 out of 10, Excellent, (1,002 reviews)
"Great breakfast, easy access, close to shopping and dining."
Linda
The price is NZ$184
includes taxes & fees
31 May - 1 June
Baymont by Wyndham Effingham
Baymont by Wyndham EffinghamEffingham
8.2 out of 10, Very good, (1,010 reviews)
"Convenient location and great staff. Would stay again"
Janet
The price is NZ$153
includes taxes & fees
26 June - 27 June
Best Western Plus MidAmerica Hotel
Best Western Plus MidAmerica HotelMascoutah
9.0 out of 10, Wonderful, (1,003 reviews)
"Very satisfied with my stay, definitely would go back next time I’m in town"
Kevin
The price is NZ$221
includes taxes & fees
31 May - 1 June
Ramada by Wyndham Vandalia
Ramada by Wyndham VandaliaVandalia
7.8 out of 10, Good, (841 reviews)
"The room was nice and the staff was very helpful"
Tammy
The price is NZ$162
includes taxes & fees
31 May - 1 June
Quality Inn & Suites Vandalia near I-70 and Hwy 51
Quality Inn & Suites Vandalia near I-70 and Hwy 51Vandalia
8.4 out of 10, Very good, (1,010 reviews)
"Clean rooms and the staff was great"
GREGORY s
The price is NZ$132
includes taxes & fees
31 May - 1 June
Holiday Inn Express & Suites Mount Vernon by IHG
Holiday Inn Express & Suites Mount Vernon by IHGMount Vernon
9.0 out of 10, Wonderful, (1,009 reviews)
"Breakfast was really good and the staff were friendly!"
Todd
The price is NZ$220
includes taxes & fees
7 June - 8 June
Cobblestone Inn & Suites - Altamont
Cobblestone Inn & Suites - AltamontAltamont
9.6 out of 10, Exceptional, (863 reviews)
"Great place to stay"
Tonya
The price is NZ$166
includes taxes & fees
27 May - 28 May
Comfort Inn & Suites Marion I-57
Comfort Inn & Suites Marion I-57Marion
9.4 out of 10, Exceptional, (1,002 reviews)
"Welcoming, clean, and great breakfast. "
Kelly
The price is NZ$263
includes taxes & fees
31 May - 1 June
Holiday Inn Effingham by IHG
Holiday Inn Effingham by IHGEffingham
9.2 out of 10, Wonderful, (681 reviews)
"Nice, clean place to stay during a road trip!"
Renee
The price is NZ$201
includes taxes & fees
21 June - 22 June
Best Western Delta Inn
Best Western Delta InnEffingham
9.0 out of 10, Wonderful, (1,008 reviews)
"Nice quick stay"
Bri
The price is NZ$212
includes taxes & fees
14 June - 15 June
Drury Inn & Suites Marion
Drury Inn & Suites MarionMarion
9.4 out of 10, Exceptional, (1,006 reviews)
"Breakfast and eating area was excellent "
Susan
The price is NZ$243
includes taxes & fees
3 June - 4 June
Days Inn & Suites by Wyndham Casey
Days Inn & Suites by Wyndham CaseyCasey
7.6 out of 10, Good, (872 reviews)
"The staff was really nice"
Tressia
The price is NZ$135
includes taxes & fees
27 May - 28 May
SureStay Hotel by Best Western Whittington Rend Lake
SureStay Hotel by Best Western Whittington Rend LakeWhittington
8.8 out of 10, Excellent, (964 reviews)
"The property in conveniently located to Rend Lake State Park right off the interstate. I found the property clean and the staff attentive to your needs. "
Jim
The price is NZ$162
includes taxes & fees
3 June - 4 June
Ramada by Wyndham Effingham
Ramada by Wyndham EffinghamEffingham
7.4 out of 10, Good, (1,004 reviews)
"Good stay for a one night stay over a road trip."
Breno
The price is NZ$123
includes taxes & fees
6 June - 7 June
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Southern Illinois attractions
Learn more about Southern Illinois
Discover the culture and history of this region shaped by indigenous and pioneering communities and spend time in its peaceful, picturesque landscapes.
Photo by Southernmost Illinois Tourism Bureau
Open Photo by Southernmost Illinois Tourism Bureau
Top Southern Illinois Hotel Reviews
Quality Inn & Suites Metropolis I-24
2/10 Terrible
More cheap accommodation in Southern Illinois
Super 8 by Wyndham O'Fallon
1100 Eastgate Dr O'Fallon IL
The price is NZ$120 per night from 16 June to 17 June
NZ$120
16 June - 17 June
includes taxes & fees
6.8/10 (1,012 reviews)
Explore a world of travel with Expedia
- Cheap Hotels in Grayville
- Spa Hotels in Carbondale
- Luxury Hotels in Marion
- Luxury Hotels in Southeast Illinois
- Pet Friendly Hotels in Mount Vernon
- Hilton Hotels in Whittington
- Marriott Hotels & Resorts in Carterville
- Dix Hotels
- Marion County Hotels
- Christopher Hotels
- Flora Hotels
- Sims Hotels
- Odin Hotels
- Cisne Hotels
- Tamaroa Hotels
- Centralia Hotels
- Bonnie Hotels
- Elkville Hotels
- Carlyle Hotels
- Ina Hotels
- Johnston City Hotels
- Belle Rive Hotels
- Nashville Hotels
- Enfield Hotels
- Benton Hotels
- Galatia Hotels
- Buckner Hotels
- Hotels near Bell Tower Park
- Whittington Hotels
- Sesser Hotels
- Mount Vernon Hotels
- Fairfield Hotels
- West Frankfort Hotels
- Patoka Hotels
- Herrin Hotels
- Du Quoin Hotels
- Hoyleton Hotels
- Farmstay in Southeast Illinois
- Caravan Parks in Du Quoin
- Motels in Southern Illinois
- Cabin Rentals in Southern Illinois
- Resort in Southern Illinois
- Motels in Sparta
- Lodges in Pomona
- Apartments in Ava
- Motels in Dix
- Cabin Rentals in Wolf Creek
- Cottages in Cobden
- Motels in Marion
- Cabin Rentals in Benton
- Bremen Holidays
- Ferne Clyffe State Park
- Herald Holidays
- William Jennings Bryan Boyhood Home and Museum
- Walsh Holidays
- Pomona Winery
- Herrin Holidays
- Carmi Holidays
- Sih Medical Group
- Heartland Regional Medical Center
- Lake of Egypt
- Christopher Holidays
- Marissa Holidays
- Du Quoin Holidays
- Sparta Country Club
- King City Square Shopping Center
- Ken Gray Presidential Hall of Fame
- Salem Fairgrounds
- Opdyke Holidays
- Visit West Frankfort
- Visit Ozark
- Visit Tunnel Hill
- Visit Makanda
- Visit Johnston City
- Visit Mount Vernon
- Visit West Salem
- Visit Goreville
- Visit Maunie
- Visit Sesser
- Visit Cisne
- Visit Herrin
- Visit Wertenberg
- Visit Wamac
- Pet-Friendly Holiday Packages Southeast Illinois
- Car hire in Avis Fort Lauderdale Cruiseport Shuttle-2520 Miami Rd
- Car hire Mount Vernon
- Car hire Carmi
- Hertz Rental Cars in Southern Illinois
- Global Rent a Car Rental Cars in Southern Illinois
- Dollar Rental Cars in Southern Illinois
- Enterprise Rental Cars in Benton
- Hertz Rental Cars in Southwest Illinois
