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Top Romantic Southeast Missouri Hotels

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO

5 hours drive from Mark Twain National Forest

Stay at this apartment in Cape Girardeau. Enjoy free Wi-Fi, laundry facilities and patios. Popular attractions Riverfront Park and eDen Spa & Salon are located ...

10/10 Exceptional! (225 reviews)

Amazing place to stay at the Cape!

Reviewed on 12 Apr 2026

Echo Bluff State Park

34489 Echo Bluff Dr Eminence MO

43 min drive from Mark Twain National Forest

Stay at this business-friendly hotel in Eminence. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Popular attractions Echo Bluff State Park and Current ...

9.4/10 Exceptional! (246 reviews)

Would definitely book at Echo Bluff again. The cabins were spacious and very clean. The balcony was great for morning coffee and stargazing at night with views of the lodge and park. Staff was super friendly and we loved the restaurant as well.

Reviewed on 28 Apr 2026

See all 658 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.