Photo by JG Morris

Plan, book, travel with confidence
Better together
Save up to NZ$616 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Romantic Southeast Missouri Hotels

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau MO

5 hours drive from Mark Twain National Forest

Stay at this apartment in Cape Girardeau. Enjoy free Wi-Fi, a water park and laundry facilities. Popular attractions Riverfront Park and eDen Spa & Salon are ...

9.8/10 Exceptional! (173 reviews)

Great location, quality bedding and pillows, and other comfortable amenities for a short getaway in historic downtown Cape Girardeau. Excellent value!

Reviewed on 15 Dec 2025

Echo Bluff State Park

34489 Echo Bluff Dr Eminence MO

43 min drive from Mark Twain National Forest

Stay at this business-friendly hotel in Eminence. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Popular attractions Echo Bluff State Park and Current ...

9.4/10 Exceptional! (220 reviews)

This entire trip was inspired by Tina, a staff member. I met Tina passing through the area and she provided me with a lot of information which gave me the idea to plan a weekend trip with my wife. The lodge room we had was clean and comfortable, My wife and I had a wonderful time exploring most of ...

Reviewed on 19 Jan 2026

See all 623 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.